Value stream mapping as a lean manufacturing tool: A new account approach for cost saving in a textile company

[EN] Companies around the world are under pressure to reduce their prices to be competitive. In order to keep profitability, they are adopting lean manufacturing (LM) and its tools to reduce waste and, consequently, the costs. Value stream mapping (VSM) is an efficient LM tool, identifying production flow waste. When it is possible to combine VSM with other LM tool, such as Kanban, a substantial impact in inventory reduction is reached. Additionally, the conventional account system shows limitations in the costs reduction to keep up with LM. The purpose of this paper is to present the results obtained by the application of the VSM combined with Kanban and the new account approach to measure the effectiveness of the cost reduction in the finished goods inventory. Considering that LM tools application in the textile segment has not an expressive number of researches, four hypothesis are presented and validated. 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Levantamento fitossociológico de plantas daninhas em cafezal orgânico.

A adequação de um cafezal para o sistema orgânico causa grande mudança no sistema de manejo de plantas daninhas, mas as informações sobre o comportamento da comunidade infestante em áreas de cultivo de café orgânico são escassas no Brasil. Objetivou-se com este trabalho realizar um levantamento fitossociológico da comunidade infestante em três cafezais (variedades Mundo Novo, Bourbon Vermelho e Obatã) desenvolvidos em sistema orgânico, no município de Garça (SP). Nas três áreas estudadas foram arremessados ao acaso cem quadrados metálicos com área vazada de 0,25 m2, nas entrelinhas da cultura. As espécies contidas no interior dos quadros foram identificadas segundo a espécie botânica, nome popular e família. A partir dos resultados, determinaram-se os parâmetros fitossociológicos: frequência, densidade, abundância, frequência relativa, densidade relativa, abundância relativa, índice de valor de importância e similaridade florísticas pelos métodos de Simple Matching de Sneath & Sokal e similaridade de Sorensen. As famílias que mais se destacaram, com maior número de espécies nas três áreas foram Poaceae e Asteraceae. Houve alta similaridade em todos os contrastes testados, já que pelo menos metade das espécies identificadas foi comum às duas áreas contrastadas

New drugs from traditional medicines: pharmacological evaluation of plant extracts from Chapada Diamantina (Brazil)

Plants are rich sources of medicines and Brazil is among the most biodiverse nations in the world.info:eu-repo/semantics/publishedVersio

Climate proofing the renewable electricity deployment in Europe - Introducing climate variability in large energy systems models

Climate and weather conditions influence energy demand. as well as electricity generation, especially due to the strong development of renewable energy. The changes of the European energy mix, together with ongoing climate change, raise a number of questions on impact on the electricity sector. In this paper we present results for the whole of the European power sector regarding on how considering current and future climate variability affects the results of a TIMES energy system model for the whole European power sector (eTIMES-EU) up to 2050. For each member-state we consider six climate projections to generate future capacity factors for wind, solar and hydro power generation. as well as temperature impact on electricity demand for heating and cooling. These are input into the eTIMES-EU model to assess how climate affects the optimal operation of the power system and if current EU-wide RES and emissions target deployment may be affected. Results show that although at EU-wide level there are no substantial changes, there are significant differences in countries RES deployment (especially wind and solar) and in electricity trade.info:eu-repo/semantics/publishedVersio

A New Strategy To Identify Rare Blood Donors: Single Polymerase Chain Reaction Multiplex Snapshot Reaction For Detection Of 16 Blood Group Alleles

Background. As an alternative to phenotyping, large-scale DNA-based assays, which are feasible for high-throughput donor red blood cell typing, were developed for determination of blood group polymorphisms. However, high-throughput genotyping platforms based on these technologies are still expensive and the inclusion of single nucleotide polymorphisms and analysis of the alleles depend on the manufacturer's determination. To overcome this limitation and in order to develop an assay to enable the screening of rare donors, we developed a SNaPshot assay for analysis of nine single nucleotide polymorphisms related to antigens that are difficult to assess using conventional serology. Materials and methods. The single polymerase chain reaction multiplex SNaPshot reaction was optimized to identify nine single nucleotide polymorphisms determining 16 alleles: KEL*3/KEL*4, KEL*6/KEL*7, DI*1/DI*2, DI*3/DI*4, YT*1/YT*2, CO*1/CO*2, DO*1/DO*2, DO*4, DO*5. We designed a single multiplex PCR with primers encompassing the blood group single nucleotide polymorphisms and performed an internal reaction with probe primers able to discriminate the alleles after fragment analysis. The SNaPshot assay was validated with 140 known alleles previously determined by PCR restriction fragment length polymorphism. Results. We were able to simultaneous detect nine single nucleotide polymorphisms defining 16 blood group alleles on an assay based on a multiplex PCR combined with a single base extension using genomic DNA. Discussion. 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The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment.

Breast cancer is a high-burden malignancy for society, whose impact boosts a continuous search for novel diagnostic and therapeutic tools. Among the recent therapeutic approaches, photothermal therapy (PTT), which causes tumor cell death by hyperthermia after being irradiated with a light source, represents a high-potential strategy. Furthermore, the effectiveness of PTT can be improved by combining near infrared (NIR) irradiation with gold nanoparticles (AuNPs) as photothermal enhancers. Herein, an alternative synthetic method using rosmarinic acid (RA) for synthesizing AuNPs is reported. The RA concentration was varied and its impact on the AuNPs physicochemical and optical features was assessed. Results showed that RA concentration plays an active role on AuNPs features, allowing the optimization of mean size and maximum absorbance peak. Moreover, the synthetic method explored here allowed us to obtain negatively charged AuNPs with sizes favoring the local particle accumulation at tumor site and maximum absorbance peaks within the NIR region. In addition, AuNPs were safe both in vitro and in vivo. In conclusion, the synthesized AuNPs present favorable properties to be applied as part of a PTT system combining AuNPs with a NIR laser for the treatment of breast cancer