Un discurso sanitario para un proyecto político. La educación sanitaria en los medios comunicación de masas durante el primer franquismo

Making used of the radio conferences organized by «Jefatura Provincial de Sanidad» of Málaga during 1939 and 1940 on maternal and infant hygiene, which were published, in this study we analyse the relationship between politics and health education. The article show how the popularization of medicine was a resource used by national-syndicalism more than sanitary information for the population during early years of Francoism.El análisis de los discursos expuestos en un ciclo de conferencias radiadas durante los años 1939-1940 en la ciudad de Málaga sobre higiene materno-infantil, organizado por la Jefatura Provincial de Sanidad, nos permite poner de manifiesto cómo se utiliza un recurso como la divulgación de contenidos sanitarios como parte de un proyecto político, el nacional-sindicalismo, al que sirvió como elemento vehiculizador

B-LEARNING AND MOODLE AS A STRATEGY IN UNIVERSITY EDUCATION: LATIN AMERICA CASE BY 2017-2022

A documentary review was carried out on the production and publication of research papers concerning studying B-learning, Higher Education, and Moodle as a strategy in university education. The purpose of the bibliometric analysis proposed in this paper was to know the main characteristics of the volume of publications registered in the Scopus database during the period 2017-2022 and to identify the current situation in Ecuadorian institutions regarding the study of the variables mentioned above, achieving the identification of 78 publications in total. The information provided by the said platform was organized employing graphs and figures categorizing the information by Year of Publication, Country of Origin, Area of Knowledge and Type of Publication. Once these characteristics were described, a qualitative analysis was used to refer to the position of different authors on the proposed topic. Among the main findings of this research, it is found that Spain, with 28 publications, was the country with the highest scientific production registered in the name of authors affiliated with institutions of that nation. The area of knowledge that made the greatest contribution to the construction of bibliographic material referring to the study of B-learning, Higher Education, Moodle as a strategy in university education was Social Sciences with 41 published documents, and the type of publication that was most used during the period mentioned above was the journal article, representing 56% of the total scientific production

Primer consenso en leucemia linfocítica crónica de la agrupación mexicana para el estudio de la hematología: epidemiología, diagnóstico y tratamiento

La leucemia linfocítica crónica (LLC) es la leucemia crónica menos frecuente en México. En consideración a los avances recientes, a una mejor clasificación pronóstica y a la introducción de nuevas modalidades terapéuticas, la Agrupación Mexicana para el Estudio de la Hematología organizó el primer consenso mexicano en leucemia linfocítica crónica. Este consenso se llevó a cabo en Cancún, Quintana Roo, México, en Septiembre del 2007. Los objetivos de esta reunión fueron actualizar y compartir los conocimientos de la enfermedad entre los especialistas mexicanos, con el fin de mejorar el diagnóstico y el pronóstico de la LLC en México. En el artículo se discute los aspectos clínicos, diagnósticos y terapéuticos de la LLC

A Multitrait Genetic Study of Hemostatic Factors and Hemorrhagic Transformation after Stroke Treatment

BACKGROUND: Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the only pharmacologic intervention available in the ischemic stroke acute phase. This treatment is associated with an increased risk of intracerebral hemorrhages, known as hemorrhagic transformations (HTs), which worsen the patient\u27s prognosis. OBJECTIVES: to investigate the association between genetically determined natural hemostatic factors\u27 levels and increased risk of HT after r-tPA treatment. METHODS: Using data from genome-wide association studies on the risk of HT after r-tPA treatment and data on 7 hemostatic factors (factor [F]VII, FVIII, von Willebrand factor [VWF], FXI, fibrinogen, plasminogen activator inhibitor-1, and tissue plasminogen activator), we performed local and global genetic correlation estimation multitrait analyses and colocalization and 2-sample Mendelian randomization analyses between hemostatic factors and HT. RESULTS: Local correlations identified a genomic region on chromosome 16 with shared covariance: fibrinogen-HT, P = 2.45 × 10 CONCLUSION: We identified 4 shared loci between hemostatic factors and HT after r-tPA treatment, suggesting common regulatory mechanisms between fibrinogen and VWF levels and HT. Further research to determine a possible mediating effect of fibrinogen on HT risk is needed

