Volumetric budget and grain-size fractionation of a geological sediment routing system: Eocene Escanilla Formation, south-central Pyrenees

The supply of sediment and its characteristic grain-size mix are key controls on depositional facies and stratigraphic architectures in sedimentary basins. Consequently, constraints on sediment caliber, budgets, and fluxes are a prerequisite for effective stratigraphic prediction. Here, we investigate a mid- to late Eocene (41.6–33.9 Ma) sediment routing system in the Spanish Pyrenees. We derive a full volumetric sediment budget, weighted for grain-size fractions, partitioned between terrestrial and marine depositional sectors, and we quantify sediment fluxes between depocenters. The paleo–sediment routing system was controlled by syndepositional thrust tectonics and consisted of two major feeder systems eroding the high Pyrenees that supplied a river system draining parallel to the regional tectonic strike and that ultimately exported sediment to coastal, shallow- marine and deep-marine depo centers. We show significant changes in both the volume and grain-size distribution of sediment eroded from the Pyrenean mountain belt during three different time intervals in the mid- to late Eocene, which controlled the characteristics of stratigraphy preserved in a series of wedge-top basins The time-averaged sediment discharge from source areas increased from ~250 km3/m.y. to 700 km3/m.y. over the 7.7 m.y. interval investigated. This temporal increase in sediment supply caused major westward progradation of facies belts and led to substantial sediment bypass through the terrestrial routing system to the (initially) marine Jaca Basin. The grain-size mix, measured as size fractions of gravel, sand, and fi ner than sand, also changed over the three time intervals intervals. Integration of volumetric and grain-size information from source to sink provides an estimate of the long-term grain-size distribution of the sediment supply, comprising 9% gravel, 24% sand, and 67% finer than sand. The techniques and concepts used in the Escanilla study can profitably be applied to paleo–sediment routing systems in other tectonic and climatic settings and to catchments with a range of bedrock lithology and vegetation. This will promote a better generic understanding of the dynamics of source-to sink systems and provide a powerful tool for forward stratigraphic modeling. The sediment routing system approach has the potential to contribute strongly to new models of sequence stratigraphy

Cosmic Vortons and Particle Physics Constraints

We investigate the cosmological consequences of particle physics theories that admit stable loops of superconducting cosmic string - {\it vortons}. General symmetry breaking schemes are considered, in which strings are formed at one energy scale and subsequently become superconducting in a secondary phase transition at what may be a considerably lower energy scale. We estimate the abundances of the ensuing vortons, and thereby derive constraints on the relevant particle physics models from cosmological observations. These constraints significantly restrict the category of admissible Grand Unified theories, but are quite compatible with recently proposed effects whereby superconducting strings may have been formed close to the electroweak phase transition.Comment: 33 pages, 2 figures, RevTe

Cosmic D-Strings and Vortons in Supergravity

Recent developments in string inspired models of inflation suggest that D-strings are formed at the end of inflation. Within the supergravity model of D-strings there are 2(n-1) chiral fermion zero modes for a D-string of winding n. Using the bounds on the relic vorton density, we show that D-strings with winding number n>1 are more strongly constrained than cosmic strings arising in cosmological phase transitions. The D-string tension of such vortons, if they survive until the present, has to satisfy 8\pi G_N \mu \lesssim p 10^{-26} where p is the intercommutation probability. Similarly, D-strings coupled with spectator fermions carry currents and also need to respect the above bound. D-strings with n=1 do not carry currents and evade the bound. We discuss the coupling of D-strings to supersymmetry breaking. When a single U(1) gauge group is present, we show that there is an incompatibility between spontaneous supersymmetry breaking and cosmic D-strings. We propose an alternative mechanism for supersymmetry breaking, which includes an additional U(1), and might alleviate the problem. We conjecture what effect this would have on the fermion zero modes.Comment: 11 page

Pregnant Patients Using Opioids: Treatment Access Barriers in the Age of COVID-19

