Variation in responses to incretin therapy: modifiable and non-modifiable factors

Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose regulation and weight loss. Glucagon-like peptide-1 (GLP-1) and glucose-stimulated insulinotropic polypeptide (GIP) are the incretin hormones that provide the foundations for these drugs. While these therapies have been highly effective for some, the results are variable. Incretin therapies target the class B G protein-coupled receptors GLP-1R and GIPR, expressed mainly in the pancreas and the hypothalamus, while some therapeutical approaches include additional targeting of the related glucagon receptor (GCGR) in the liver. The proper functioning of these receptors is crucial for incretin therapy success and here we review several mechanisms at the cellular and molecular level that influence an individual’s response to incretin therapy

Spectropolarimetry of the H-alpha line in Herbig Ae/Be stars

Using the HiVIS spectropolarimeter built for the Haleakala 3.7m AEOS telescope, we have obtained a large number of high precision spectropolarimetrc observations (284) of Herbig AeBe stars collected over 53 nights totaling more than 300 hours of observing. Our sample of five HAeBe stars: AB Aurigae, MWC480, MWC120, MWC158 and HD58647, all show systematic variations in the linear polarization amplitude and direction as a function of time and wavelength near the H-alpha line. In all our stars, the H-alpha line profiles show evidence of an intervening disk or outflowing wind, evidenced by strong emission with an absorptive component. The linear polarization varies by 0.2% to 1.5% with the change typically centered in the absorptive part of the line profile. These observations are inconsistent with a simple disk-scattering model or a depolarization model which produce polarization changes centered on the emmissive core. We speculate that polarized absorption via optical pumping of the intervening gas may be the cause.Comment: Accepted for publication in ApJ Letter

Patterns of antenal sensilla of Panstrongylus megistus from three Brazilian states

The objective of the present study was to analyze and describe the phenotype of the antennal sensilla of Panstrongylus megistus, one of the epidemiologically most important species of triatomines in Brazil. Specimens from the Brazilian states of Goiás (GO), Minas Gerais (MG), and Rio Grande do Sul (RS) were compared, based on studies of four types of sensilla on three antennal segments: thick-walled trichoid (TK), thin-walled trichoid (TH), bristles (BR), and basiconica (BA). Discriminant analysis allowed the separation of the RS specimens from those of GO and MG. Multivariate discriminant analysis demonstrated that the sensilla of males differed from those of females, the variables with greatest weight being the BA of all three segments and the TK of flagellum 1. The basiconica sensilla were significantly more abundant in females, on all three segments. Antennal sensilla patterns also demonstrated significant differences among P. megistus specimens.Fil: Villela, M. M.. Fundación Oswaldo Cruz; BrasilFil: Catala, Silvia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Universidad Nacional de Catamarca. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Secretaría de Industria y Minería. Servicio Geológico Minero Argentino. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja. - Provincia de La Rioja. Centro Regional de Investigaciones Científicas y Transferencia Tecnológica de La Rioja; ArgentinaFil: Juberg, J.. Instituto Oswaldo Cruz; Brasil. Fundación Oswaldo Cruz; BrasilFil: Silva, I. G.. Universidade Federal de Goiás; BrasilFil: Dias, J. C. P.. Fundación Oswaldo Cruz; Brasi

Engage D2.2 Final Communication and Dissemination Report

This deliverable reports on the communication and dissemination activities carried out by the Engage consortium over the duration of the network. Planned activities have been adapted due to the Covid-19 pandemic, however a full programme of workshops and summer schools has been organised. Support has been given to the annual SESAR Innovation Days conference and there has been an Engage presence at many other events. The Engage website launched in the first month of the network. This was later joined by the Engage ‘knowledge hub’, known as the EngageWiki, which hosts ATM research and knowledge. The wiki provides a platform and consolidated repository with novel user functionality, as well as an additional channel for the dissemination of SESAR results. Engage has also supported and publicised numerous research outputs produced by PhD candidates and catalyst fund projects

Engage D2.1 Communication plan, website, and visual identity material

The purpose of this document, Deliverable 2.1, is to describe the dissemination plan, dissemination policy and initial dissemination products of the SESAR 2020 Exploratory Research action Engage, taking into account its specifications and the target audience. The following pages document the corresponding tasks involved in D2.1

Engage D3.7 Update on the Engage repository and knowledge hub functionality (initial)

This initial report describes the planned functionality and features of the forthcoming Engage wiki and establishes the scope of the ATM concepts roadmap

Characterisation of the magnetic field of the Herbig Be star HD 200775

After our recent discovery of four magnetic Herbig stars, we have decided to study in detail one of them, HD 200775, to determine if its magnetic topology is similar to that of the main sequence magnetic stars. With this aim, we monitored this star in Stokes I and V over more than two years, using the new spectropolarimeters ESPaDOnS at CFHT, and Narval at TBL. Using our data, we find that HD 200775 is a double-lined spectroscopic binary system, whose secondary seems similar, in temperature, to the primary. We determine the luminosity ratio of the system, and using the luminosity of the system found in literature, we derive the luminosity of both stars. From our measurements of the radial velocities of both stars we determine the ephemeris and the orbital parameters of the system. We have fitted 30 Stokes V profiles simultaneously, using a chi2 minimisation method, with a decentered-dipole model. The best-fit model provides a rotation period of 4.3281 d an inclination angle of 60 degrees, and a magnetic obliquity angle of 125 degrees. The polar strength of the magnetic dipole field is 1000 G, which is decentered by 0.05 R* from the center of the star. The derived magnetic field model is qualitatively identical to those commonly observed in the Ap/Bp stars, which bring strong argument in favour of the fossil field hypothesis, to explain the origin of the magnetic fields in the main sequence Ap/Bp stars. Our determination of the inclination of the rotation axis leads to a radius of the primary which is smaller than that derived from the HR diagram position. This can be explained by a larger intrinsic luminosity of the secondary relative to the primary, due to a larger circumstellar extinction of the secondary relative to the primary.Comment: Accepted for publication in MNRAS, 14 pages, 10 figure

Engage D5.3 Postgraduate research and events database (initial version)

This document describes the methodology applied to the design and population of the initial version of the postgraduate research and events database. The database contains information on European and international conferences, workshops, summer schools, training courses and other relevant events. Please note that a later report (D3.9) describes the final database content, as used in the Engage wiki

Investigating the pre-main sequence magnetic chemically peculiar system HD 72106

The origin of the strong magnetic fields observed in chemically peculiar Ap and Bp stars stars has long been debated. The recent discovery of magnetic fields in the intermediate mass pre-main sequence Herbig Ae and Be stars links them to Ap and Bp stars, providing vital clues about Ap and Bp stars and the origin and evolution of magnetic fields in intermediate and high mass stars. A detailed study of one young magnetic B star, HD 72106A, is presented. This star appears to be in a binary system with an apparently normal Herbig Ae star. A maximum longitudinal magnetic field strength of +391 +/- 65 G is found in HD 72106A, as are strong chemical peculiarities, with photospheric abundances of some elements ranging up to 100x above solar.Comment: 8 pages, 6 figures. Proceeding of the 2006 conference of the Special Astrophysical Observatory of the Russian Academy of Science