A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment

[Background] Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the only pharmacologic intervention available in the ischemic stroke acute phase. This treatment is associated with an increased risk of intracerebral hemorrhages, known as hemorrhagic transformations (HTs), which worsen the patient’s prognosis.[Objectives] To investigate the association between genetically determined natural hemostatic factors’ levels and increased risk of HT after r-tPA treatment.[Methods] Using data from genome-wide association studies on the risk of HT after r-tPA treatment and data on 7 hemostatic factors (factor [F]VII, FVIII, von Willebrand factor [VWF], FXI, fibrinogen, plasminogen activator inhibitor-1, and tissue plasminogen activator), we performed local and global genetic correlation estimation multitrait analyses and colocalization and 2-sample Mendelian randomization analyses between hemostatic factors and HT.[Results] Local correlations identified a genomic region on chromosome 16 with shared covariance: fibrinogen-HT, P = 2.45 × 10−11. Multitrait analysis between fibrinogen-HT revealed 3 loci that simultaneously regulate circulating levels of fibrinogen and risk of HT: rs56026866 (PLXND1), P = 8.80 × 10−10; rs1421067 (CHD9), P = 1.81 × 10−14; and rs34780449, near ROBO1 gene, P = 1.64 × 10−8. Multitrait analysis between VWF-HT showed a novel common association regulating VWF and risk of HT after r-tPA at rs10942300 (ZNF366), P = 1.81 × 10−14. Mendelian randomization analysis did not find significant causal associations, although a nominal association was observed for FXI-HT (inverse-variance weighted estimate [SE], 0.07 [−0.29 to 0.00]; odds ratio, 0.87; 95% CI, 0.75-1.00; raw P = .05).[Conclusion] We identified 4 shared loci between hemostatic factors and HT after r-tPA treatment, suggesting common regulatory mechanisms between fibrinogen and VWF levels and HT. Further research to determine a possible mediating effect of fibrinogen on HT risk is needed.This study is supported in part by the National Heart, Lung, and Blood Institute grants HL134894, HL139553, and HL141291. G.T.-S. is supported by the Pla Estratègic de Recerca i Innovació en Salut grant from the Catalan Department of Health for junior research personnel (SLT017/20/000100). M.S.-L. is supported by a Miguel Servet contract from the Instituto de Salud Carlos III (ISCIII) Spanish Health Institute (CPII22/00007) and cofinanced by the European Social Fund. E.M. is supported by a Río Hortega Contract (CM18/00198) from the ISCIII. J.C.-M. is supported by an Agència de Gestió d’Ajuts Universitaris i de Recerca Contract (FI_DGR 2020, grant number 2020FI_B1 00157) cofinanced by the European Social Fund. C.G.-F. is supported by a Sara Borrell Contract (CD20/00043) from ISCIII and Fondo Europeo de Desarrollo Regional (ISCIII- FEDER). M.L. is supported by a Contratos Predoctorales de Formación en Investigación en Salud Contract from the ISCIII (FI19/00309).Peer reviewe

Colombian consensus recommendations for diagnosis, management and treatment of the infection by SARS-COV-2/ COVID-19 in health care facilities - Recommendations from expert´s group based and informed on evidence

La Asociación Colombiana de Infectología (ACIN) y el Instituto de Evaluación de Nuevas Tecnologías de la Salud (IETS) conformó un grupo de trabajo para desarrollar recomendaciones informadas y basadas en evidencia, por consenso de expertos para la atención, diagnóstico y manejo de casos de Covid 19. Estas guías son dirigidas al personal de salud y buscar dar recomendaciones en los ámbitos de la atención en salud de los casos de Covid-19, en el contexto nacional de Colombia

Variation of a benthic heterotrophic bacteria community with different respiratory metabolisms in Coyuca de Benítez coastal lagoon (Guerrero, Mexico)

