Comment: On Random Scan Gibbs Samplers

Comment on ``On Random Scan Gibbs Samplers'' [arXiv:0808.3852]Comment: Published in at http://dx.doi.org/10.1214/08-STS252B the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

Poly(hydroxyalkanoate) production by Cupriavidus necator from fatty waste can be enhanced by phaZ1 inactivation

PHA production from waste oils or fats requires microorganisms that should be both excellent PHA producers and equipped with enzymatic activities allowing hydrolysation of triglycerides. Unfortunately, microbes with the combination of substrate-utilization and PHA production are not currently available, and the strategies to be adopted are the use of costly commercial enzymes, or genetic modification of microorganisms exhibiting high PHA product yields. In the present work, after a general investigation on the ability of Cupriavidus necator to grow on a number of fatty substrates, the possibility to enhance PHA production by limiting intracellular depolymerisation, was investigated. By knocking out the related phaZ1 gene, the construction of C. necator recombinant strains impaired in depolymerase (PhaZ1) activity was achieved. The polymer yield of the recombinant strain was finally compared to that of the parental C. necator DSM 545

Weighing the black holes in ultraluminous X-ray sources through timing

We describe a new method to estimate the mass of black holes in Ultraluminous X-ray Sources (ULXs). The method is based on the recently discovered ``variability plane'', populated by Galactic stellar-mass black-hole candidates (BHCs) and supermassive active galactic nuclei (AGNs), in the parameter space defined by the black-hole mass, accretion rate and characteristic frequency. We apply this method to the two ULXs from which low-frequency quasi-periodic oscillations have been discovered, M82 X-1 and NGC 5408 X-1. For both sources we obtain a black-hole mass in the range 100~1300 Msun, thus providing evidence for these two sources to host an intermediate-mass black hole.Comment: 5 pages, 2 figures, Accepted by MNRA

The complex time behaviour of the microquasar GRS 1915+105 in the \rho-class observed with BeppoSAX. III: The hard X-ray delay and limit cycle mapping

The microquasar GRS1915+105 was observed by BeppoSAX in October 2000 for about ten days while the source was in \rho-mode, which is characterized by a quasi-regular type I bursting activity. This paper presents a systematic analysis of the delay of the hard and soft X-ray emission at the burst peaks. The lag, also apparent from the comparison of the [1.7-3.4] keV light curves with those in the [6.8-10.2] keV range, is evaluated and studied as a function of time, spectral parameters, and flux. We apply the limit cycle mapping technique, using as independent variables the count rate and the mean photon rate. The results using this technique were also cross-checked using a more standard approach with the cross-correlation methods. Data are organized in runs, each relative to a continuous observation interval. The detected hard-soft delay changes in the course of the pointing from about 3 s to about 10 s and presents a clear correlation with the baseline count rate.Comment: accepted for publication in A&

Rate-Control or Rhythm-Contol: Where do we stand?

Atrial fibrillation is the most common sustained rhythm disturbance and its prevalence is increasing worldwide due to the progressive aging of the population. Current guidelines clearly depict the gold standard management of acute symptomatic atrial fibrillation but the best-long term approach for first or recurrent atrial fibrillation is still debated with regard to quality of life, risk of new hospitalizations, and possible disabling complications, such as thromboembolic stroke, major bleeds and death. Some authors propose that regaining sinus rhythm in all cases, thus re-establishing a physiologic cardiac function not requiring a prolonged antithrombotic therapy, avoids the threat of intracranial or extracranial haemorrhages due to Vitamin K antagonists or aspirin. On the contrary, advocates of a rate control approach with an accurate antithrombotic prophylaxis propose that such a strategy may avoid the risk of cardiovascular and non cardiovascular side effects related to antiarrhythmic drugs. This review aims to explore the state of our knowledge in order to summarize evidences and issues that need to be furthermore clarified

The strong weak convergence of the quasi-EA

In this paper, we investigate the convergence of a novel simulation scheme to the target diffusion process. This scheme, the Quasi-EA, is closely related to the Exact Algorithm (EA) for diffusion processes, as it is obtained by neglecting the rejection step in EA. We prove the existence of a myopic coupling between the Quasi-EA and the diffusion. Moreover, an upper bound for the coupling probability is given. Consequently we establish the convergence of the Quasi-EA to the diffusion with respect to the total variation distance

Discovery of coherent millisecond X-ray pulsations in Aql X-1

We report the discovery of an episode of coherent millisecond X-ray pulsation in the neutron star low-mass X-ray binary Aql X-1. The episode lasts for slightly more than 150 seconds, during which the pulse frequency is consistent with being constant. No X-ray burst or other evidence of thermonuclear burning activity is seen in correspondence with the pulsation, which can thus be identified as occurring in the persistent emission. The pulsation frequency is 550.27 Hz, very close (0.5 Hz higher) to the maximum reported frequency from burst oscillations in this source. Hence we identify this frequency with the neutron star spin frequency. The pulsed fraction is strongly energy dependent, ranging from 10% (16-30 keV). We discuss possible physical interpretations and their consequences for our understanding of the lack of pulsation in most neutron star low-mass X-ray binaries. If interpreted as accretion-powered pulsation, Aql X-1 might play a key role in understanding the differences between pulsating and non-pulsating sources.Comment: 5 pages, 3 figures, accepted by ApJ Letters after minor revisions. Slightly extended discussion. One author added. Uses emulateapj.cl