A Comprehensive Echinacea Germplasm Collection Located at the North Central Regional Plant Introduction Station, Ames, Iowa

Echinacea is a well-established, high-value crop, both as an ornamental and dietary supplement. A comprehensive collection of Echinacea germplasm is currently held at the USDA-ARS North Central Regional Plant Introduction Station (NCRPIS) in Ames, Iowa, and is available via seed distribution for research purposes . The NCRPIS\u27s mission includes: (1) The conservation of genetically diverse crop germplasm through collection and acquisition; (2) The conduct of germplasm-related research; and (3) The encouragement of the use of the germplasm collections and associated information for research, crop improvement, and product development. Representing all nine species collected throughout their respective North American geographic ranges, the Echinacea collect.ion includes 159 accessions (Table 1). Extensive morphological characterization data associated with t.he collection have been assembled and are available to researchers to aid in select.ion criteria. The collection has been used extensively for various research projects ranging from ornamental breeding studies for the horticulture trade to HPLC analysis of metabolites of interest to the phytopharmaceutical industry. Germplasm is collected and made available for distribution through a series of steps. Those steps include: (1) Acquisition and exploration; (2) Regeneration and evaluation; (3) Dormancy and germination stu dies; (4) Seed propagation in field cages with pollinating insects; (5) Harvesting, drying, cleaning, and processing seeds; (6) Long-term storage under cont.rolled conditions; and (7) Distribution for research purposes

Understanding Displacement, (Forced) Migration and Historical Trauma: The Contribution of Feminist New Materialism

Feminist new materialist theory has taken up the challenge of reconfiguring politics, ethics and justice in ways that critically account for contemporary forms of materiality, affect and embodiment at work in the contemporary world. There is much at stake in such a project. The crisis of displacement, we argue, is the crisis of capitalism as it impacts on the biosphere of planet earth, necessitating an approach that can account for all the processes essential to life and living. In this paper our intention is to suggest ways of understanding displacement that unites social and environmental justice, while simultaneously merging ethical, political, ontological and epistemological concerns. Building on the nexus of capitalism and displacement, we investigate the confluence of the necropolitical (Mbembe 2003) and the necrobiopolitical (Bubandt 2017; Cooper 2008) as we sketch an uncanny tableau of more-than-human displacements across various entangled cenes – the Anthropocene, Capitalocene, Plantationocene, Shadowcene and Chthulucene. Our intention is to displace, trouble and haunt the centrality of the purely human in social work. The unfolding crisis of capitalism, we argue, is a crisis of displacement for all forms of life; a crisis that necessitates troubling humanist formulations of justice, care and ethics

Parallel and I/O-efficient randomisation of massive networks using global curveball trades

Graph randomisation is a crucial task in the analysis and synthesis of networks. It is typically implemented as an edge switching process (ESMC) repeatedly swapping the nodes of random edge pairs while maintaining the degrees involved [23]. Curveball is a novel approach that instead considers the whole neighbourhoods of randomly drawn node pairs. Its Markov chain converges to a uniform distribution, and experiments suggest that it requires less steps than the established ESMC [6]. Since trades however are more expensive, we study Curveball’s practical runtime by introducing the first efficient Curveball algorithms: the I/O-efficient EM-CB for simple undirected graphs and its internal memory pendant IM-CB. Further, we investigate global trades [6] processing every node in a single super step, and show that undirected global trades converge to a uniform distribution and perform superior in practice. We then discuss EM-GCB and EMPGCB for global trades and give experimental evidence that EM-PGCB achieves the quality of the state-of-the-art ESMC algorithm EM-ES [15] nearly one order of magnitude faster

Miniaturized thin-film filters to connect multiple self-written waveguides

Self-written waveguides (SWWs) have been well investigated within the last decades. In most cases, they are used as low-loss coupling structures, i.e., to connect buried optical structures in photonic integrated circuits. In this work, we extend the field of possible applications for SWWs by embedding a novel thin-film filter to split the beam and connect multiple output ports simultaneously. The multilayer design of the dielectric filter can be customized to enable its application as a dichroic beamsplitter for photonic networks. The embedded thin-film filter was characterized in detail and used to connect an additional optical sensing element, which is also based on SWWs, to demonstrate its usability for measurement of physical quantities

CARbon DIoxide for the treatment of Febrile seizures: rationale, feasibility, and design of the CARDIF-study

