The clinical link between type D personality and diabetes

Introduction: Type D personality consists of a mixture of high levels of negative affectivity and social inhibition, resulting in a stable tendency to experience negative emotions, by inhibiting the expression of these emotions. We have reanalyzed the clinically relevant studies examining the role of this personality profile in diabetes, by providing a qualitative synthesis of the data. In this regard, the aim of this study is to provide a systematic review by evaluating the clinical link between Type D personality and diabetes. Method: When focusing on PRISMA guidelines, we have performed a comprehensive research of the literature on PubMed, Scopus, ScienceDirect, ISI Web of Science, PsycINFO, and Google Scholar by using search terms as "distressed personality" OR (i.e., Boolean operator) "Type D personality" combined with the Boolean "AND" operator with "diabetes." Results: A total of seven research studies were identified and included in the review. Type D was found to be more prevalent in diabetes patients than controls. As regards the specific association with diabetes variables, Type D personality is a significant predictor of both poor medication adherence and unhealthy behaviors, by predicting negative mental health consequences also (i.e., depressed mood, anhedonia, and anxiety). Conclusion: Our review emphasized for the first time that Type D personality affects clinical factors in patients with diabetes by provoking adverse outcomes. The core implication of the study comprises the clinical relevance to detect, from a clinimetric point of view, Type D personality in diabetes in order to prevent potentially negative clinical outcomes

Low concentrations of transforming growth factor-beta-1 induce tubulogenesis in cultured mammary epithelial cells

BACKGROUND: Formation of branching tubes is a fundamental step in the development of glandular organs. To identify extracellular cues that orchestrate epithelial tubulogenesis, we employed an in vitro assay in which EpH4-J3B1A mammary epithelial cells form spheroidal cysts when grown in collagen gels under serum-free conditions, but form branching tubules in the presence of fetal calf serum (FCS). RESULTS: Initial experiments showed that the tubulogenesis-inducing activity of FCS was markedly increased by heating (70°C) or transient acidification to pH3. We therefore hypothesized that the tubulogenic agent was transforming growth factor-beta (TGF-beta), a cytokine that is present in serum in latent form and can be activated by heat or acid treatment. We found indeed that the tubulogenic activity of acidified FCS is abrogated by addition of either SB-431542, a selective inhibitor of the TGF-beta type I receptor, or a neutralizing antibody to TGF-beta-1. On the other hand, addition of low concentrations (20–100 pg/ml) of exogenous TGF-beta-1 recapitulated the effect of acidified FCS in inducing morphogenesis of hollow tubes. In contrast, higher concentrations of TGF-beta-1 induced the formation of thin cellular cords devoid of a detectable lumen. To gain insight into the mechanisms underlying TGF-beta-1-induced tube formation, we assessed the potential role of matrix metalloproteinases (MMPs). By western blot and gelatin zymography, we observed a dose-dependent increase in MMP-9 upon TGF-beta-1 treatment. Tube formation was suppressed by a synthetic broad-spectrum metalloproteinase inhibitor, by recombinant tissue inhibitor of metalloproteinases-2 (TIMP-2) and by a selective inhibitor of MMP-9, indicating that this morphogenetic process requires the activity of MMP-9. CONCLUSION: Altogether, our results provide evidence that, at low concentrations, TGF-beta-1 promotes MMP-dependent branching tubulogenesis by mammary epithelial cells in vitro, and suggest that it plays a similar role during mammary gland development in vivo

Evaluation of a Wildlife Education Exhibit for Youth

Understanding the ability of educational exhibits to communicate information effectively is important in all Extension programs. We evaluated the influence of a table-top exhibit entitled Threats to Pennsylvania\u27s Wildlife. In fair and classroom settings, participants in grades 5-7 (N=698) were randomly assigned to one of two experimental groups. One group participated in a pre- and post-survey; the other completed only a post-survey after viewing the exhibit. Results demonstrate that table-top exhibits are useful in conveying basic information and facilitating learning; however, the overall effectiveness of this exhibit was only about 10% and may have been influenced by additional confounding factors

Mass Spectrometric and Computational Study of SnPb in the Gas Phase

The SnPb molecule has been identified in a Knudsen effusion mass spectrometry experiment. The direct dissociation reaction and two isomolecular exchange reactions involving the Sn(2) and Pb(2) molecules have been studied, in the 1426-1705 K range of temperatures, using both second and third law procedures. The D(degree)0(SnPb,g) has been derived, for the first time, as (122.6+/-4.0) kJ mol(-1). Density functional and ab initio calculations up to the coupled clusters level of theory were also performed. In addition, the anion dissociation energy D(degree)0(SnPb(-),g) of (179.2+/-4.2) kJ mol(-1) was determined using the D(degree)0(SnPb,g) mass spectrometric value derived in this investigation and literature data

Sensitivity and concurrent validity of the Japanese version of the Euthymia scale: a clinimetric analysis

