Using MiniBooNE neutral current elastic cross section results to constrain 3+1 sterile neutrino models

The MiniBooNE Neutral Current Elastic (NCEL) cross section results are used to extract limits in the $\Delta m^{2}-\sin^{2}\vartheta_{\mu s}$ plane for a 3+1 sterile neutrino model with a mass splitting $0.1 \leq \Delta m^{2} \leq 10.0$ eV$^{2}$. GENIE is used with a cross section model close to the one employed by MiniBooNE to make event rate predictions using simulations on the MiniBooNE target material CH$_{2}$. The axial mass is a free parameter in all fits. Sterile modifications to the flux and changes to the cross section in the simulation relate the two and allow limits to be set on sterile neutrino mixing using cross section results. The large axial mass problem makes it necessary for experiments to perform their own axial mass fits, but a prior fit to the same dataset could mask a sterile oscillation signal if the sterile and cross section model parameters are not independent. We find that for the NCEL dataset there are significant correlations between the sterile and cross section model parameters, making a fit to both models simultaneously necessary to get robust results. Failure to do this results in stronger than warranted limits on the sterile parameters. The general problems that the current uncertainty on charged-current quasi-elastic (CCQE) and NCEL cross sections at MiniBooNE energies pose for sterile neutrino measurements are discussed.Comment: Final version accepted for publication in JHE

Effect of Larval Nutrition on Maternal mRNA Contribution to the Drosophila Egg.

Embryonic development begins under the control of maternal gene products, mRNAs and proteins that the mother deposits into the egg; the zygotic genome is activated some time later. Maternal control of early development is conserved across metazoans. Gene products contributed by mothers are critical to many early developmental processes, and set up trajectories for the rest of development. Maternal deposition of these factors is an often-overlooked aspect of parental investment. If the mother experiences challenging environmental conditions, such as poor nutrition, previous studies in Drosophila melanogaster have demonstrated a plastic response wherein these mothers may produce larger eggs to buffer the offspring against the same difficult environment. This additional investment can produce offspring that are more fit in the challenging environment. With this study, we ask whether D. melanogaster mothers who experience poor nutrition during their own development change their gene product contribution to the egg. We perform mRNA-Seq on eggs at a stage where all mRNAs are maternally derived, from mothers with different degrees of nutritional limitation. We find that nutritional limitation produces similar transcript changes at all degrees of limitation tested. Genes that have lower transcript abundance in nutritionally limited mothers are those involved in translation, which is likely one of the most energetically costly processes occurring in the early embryo. We find an increase in transcripts for transport and localization of macromolecules, and for the electron transport chain. The eggs produced by nutrition-limited mothers show a plastic response in mRNA deposition, which may better prepare the future embryo for development in a nutrition-limited environment

Practical Strategies and Advice for Managing Ethical Concerns in End-of-Life Research

poster abstractProblem/Issue Statement A growing national interest in improving end-of-life care has increased the amount of research involving dying patients and their families. However, questions about how to best balance the pressing need for research with protecting participants trouble both investigators and institutional review boards (IRBs). Furthermore, ethical concerns were identified as a potential barrier to advancing end-of-life science at the 2004 NIH State of the Science Consensus Conference. This NIH-funded study describes ethical concerns and practical strategies for managing ethical challenges in the conduct of end-of-life research. Description of Research Methods: A qualitative, exploratory case study design followed the development of end-of-life research from proposal generation through the review process. Inclusion criteria mirrored those used in the NIH State of the Science Report. Cases were identified through a search of active studies in the NIH RePORT database and an internet search of active research funded by private foundations and institutions. Data were collected from a purposive sample of 34 principal investigators who participated by phone in semistructured interviews and provided document data regarding their experiences with the grant and IRB review processes. Interviews were recorded and transcribed with identifying information removed to protect confidentiality. Relevant document data were extracted and de-identified. Data were analyzed using exploratory qualitative case study methods. Results: The most common ethical concerns about research with end-of-life populations were recruitment strategies, the burden of study procedures, and population vulnerability. Strategies to address these concerns included gathering data about the benefits of research participation, consulting with the IRB and with more experienced researchers, using non-threatening language in the consent and other materials, being flexible in data collection protocols to accommodate participant limitations, creating back-up plans in the event of crisis, partnering with clinicians to ensure prompt attention to symptom reports, and addressing the training and emotional needs of research staff . PIs advise IRBs to seek out expert consultants for end-of-life studies, work collaboratively with investigators, simplify the consent process, and be open to the benefits of research participation for dying patients and their families rather than assuming harm will occur. Conclusion: Investigators use a variety of strategies to manage ethical issues in the conduct of end-oflife research. They advise IRBs to seek out expertise, enhance knowledge of the population, and work collaboratively with investigators. Future research will focus on gathering systematic data regarding the experiences of dying patients and their families with end-of-life research

