Interfície pel comandament teleoperat d'útils quirúrgics

L'objectiu d'aquest projecte de final de carrera consisteix en el disseny d'una interfície capaç de sensoritzar els moviments d'un instrument quirúrgic durant una intervenció laparoscòpica. Aquest sistema permetrà comandar l'element terminal d'un robot en teleoperació

Interfície pel comandament teleoperat d'útils quirúrgics

L'objectiu d'aquest projecte de final de carrera consisteix en el disseny d'una interfície capaç de sensoritzar els moviments d'un instrument quirúrgic durant una intervenció laparoscòpica. Aquest sistema permetrà comandar l'element terminal d'un robot en teleoperació

Dependence of impedance of embedded single cells on cellular behaviour

Non-invasive single cell analyses are increasingly required for the medicaldiagnostics of test substances or the development of drugs and therapies on the single celllevel. For the non-invasive characterisation of cells, impedance spectroscopy whichprovides the frequency dependent electrical properties has been used. Recently,microfludic systems have been investigated to manipulate the single cells and tocharacterise the electrical properties of embedded cells. In this article, the impedance ofpartially embedded single cells dependent on the cellular behaviour was investigated byusing the microcapillary. An analytical equation was derived to relate the impedance ofembedded cells with respect to the morphological and physiological change ofextracellular interface. The capillary system with impedance measurement showed afeasibility to monitor the impedance change of embedded single cells caused bymorphological and physiological change of cell during the addition of DMSO. By fittingthe derived equation to the measured impedance of cell embedded at different negativepressure levels, it was able to extrapolate the equivalent gap and gap conductivity betweenthe cell and capillary wall representing the cellular behaviour

Stochastic Particle Barcoding for Single-Cell Tracking and Multiparametric Analysis

This study presents stochastic particle barcoding (SPB), a method for tracking cell identity across bioanalytical platforms. In this approach, single cells or small collections of cells are co-encapsulated within an enzymatically-degradable hydrogel block along with a random collection of fluorescent beads, whose number, color, and position encode the identity of the cell, enabling samples to be transferred in bulk between single-cell assay platforms without losing the identity of individual cells. The application of SPB is demonstrated for transferring cells from a subnanoliter protein secretion/phenotyping array platform into a microtiter plate, with re-identification accuracies in the plate assay of 96±2%. Encapsulated cells are recovered by digesting the hydrogel, allowing subsequent genotyping and phenotyping of cell lysates. Finally, a model scaling is developed to illustrate how different parameters affect the accuracy of SPB and to motivate scaling of the method to thousands of unique blocks.Ragon Institute of MGH, MIT and HarvardNational Cancer Institute (U.S.) (Koch Institute Support (Core) Grant P30-CA14051)National Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service Award (1F32CA180586

Interfície pel comandament teleoperat d'útils quirúrgics

L'objectiu d'aquest projecte de final de carrera consisteix en el disseny d'una interfície capaç de sensoritzar els moviments d'un instrument quirúrgic durant una intervenció laparoscòpica. Aquest sistema permetrà comandar l'element terminal d'un robot en teleoperació

Dependence of Impedance of Embedded Single Cells on Cellular Behaviour

Non-invasive single cell analyses are increasingly required for the medicaldiagnostics of test substances or the development of drugs and therapies on the single celllevel. For the non-invasive characterisation of cells, impedance spectroscopy whichprovides the frequency dependent electrical properties has been used. Recently,microfludic systems have been investigated to manipulate the single cells and tocharacterise the electrical properties of embedded cells. In this article, the impedance ofpartially embedded single cells dependent on the cellular behaviour was investigated byusing the microcapillary. An analytical equation was derived to relate the impedance ofembedded cells with respect to the morphological and physiological change ofextracellular interface. The capillary system with impedance measurement showed afeasibility to monitor the impedance change of embedded single cells caused bymorphological and physiological change of cell during the addition of DMSO. By fittingthe derived equation to the measured impedance of cell embedded at different negativepressure levels, it was able to extrapolate the equivalent gap and gap conductivity betweenthe cell and capillary wall representing the cellular behaviour

