Quebrada Verde educational institute

El presente proyecto plantea un prototipo repetible para infraestructura educativa en territorios en pendiente, el cual busca reconfigurar los espacios tradicionales de circulación, aprendizaje y de la relación con la comunidad. Tomando el emplazamiento dentro de una topografía en pendiente, como oportunidad para el desarrollo de una solución arquitectónica que permita la inserción en este tipo de condicionantes naturales recurrentes en Perú; e incorporándolas en el desarrollo de nuevas oportunidades espaciales fuera de los ambientes convencionales de educación. Conceptualmente, el proyecto parte de la abstracción de las dinámicas de ocupación urbana espontánea y la masividad de los ecosistemas de quebradas. Resultando en un punto de partida para la reinterpretación del proyecto como una "Quebrada Recorrible", que desarrolla una nueva estrategia de organización espacial que reconfigura el espacio central y las circulaciones en "calles de aprendizaje" a favor de las actuales necesidades pedagógicas y contextualizadas a las particularidades locales. De manera que, las "quebradas" del proyecto se perciben como un punto de coexistencia entre los ecosistemas urbanos - naturales y lo pedagógico. A través de una relación simbiótica en la que la propuesta se nutre de la esencia del lugar, mientras que el proyecto enlaza los aspectos contextuales, educativas y de identidad local, a través del diseño arquitectónico y la articulación de los aspectos funcionales, formales, conceptuales, espaciales y técnicos implicados. Ello a partir de la presente investigación académica y profundización de las condicionantes teóricas, conceptuales, históricas, referencias proyectuales, lugar, usuario, y la consolidación de estos en la propuesta lograda.The present educational project seeks to reconfigure traditional transit and learning spaces, taking advantage of its placement in a rugged topography, as an opportunity to develop an architectural solution to this frequent geographic condition in Peru; it generates new spacial opportunities outside the conventional ones. Conceptually, the project is created from the abstraction of dynamic spontaneous urban occupation and the massive hilly ecosystems, which results in a starting point for the reinterpretation of a “Walkable Ravine”. This ultimately relinquishes the central space and traditional transit areas into “streets of learning” in order to make a way for new pedagogical needs. In this way, the “streets of learning” are perceived as a point of coexistence between urban and natural ecosystems as well as pedagogical and contemporary architecture. Through a symbiotic relationship, architecture is nourished by nature, while the project articulates its own contextual and educational aspects, in addition to its local identity, through the architecture design and the articulation of the contextual, functional, formal, conceptual, spacial and technical aspects involved. Based on the present academic investigation and deepening of the theorical, conceptual, history, pedagogical factors, project references, investigation of the place, user, and the consolidation of all these aspects in the architectural proposal achieved.Tesi

Diseño y construcción de un servicio de análisis de llamadas para áreas de calidad en servicio al cliente

Dentro de las áreas de calidad de los call centers se presenta a menudo un problema en la revisión y el monitoreo de las llamadas en donde no se tiene un control total en todas las interacciones ya que los asesores no pueden revisar todas las grabaciones que se generan al día, perdiendo así la retroalimentación de las anomalías que se presentan, basados en este problema y como planteamiento a una solución se busca construir un servicio de análisis y de auditoria para las áreas del servicio al cliente usando la conversión de voz a texto y el análisis del lenguaje natural para aumentar la cantidad de llamadas revisadas y con esto disminuir los tiempos de monitoreo de los call centers. Para plantear una solución a este problema se realiza un estudio descriptivo en donde a partir del problema presentado se buscan las diferentes variables que permitan tener una solución efectiva, para la solución de dicho estudio se realizan diferentes fases para cumplir a cabalidad con el resultado teniendo en cuenta como primera instancia el desarrollo y especificación del producto donde se definen los requerimientos, la arquitectura y la infraestructura, para seguir con el entrenamiento de machine learning en donde se realizan los diferentes procesos con las herramientas de AWS, poniendo las reglas y verificando que el entrenamiento cumpla con el objetivo de detectar las anomalías y malas palabras en las llamadas, para con esto poder realizar la construcción del software mostrando todo los elementos que serán visibles a la hora del uso de la herramienta cada una con la explicación de su funcionamiento, basados en el desarrollo realizado para la solución al problema presentado se logra evidenciar que se encuentra una solución efectiva con los diferentes indicadores evaluados en el modelo de entrenamiento, en la cantidad de llamadas que pueden ser analizadas por la herramienta, la reducción de costos que se presenta con la ejecución de este proceso y de esta forma también muestra los indicadores que no son evaluados por el proceso por limitaciones técnicas y el alcance de construcción de esta herramienta, con estos factores que se encontraron en la solución, el resultado muestra diferentes beneficios que se pueden evidenciar con las llamadas cargadas por la herramienta, se logra tener una retroalimentación de la cantidad total sin tener que evaluar llamadas al azar, así como disminuir el tiempo de ejecución de las revisiones para mejorar los indicadores del servicio al cliente

