CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Cuadro clínico, en especial el psiquiátrico, del síndrome de Morgagni-Stewart-Morel

Se analizan 14 casos de hiperostosis frontal interna, después de una breve revisión del estado actual de nuestros conocimientos acerca de este síndrome. Especialmente se plantea el problema de la especificidad del síndrome psíquico que lo acompaña, y se llega a la conclusión de que, si bien no puede hablarse de un cuadro psíquico unívoco, existe una relación con la índole de las perturbaciones somáticas, de forma que puede enjuiciarse a ambas, no como dependientes la una de la otra, sino las dos conjuntamente dependientes del proceso patogénico fundamental. Se llama la atención también sobre síntomas de la esfera somática que han pasado desapercibidos hasta ahora. Se concede el mayor interés de esta investigación al hecho de poder sacar, por la analogia con otros procesos patológicos, alguna luz sobre síntomas psíquicos presentes en distintas entidades nosológicas de la Psiquiatria actual

The Transatlantic Element: Psychoanalysis, Exile, Circulation of Ideas and Institutionalization between Spain and Argentina

peer reviewedFrom the early diffusion of Freud's ideas to the development and institutionalization of the Lacanian movement, the Argentine and Spanish psychoanalytic histories have had repeated points of contact. In fact, almost all stages of the Spanish analytical sphere have been shaped by the presence of an 'Argentine element'. This article aims to explore the history of these encounters between the Spanish and Argentine psychoanalytic worlds. Following the chronology of events, it focuses on the different aspects of this history and shows how the causes, the nature and the consequences of the exchanges evolved. © Edinburgh University Press

Exploring the Spanish youth audience’s interpretation of loving relationships

This study examines the extent to which Spanish youth audiences appropriate television fiction and engage in the acceptance and construction of loving stereotypes. It specifically looks at how they identify different kinds of loving relationships. It also explores the intertextual and extratextual interactions they establish in their interpretations. The methodology undertaken is the focus group, and the sample is university students from four different faculties and universities in Spain. The series chosen as a corpus are two from the United States and one from Spain. Interpretive differences and similarities were studied according to the gender and education of the subjects. Finally, a reflection is made on how youth audiences interact in terms of gender and sexual identity markers in the representations of the loving relationships in the series studied