Objectives:Before the COVID-19 pandemic, many pregnant patients experienced barriers in accessing opioid use disorder (OUD) medication. This project surveyed buprenorphine treatment clinics to determine how many accepted pregnant women before and then during the pandemic. Of those clinics accepting pregnant patients during the pandemic, respondents were asked what services were provided and what forms of payment they accepted.Methods:Between July and September 2020, phone contact was made with every sixth unduplicated clinic in North Carolina listed in the Substance Abuse and Mental Health Administration treatment locator (N = 490 clinics). The response rate was 53%.Results:Of the 128 clinics responding, 62 clinics (48%) failed to treat pregnant patients both before and during the pandemic, whereas 66 clinics (52%) accepted pregnant patients before the COVID-19 pandemic, with only 44 (66%) of these clinics accepting pregnant patients during the pandemic. Thus, 33% fewer clinics accepted pregnant women for OUD treatment. Of these 44 clinics, 52% provided same-day intake, 45% prescribed naltrexone, and 57% offered detoxification with opioid agonists. Self-pay (95%), private insurance (77%), and Medicaid (55%) were accepted as payment. Clinics commonly reported providing individual counseling (86%). No clinics provided childcare or transportation.Conclusions:Almost half of the buprenorphine clinics in North Carolina turned away pregnant patients before the pandemic. During the pandemic, only 34% accepted pregnant patients, with 33% clinics that had provided medication treatment before the pandemic declining to treat pregnant patients for OUD. Thus, it is critical that policymakers ensure OUD treatment clinics accept pregnant patients

Structure of the ovaries of the Nimba otter shrew, Micropotamogale lamottei, and the Madagascar hedgehog tenrec, Echinops telfairi

The otter shrews are members of the subfamily Potamogalinae within the family Tenrecidae. No description of the ovaries of any member of this subfamily has been published previously. The lesser hedgehog tenrec, Echinops telfairi, is a member of the subfamily Tenrecinae of the same family and, although its ovaries have not been described, other members of this subfamily have been shown to have ovaries with non-antral follicles. Examination of these two species illustrated that non-antral follicles were characteristic of the ovaries of both species, as was clefting and lobulation of the ovaries. Juvenile otter shrews range from those with only small follicles in the cortex to those with 300- to 400-mu m follicles similar to those seen in non-pregnant and pregnant adults. As in other species, most of the growth of the oocyte occurred when follicles had one to two layers of granulosa cells. When larger follicles became atretic in the Nimba otter shrew, hypertrophy of the theca interna produced nodules of glandular interstitial tissue. In the tenrec, the hypertrophying theca interna cells in most large follicles appeared to undergo degeneration. Both species had some follicular fluid in the intercellular spaces between the more peripheral granulosa cells. It is suggested that this fluid could aid in separation of the cumulus from the remaining granulosa at ovulation. The protruding follicles in lobules and absence of a tunica albuginea might also facilitate ovulation of non-antral follicles. Ovaries with a thin-absent tunica albuginea and follicles with small-absent antra are widespread within both the Eulipotyphla and in the Afrosoricida, suggesting that such features may represent a primitive condition in ovarian development. Lobulated and deeply crypted ovaries are found in both groups but are not as common in the Eulipotyphla making inclusion of this feature as primitive more speculative. Copyright (C) 2005 S. Karger AG, Basel

Involvement of autophagy in hypoxic-excitotoxic neuronal death.

Neuronal autophagy is increased in numerous excitotoxic conditions including neonatal cerebral hypoxia-ischemia (HI). However, the role of this HI-induced autophagy remains unclear. To clarify this role we established an in vitro model of excitotoxicity combining kainate treatment (Ka, 30 µM) with hypoxia (Hx, 6% oxygen) in primary neuron cultures. KaHx rapidly induced excitotoxic death that was completely prevented by MK801 or EGTA. KaHx also stimulated neuronal autophagic flux as shown by a rise in autophagosome number (increased levels of LC3-II and punctate LC3 labeling) accompanied by increases in lysosomal abundance and activity (increased SQSTM1/p62 degradation, and increased LC3-II levels in the presence of lysosomal inhibitors) and fusion (shown using an RFP-GFP-LC3 reporter). To determine the role of the enhanced autophagy we applied either pharmacological autophagy inhibitors (3-methyladenine or pepstatinA/E64) or lentiviral vectors delivering shRNAs targeting Becn1 or Atg7. Both strategies reduced KaHx-induced neuronal death. A prodeath role of autophagy was also confirmed by the enhanced toxicity of KaHx in cultures overexpressing BECN1 or ATG7. Finally, in vivo inhibition of autophagy by intrastriatal injection of a lentiviral vector expressing a Becn1-targeting shRNA increased the volume of intact striatum in a rat model of severe neonatal cerebral HI. These results clearly show a death-mediating role of autophagy in hypoxic-excitotoxic conditions and suggest that inhibition of autophagy should be considered as a neuroprotective strategy in HI brain injuries

