Modellazione efficiente agli elementi finiti per l’analisi a collasso di strutture incollate complesse

Il lavoro verifica l’applicabilità di un modello semplificato agli elementi finiti per l’analisi a collasso post elastico di strutture incollate complesse in parete sottile. Al fine di superare le limitazioni dei modelli di letteratura come l’uso di elementi speciali, il lavoro sfrutta un modello ridotto già presentato dagli autori in campo elastico. Tale modello è basato sulla rappresentazione degli aderendi mediante elementi semistrutturali (piastre o gusci) e dell’adesivo per mezzo di speciali elementi coesivi. La continuità strutturale tra aderendi e adesivo è ottenuta mediante vincoli interni (tied mesh) che accomunano i gradi di libertà dei nodi mutuamente affacciati di aderendi ed adesivo. La struttura analizzata è un simulacro di incollaggio industriale e produce nella strato adesivo una sollecitazione complessa, analizzabile solo con modelli numerici. Si considera una struttura tubolare in parete sottile a sezione quadrata, fatta di due spezzoni posti testa a testa e incollati con fazzoletti di lamiera sui quattro lati. La struttura è sottoposta a flessione a tre punti fino al cedimento e la zona incollata posta disassata rispetto al punto di applicazione del carico riceve una sollecitazione indiretta. I risultati dell’analisi FEM, confrontati direttamente con le curve sperimentali forza-spostamento, evidenziano una buona accuratezza del metodo, in termini di rigidezza, forza massima e comportamento post elastico della struttura, accompagnati da ridotte dimensioni del modello e tempi di calcolo molto contenuti. Grazie a questi vantaggi, la procedura si presta ad effettuare l’analisi di strutture incollate complesse, altrimenti ingestibili se affrontate con una modellazione agli elementi finiti tradizionale

A Comparison between Rotating Squares and Anti-Tetrachiral Systems: Influence of Ligaments on the Multi-Axial Mechanical Response

Rotating unit systems are one of the most important and well-known classes of auxetic mechanical metamaterials. As their name implies, when loaded, these systems deform primarily via rotation of blocks of material, which may be connected together either directly through joints (or ‘joint-like’ connections made by overlapping vertices of the rotating units) as in the case of rotating rigid polygonal-unit systems or by ligaments/ribs as in the case of chiral honeycombs. In this work, we used Finite Element Analysis to investigate the effect which the presence/absence of ligaments has on the on-axis and off-axis mechanical properties of these systems by analysing two of the most well-known structures which characterise these two cases: the rotating square system and the anti-tetrachiral honeycomb. It was found that while the presence of ligaments has a negligible effect on the on-axis Poisson’s ratio of these systems, it has a profound influence on nearly all other mechanical properties as well as on the off-axis loading behaviour. Systems with ligaments were found to exhibit a high level of anisotropy and also a severely reduced level of stiffness in comparison to their non-ligamented counterparts. On the other hand, the rotating square system suffers from high localized stress-intensities and has a very low strain-tolerance threshold. In addition, an optimized ‘hybrid’ geometry which is specifically designed to capture the best features of both the anti-tetrachiral and rotating square system, was also analysed. This work shows the main differences between ligament-based and non-ligament-based auxetic structures and also highlights the importance of considering the off-axis mechanical response in addition to the on-axis properties when investigating such systems

Experimental characterization of pull-in parameters for an electrostatically actuated cantilever

MEMS-NEMS applications extensively use micro-nano cantilever structures as actuation system, thanks to their intrinsically simple end efficient configuration. Under the action of an electrostatic actuation voltage the can- tilever deflects, until it reaches the maximum value of the electrostatic actuation voltage, namely the pull-in voltage. This limits its operating point and is a critical issue for the switching of the actuator. The present work aims to experimentally measure the variation of the pull-in voltage and the tip deflection for different geometri- cal parameters of an electrostatically actuated cantilever. First, by relying on a nonlinear differential model from the literature, we designed and built a macro-scale cantilever switch, which can be simply adapted to different configurations. Second, we experimentally investigated the effect of the free length of the suspended electrode, and of the gap from the ground, on the pull-in response. The experimental results always showed a close agree- ment with the analytical predictions, with a maximum relative error lower that 10% for the pull-in voltage, and a relative difference lower than 18% for the pull-in deflection

Experimental and numerical analysis of a liquid aluminium injector for an Al-H2O based hydrogen production system

