63 research outputs found
Arrival directions of cosmic rays of E .4 EeV
The anisotropy of cosmic rays observed by the Utah Fly's Eye detector has been studied. Emphasis has been placed on examining distributions of events in galactic coordinates. No statistically significant departure from isotropy has been observed for energies greater than 0.4 EeV (1 EeV = 10 to the 18th power eV). Results of the standard harmonic analysis in right ascension are also presented
Atmospheric Muon Flux at Sea Level, Underground, and Underwater
The vertical sea-level muon spectrum at energies above 1 GeV and the
underground/underwater muon intensities at depths up to 18 km w.e. are
calculated. The results are particularly collated with a great body of the
ground-level, underground, and underwater muon data. In the hadron-cascade
calculations, the growth with energy of inelastic cross sections and pion,
kaon, and nucleon generation in pion-nucleus collisions are taken into account.
For evaluating the prompt muon contribution to the muon flux, we apply two
phenomenological approaches to the charm production problem: the recombination
quark-parton model and the quark-gluon string model. To solve the muon
transport equation at large depths of homogeneous medium, a semi-analytical
method is used. The simple fitting formulas describing our numerical results
are given. Our analysis shows that, at depths up to 6-7 km w. e., essentially
all underground data on the muon intensity correlate with each other and with
predicted depth-intensity relation for conventional muons to within 10%.
However, the high-energy sea-level data as well as the data at large depths are
contradictory and cannot be quantitatively decribed by a single nuclear-cascade
model.Comment: 47 pages, REVTeX, 15 EPS figures included; recent experimental data
and references added, typos correcte
A High Statistics Search for Ultra-High Energy Gamma-Ray Emission from Cygnus X-3 and Hercules X-1
We have carried out a high statistics (2 Billion events) search for
ultra-high energy gamma-ray emission from the X-ray binary sources Cygnus X-3
and Hercules X-1. Using data taken with the CASA-MIA detector over a five year
period (1990-1995), we find no evidence for steady emission from either source
at energies above 115 TeV. The derived upper limits on such emission are more
than two orders of magnitude lower than earlier claimed detections. We also
find no evidence for neutral particle or gamma-ray emission from either source
on time scales of one day and 0.5 hr. For Cygnus X-3, there is no evidence for
emission correlated with the 4.8 hr X-ray periodicity or with the occurrence of
large radio flares. Unless one postulates that these sources were very active
earlier and are now dormant, the limits presented here put into question the
earlier results, and highlight the difficulties that possible future
experiments will have in detecting gamma-ray signals at ultra-high energies.Comment: 26 LaTeX pages, 16 PostScript figures, uses psfig.sty to be published
in Physical Review
Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects
Over the last decade, pioneering liver-directed gene therapy trials for haemophilia B have achieved sustained clinical improvement after a single systemic injection of adeno-associated virus (AAV) derived vectors encoding the human factor IX cDNA. These trials demonstrate the potential of AAV technology to provide long-lasting clinical benefit in the treatment of monogenic liver disorders. Indeed, with more than ten ongoing or planned clinical trials for haemophilia A and B and dozens of trials planned for other inherited genetic/metabolic liver diseases, clinical translation is expanding rapidly. Gene therapy is likely to become an option for routine care of a subset of severe inherited genetic/metabolic liver diseases in the relatively near term. In this review, we aim to summarise the milestones in the development of gene therapy, present the different vector tools and their clinical applications for liver-directed gene therapy. AAV-derived vectors are emerging as the leading candidates for clinical translation of gene delivery to the liver. Therefore, we focus on clinical applications of AAV vectors in providing the most recent update on clinical outcomes of completed and ongoing gene therapy trials and comment on the current challenges that the field is facing for large-scale clinical translation. There is clearly an urgent need for more efficient therapies in many severe monogenic liver disorders, which will require careful risk-benefit analysis for each indication, especially in paediatrics
A ribosomal DNA fragment of Listeria monocytogenes and its use as a genus-specific probe in an aqueous-phase hybridization assay
The photonuclear energy loss of cosmic-ray muons and its relation with photon-nucleon cross-section
Voting in the Eurovision Song Contest
The Eurovision Song Contest is not only the largest song contest worldwide but also probably the world’s largest election for a non-political office. In this article, we are interested in the voting behaviour of Eurovision viewers. Do they vote sincerely, strategically according to rational choice assumptions (i.e. for the song they believe will be the likely winner) or for another song? Using data from a large-scale survey carried out in Europe, we find interesting voting patterns with regard to these questions. Roughly one-fourth of the survey participants would vote for either their preferred song or for the song they think will win. However, the percentage of strategic voters is lower (11%). In contrast, many individuals (i.e. 36% of participants) would vote for another song, one that is neither their preferred song, the likely winner, nor a rational choice. The reasoning behind these remaining votes may include neighbourhood voting, ethnic voting, and voting for one’s favourite European country
- …