730 research outputs found
The potential of low-intensity and online interventions for depression in low- and middle-income countries
The World Health Organization (WHO) reports that low- and middle-income countries (LMICs) are confronted with a serious âmental health gapâ, indicating an enormous disparity between the number of individuals in need of mental health care and the availability of professionals to provide such care (WHO in 2010). Traditional forms of mental health services (i.e. face-to-face, individualised assessments and interventions) are therefore not feasible. We propose three strategies for addressing this mental health gap: delivery of evidence-based, low-intensity interventions by non-specialists, the use of transdiagnostic treatment protocols, and strategic deployment of technology to facilitate access and uptake. We urge researchers from all over the world to conduct feasibility studies and randomised controlled studies on the effect of low-intensity interventions and technology supported (e.g. online) interventions in LMICs, preferably using an active control condition as comparison, to ensure we disseminate effective treatments in LMICs
Spectroscopic Analysis of H I Absorption Line Systems in 40 HIRES Quasars
We list and analyze H I absorption lines at redshifts 2 < z < 4 with column
density (12 < log(N_HI) < 19) in 40 high-resolutional (FWHM = 8.0 km/s) quasar
spectra obtained with the Keck+HIRES. We de-blend and fit all H I lines within
1,000 km/s of 86 strong H I lines whose column densities are log(N_HI/[cm^-2])
> 15. Unlike most prior studies, we use not only Lya but also all visible
higher Lyman series lines to improve the fitting accuracy. This reveals
components near to higher column density systems that can not be seen in Lya.
We list the Voigt profile fits to the 1339 H I components that we found. We
examined physical properties of H I lines after separating them into several
sub-samples according to their velocity separation from the quasars, their
redshift, column density and the S/N ratio of the spectrum. We found two
interesting trends for lines with 12 < log(N_HI) < 15 which are within 200-1000
km/s of systems with log(N_HI) > 15. First, their column density distribution
becomes steeper, meaning relatively fewer high column density lines, at z <
2.9. Second, their column density distribution also becomes steeper and their
line width becomes broader by about 2-3 km/s when they are within 5,000 km/s of
their quasar.Comment: 32 pages, 14 figures, accepted for publication in the Astronomical
Journal. A complete version with all tables and figures is available at
http://www.astro.psu.edu/users/misawa/pub/Paper/40hires.ps.g
Partial purification of a serum factor that causes necrosis of tumors.
Tumor necrosis can be induced in transplanted mouse methylcholanthrene-induced sarcoma by a tumor necrosis factor in the serum of mice infected with bacillus Calmette-Guérin and given bacterial endotoxin. Sera from normal mice, endotoxin-treated mice, and mice infected with bacillus Calmette-Guérin do not contain this factor. A 20- to 30-fold purification of the serum factor has been achieved by (NH4)2SO4 fractionation, Sephadex G-100 and G-200 gel filtration, and preparative polyacrylamide electrophoresis. Tumor necrosis factor is not bacterial endotoxin. It migrates with alpha-globulins, is made up of at least four subunits, and has a molecular weight of about 150,000. The active factor is a glycoprotein that contains sialic acid and galactosamine
Intergalactic UV Background Radiation Field
We have performed proximity effect analysis of low and high resolution data,
considering detailed frequency and redshift dependence of the AGN spectra
processed through galactic and intergalactic material. We show that such a
background flux, calculated using the observed distribution of AGNs, falls
short of the value required by the proximity effect analysis by a factor of
2.7. We have studied the uncertainty in the value of the required flux
due to its dependence on the resolution, description of column density
distribution, systemic redshifts of QSOs etc. We conclude that in view of these
uncertainties the proximity effect is consistent with the background
contributed by the observed AGNs and that the hypothesized presence of an
additional, dust extinct, population of AGNs may not be necessary.Comment: To be published in the Journal of Astronomy and Astrophysics aasms, 2
figures, 2 tables. Paper replaced to include the figure
The D/H Ratio in the Interstellar Medium toward the White Dwarf PG0038+199
We determine the D/H ratio in the interstellar medium toward the DO white
dwarf PG0038+199 using spectra from the Far Ultraviolet Spectroscopic Explorer