This paper investigates pressurised injection system for liquid aluminium for a cogeneration system based on the Al–H2O reaction. The reaction produces hydrogen and heat which is used for super-heating vapour for a steam cycle. The aluminium combustion with water generates also alumina as a byproduct; the aluminium oxide can be recycled and transformed back to aluminium. Thus, aluminium can be exploited as energy carrier in order to transport energy from the alumina recycling plant to the place where the cogeneration system is located. The water is also used in a closed loop; indeed, the amount of water produced employing the hydrogen obtained by the proposed system corresponds to the oxidizing water for the Al/H2O reaction. The development of a specific test rig designed for investigating the liquid aluminium injection is presented in this research study. The injector nozzle is investigated by means of numerical thermal and structural analysis. The calculations are compared and validated against the experimental measurements carried out on ad-hoc developed test rig. A good agreement between the numerical results and the experimental values is found and the new design of the nozzle is devised

A novel method for the simultaneous determination of drugs of abuse, ethyl glucuronide and synthetic opioids in human hair through a single digestion, purification and analysis in LC-MS/MS

Polydrug use is a serious health and social problem worldwide. Over the past several years, there has been an increasing tendency to combine narcotics, alcohol, sedatives, and/or stimulants. To the traditional drugs of abuse and alcohol, an increase of new abuse drugs such as synthetic opioids has been added. In the current study, the development and validation of an innovative and fast analytical procedure has been presented to determine drugs of abuse, ethyl glucuronide and synthetics opioids in 30 mg of human hair through a single digestion, purification and analysis in LC-MS/MS. A combine simple preparation of hair sample followed to a single chromatographic run of 10 min has been proposed. A full validation for 54 target analytes for the parameters of selectivity, linearity, limit of detection, limit of quantification, accuracy, precision, matrix effects, recovery, and dilution integrity was successful completed. The method was linear in different ranges with r values of at least 0.990; the value to the validated LLOQ values were in the range 0.1-100 pg/mg. The method offered satisfactory precisions (CV<15 % and accuracy +/- 20 %). In conclusion, a significant reduction in the overall times of the analytical procedure and the reduction of consumables costs make this method extremely advantageous and undoubtedly useful in routine laboratory workflow analyses and open the way to the prospect of a further implementation which also includes other classes of xenobiotics

Modellazione efficiente agli elementi finiti per l’analisi a collasso di strutture incollate complesse

Il lavoro verifica l’applicabilità di un modello semplificato agli elementi finiti per l’analisi a collasso post elastico di strutture incollate complesse in parete sottile. Al fine di superare le limitazioni dei modelli di letteratura come l’uso di elementi speciali, il lavoro sfrutta un modello ridotto già presentato dagli autori in campo elastico. Tale modello è basato sulla rappresentazione degli aderendi mediante elementi semistrutturali (piastre o gusci) e dell’adesivo per mezzo di speciali elementi coesivi. La continuità strutturale tra aderendi e adesivo è ottenuta mediante vincoli interni (tied mesh) che accomunano i gradi di libertà dei nodi mutuamente affacciati di aderendi ed adesivo. La struttura analizzata è un simulacro di incollaggio industriale e produce nella strato adesivo una sollecitazione complessa, analizzabile solo con modelli numerici. Si considera una struttura tubolare in parete sottile a sezione quadrata, fatta di due spezzoni posti testa a testa e incollati con fazzoletti di lamiera sui quattro lati. La struttura è sottoposta a flessione a tre punti fino al cedimento e la zona incollata posta disassata rispetto al punto di applicazione del carico riceve una sollecitazione indiretta. I risultati dell’analisi FEM, confrontati direttamente con le curve sperimentali forza-spostamento, evidenziano una buona accuratezza del metodo, in termini di rigidezza, forza massima e comportamento post elastico della struttura, accompagnati da ridotte dimensioni del modello e tempi di calcolo molto contenuti. Grazie a questi vantaggi, la procedura si presta ad effettuare l’analisi di strutture incollate complesse, altrimenti ingestibili se affrontate con una modellazione agli elementi finiti tradizionale

Indications for flexible fiberoptic bronchoscopy and its safety in the very elderly

