GRANULOMA CENTRAL DE CÉLULAS GIGANTES

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Investigating the impact of poverty on colonization and infection with drug-resistant organisms in humans: a systematic review

Background Poverty increases the risk of contracting infectious diseases and therefore exposure to antibiotics. Yet there is lacking evidence on the relationship between income and non-income dimensions of poverty and antimicrobial resistance. Investigating such relationship would strengthen antimicrobial stewardship interventions. Methods A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Ovid, MEDLINE, EMBASE, Scopus, CINAHL, PsychINFO, EBSCO, HMIC, and Web of Science databases were searched in October 2016. Prospective and retrospective studies reporting on income or non-income dimensions of poverty and their influence on colonisation or infection with antimicrobial-resistant organisms were retrieved. Study quality was assessed with the Integrated quality criteria for review of multiple study designs (ICROMS) tool. Results Nineteen articles were reviewed. Crowding and homelessness were associated with antimicrobial resistance in community and hospital patients. In high-income countries, low income was associated with Streptococcus pneumoniae and Acinetobacter baumannii resistance and a seven-fold higher infection rate. In low-income countries the findings on this relation were contradictory. Lack of education was linked to resistant S. pneumoniae and Escherichia coli. Two papers explored the relation between water and sanitation and antimicrobial resistance in low-income settings. Conclusions Despite methodological limitations, the results suggest that addressing social determinants of poverty worldwide remains a crucial yet neglected step towards preventing antimicrobial resistance

Partonic description of a supersymmetric p-brane

We consider supersymmetric extensions of a recently proposed partonic description of a bosonic p-brane which reformulates the Nambu-Goto action as an interacting multi-particle action with Filippov-Lie algebra gauge symmetry. We construct a worldline supersymmetric action by postulating, among others, a p-form fermion. Demanding a local worldline supersymmetry rather than the full worldvolume supersymmetry, we circumvent a known no-go theorem against the construction of a Ramond-Neveu-Schwarz supersymmetric action for a p-brane of p>1. We also derive a spacetime supersymmetric Green-Schwarz extension from the preexisting kappa-symmetric action.Comment: 1+16 pages, no figure; References added and Concluding section expanded. Final version to appear in JHE

Positivity, entanglement entropy, and minimal surfaces

The path integral representation for the Renyi entanglement entropies of integer index n implies these information measures define operator correlation functions in QFT. We analyze whether the limit $n\rightarrow 1$, corresponding to the entanglement entropy, can also be represented in terms of a path integral with insertions on the region's boundary, at first order in $n-1$. This conjecture has been used in the literature in several occasions, and specially in an attempt to prove the Ryu-Takayanagi holographic entanglement entropy formula. We show it leads to conditional positivity of the entropy correlation matrices, which is equivalent to an infinite series of polynomial inequalities for the entropies in QFT or the areas of minimal surfaces representing the entanglement entropy in the AdS-CFT context. We check these inequalities in several examples. No counterexample is found in the few known exact results for the entanglement entropy in QFT. The inequalities are also remarkable satisfied for several classes of minimal surfaces but we find counterexamples corresponding to more complicated geometries. We develop some analytic tools to test the inequalities, and as a byproduct, we show that positivity for the correlation functions is a local property when supplemented with analyticity. We also review general aspects of positivity for large N theories and Wilson loops in AdS-CFT.Comment: 36 pages, 10 figures. Changes in presentation and discussion of Wilson loops. Conclusions regarding entanglement entropy unchange