Grading scale for prediction of outcome in primary intracerebral hemorrhages

Polycrystalline thin films of Ge-C were grown on Si (1 1 1) substrates by means of reactive pulsed laser deposition with methane pressure of 100 mTorr. Effect substrate temperature, Ts, on C incorporation to substitutional sites (x) in Ge1-xCx was investigated systematically by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analyzes. The substrate temperatures were ranging from 250 to 400 °C. The substitutional C composition x in the films by XRD were estimated using the Vegard's linear law. The maximum value of x calculated by XRD was 0.032 for Ts of 350 °C. The position of the C 1s peak at 283.4 eV in the XPS spectrum confirmed the germanium-carbon alloys. XRD measurements indicated that x increased with Ts from 250 °C to 350 °C. At T s = 400 °C, the estimation of x was lowered. However, the C content calculated by XPS analyzes increased with Ts being more these values than substitutional C composition x. XPS and XRD analyzes demonstrate that the remaining C atoms are incorporated to interstitial sites. The use of the Ts plays important roles in the incorporation of substitutional C and in restraining C-cluster formation in the reactive pulsed laser deposition growth of Ge-C/Si. " 2010 Elsevier B.V. All rights reserved.",,,,,,"10.1016/j.apsusc.2011.01.011",,,"http://hdl.handle.net/20.500.12104/41807","http://www.scopus.com/inward/record.url?eid=2-s2.0-79951680387&partnerID=40&md5=3fa512be932d6ab0c665a504f624aff6",,,,,,"11",,"Applied Surface Science",,"500

Process for the production of Pen V acylase from Streptomyces Lavendula

Penicillin VThe invention relates to a method of producing the penicillin V acylase enzyme from Streptomyces lavendulae in recombinant micro-organisms. The inventive enzyme production method comprises the following steps: (1) identification of the DNA corresponding to the pva gene, which encodes the penicillin V acylase enzyme from S. lavendulae ATCC 13664, (2) cloning of said gene in a vector suited to the host cell used, (3) cultivation of recombinant host cells bearing the pva gene, and (4) recovery of the enzyme from the cell culture. The PVA enzyme thus obtained is used in the individual production of ss-lactamic antibiotics, particularly 6-aminopenicillanic (6-APA) acid from penicillin V, although other penicillins (K, F, and dihydro-F) can also be used as a substrate

Accelerated surgery versus standard care in hip fracture (HIP ATTACK) : an international, randomised, controlled trial

Background: Observational studies have suggested that accelerated surgery is associated with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed whether accelerated surgery could reduce mortality and major complications. Methods: HIP ATTACK was an international, randomised, controlled trial done at 69 hospitals in 17 countries. Patients with a hip fracture that required surgery and were aged 45 years or older were eligible. Research personnel randomly assigned patients (1:1) through a central computerised randomisation system using randomly varying block sizes to either accelerated surgery (goal of surgery within 6 h of diagnosis) or standard care. The coprimary outcomes were mortality and a composite of major complications (ie, mortality and non-fatal myocardial infarction, stroke, venous thromboembolism, sepsis, pneumonia, life-threatening bleeding, and major bleeding) at 90 days after randomisation. Patients, health-care providers, and study staff were aware of treatment assignment, but outcome adjudicators were masked to treatment allocation. Patients were analysed according to the intention-to-treat principle. This study is registered at ClinicalTrials.gov (NCT02027896). Findings: Between March 14, 2014, and May 24, 2019, 27 701 patients were screened, of whom 7780 were eligible. 2970 of these were enrolled and randomly assigned to receive accelerated surgery (n=1487) or standard care (n=1483). The median time from hip fracture diagnosis to surgery was 6 h (IQR 4\u20139) in the accelerated-surgery group and 24 h (10\u201342) in the standard-care group (p<0\ub70001). 140 (9%) patients assigned to accelerated surgery and 154 (10%) assigned to standard care died, with a hazard ratio (HR) of 0\ub791 (95% CI 0\ub772 to 1\ub714) and absolute risk reduction (ARR) of 1% ( 121 to 3; p=0\ub740). Major complications occurred in 321 (22%) patients assigned to accelerated surgery and 331 (22%) assigned to standard care, with an HR of 0\ub797 (0\ub783 to 1\ub713) and an ARR of 1% ( 122 to 4; p=0\ub771). Interpretation: Among patients with a hip fracture, accelerated surgery did not significantly lower the risk of mortality or a composite of major complications compared with standard care. Funding: Canadian Institutes of Health Research