928 research outputs found
Celiac disease
Celiac disease is a chronic intestinal disease caused by intolerance to gluten. It is characterized by immune-mediated enteropathy, associated with maldigestion and malabsorption of most nutrients and vitamins. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. The main symptoms are: stomach pain, gas, and bloating, diarrhea, weight loss, anemia, edema, bone or joint pain. Prevalence for clinically overt celiac disease varies from 1:270 in Finland to 1:5000 in North America. Since celiac disease can be asymptomatic, most subjects are not diagnosed or they can present with atypical symptoms. Furthermore, severe inflammation of the small bowel can be present without any gastrointestinal symptoms. The diagnosis should be made early since celiac disease causes growth retardation in untreated children and atypical symptoms like infertility or neurological symptoms. Diagnosis requires endoscopy with jejunal biopsy. In addition, tissue-transglutaminase antibodies are important to confirm the diagnosis since there are other diseases which can mimic celiac disease. The exact cause of celiac disease is unknown but is thought to be primarily immune mediated (tissue-transglutaminase autoantigen); often the disease is inherited. Management consists in life long withdrawal of dietary gluten, which leads to significant clinical and histological improvement. However, complete normalization of histology can take years
Celiac disease
Celiac disease is a chronic intestinal disease caused by intolerance to gluten. It is characterized by immune-mediated enteropathy, associated with maldigestion and malabsorption of most nutrients and vitamins. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. The main symptoms are: stomach pain, gas, and bloating, diarrhea, weight loss, anemia, edema, bone or joint pain. Prevalence for clinically overt celiac disease varies from 1:270 in Finland to 1:5000 in North America. Since celiac disease can be asymptomatic, most subjects are not diagnosed or they can present with atypical symptoms. Furthermore, severe inflammation of the small bowel can be present without any gastrointestinal symptoms. The diagnosis should be made early since celiac disease causes growth retardation in untreated children and atypical symptoms like infertility or neurological symptoms. Diagnosis requires endoscopy with jejunal biopsy. In addition, tissue-transglutaminase antibodies are important to confirm the diagnosis since there are other diseases which can mimic celiac disease. The exact cause of celiac disease is unknown but is thought to be primarily immune mediated (tissue-transglutaminase autoantigen); often the disease is inherited. Management consists in life long withdrawal of dietary gluten, which leads to significant clinical and histological improvement. However, complete normalization of histology can take years
Motion of four-dimensional rigid body around a fixed point: an elementary approach. I
The goal of this note is to give the explicit solution of Euler-Frahm
equations for the Manakov four-dimensional case by elementary means. For this,
we use some results from the original papers by Schottky [Sch 1891], Koetter
[Koe 1892], Weber [We 1878], and Caspary [Ca 1893]. We hope that such approach
will be useful for the solution of the problem of -dimensional top.Comment: LaTeX, 9 page
Biochemistry and functional aspects of human glandular kallikreins
Human urinary kallikrein was purified by gel filtration on Sephacryl S-200 and affinity chromatography on aprotinin-Sepharose, followed by ion exchange chromatography on DEAE-Sepharose. In dodecylsulfate gel electrophoresis two protein bands with molecular weights of 41,000 and 34,000 were separated. The amino acid composition and the carbohydrate content of the kallikrein preparation were determined; isoleucine was identified as the only aminoterminal amino acid. The bimolecular velocity constant for the inhibition by diisopropyl fluorophosphate was determined as 9±2 l mol–1 min–1. The hydrolysis of a number of substrates was investigated and AcPheArgOEt was found to be the most sensitive substrate for human urinary kallikrein. Using this substrate an assay method for kallikrein in human urine was developed.
It was shown by radioimmunoassay that pig pancreatic kallikrein can be absorbed in the rat intestinal tract. Furthermore, in dogs the renal excretion of glandular kallikrein from blood was demonstrated by radioimmunological methods
Local Moment Formation in the Periodic Anderson Model with Superconducting Correlations
We study local moment formation in the presence of superconducting
correlations among the f-electrons in the periodic Anderson model. Local
moments form if the Coulomb interaction U>U_cr. We find that U_cr is
considerably stronger in the presence of superconducting correlations than in
the non-superconducting system. Our study is done for various values of the
f-level energy and electronic density. The smallest critical U_cr values occur
for the case where the number of f- electrons per site is equal to one. In the
presence of d-wave superconducting correlations we find that local moment
formation presents a quantum phase transition as function of pressure. This
quantum phase transition separates a region where local moments and d-wave
superconductivity coexist from another region characterized by a
superconducting ground state with no local moments. We discuss the possible
relevance of these results to experimental studies of the competition between
magnetic order and superconductivity in CeCu_2Si_2.Comment: 4 pages. accepted for publication in Phys. Rev.
Coexistence of antiferromagnetism and superconductivity in heavy-fermions systems
We report the novel pressure(P)-temperature(T) phase diagrams of
antiferromagnetism (AF) and superconductivity (SC) in CeRhIn, CeIn and
CeCuSi revealed by the NQR measurement. In the itinerant helical magnet
CeRhIn, we found that the N\'eel temperature is reduced at
1.23 GPa with an emergent pseudogap behavior. The coexistence of AF and SC is
found in a narrow P range of 1.63 - 1.75 GPa, followed by the onset of SC with
line-node gap over a wide P window 2.1 - 5 GPa. In CeIn, the localized
magnetic character is robust against the application of pressure up to
1.9 GPa, beyond which the system evolves into an itinerant regime in which the
resistive superconducting phase emerges. We discuss the relationship between
the phase diagram and the magnetic fluctuations. In CeCuSi, the SC and
AF coexist on a microscopic level once its lattice parameter is expanded. We
remark that the underlying marginal antiferromagnetic state is due to
collective magnetic excitations in the superconducting state in CeCuSi.
An interplay between AF and SC is discussed on the SO(5) scenario that unifies
AF and SC. We suggest that the SC and AF in CeCuSi have a common
mechanism.Comment: 6 pages, 5 figures, proceeding of ISSP200
Correlation gap in the heavy-fermion antiferromagnet UPd_2Al_3
The optical properties of the heavy-fermion compound UPdAl have been
measured in the frequency range from 0.04 meV to 5 meV (0.3 to 40 cm) at
temperatures K. Below the coherence temperature K, the hybridization gap opens around 10 meV. As the temperature decreases
further ( K), a well pronounced pseudogap of approximately 0.2 meV
develops in the optical response; we relate this to the antiferromagnetic
ordering which occurs below K. The frequency dependent mass and
scattering rate give evidence that the enhancement of the effective mass mainly
occurs below the energy which is associated to the magnetic correlations
between the itinerant and localized 5f electrons. In addition to this
correlation gap, we observe a narrow zero-frequency conductivity peak which at
2 K is less than 0.1 meV wide, and which contains only a fraction of the
delocalized carriers. The analysis of the spectral weight infers a loss of
kinetic energy associated with the superconducting transition.Comment: RevTex, 15 pages, 7 figure
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