255 research outputs found
El problema diagnóstico de la IC: papel del péptido natriurético ventricular (BNP) y futura utilidad en el ámbito de la atención primaria
Reducción de psicofármacos en aguas residuales después de la filtración con membranas
Se analiza la presencia de diferentes psicofármacos en el agua residual y los rendimientos de eliminación obtenidos en una depuradora convencional. Los psicofármacos prácticamente no se eliminan en el tratamiento biológico. Sin embargo, se ha obtenido una biodegradación considerable debido al tipo de compuesto y de la edad del fango. Además se estudian las retenciones de estos compuestos empleando tratamientos terciarios convencionales y plantas piloto de ultrafiltración y nanofiltración. Las eliminaciones obtenidas no difieren demasiado de un tipo de membrana a otro a pesar del diferente tamaño de paso entre ella
Principales reacciones adversas que presentan mujeres de 15-30 años, ingresadas en la sala de labor y parto del Hospital Materno Infantil Dr. Fernando Vélez Paíz con el uso de oxitocina sintética de 5UI, 10UI, 20UI Managua, Enero-Septiembre 2010
La Regulación del Despido en el Reino Unido
El presente trabajo versa sobre la institución del Despido en el Reino Unido estableciendo tanto su régimen como su protección, sin perjuicio de las pequeñas excepciones existentes con Irlanda del Norte las cuáles tambien quedarán indicadas en el mismo
Nutraceutical Supplementation Ameliorates Visual Function, Retinal Degeneration, and Redox Status in rd10 Mice
Retinitis pigmentosa (RP) is a group of inherited retinal dystrophies characterized by progressive degeneration of photoreceptor cells. Ocular redox status is altered in RP suggesting oxidative stress could contribute to their progression. In this study, we investigated the effect of a mixture of nutraceuticals with antioxidant properties (NUT) on retinal degeneration in rd10 mice, a model of RP. NUT was orally administered to rd10 mice from postnatal day (PD) 9 to PD18. At PD18 retinal function and morphology were examined by electroretinography (ERG) and histology including TUNEL assay, immunolabeling of microglia, Müller cells, and poly ADP ribose polymers. Retinal redox status was determined by measuring the activity of antioxidant enzymes and some oxidative stress markers. Gene expression of the cytokines IL-6, TNFα, and IL-1β was assessed by real-time PCR. NUT treatment delayed the loss of photoreceptors in rd10 mice partially preserving their electrical responses to light stimuli. Moreover, it ameliorated redox status and reduced inflammation including microglia activation, upregulation of cytokines, reactive gliosis, and PARP overactivation. NUT ameliorated retinal functionality and morphology at early stages of RP in rd10 mice. This formulation could be useful as a neuroprotective approach for patients with RP in the future
Innovative learning and teaching methodology in electronic technology area: A case of study in computer science university degrees
This paper describes an experience that has been
carried out by several professors in different subjects. Our
experience is framed within the First Plan in Teaching of the
University of Seville. All involved subjects belong to the
electronic technology area and from three Computer Science
degrees. We propose to use, in a combined way, some learning
techniques: cooperative learning as complement to traditional
learning, role-playing technique and jigsaw technique. We have
considered a base methodology but in each subject a variant of it
has been accomplished. We have used several evaluation
techniques, such as reciprocal evaluation, electronic portfolio and
check lists. Applying our methodology helps us to detect learning
problems before the term ends. Also, in tune with the framework
of the European Higher Education Area (EHEA), our methology
gives a boost to develop transversal competences as important as
work (or study) management, empathy and understanding of
other members in a workgroup, conflict resolution, capacity to
make decisions as well as coordinate and communicate with other
members in a workgroup and also with the professor
COVID Obesity: A One-Year Narrative Review