Background: Euthymia is characterized by the lack of mood disorders, the presence of positive affects, psychological flexibility and well-being, a unifying outlook on life, and resistance to stress. The Euthymia Scale (ES) is a 10-item self-rating clinimetric index assessing euthymia. Objectives: The present study was conducted to examine the clinimetric sensitivity and concurrent validity of the Japanese version of the Euthymia Scale (ES-J). Methods: A cross-sectional online survey was conducted. The Mini-International Neuropsychiatric Interview was used to determine the presence of past or current major depressive episodes (MDE). The clinimetric sensitivity was evaluated using the Analysis of Variance (ANOVA). Pearson’s correlation coefficients were performed to examine the concurrent validity of the ES-J. Results: A total of 1030 eligible participants completed the survey. The ES-J differentiated healthy subjects from complete remission (i.e., those with a past history of MDE without current MDE) (p < 0.001), from those with past or current history of MDE (p < 0.001), subjects with current MDE from those with sub-threshold symptoms of depression (p < 0.001), and healthy participants from subjects with moderate to severe symptoms of psychological distress (p < 0.001). The associations between the ES-J and measures of psychological well-being, resilience, life satisfaction, and social support were significantly positive (0.353 < r < 0.666, p < 0.001). A negative relationship between the ES-J and measures of psychological distress was also found (r = − 0.595, p < 0.001). Conclusions: The findings of the present study indicated that the ES-J is a valid and highly sensitive clinimetric index, which can be used as a screening measure in the clinical process of assessment of recovery, particularly when symptoms are expected to be mild and/or when dealing with subclinical symptoms of psychological distress and depression. The findings of this study also support the use of the ES-J to detect vulnerability to depression and to identify subjects at higher risk of relapse

The optimal management of the prosumer's resources via stochastic programming

This paper deals with the optimal home energy management problem faced by a smart prosumer equipped with PV panels and storage systems. The stochastic programming framework is adopted with the aim of explicitly accounting for the inherent uncertainty affecting the main problem parameters (i.e. generation from renewable energy sources and demands). The problem provides the prosumer with the optimal scheduling of the shiftable loads and operations of the available storage systems that minimizes the expected overall electricity cost. Preliminary results, collected on three different categories of residential prosumers, have shown the effectiveness of the proposed approach in terms of cost saving. Keywords: Home energy management systems, Optimal scheduling, Renewable energy, Stochastic programming, Storage devic

Method to link data in 3D environment

The aim of this work is to discuss a novel method to access information through an interactive 3D model that has has a connection to places in the real world. This information can be textual (historical, artistic and architectural), photographic (textures, views, plans) and spatial (3D data). The geographical aspects introduce some complexities, but they allow a common and uniform access to the data. The proposed method links information to extended zones of the 3D space and can be used with 3D models that are not subdivided in logical zones, like meshes generated by 3D scanners. The use of an intuitive ranking function lets one find the relevant information by just “looking around”. The possibility to acquire, process and analyse geographic information without the need for installing proprietary GIS software or having deep GIS knowledge has been taken into account in this work, so as to make information more accessible to a larger audience. The method is applied on two case studies: the Napoleone Square in Lucca (Italy) and the crypt of the Cathedral of St. Servatius in Quedlinburg (Sachsen-Anhalt, Germany). In the case in Quedlinburg we wanted to integrate the data produced in the last seven years, during an important investigation and conservation program, that has used extensively GIS format as documentation tool

Charlson Comorbidity Index: A Critical Review of Clinimetric Properties

The present critical review was conducted to evaluate the clinimetric properties of the Charlson Comorbidity Index (CCI), an assessment tool designed specifically to predict long-term mortality, with regard to its reliability, concurrent validity, sensitivity, incremental and predictive validity. The original version of the CCI has been adapted for use with different sources of data, ICD-9 and ICD-10 codes. The inter-rater reliability of the CCI was found to be excellent, with extremely high agreement between self-report and medical charts. The CCI has also been shown either to have concurrent validity with a number of other prognostic scales or to result in concordant predictions. Importantly, the clinimetric sensitivity of the CCI has been demonstrated in a variety of medical conditions, with stepwise increases in the CCI associated with stepwise increases in mortality. The CCI is also characterized by the clinimetric property of incremental validity, whereby adding the CCI to other measures increases the overall predictive accuracy. It has been shown to predict long-term mortality in different clinical populations, including medical, surgical, intensive care unit (ICU), trauma, and cancer patients. It may also predict in-hospital mortality, although in some instances, such as ICU or trauma patients, the CCI did not perform as well as other instruments designed specifically for that purpose. The CCI thus appears to be clinically useful not only to provide a valid assessment of the patient’s unique clinical situation, but also to demarcate major diagnostic and prognostic differences among subgroups of patients sharing the same medical diagnosis

the optimal electric energy procurement problem under reliability constraints

Abstract We consider the problem faced by a large consumer that has to define the procurement plan to cover its energy needs. The uncertain nature of the problem, related to the spot price and energy needs, is dealt by the stochastic programming framework. The proposed approach provides the decision maker with a proactive strategy that covers the energy needs with a high reliability level and integrates the Conditional Value at Risk (CVaR) measure to control potential losses. We apply the approach to a real case study and emphasize the effect of the reliability value choice and the difference between risk neutral and adverse positions

The clinical consequence of positive mental health in psychotherapy

The current commentary is aimed at critically analyzing the document Psychotherapies for Anxiety and Depression: benefits and costs by focusing on specific theoretical concepts and empirical evidences arising from research studies fulfilled in the area of study of Clinical and Health Psychology. Specifically, the following were the main topics on which we are focused on: i) the clinical consequence potentially resulting from considering the psychological well-being and the euthymia condition as the main targets of a psychotherapeutic treatment; ii) a critical reappraisal of the clinical inadequacy of the evidence based model in psychotherapy; iii) clinimetrics as a clinically based measurement method for evaluating the psychological well-being of a patient after a psychotherapeutic intervention