Aplicación interuniversitaria del aprendizaje basado en retos en la asignatura de Mejora Genética Animal

[EN] This paper presents the results of the first year of the inter-university implementation of challenge-based learning (CBL) in animal breeding. The challenge faced by students from the Universitat Autónoma de Barcelona, the Universidad Politécnica de Madrid and the Universitat Politècnica de València consisted of managing the genetic improvement of a cattle herd in an environment with real management and economic constraints using DCBSP software. The results obtained by the students in the challenge showed an improvement throughout the challenge, which would indicate its usefulness in learning the application of animal breeding. Regarding the students' evaluation of the challenge. The results of the surveys showed high satisfaction with this type of learning in all universities, although they indicated possible improvements in the initial explanation of the challenge. The experience during the first course of pilot application of the CBL has been very positive from the point of view of student participation and motivation, as well as with the development of critical thinking through the practical application of theoretical concepts.[ES] En este trabajo se presentan los resultados del primer año de la implementación interuniversitaria del aprendizaje basado en retos en la asignatura de Mejora Genética Animal. El reto al que se enfrentaron los alumnos de la Universitat Autònoma de Barcelona, la Universidad Politécnica de Madrid y la Universitat Politècnica de València consistió en gestionar la mejora genética de un rebaño de vacuno lechero en un entorno con limitaciones de manejo y económicas reales a través de un software informático DCBS. Los resultados obtenidos por los alumnos en el reto evidenciaron una mejoría a lo largo del mismo, lo que indicaría su utilidad en el aprendizaje de la aplicación de de la mejora genética animal. Respecto a la valoración del reto por parte de los estudiantes, los resultados de las encuestas mostraron una satisfacción elevada con este tipo de aprendizaje en todas las universidades, aunque indicaron posibles mejoras en la explicación incial del reto. La experiencia durante el primer curso de aplicación piloto del ABR ha sido muy positiva tanto desde un punto de vista de participación y motivación de los alumnos, como con el desarrollo del pensamiento crítico a través de la aplicación práctica de conceptos teóricos.Ibáñez Escriche, N.; Casto Rebollo, C.; Formoso-Rafferty Castilla, N.; González Recio, O.; Casellas Vidal, J. (2021). Aplicación interuniversitaria del aprendizaje basado en retos en la asignatura de Mejora Genética Animal. En IN-RED 2021: VII Congreso de Innovación Edicativa y Docencia en Red. Editorial Universitat Politècnica de València. 104-113. https://doi.org/10.4995/INRED2021.2021.13464OCS10411

A Genetic Predictive Model for Canine Hip Dysplasia : Integration of Genome Wide Association Study (GWAS) and Candidate Gene Approaches

Canine hip dysplasia is one of the most prevalent developmental orthopedic diseases in dogs worldwide. Unfortunately, the success of eradication programs against this disease based on radiographic diagnosis is low. Adding the use of diagnostic genetic tools to the current phenotype-based approach might be beneficial. The aim of this study was to develop a genetic prognostic test for early diagnosis of hip dysplasia in Labrador Retrievers. To develop our DNA test, 775 Labrador Retrievers were recruited. For each dog, a blood sample and a ventrodorsal hip radiograph were taken. Dogs were divided into two groups according to their FCI hip score: control (A/B) and case (D/E). C dogs were not included in the sample. Genetic characterization combining a GWAS and a candidate gene strategy using SNPs allowed a case-control population association study. A mathematical model which included 7 SNPs was developed using logistic regression. The model showed a good accuracy (Area under the ROC curve = 0.85) and was validated in an independent population of 114 dogs. This prognostic genetic test represents a useful tool for choosing the most appropriate therapeutic approach once genetic predisposition to hip dysplasia is known. Therefore, it allows a more individualized management of the disease. It is also applicable during genetic selection processes, since breeders can benefit from the information given by this test as soon as a blood sample can be collected, and act accordingly. In the authors' opinion, a shift towards genomic screening might importantly contribute to reducing canine hip dysplasia in the future. In conclusion, based on genetic and radiographic information from Labrador Retrievers with hip dysplasia, we developed an accurate predictive genetic test for early diagnosis of hip dysplasia in Labrador Retrievers. However, further research is warranted in order to evaluate the validity of this genetic test in other dog breeds