On 11 March 2020, coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization (WHO). This study focuses on a narrative review about the illness during the first year of the pandemic in relation to obesity. Databases were used to search studies published up to 8 December 2020. In total, 4430 articles and other scientific literature were found, and 24 articles were included in this one-year narrative review. The mean BMI value of severe COVID-19 patients ranged from 24.5 to 33.4 kg/m2, versus <18.5 to 24.3 kg/m2 for non-severe patients. Articles using the terms obesity or overweight without indicating the BMI value in these patients were common, but this is not useful, as the anthropometric parameters, when not defined by this index, are confusing due to the classification being different in the West compared to among Asian and Korean criteria-based adults. We proposed a new term, called COVID obesity, to define the importance of this anthropometric parameter, among others, in relation with this pandemic
Hist-Pharm App: Desarrollo de una herramienta digital, en el entorno App, para el aprendizaje de la Historia de la Farmacia
El proyecto pretende desarrollar –y poner en funcionamiento- una herramienta digital Hist-Pharm App, en el entorno docente, como estrategia para fomentar el aprendizaje y el razonamiento, crítico y científico, del alumnado en temas relacionados con la Historia de la Farmacia
Efficacy and safety study of an eyelid gel after repeated nocturnal application in healthy contact lens users and non-users
Purpose: To evaluate skin biocompatibility of a nighttime hydrating eyelid gel and possible ocular surface effects in contact lens users (CLU) and non-contact lens users (NCLU). The formulation is registered as a medical device as Tridocosahexaenoine-AOX® (TDHA-AOX) (a concentrated DHA triglyceride), containing also hyaluronic acid (HA).
Methods: A prospective, randomized, masked clinical trial was performed with 62 participants of both sexes, aged 20–70 years, split into: (1) CLU (n = 30) and (2) NCLU (n = 32). All participants were instructed to apply a single dose of the moisturizing gel (containing TDHA-AOX and HA) nightly to the upper and inner eyelids of their right eye (RE) only, and during 2 consecutive weeks. Personal interviews, questionnaires, ophthalmic examinations and reflex tear collection were performed. Ophthalmological parameters included ocular surface response and contact lens status. Levels of satisfaction/adverse events were also recorded. Biochemical parameters included basal and final determination of pro-inflammatory mediator molecules in tear samples by multiplex analyses. Statistics were done by the SPSS 24.0 program.
Results: The CLU group had higher OS dysfunction than NCLU, but overall clinical parameters (corneal staining, and Schirmer/FBUT tests) and OSDI scores showed significant improvement in CLU individuals as compared to the NCLU participants, at the end of study. CLDEQ-8 scores pinpointed significant amelioration in initial risk of developing DEs by applying eyelid gel. Multiplex analyses demonstrated significantly lower VEGF expression levels (p < 0,05) in tears among the CLU compared to NCLU after nightly application of eyelid gel.
Conclusions: Eyelid gel appeared to safely and efficiently provide hydration and decongestion of the skin and amelioration of the ocular surface during sleep
Superparamagnetic iron oxide nanoparticles decorated mesoporous silica nanosystem for combined antibiofilm therapy
A crucial challenge to face in the treatment of biofilm-associated infection is the ability of bacteria to develop resistance to traditional antimicrobial therapies based on the administration of antibiotics alone. This study aims to apply magnetic hyperthermia together with controlled antibiotic delivery from a unique magnetic-responsive nanocarrier for a combination therapy against biofilm. The design of the nanosystem is based on antibiotic-loaded mesoporous silica nanoparticles (MSNs) externally functionalized with a thermo-responsive polymer capping layer, and decorated in the outermost surface with superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs are able to generate heat upon application of an alternating magnetic field (AMF), reaching the temperature needed to induce a change in the polymer conformation from linear to globular, therefore triggering pore uncapping and the antibiotic cargo release. The microbiological assays indicated that exposure of E. coli biofilms to 200 µg/mL of the nanosystem and the application of an AMF (202 kHz, 30 mT) decreased the number of viable bacteria by 4 log10 units compared with the control. The results of the present study show that combined hyperthermia and antibiotic treatment is a promising approach for the effective management of biofilm-associated infections.Depto. de Química en Ciencias FarmacéuticasFac. de FarmaciaTRUEpu
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