Being on-call: an exploration of the experiences of doctors and significant others

Previous research has not compared proximal and distal doctors’ subjective evaluations of their on-call experiences and there is a dearth of evidence on the impact of being on-call on doctors’ personal lives. The aim of this thesis was to explore on-call doctors (i.e. proximal and distal) and significant others’ (SOs) perceptions of their experiences when they or their partners are on-call. The thesis also sought to uncover the meaning of being on-call for the participants’ family and social lives. Consistent with qualitative methodology, 25 semi structured interviews were conducted with 18 Trinbagonian doctors who worked on-call and seven Trinbagonian SOs whose partners worked on-call. Thematic analysis was used to search for commonalities in the meaning of the experience between and within the groups. The findings revealed that the participants were ambivalent in their perceptions of their on-call experience (i.e. it could not be classified as either favourable or unfavourable). Themes centred on the doctors’ acceptance of their on-call duties despite describing their experience as tiring, stressful and dangerous. They also emphasised SOs’ perceptions of their partners’ on-call as no longer an issue. Nevertheless, it was a source of distraction and they remained concerned about their partners’ safety when responding to call-outs. Being on-call also had implications for how the doctors and SOs managed their intimate and parent-child relationships and the extent to which they engaged in non-work activities. These implications differed according to on-call category and gender - the latter of which was indicative of the reproduction of wider Trinbagonian gendered ideologies within social structures. The study suggests that strategies geared towards improving the on-call experience of doctors should reflect distinctions in the on-call experiences of proximal and distal doctors and role expectations of men and women doctors. It should also incorporate the experiences of those who live with them

Retaining health carers:the role of personal and organisation job resources

Purpose: The purpose of this paper is to identify key personal and organisational resources that influence the engagement, well-being and job satisfaction of healthcare professionals working in Australia.  Design/methodology/approach: Using the job demands–resources model, this study investigates how employee resources and organisation resources influence engagement, well-being and job satisfaction of health professionals in Australian hospitals. The authors collected survey data from a sample of healthcare professionals (n=217) working in three hospitals in New South Wales, Australia.  Findings: The results confirm the importance of the emotional health of employees on their well-being. The results concur with existing research that employees with higher levels of emotional health have more positive emotional and social interactions, and thus exhibit higher levels of well-being at work. The study also uncovers certain aspects of emotional health that can influence a range of employee outcomes.  Practical implications: The findings link human resource management practices to unique motivators of healthcare professionals which, in turn, are likely to improve engagement, well-being and job satisfaction.  Originality/value: The study highlights specific resources that support greater levels of well-being, engagement and job satisfaction in Australian hospitals

Administrators' perspectives on ethical issues in long-term care research

ETHICAL ISSUES ARE A SIGNIFICANT potential barrier to much-needed research in long-term care settings. LTC stakeholder perspectives are largely absent from the development of regulation and guidelines. Fifteen long-term care administrators were interviewed as part of a study of ethical issues in community-based, long-term care research. Established qualitative procedures for conducting content analysis were used to organize the data. Findings suggest that existing mechanisms to protect human subjects do not take into account important differences between academic and long-term care settings. The full potential of LTC research will not be realized until supportive processes to enhance human subjects protections are developed in a way that is reflective of the LTC environment

Geologic studies to identify the source for high levels of radium and barium in Illinois ground-water supplies: a preliminary report

Analyses of water from municipal wells in Illinois by the Illinois Environmental Protection Agency showed that more than 300 wells exceeded the upper limit, 3 picocuries/liter (U.S. Public Health Service, 1962), for gross alpha radiation in drinking water. More than 30 wells exceeded the upper limit, 1 milligram/liter (U.S. Public Health Service, 1962), for barium in drinking water. High levels of radiation in ground water were more extensive in areal distribution than the high levels of barium. All of the affected wells were finished in bedrock, primarily in rocks of the Cambrian and Ordovician Systems of northern Illinois. The geologic settings in which the high levels of radiation and barium were documented indicated that the problem was not restricted to Illinois.The source of the radiation in ground water was thought to be the natural occurrence of the radioactive elements.uranium-238 and thorium-232 in the aquifer rocks. Analyses of a limited number of rock samples indicated that uranium and thorium concentrations were highest in fine-grained sediments in the aquifer systems; the highest concentration was in shales that confine the aquifer.The occurrence of natural radioisotopes in ground water was thought to be complex, involving source rocks, ground water chemistry, and the hydraulic stress placed on the aquifer.Chemical analyses of rock samples indicated that high concentrations of barium were widespread in rocks of the Cambrian and Ordovician Systems. The concentration of barium in ground water was controlled by solubility equilibria reactions with sulfate ion. A map showing sulfate ion concentration in the Cambrian-Ordovician Aquifer could be used to delimit regions where barium might occur at concentrations exceeding 1 milligram/liter.U.S. Department of the InteriorU.S. Geological Surve