Evaluation de la prise en charge du surpoids et de l obésité de l adulte par les médecins généralistes (enquête qualitative auprès de 115 médecins généralistes de Seine-Saint-Denis)

PARIS7-Xavier Bichat (751182101) / SudocSudocFranceF

La consommation de produits sucrés évolue selon les effets secondaires dus aux traitements en oncologie

Le groupe de recherche NEODIA a pour objectif de comprendre le comportement alimentaire des patients traités pour un cancer et de proposer des approches culinaires pertinentes et adaptées. Nos travaux en analyse sensorielle ont montré une évolution de la perception de la saveur sucrée avec une augmentation du seuil de sensibilité et de la tolérance au sucre chez 25% des patients en oncologie [1]. La poursuite de l'étude se tourne vers l'évolution de la consommation en produits sucrés depuis la maladie et son interprétation

La consommation de produits sucrés évolue selon les effets secondaires dus aux traitements en oncologie

Le groupe de recherche NEODIA a pour objectif de comprendre le comportement alimentaire des patients traités pour un cancer et de proposer des approches culinaires pertinentes et adaptées. Nos travaux en analyse sensorielle ont montré une évolution de la perception de la saveur sucrée avec une augmentation du seuil de sensibilité et de la tolérance au sucre chez 25% des patients en oncologie [1]. La poursuite de l'étude se tourne vers l'évolution de la consommation en produits sucrés depuis la maladie et son interprétation

Different Levels of DNA Methylation Detected in Human Sperms after Morphological Selection Using High Magnification Microscopy

Objective. To analyze DNA methylation levels between two groups of spermatozoa taken from the same sample, following morphological selection by high magnification (HM) at 6100x microscopy. A prospective study was conducted and studied 876 spermatozoa from 10 randomly selected men. Sperm morphology was characterized at HM according to criteria previously established. High-scoring Score 6 and low-scoring Score 0 sperm were selected. Sperm DNA methylation level was assessed using an immunoassay method targeting 5-methylcytosine residues by fluorescence microscopy with imaging analysis system to detect DNA methylation in single spermatozoon. Results. In total, 448 S6 spermatozoa and 428 S0 spermatozoa were analyzed. A strong relationship was found between sperm DNA methylation levels and sperm morphology observed at HM. Sperm DNA methylation level in the S6 group was significantly lower compared with that in the S0 group (p<10-6), OR = 2.4; and p<0.001, as determined using the Wilcoxon test. Conclusion. Differences in DNA methylation levels are associated with sperm morphology variations as observed at HM, which allows spermatozoa with abnormal levels to be discarded and ultimately decrease birth defects, malformations, and epigenetic diseases that may be transmitted from sperm to offspring in ICSI

Les pratiques éducatives parentales en matière d’alimentation évaluées par les enfants : validation d’une échelle de mesure

Les pratiques éducatives parentales en matière d’alimentation évaluées par les enfants : validation d’une échelle de mesure. 9. Journées francophones de nutrition (JFN

Parental practices perceived by children using a French version of the Kids' Child Feeding Questionnaire.

WOS:000293677900024International audienceAbout 18% of 6-11-year-old French children are overweight, of whom 3.3% are obese. Parental feeding practices, especially restriction and pressure-to-eat, seem to promote overeating in children. Since no tool was available for the perception of parental feeding practices of French children, our aim was to validate a French version of the Kids'Child Feeding Questionnaire (KCFQ, Carper, Orlet Fischer, & Birch, 2000), and to determine the relationship between KCFQ's dimensions and children's standardised body mass index (BMI z-scores). The questionnaire was completed by 240 normal-weighted or overweight children between the age of 9 and 11. The validation was based on a confirmatory factor analysis. The internal consistency of factors was confirmed using Cronbach's coefficients. After deleting some items (3 for the pressure-to-eat subscale and 3 for the restriction subscale), the two-factor model (pressure-to-eat, restriction) provided an acceptable fit (χ² (34)=64; RMSEA=.06; CFI=0.93; NNFI=.90), and satisfactory internal consistency. Children's perception of restriction was significantly and positively correlated with BMI z-scores (r=36, p<.001), whereas their perception of pressure-to-eat was not significantly associated with BMI z-scores (r=-.09, p=.24). This scale appears to be a sound tool for highlighting children's perceptions of parental feeding practices, and their links to weight status

Néphropathies secondaires à un déficit en cobalamine C : première étude histopathologique comparative

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Molecular Profiling of Spermatozoa Reveals Correlations between Morphology and Gene Expression: A Novel Biomarker Panel for Male Infertility

International audienceChoosing spermatozoa with an optimum fertilizing potential is one of the major challenges in assisted reproductive technologies (ART). This selection is mainly based on semen parameters, but the addition of molecular approaches could allow a more functional evaluation. To this aim, we used sixteen fresh sperm samples from patients undergoing ART for male infertility and classified them in the high-and poor-quality groups, on the basis of their morphology at high magnification. Then, using a DNA sequencing method, we analyzed the spermatozoa methylome to identify genes that were differentially methylated. By Gene Ontology and protein-protein interaction network analyses, we defined candidate genes mainly implicated in cell motility, calcium reabsorption, and signaling pathways as well as transmembrane transport. RT-qPCR of high-and poorquality sperm samples allowed showing that the expression of some genes, such as AURKA, HDAC4, CFAP46, SPATA18, CACNA1C, CACNA1H, CARHSP1, CCDC60, DNAH2, and CDC88B, have different expression levels according to sperm morphology. In conclusion, the present study shows a strong correlation between morphology and gene expression in the spermatozoa and provides a biomarker panel for sperm analysis during ART and a new tool to explore male infertility

Hypoalbuminemia and hypergammaglobulinemia are associated with an increased infection risk in patients with myeloid malignancies treated with azacitidine. A 3-year monocentric retrospective study

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