F-term strings in the Bogomol'nyi limit are also BPS states

We derive the Bogomol'nyi equations for supersymmetric Abelian F-term cosmic strings in four-dimensional flat space and show that, contrary to recent statements in the literature, they are BPS states in the Bogomol'nyi limit, but the partial breaking of supersymmetry is from N=2. The second supersymmetry is not obvious in the N=1 formalism, so we give it explicitly in components and in terms of a different set of N=1 chiral superfields. We also discuss the appearance of a second supersymmetry in D-term models, and the relation to N=2 F-term models. The analysis sheds light on an apparent paradox raised by the recent observation that D-term strings remain BPS when coupled to N=1 supergravity, whereas F-term strings break the supersymmetry completely, even in the Bogomol'nyi limit. Finally, we comment on their semilocal extensions and their relevance to cosmology.Comment: 11 pages; References added, minor corrections, matches published versio

Oscillation damping of chiral string loops

Chiral cosmic string loop tends to the stationary (vorton) configuration due to the energy loss into the gravitational and electromagnetic radiation. We describe the asymptotic behaviour of near stationary chiral loops and their fading to vortons. General limits on the gravitational and electromagnetic energy losses by near stationary chiral loops are found. For these loops we estimate the oscillation damping time. We present solvable examples of gravitational radiation energy loss by some chiral loop configurations. The analytical dependence of string energy with time is found in the case of the chiral ring with small amplitude radial oscillations.Comment: 10 pages, 2 figures. Accepted for publication in Physical Review

Stealth Branes

We discuss the brane world model of Dvali, Gabadadze and Porrati in which branes evolve in an infinite bulk and the brane curvature term is added to the action. If Z_2 symmetry between the two sides of the brane is not imposed, we show that the model admits the existence of "stealth branes" which follow the standard 4D internal evolution and have no gravitational effect on the bulk space. Stealth branes can nucleate spontaneosly in a Minkowski bulk. This process is described by the standard 4D quantum cosmology formalism with tunneling boundary conditions for the brane world wave function. The notorious ambiguity in the choice of boundary conditions is fixed in this case due to the presence of the embedding spacetime. We also point to some problematic aspects of models admitting stealth brane solutions.Comment: 24 pages; Final version, to appear in Phys. Rev. D. The discussion of "embeddability obstruction" is removed (thanks to Takahiro Tanaka who convinced us that there is no such obstruction

Fermion zero modes in N=2 supervortices

We study the fermionic zero modes of BPS semilocal magnetic vortices in N=2 supersymmetric QED with a Fayet-Iliopoulos term and two matter hypermultiplets of opposite charge. There is a one-parameter family of vortices with arbitrarily wide magnetic cores. Contrary to the situation in pure Nielsen-Olesen vortices, new zero modes are found which get their masses from Yukawa couplings to scalar fields that do not wind and are non-zero at the core. We clarify the relation between fermion mass and zero modes. The new zero modes have opposite chiralities and therefore do not affect the net counting (left minus right) of zero modes coming from index theorems but manage to evade other index theorems in the literature that count the total number (left plus right) of zero modes in simpler systems.Comment: 9 pages, 1 figure. Uses Revtex4. Revised version includes discussion about the back-reaction of the fermions on the background vortex. Version to be published in Phys. Rev.