(FUSE), with ground-based support from Keck HIRES. We employ curve of growth,
apparent optical depth and profile fitting techniques to measure column
densities and limits of many other species (H2, NaI, CI, CII, CIII, NI, NII,
OI, SiII, PII, SIII, ArI and FeII) which allow us to determine related ratios
such as D/O, D/N and the H2 fraction. Our efforts are concentrated on measuring
gas-phase D/H, which is key to understanding Galactic chemical evolution and
comparing it to predictions from Big Bang nucleosynthesis. We find column
densities log N(HI) = 20.41+-0.08, log N(DI)=15.75+-0.08 and log N(H2) =
19.33+-0.04, yielding a molecular hydrogen fraction of 0.14+-0.02 (2 sigma
errors), with an excitation temperature of 143+-5K. The high HI column density
implies that PG0038+199 lies outside of the Local Bubble; we estimate its
distance to be 297 (+164,-104)pc (1 sigma). D/[HI+2H2] toward PG0038+199 is
1.91(+0.52,-0.42) e-5 (2 sigma). There is no evidence of component structure on
the scale of Delta v > 8 km/s based on NaI, but there is marginal evidence for
structure on smaller scales. The D/H value is high compared to the majority of
recent D/H measurements, but consistent with the values for two other
measurements at similar distances. D/O is in agreement with other distant
measurements. The scatter in D/H values beyond ~100pc remains a challenge for
Galactic chemical evolution.Comment: 59 pages, 7 tables, 18 figures (1 standalone), accepted by ApJ v2
minor typos correcte
Limits on Active-Sterile Neutrino Mixing and the Primordial Deuterium Abundance
Studies of limits on active-sterile neutrino mixing derived from big bang
nucleosynthesis considerations are extended to consider the dependance of these
constraints on the primordial deuterium abundance. This study is motivated by
recent measurements of D/H in quasar absorption systems, which at present yield
discordant results. Limits on active-sterile mixing are somewhat relaxed for
high D/H. For low D/H (), no active-sterile neutrino
mixing is allowed by currently popular upper limits on the primordial He
abundance . For such low primordial D/H values, the observational inference
of active-sterile neutrino mixing by upcoming solar neutrino experiments would
imply that has been systematically underestimated, unless there is new
physics not included in standard BBN.Comment: 10 pages + 2 figures, uses revtex macros, submitted to Phys. Rev. D.
Corrected figure captions and an added referenc
From Espresso to Codex
CODEX and ESPRESSO are concepts for ultra-stable, high-resolution
spectrographs at the E-ELT and VLT, respectively. Both instruments are well
motivated by distinct sets of science drivers. However, ESPRESSO will also be a
stepping stone towards CODEX both in a scientific as well as in a technical
sense. Here we discuss this role of ESPRESSO with respect to one of the most
exciting CODEX science cases, i.e. the dynamical determination of the cosmic
expansion history.Comment: To appear in the Proceedings of the Workshop "Science with the VLT in
the ELT era", 8-12 October 2007, Garching, A. Moorwood, e
Spatial Variability in the Ratio of Interstellar Atomic Deuterium to Hydrogen. I. Observations toward delta Orionis by the Interstellar Medium Absorption Profile Spectrograph
Studies of the abundances of deuterium in different astrophysical sites are
of fundamental importance to answering the question about how much deuterium
was produced during big bang nucleosynthesis and what fraction of it was
destroyed later. With this in mind, we used the Interstellar Medium Absorption
Profile Spectrograph (IMAPS) on the ORFEUS-SPAS II mission to observe at a
wavelength resolution of 4 km/s (FWHM) the L-delta and L-epsilon absorption
features produced by interstellar atomic deuterium in the spectrum of delta Ori
A. A chi-square analysis indicated that 0.96 < N(D I)< 1.45e15 cm^{-2} at a 90%
level of confidence, and the gas is at a temperature of about 6000K. To obtain
an accurate value of N(H I) needed for a determination of the atomic ratio of D
to H, we measured the L-alpha absorption features in 57 spectra of delta Ori in
the IUE archive. From our measurement of N(H I)= 1.56e20 cm^{-2}, we found that
N(D I)/N(H I)= 7.4(+1.9,-1.3)e-6 (90% confidence). Our result for D/H contrasts
with the more general finding along other lines of sight that D/H is
approximately 1.5e-5. The underabundance of D toward delta Ori A is not
accompanied by an overabundance of N or O relative to H, as one might expect if
the gas were subjected to more stellar processing than usual.Comment: 37 pages, 6 figures. Submitted to the Astrophysical Journa
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