Aim. To evaluate the indications and the safety of fiberoptic bronchoscopy (FOB) with bronchoalveolar lavage (BAL), protected specimen brushing (PSB), endobronchial biopsy (EBB), and transbronchial biopsy (TBB) in a population of very elderly patients. Methods. We performed a retrospective study of all adult patients, aged 50 years or older, who underwent FOB in the Bronchology Unit of the University of Parma Hospital between 1 January, 2003 and 31 April, 2005. Bronchoscopy records of 436 consecutive patients, including 191 patients, 75 yrs of age and older ("very elderly"; =>75 yrs), were reviewed. Results. Patients aged 75 years were no different with regard to gender, BMI, baseline FEV1/FVC ratio, baseline SaO2, and blood pressure. The primary indication in patients aged <75 years, was to assist in the diagnosis of a pulmonary mass of unknown aetiology (33%) and to remove secretions in the very elderly patients (31%). Indications for FOB and sampling procedures in the two groups were similar. Approximately 30% of patients in each group required supplemental oxygen during the procedure and fever occurred in 9.2% and 10.3% of patients, respectively.Hypertension and bleeding were relatively rare and did not occur more often in the very elderly. Conclusions. Indication for FOB did not vary with age and adverse events in both groups were uncommon and generally not severe

Spatially restricted expression of PlOtp, a Paracentrotus lividus Orthopedia-related homeobox gene, is correlated with oral ectodermal patterning and skeletal morphogenesis in late-cleavage sea urchin embryos

Several homeobox genes are expressed in the sea urchin embryo but their roles in development have yet to be elucidated. Of particular interest are homologues of homeobox genes that in mouse and Drosophila are involved in patterning the developing central nervous system (CNS). Here, we report the cloning of an orthpedia (Otp)-related gene from Paracentrotus lividus, PlOtp. Otp is a single copy zygotic gene that presents a unique and highly restricted expression pattern. Transcripts were first detected at the mid-gastrula stage in two pairs of oral ectoderm cells located in a ventrolateral position, overlying primary mesenchyme cell (PMC) clusters. Increases in both transcript abundance and the number of Otp-expressing cells were observed at prism and pluteus stages. Otp transcripts are symmetrically distributed in a few ectodermal cells of the oral field. Labelled cells were observed close to sites of active skeletal rod growth (tips of the budding oral and anal arms), and at the juxtaposition of stomodeum and foregut. Chemicals known to perturb PMC patterning along animal-vegetal and oral-aboral axes altered the pattern of Otp expression. Vegetalization by LiCl caused a shift in Otp-expressing cells toward the animal pole, adjacent to shifted PMC aggregates. Nickel treatment induced expression of the Otp gene in an increased number of ectodermal cells, which adopted a radialized pattern. Finally, ectopic expression of Otp mRNA affected patterning along the oral-aboral axis and caused skeletal abnormalities that resembled those exhibited by nickel-treated embryos. From these results, we conclude that the Otp homeodomain gene is involved in short-range cell signalling within the oral ectoderm for patterning the endoskeleton of the larva through epithelial-mesenchymal interactions

Transabdominal ultrasonographic measurement of caudal vena cava to aorta derived ratios in clinically healthy neonatal foals

Background: Ultrasonographic measurement of the vena cava and aorta (Ao) diameters and their ratios have been suggested to be a reliable way of quantifying hypovolemia. Objective: To evaluate the feasibility and reliability of an ultrasonographic technique for measurement of Ao and caudal vena cava (CVC) and derived ratios using three different acoustic windows in a population of healthy neonatal foals. Correlation between Ao and CVC measurements and ratios and foals' age or bodyweight were also investigated. Methods: In 14 healthy foals aged less than 7 days, the diameters of the Ao and of the CVC in long and short axis were measured by two observers from images obtained using three different ultrasonographic imaging planes (left dorsal, left ventral and right views). The Ao and CVC cross-sectional area and the CVC/Ao diameter and area ratios were calculated. Image quality was subjectively assessed. Intraobserver and interobserver reliabilities for image quality scores and measurements were evaluated between the two observers. Simple linear regression models were used to identify correlations between the CVC/Ao measurements and ratios and the age and bodyweight of the foals. Results: The left ventral view showed the highest reliability. A correlation between bodyweight and the short axis measurement of the CVC was found (R2 = 0.385; p = 0.018). Age was positively correlated with the long axis of measurement of the CVC (R2 = 0.426; p = 0.011) and CVC/Ao diameter ratio (R2 = 0.625; p = 0.001). Conclusions: The left ventral view allows the Ao and CVC cross sections to be easily visualized and measured in neonatal foals in right lateral recumbency