Dispositivo de detección pasiva de eventos

[ES] Con consumo nulo de energía hasta que tiene lugar un evento alarmante, ya que aprovecha la ventaja de la transición de fase de un material PCM (2) (material de cambio de fase) para monitorizar eventos físicos/químicos relevantes. Si el material PCM (2) es conductor de iones, el dispositivo comprende una batería activada por líquido (1), un material PCM (2) no conductor de iones, situado en contacto con la batería activada por líquido (1), y un módulo electrónico (4), conectado a la batería activada por líquido (1), que se activa con la batería. Si el material PCM (2) es un material PCM (2) no conductor de iones, el dispositivo comprende adicionalmente un líquido conductor de iones, y donde dicho material PCM (2) no conductor de iones se sitúa como una barrera entre el líquido conductor de iones y la batería activada por líquido (1).[EN] With no power consumption until an alarming event takes place, since it takes advantage of the phase transition from a PCM (2) material (phase change material) to monitor relevant physical/chemical events. If the PCM material (2) is ion conductor, the device comprises a liquid-activated battery (1), a PCM (2) non-ion conductor, located in contact with the battery activated by liquid (1), and a Electronic module (4), connected to the battery activated by liquid (1), which is activated with the battery. If the PCM (2) material is a PCM (2) non-ion conductor, the device further comprises an ion conductive liquid, and wherein said PCM (2) non-ion conductor is located as a barrier between the conductive liquid of ions and the battery activated by liquid (1).NoConsejo Superior de Investigaciones Científicas (CSIC), Institució Catalana de Recerca i Estudis Avançats (ICREA), Fuelium, S.L., Universitat Autonònoma de BarcelonaB2 Patente con examen previ

Design, development and application of a bioelectrochemical detection system for meat tenderness prediction.

The analytical method described, based on antibody-antigen bio-recognition and the measuring system for amperometric detection, was designed for accurate, easy to use and cost effective quantification of calpastatin, a meat tenderness biomarker. The novel assay for calpastatin quantification was integrated in a portable electrochemical device known as the Tendercheck system and was used to analyze meat samples collected from animals of different breeds and ages. The data obtained were correlated (R(2)=0.62) with Warner Bratzler Shear Force (WBSF) measurements, a routinely used method for meat tenderness determination

다층 밴드 및 다층 밴드 제조 방법

다층 밴드 및 다층 밴드의 제조 방법이 개시된다. 다층 밴드는, 복수의 중첩된 층에 의해 형성된 적어도 하나의 배터리 구조(10)를 유지하도록 구성된 지지체(1)를 포함하고, 상기 복수의 중첩된 층은 다공성 재료(11) 및 적어도 2개의 전기 활성 전극(12, 13), 하나의 산화 전극(12) 및 하나의 환원 전극(13)을 포함하며, 상기 전기 활성 전극(12, 13)은 전기 활성 전극들 사이에서 특정 거리를 가지며 분리되고 상기 다공성 재료(11)와 접촉한다. 상기 배터리 구조(10)는 다공성 재료(11)의 주어진 영역 속으로 배터리 전해질로서 작용하는 유체가 첨가될 때 활성화되고 상기 유체가 모세관에 의해 다공성 재료(11) 속으로 함침되는 동안에 전기 에너지를 제공하도록 구성되며, 상기 중첩된 층은 지지체(1)의 길이를 따라 종 방향으로 연장되는 평행 스트립으로 구성되어, 상기 다층 밴드는 횡 방향으로 절단될 수 있어서 각각 다공성 재료(11) 및 적어도 2개의 전기 활성 전극(12, 13)을 포함하며 동일하거나 상이한 폭을 가진 개별 배터리를 제공한다.NoConsejo Superior de Investigaciones Científicas (España), lnstitució Catalana de Recerca i Estudis Avançats (ICREA), Fuelium, S