The fluctuations of the number, biomass and composition of the heterotrophic community were studied daily for two days, according to depth, pH, Eh, O2 and organic carbon concentration within a zone of the canal between the Coyuca de Benítez lagoon (Guerrero, Mexico) and the coastal waters. At the three moments of the day studied (6 am, 2 pm and 10 pm), the oxygen concentrations in the overlying water and in the superficial sediment layer were near air-saturation in the diurnal samplings (582 µM at 6 am and 665 µM at 2 pm), and sub-satured during the night (158 µM). In the sediments, the models of vertical distribution of Eh and organic carbon distributions were very irregular due to the bio-perturbation of the benthic, meio- and macrofauna, whose activity allows the superficial organic carbon to migrate towards sediment deeper layers. Vertical distribution of the different viable bacteria populations seems to be related to the hydrodynamic patterns of the communicating canal and sediments heterogeneity. In the sediment column, the heterotrophic bacteria total number varied from 6.8 to 20.3 x 108 cells cm-3. The highest heterotrophic bacterial biomass values were encountered during the diurnal samplings (39.2 µgC.l-1 at 6 am and 34.4 µgC.l-1 at 2 pm) and the lowest during the night (9.7 µgC.l-1). The fluctuations of viable heterotrophic bacteria populations with different respiratory metabolisms (aerobic, microaerophilic and anaerobic) can be explained by the existence of suboxic microniches that appear when particles of sediment are resuspended due to the water circulation and the benthic infauna excavating activity, that allows the supernatant water oxygen to penetrate through its galleries towards deeper sediment zones. The statistical analysis (Multiple lineal regression model r²≥ 0.5) showed that the on the whole, the hydrological parameters are not influence over the bacterial number and bacterial biomass distribution (r²≤ 0.5), Nevertheless, the variations of the heterotrophic bacteria community observed in the two days sampling, seem to be governed (with F-values of 0.6 to 0.9) by the irregular flows of bio-available organic material and the sediment porosity. Rev. Biol. Trop. 55 (1): 157-169. Epub 2007 March. 31.Las fluctuaciones en el número, biomasa y composición de la comunidad bacteriana heterotrófica fueron estudiadas con respecto a la profundidad y a los cambios de profundidad, pH, Eh, O2 y concentración de carbono orgánico, durante un período corto de tiempo (diarias durante 2 días), en una zona del canal que comunica la laguna de Coyuca de Benítez (Guerrero, México) con las aguas costeras. Durante los tres momentos del día (6 am, 2 pm y 10 pm) estudiados, las concentraciones de oxígeno en el agua sobrenadante y en la película superficial del sedimento se encontraron próximas a la de saturación del aire durante los muestreos diurnos (582 µM a las 6 am y de 665 µM a las 2 pm) y de subsaturación durante la noche (158 µM). En los sedimentos, los modelos de distribución vertical del Eh y del carbono orgánico fueron muy irregulares debido a la bioperturbación causada por la meio- y macrofauna béntica, ya que su actividad excavadora per-mite que del carbono orgánico superficial pase a las capas más profundas del sedimento. La distribución vertical de la comunidad bacteriana heterotrófica viable parece estar ligada a la hidrodinámica del canal de comunicación y a la heterogeneidad de los sedimentos. En la columna de sedimento, el número total de bacterias heterótrofas variaron entre 6.8 y 20.3 x 10(8) cel cm-3. Los valores más altos de biomasa bacteriana heterótrofa se registraron en los muestreos realizados de día (39.2 µgC.l-1 a las 6 am y 33.4 µgC.l-1 a las 2 pm) y los menores durante la noche (9.7µgC. l-1). Las fluctuaciones del número de bacterias viables con diferentes metabolismos respiratorio (aeróbicos, microaerofílicos y anaeróbicos), se pueden explicar por la existencia de micronichos subóxicos que se forman debido a la resuspensión de partículas sedimentarias por la circulación del agua y por acción de las actividades de excavación de los organismos bentónicos que a través de sus galerías permiten que el oxígeno del agua sobrenadante penetre a las zonas más profundas del sedimento. El análisis estadístico (Modelo de regresión lineal múltiple r²≥ 0.5) señaló que no hubo una relación directa entre los parámetros hidrológicos y la abundancia de las poblaciones bacterianas (r²≤ 0.5). Sin embargo, las variaciones de la comunidad bacteriana heterotrófica observada durante los dos días de muestreo, pareció estar gobernada por los flujos irregulares de materia orgánica biodisponible y por la porosidad del sedimento (F-valores de 0.6 a 0.9