Background: 2-8% of all children aged between 6 months and 5 years have febrile seizures. Often these seizures cease spontaneously, however depending on different national guidelines, 20-40% of the patients would need therapeutic intervention. For seizures longer than 3-5 minutes application of rectal diazepam, buccal midazolam or sublingual lorazepam is recommended. Benzodiazepines may be ineffective in some patients or cause prolonged sedation and fatigue. Preclinical investigations in a rat model provided evidence that febrile seizures may be triggered by respiratory alkalosis, which was subsequently confirmed by a retrospective clinical observation. Further, individual therapeutic interventions demonstrated that a pCO2-elevation via re-breathing or inhalation of 5% CO2 instantly stopped the febrile seizures. Here, we present the protocol for an interventional clinical trial to test the hypothesis that the application of 5% CO2 is effective and safe to suppress febrile seizures in children. Methods: The CARDIF (CARbon DIoxide against Febrile seizures) trial is a monocentric, prospective, double-blind, placebo-controlled, randomized study. A total of 288 patients with a life history of at least one febrile seizure will be randomized to receive either carbogen (5% CO2 plus 95% O2) or placebo (100% O2). As recurrences of febrile seizures mainly occur at home, the study medication will be administered by the parents through a low-pressure can fitted with a respiratory mask. The primary outcome measure is the efficacy of carbogen to interrupt febrile seizures. As secondary outcome parameters we assess safety, practicability to use the can, quality of life, contentedness, anxiousness and mobility of the parents. Prospect: The CARDIF trial has the potential to develop a new therapy for the suppression of febrile seizures by redressing the normal physiological state. This would offer an alternative to the currently suggested treatment with benzodiazepines. This study is an example of academic translational research from the study of animal physiology to a new therapy

uC: Ubiquitous Collaboration Platform for Multimodal Team Interaction Support

A human-centered computing platform that improves teamwork and transforms the “human- computer interaction experience” for distributed teams is presented. This Ubiquitous Collaboration, or uC (“you see”), platform\u27s objective is to transform distributed teamwork (i.e., work occurring when teams of workers and learners are geographically dispersed and often interacting at different times). It achieves this goal through a multimodal team interaction interface realized through a reconfigurable open architecture. The approach taken is to integrate: (1) an intuitive speech- and video-centric multi-modal interface to augment more conventional methods (e.g., mouse, stylus and touch), (2) an open and reconfigurable architecture supporting information gathering, and (3) a machine intelligent approach to analysis and management of heterogeneous live and stored sensor data to support collaboration. The system will transform how teams of people interact with computers by drawing on both the virtual and physical environment

Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study

INTRODUCTION: Non-excitable muscle membrane indicates critical illness myopathy (CIM) during early critical illness. We investigated predisposing risk factors for non-excitable muscle membrane at onset of critical illness. METHODS: We performed sequential measurements of muscle membrane excitability after direct muscle stimulation (dmCMAP) in 40 intensive care unit (ICU) patients selected upon a simplified acute physiology (SAPS-II) score >OR= 20 on 3 successive days within 1 week after ICU admission. We then investigated predisposing risk factors, including the insulin-like growth factor (IGF)-system, inflammatory, metabolic and hemodynamic parameters, as well as suspected medical treatment prior to first occurrence of abnormal dmCMAP. Nonparametric analysis of two-factorial longitudinal data and multivariate analysis were used for statistical analysis. RESULTS: 22 patients showed abnormal muscle membrane excitability during direct muscle stimulation within 7 (5 to 9.25) days after ICU admission. Significant risk factors for the development of impaired muscle membrane excitability in univariate analysis included inflammation, disease severity, catecholamine and sedation requirements, as well as IGF binding protein-1 (IGFBP-I), but did not include either adjunctive hydrocortisone treatment in septic shock, nor administration of neuromuscular blocking agents or aminoglycosides. In multivariate Cox regression analysis, interleukin-6 remained the significant risk factor for the development of impaired muscle membrane excitability (HR 1.006, 95%-CI (1.002 to 1.011), P = 0.002). CONCLUSIONS: Systemic inflammation during early critical illness was found to be the main risk factor for development of CIM during early critical illness. Inflammation-induced impairment of growth-factor mediated insulin sensitivity may be involved in the development of CIM

Poor fit to the multispecies coalescent is widely detectable in empirical data

Model checking is a critical part of Bayesian data analysis, yet it remains largely unused in systematic studies. Phylogeny estimation has recently moved into an era of increasingly complex models that simultaneously account for multiple evolutionary processes, the statistical fit of these models to the data has rarely been tested. Here we develop a posterior predictive simulation-based model check for a commonly used multispecies coalescent model, implemented in *BEAST, and apply it to 25 published data sets. We show that poor model fit is detectable in the majority of data sets; that this poor fit can mislead phylogenetic estimation; and that in some cases it stems from processes of inherent interest to systematists. We suggest that as systematists scale up to phylogenomic data sets, which will be subject to a heterogeneous array of evolutionary processes, critically evaluating the fit of models to data is an analytical step that can no longer be ignored. [Gene duplication and extinction; gene tree; hybridization; model fit; multispecies coalescent; next-generation sequencing; posterior predictive simulation; species delimitation; species tree.] © The Author(s) 2013

THE EFFECT OF TONE ON THE SUCCESSIVE COMPARISON OF BRIGHTNESS

Last updated: 6/12/200