Collaboration for the Internationalization of Research and Development: Opportunities for Colombia in the Post-Pandemic Term

Within the new world scenario, the internationalization of science, technology and innovation represents a fast track for the development of nations and the solution of the global challenges posed by the 2030 Agenda. The above reflects on the importance of science and technology as determining factors to promote sustainable development and especially to overcome any scenario of health and economic crisis generated by the Covid-19 pandemic, which has promoted the creation of programs that are in favor of investment in human resources and infrastructure to strengthen local capacities, long-term financing for the development of scientific and technological projects, as well as the implementation of new mechanisms that favor the institutionalization of science, technology and innovation policies

Proyecto GoGetFit App

El presente trabajo de investigación realiza el análisis y desarrollo de una idea de negocio que busca impulsar y motivar a las personas a mejorar sus hábitos alimenticios. En base a entrevistas realizadas tanto a usuarios potenciales como expertos, se ha podido identificar que gran parte de la población limeña basa su dieta en comentarios o publicaciones vistos en redes sociales y medios; así también, consideran que para obtener mejoras físicas es necesario reducir sus porciones, por lo cual hemos decidido brindar una posible solución a este problema mediante el desarrollo de una aplicación que te permita ingresar datos y cualidades físicas personales, con la finalidad de realizar un conteo de calorías necesarias a consumir al día para cumplir objetivos. Para llevar a cabo este proyecto, se realizaron diversos experimentos que han contribuido para validar la viabilidad de nuestro negocio y a medir el nivel de aceptación de este. Entre estos experimentos podemos resaltar el uso de un landing page para medir la intención de compra, así como el empleo de estrategias de marketing para dar a conocer nuestros servicios. Así mismo, realizamos una proyección de ventas que nos ha permitido estimar las ganancias que obtendríamos con nuestro negocio puesto en marcha a lo largo del tiempo. Finalmente, se realizaron las conclusiones y recomendaciones oportunas de nuestro proyecto.This research work carries out the analysis and development of a business idea that seeks to promote and motivate people to improve their eating habits. Based on interviews conducted with both potential users and experts, it has been possible to identify that a large part of the Lima population bases their diet on comments or posts seen on social media and virtual platforms. Likewise, they consider that to obtain physical improvements it is necessary to reduce their portions, for which we have decided to provide a possible solution to their problem by developing an application that allows you to enter personal data and physical qualities, in order to perform a count of calories necessary to consume per day to meet objectives. To carry out this project, various experiments were carried out that have contributed to validate the viability of our business and to measure the level of acceptance of it. Among these experiments we can highlight the use of a landing page to measure purchase intention, as well as the use of marketing strategies to publicize our services. Likewise, we carried out a sales projection that has allowed us to estimate the profits that we would obtain with our business launched over time. Finally, the appropriate conclusions and recommendations of our project were made.Trabajo de investigació

Reversal of SARS-CoV2-Induced Hypoxia by Nebulized Sodium Ibuprofenate in a Compassionate Use Program

