Obesity, metabolic syndrome and diabetes: cardiovascular implications and therapy

Obesity, metabolic syndrome, and type-2 diabetes mellitus are 3 interrelated conditions that share a number of pathophysiological mechanisms and that are frequently observed to lead, in succession, to cardiovascular complications. The fact that their prevalence is increasing alarmingly should prompt all healthcare professionals urgently to implement measures to prevent these complications. The most effective, though also the least adopted, are those related to lifestyle modification. Drug treatment targeted at controlling risk factors (eg, hypertension, dyslipidemia, and thrombophilia), metabolic abnormalities, and excess weight is also necessary

Crystallographic and theoretical studies on a coupled chain of AF binuclear Cu(II)-fluoraspirinate complexes

We present here the low temperature (116K) crystal and molecular structure of poly-[μ-pyrazine{tetrakis-fluoraspirinate-dicopper(II)}]diacetonitrile, for short [Cu(Fasp)4Cu(pyz)]n, a 5-halogenated derivative of pharmacologically relevant copper aspirinates. We also discuss the theoretically expected magnetic and thermodynamic behavior of this interesting system for molecular magnetism.Instituto de Física La Plat

Low temperature crystal structure of natural diosgenone

The molecular structure of diosgenone, a natural steroidal sapogenin, closely related to diosgenin and isolated from Solanum nudum, was solved by single crystal X-ray diffractometry at 120 K and refined by full-matrix least-squares to an agreement factor, R1 = 0.054. It crystallizes in the monoclinic space group P21, with a = 15.1870(4) Å, b = 7.2710(2) Å, c = 21.2840(6) Å, β = 99.251(1)°, and four molecules in the unit cell (Z = 4). The results constitute the first structural report on a steroidal sapogenin from the diosgenin group.Facultad de Ciencias ExactasCentro de Química Inorgánic

A Mixed Ligand Platinum(II) Complex: Spectral Analysis, Crystal Structure, Steric Demand of the Ligand, and Bioactivity of cis-[Pt(PPh3)2(L1-O,S)]PF6 (L1-O,S = N,N-Morpholine-N′-benzoylthiourea)

A novel mixed platinum(II) complex with general formula [Pt(PPh3)2(L1-O,S)]PF6 has been synthetized and characterized by elemental analysis, molar conductivity, and by IR and NMR (1H, 13C and 31P) spectroscopic methods. The crystal structure has been determined by single-crystal X-ray crystallography. The molecule presents an almost ideal square-planar geometry, and the crystal is stabilized by weak C?H···O and C?H···F hydrogen bonds, and C?H···π stacking interactions. The steric congestion of ligands is described by ?exact? cone and solid cone angles, and the percentage of metal surface shielded by the ligands. The results are compared to closely related palladium complexes. The X-ray structure revealed the proximity of the ortho phenyl proton of one PPh3 ligand to platinum(II) showing rare intramolecular C?H···Pt anagostic binding interaction. The title complex was determined to be active against tumor cells, and it also showed a moderate inhibitory action against mycobacterium tuberculosis.Fil: Pérez, Hiram. Universidad de La Habana; CubaFil: Ramos, Raúl. Universidad de La Habana; CubaFil: Plutín, Ana M.. Universidad de La Habana; CubaFil: Mocelo, Raúl. Universidad de La Habana; CubaFil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Castellano, Eduardo E.. Universidade de Sao Paulo; BrasilFil: Batista, Alzir A.. Universidade Federal do São Carlos; Brasi

Reactivity and spectroscopy of the {Ru'(DMAP) IND.5'} fragment: an {Ru'(N'H IND.3') IND.5} analogue

Reaction of trans-Ru(DMSO)4Cl2 with DMAP (DMAP = 4-dimethylaminopyridine) yields the yellow [Ru(DMAP)6]2+ cation in good yield. The crystal and molecular structure of [Ru(DMAP)6]Cl2·6CH3CH2OH was determined by X-ray diffraction methods. The complex crystallizes in the trigonal R3̅ space group with a = b = 16.373(1), c = 20.311(1) Å, γ = 120°, and Z = 3 molecules per unit cell. The reaction of [Ru(DMAP)6]2+ in aerobic water gives the red [RuIII(DMAP)5(OH)]2+ cation. This complex shows a chemical behavior similar to [RuIII(NH3)5Cl]2+ and allows the preparation of a family of [Ru(DMAP)5L]n+ complexes. Their electronic properties indicate that the {RuII(DMAP)5} fragment is a weaker π-donor than {RuII(NH3)5}. Our density functional theory (DFT) calculations show that in {RuII(DMAP)5} the DMAP ligands can compete for the π electron density of the ruthenium making the fragment a weaker π-donor.CONICETANPCyTFAPES

Crystallographic and theoretical studies on a coupled chain of AF binuclear Cu(II)-fluoraspirinate complexes

We present here the low temperature (116K) crystal and molecular structure of poly-[μ-pyrazine{tetrakis-fluoraspirinate-dicopper(II)}]diacetonitrile, for short [Cu(Fasp)4Cu(pyz)]n, a 5-halogenated derivative of pharmacologically relevant copper aspirinates. We also discuss the theoretically expected magnetic and thermodynamic behavior of this interesting system for molecular magnetism.Instituto de Física La Plat

Structural, Spectroscopic, and Thermal Behaviour of Bis-(thiosaccharinate)- aqua-cadmium(II)

The crystal structure of the title complex, [Cd(tsac)2(H2O)], has been determined by single crystal X-ray diffraction methods. It crystallizes in the monoclinic space group C2/c (a = 12.236(3), b = 8.919(3), c = 16.655(3) A, β = 96.18(2)°, Z = 4). The molecular structure was solved from 1705 independent reflections with I > σ(I) and refined to R1 = 0.0489. Infrared and Raman spectra of the complex were recorded and are briefly discussed. Its thermal behaviour was investigated by thermogravimetry and differential thermal analysis.Instituto de Física La PlataCentro de Química Inorgánic

Low temperature crystal structure of natural diosgenone

The molecular structure of diosgenone, a natural steroidal sapogenin, closely related to diosgenin and isolated from Solanum nudum, was solved by single crystal X-ray diffractometry at 120 K and refined by full-matrix least-squares to an agreement factor, R1 = 0.054. It crystallizes in the monoclinic space group P21, with a = 15.1870(4) Å, b = 7.2710(2) Å, c = 21.2840(6) Å, β = 99.251(1)°, and four molecules in the unit cell (Z = 4). The results constitute the first structural report on a steroidal sapogenin from the diosgenin group.Facultad de Ciencias ExactasCentro de Química Inorgánic