Overconfidence in the art market: a bargaining pricing model with asymmetric disinformation

This paper develops a Nash bargaining model of price formation in the art market. Agents can be naïve, if they are overconfident and either overestimate artistic quality or underestimate their uncertainty of artistic quality, or sophisticated, if they correctly use all the available information. Overconfidence turns out to have a positive impact on both the price and the average quality of the artworks traded in the market. The impact of overconfidence on expected quality is weaker than the corresponding price increase, so sellers overcharge buyers. In addition, the buyer’s (seller’s) overconfidence has a positive (negative) impact on the likelihood of trade. If many pairs of agents may bargain simultaneously, we find that seller’s market power is negatively affected by the number of sellers and positively affected by the number of buyers. If sophisticated and naïve buyers coexist, naïve buyers exert a negative externality on the sophisticated ones, increasing the price the latter pay

Lipoplatin Treatment in Lung and Breast Cancer

The introduction of cisplatin in cancer treatment represents an important achievement in the oncologic field. Many types of cancers are now treated with this drug, and in testicular cancer patients major results are reached. Since 1965, other compounds were disovered and among them carboplatin and oxaliplatin are the main Cisplatin analogues showing similar clinical efficacy with a safer toxicity profile. Lipoplatin is a new liposomal cisplatin formulation which seems to have these characteristics. Lipoplatin was shown to be effective in NSCLC both in phase 2 and phase 3 trials, with the same response rate of Cisplatin, a comparable overall survival but less toxicity. A new protocol aiming to elucidate the double capacity of Lipoplatin to act as a chemotherapeutic and angiogenetic agent in triple-negative breast cancer patients is upcoming

Deployment requirements for deorbiting electrodynamic tether technology

In the last decades, green deorbiting technologies have begun to be investigated and have raised a great interest in the space community. Among the others, electrodynamic tethers appear to be a promising option. By interacting with the surrounding ionosphere, electrodynamic tethers generate a drag Lorentz force to decrease the orbit altitude of the satellite, causing its re-entry in the atmosphere without using propellant. In this work, the requirements that drive the design of the deployment mechanism proposed for the H2020 Project E.T.PACK—Electrodynamic Tether Technology for Passive Consumable-less Deorbit Kit—are presented and discussed. Additionally, this work presents the synthesis of the reference profiles used by the motor of the deployer to make the tethered system reach the desired final conditions. The result is a strategy for deploying electrodynamic tape-shaped tethers used for deorbiting satellites at the end of their operational life.Open Access funding provided by Università degli Studi di Padova. This work was supported by European Union’s H2020 Research and Innovation Programme under Grant Agreement No. 828902 (E.T.PACK Project). Gonzalo Sánchez-Arriaga's work is supported by the Ministerio de Ciencia, Innovación y Universidades of Spain under the Grant RYC-2014-15357

New development: Directly elected mayors in Italy: creating a strong leader doesn’t mean creating strong leadership

More than 20 years after their introduction, directly elected mayors are key players in Italian urban governance. This article explains the main effects of this reform on local government systems and provides lessons for other countries considering directly elected mayors

Characterization of Pupillary Light Response Features for the Classification of Patients with Optic Neuritis

Pupillometry is a promising technique for the potential diagnosis of several neurological pathologies. However, its potential is not fully explored yet, especially for prediction purposes and results interpretation. In this work, we analyzed 100 pupillometric curves obtained by 12 subjects, applying both advanced signal processing techniques and physics methods to extract typically collected features and newly proposed ones. We used machine learning techniques for the classification of Optic Neuritis (ON) vs. Healthy subjects, controlling for overfitting and ranking the features by random permutation, following their importance in prediction. All the extracted features, except one, turned out to have significant importance for prediction, with an average accuracy of 76%, showing the complexity of the processes involved in the pupillary light response. Furthermore, we provided a possible neurological interpretation of this new set of pupillometry features in relation to ON vs. Healthy classification

The immunological basis of tumor therapy by targeted delivery of TNFa to tumor vessels

ISSN:1742-469

Avionics System and Attitude Algorithms for a Deorbit Device Based on an Electrodynamic Tether

The main goal of the Electrodynamic Tether technology for PAssive Consumable-less deorbit Kit (E.T.PACK) project is to develop a deorbit device based on an electrodynamic tether with TRL 4 by 2022. In September 2022, its continuation, i.e. the E.T.PACK-F project, will carry on with the activities of E.T.PACK to prepare a flight model with TRL 8 that will be tested in an in-orbit demonstration mission in 2025. This work (i) describes the attitude determination and control strategy of the mission, which is used as a means of explaining its different phases and the dynamics of each one of them, (ii) provides a description of the avionics elements of the whole system, (iii) describes some of the tests performed until this moment, and (iv) summarizes the current status and the future work

The SIALON Project: Report on HIV Prevalence and Risk Behaviour Among MSM in Six European Cities

Data from 23 European countries show that the annual number of HIV diagnoses in men who have sex with men (MSM) increased by 86% between 2000 and 2006. This paper reports the main preliminary results of a bio-behavioural survey in MSM with a specific focus on HIV prevalence and use of United Nations General Assembly Special Session (UNGASS) indicators in six cities in Southern and Eastern Europe. Time-location sampling (TLS) was used. A total number of 2,356 questionnaires and 2,241 oral fluid samples were collected (invalid samples 4.1%). The data show different socio-demographic patterns across countries regarding age, level of education, living conditions, living area and self-identity. Southern European cities had the highest percentage of people who had tested for HIV and collected the result. More than 50% of respondents in the sample from Barcelona reported having used a condom last time they had anal sex (57.2%), whilst in all other cities this proportion was below 50%. The cities with the highest HIV prevalence in MSM were Barcelona (17.0%) and Verona (11.8%) whilst lower percentages were reported in Bratislava (6.1%), Bucharest (4.6%), Ljubljana (5.1%) and Prague (2.6%). The low prevalence in Eastern European cities is encouraging. However, with the level of high-risk sexual behaviour documented and the lower frequency of HIV test seeking behaviour, there is a clear risk of an increase in HIV transmission