Introduction: Sodium ibuprofenate in hypertonic saline (NaIHS) administered directly to the lungs by nebulization and inhalation has antibacterial and anti-inflammatory effects, with the potential to deliver these benefits to hypoxic patients. We describe a compassionate use program that offered this therapy to hospitalized COVID-19 patients. Methods: NaIHS (50 mg ibuprofen, tid) was provided in addition to standard of care (SOC) to hospitalized COVID-19 patients until oxygen saturation levels of > 94% were achieved on ambient air. Patients wore a containment hood to diminish aerosolization. Outcome data from participating patients treated at multiple hospitals in Argentina between April 4 and October 31, 2020, are summarized. Results were compared with a retrospective contemporaneous control (CC) group of hospitalized COVID-19 patients with SOC alone during the same time frame from a subset of participating hospitals from Córdoba and Buenos Aires. Results: The evolution of 383 patients treated with SOC + NaIHS [56 on mechanical ventilation (MV) at baseline] and 195 CC (21 on MV at baseline) are summarized. At baseline, NaIHS-treated patients had basal oxygen saturation of 90.7 ± 0.2% (74.3% were on supplemental oxygen at baseline) and a basal respiratory rate of 22.7 ± 0.3 breath/min. In the CC group, basal oxygen saturation was 92.6 ± 0.4% (52.1% were on oxygen supplementation at baseline) and respiratory rate was 19.3 ± 0.3 breath/min. Despite greater pulmonary compromise at baseline in the NaIHS-treated group, the length of treatment (LOT) was 9.1 ± 0.2 gs with an average length of stay (ALOS) of 11.5 ± 0.3 days, in comparison with an ALOS of 13.3 ± 0.9 days in the CC group. In patients on MV who received NaIHS, the ALOS was lower than in the CC group. In both NaIHS-treated groups, a rapid reversal of deterioration in oxygenation and NEWS2 scores was observed acutely after initiation of NaIHS therapy. No serious adverse events were considered related to ibuprofen therapy. Mortality was lower in both NaIHS groups compared with CC groups. Conclusions: Treatment of COVID-19 pneumonitis with inhalational nebulized NaIHS was associated with rapid improvement in hypoxia and vital signs, with no serious adverse events attributed to therapy. Nebulized NaIHS s worthy of further study in randomized, placebo-controlled trials (ClinicalTrials.gov: NCT04382768).Fil: Salva, Oscar. Clínica Independencia; ArgentinaFil: Doreski, Pablo A.. Fundación Respirar; ArgentinaFil: Giler, Celia S.. Clínica Independencia; ArgentinaFil: Quinodoz, Dario C.. Sanatorio de la Cañada; ArgentinaFil: Guzmán, Lucia G.. Sanatorio de la Cañada; ArgentinaFil: Muñoz, Sonia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Carrillo, Mariana Norma del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Porta, Daniela Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Ambasch, Germán. Sanatorio Privado Mayo; ArgentinaFil: Coscia, Esteban. Sanatorio Privado Mayo; ArgentinaFil: Tambini Diaz, Jorge L.. Sanatorio Privado Mayo; ArgentinaFil: Bueno, Germán D.. Sanatorio Privado Mayo; ArgentinaFil: Fandi, Jorge O.. Clínica Independencia; ArgentinaFil: Maldonado, Miriam A.. Sanatorio San Roque; ArgentinaFil: Peña Chiappero, Leandro E.. Sanatori San Roque; ArgentinaFil: Fournier, Fernando. Clínica Francesa; ArgentinaFil: Pérez, Hernán A.. Sanatorio Alive; Argentina. University of Maryland; Estados UnidosFil: Quiroga, Mauro A.. Instituto Modelo de Cardiología; ArgentinaFil: Sala Mercado, Javier Agustin. Instituto Modelo de Cardiología; ArgentinaFil: Martínez Picco, Carlos. Clínica del Sol; ArgentinaFil: Beltrán, Marcelo Alejandro. Hospital Dr. Alberto Duhau; ArgentinaFil: Castillo Argañarás, Luis Fernando. Hospital Dr. Alberto Duhau; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ríos, Nicolás Martínez. Quimica Luar Srl; ArgentinaFil: Kalayan, Galia I.. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; ArgentinaFil: Beltramo, Dante Miguel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Garcia, Nestor Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentin

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO

Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary file

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

Establishment of triple-negative breast cancer cells based on BMI: A novel model in the correlation between obesity and breast cancer

IntroductionObesity has been associated with an increased risk of biologically aggressive variants in breast cancer. Women with obesity often have tumors diagnosed at later stages of the disease, associated with a poorer prognosis and a different response to treatment. Human cell lines have been derived from specific subtypes of breast cancer and have served to define the cell physiology of corresponding breast cancer subtypes. However, there are no current cell lines for breast cancer specifically derived from patients with different BMIs. The availability of those breast cancer cell lines should allow to describe and unravel functional alterations linked to these comorbidities. MethodsCell cultures were established from tumor explants. Once generated, the triple negative subtype in a patient with obesity and a patient with a normal BMI were chosen for comparison. For cellular characterization, the following assays were conducted: proliferation assays, chemo – sensitivity assays for doxorubicin and paclitaxel, wound healing motility assays, matrix invasion assays, breast cancer cell growth to estradiol by chronic exposure to leptin, induction of endothelial permeability and tumorigenic potential in athymic mice with normo - versus hypercaloric diets with an evaluation of the epithelium – mesenchymal transformation proteins.ResultsTwo different cell lines, were established from patients with breast cancer: DSG-BC1, with a BMI of 21.9 kg/m2 and DSG-BC2, with a BMI of 31.5 kg/m2. In vitro, these two cell lines show differential growth rates, motility, chemosensitivity, vascular permeability, response to leptin with an activation of the JAK2/STAT3/AKT signaling pathway. In vivo, they displayed distinct tumorigenic potential. In particular, DSG-BC2, presented higher tumorigenicity when implanted in mice fed with a hypercaloric diet.DiscussionTo our knowledge, these primary cultures are the first in vitro representation of both breast cancer and obesity. DSG – BC2 presented a more aggressive in vivo and in vitro phenotype. These results support the hypothesis that breast cancer generated in an obese metabolic state may represent a contrasting variant within the same disease. This new model will allow both further comprehension, functional studies and the analysis of altered molecular mechanisms under the comorbidity of obesity and breast cancer