127 research outputs found
A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center
AbstractSegmentation of the vertebrate hindbrain into multiple rhombomeres is essential for proper formation of the cerebellum, cranial nerves and cranial neural crest. Paralog group 1 (PG1) hox genes are expressed early in the caudal hindbrain and are required for rhombomere formation. Accordingly, loss of PG1 hox function disrupts development of caudal rhombomeres in model organisms and causes brainstem defects, associated with cognitive impairment, in humans. In spite of this important role for PG1 hox genes, transcriptional targets of PG1 proteins are not well characterized. Here we use ectopic expression together with embryonic dissection to identify novel targets of the zebrafish PG1 gene hoxb1b. Of 100 genes up-regulated by hoxb1b, 54 were examined and 25 were found to represent novel hoxb1b regulated hindbrain genes. The ppp1r14al gene was analyzed in greater detail and our results indicate that Hoxb1b is likely to directly regulate ppp1r14al expression in rhombomere 4. Furthermore, ppp1r14al is essential for establishment of the earliest hindbrain signaling-center in rhombomere 4 by regulating expression of fgf3
Probing Noncommutative Space-Time in the Laboratory Frame
The phenomenological investigation of noncommutative space-time in the
laboratory frame are presented. We formulate the apparent time variation of
noncommutativity parameter in the laboratory frame due to the
earth's rotation. Furthermore, in the noncommutative QED, we discuss how to
probe the electric-like component
by the
process at future linear collider.
We may determine the magnitude and the direction of
by detailed study of the apparent time
variation of total cross section.
In case of us observing no signal, the upper limit on the magnitude of
can be determined independently of its
direction.Comment: 12 pages, 7 figures, typos are corrected, one graph have been added
in figure
Cosmological evolution of interacting dark energy in Lorentz violation
The cosmological evolution of an interacting scalar field model in which the
scalar field interacts with dark matter, radiation, and baryon via Lorentz
violation is investigated. We propose a model of interaction through the
effective coupling . Using dynamical system analysis, we study the
linear dynamics of an interacting model and show that the dynamics of critical
points are completely controlled by two parameters. Some results can be
mentioned as follows. Firstly, the sequence of radiation, the dark matter, and
the scalar field dark energy exist and baryons are sub dominant. Secondly, the
model also allows the possibility of having a universe in the phantom phase
with constant potential. Thirdly, the effective gravitational constant varies
with respect to time through . In particular, we consider a simple
case where has a quadratic form and has a good agreement with the
modified CDM and quintessence models. Finally, we also calculate the
first post--Newtonian parameters for our model.Comment: 14 pages, published versio
Discerning Noncommutative Extra Dimensions
Experimental limits on the violation of four-dimensional Lorentz invariance
imply that noncommutativity among ordinary spacetime dimensions must be small.
Noncommutativity among extra, compactified spatial dimensions, however, is far
less constrained and may have discernable collider signatures. Here we study
the experimental consequences of noncommutative QED in six dimensions, with
noncommutativity restricted to a TeV-scale bulk. Assuming the orbifold T^2/Z_2,
we construct the effective four-dimensional theory and study interactions
unique to the noncommutative case. New vertices involving the Kaluza-Klein (KK)
excitations of the photon yield order 100% corrections to the pair production
and to the decays of some of the lighter modes. We show that these effects are
difficult to resolve at the LHC, but are likely within the reach of a future
Very Large Hadron Collider (VLHC).Comment: 20 pages LaTeX, 8 eps figures (minor revisions, version to appear in
Phys. Rev. D
VFISV: Very Fast Inversion of the Stokes Vector for the Helioseismic and Magnetic Imager
In this paper we describe in detail the implementation and main properties of
a new inversion code for the polarized radiative transfer equation (VFISV: Very
Fast inversion of the Stokes vector). VFISV will routinely analyze pipeline
data from the Helioseismic and Magnetic Imager (HMI) on-board of the Solar
Dynamics Observatory (SDO). It will provide full-disk maps (40964096
pixels) of the magnetic field vector on the Solar Photosphere every 10 minutes.
For this reason VFISV is optimized to achieve an inversion speed that will
allow it to invert 16 million pixels every 10 minutes with a modest number
(approx. 50) of CPUs. Here we focus on describing a number of important
details, simplifications and tweaks that have allowed us to significantly speed
up the inversion process. We also give details on tests performed with data
from the spectropolarimeter on-board of the Hinode spacecraft.Comment: 23 pages, 9 figures (2 color). Submitted for publication to Solar
Physic
A-dependence of nuclear transparency in quasielastic A(e,e'p) at high Q^2
The A-dependence of the quasielastic A(e,e'p) reaction has been studied at
SLAC with H-2, C, Fe, and Au nuclei at momentum transfers Q^2 = 1, 3, 5, and
6.8 (GeV/c)^2. We extract the nuclear transparency T(A,Q^2), a measure of the
average probability that the struck proton escapes from the nucleus A without
interaction. Several calculations predict a significant increase in T with
momentum transfer, a phenomenon known as Color Transparency. No significant
rise within errors is seen for any of the nuclei studied.Comment: 5 pages incl. 2 figures, Caltech preprint OAP-73
Insights into the complex regulation of rpoS in Borrelia burgdorferi
Co-ordinated regulation of gene expression is required for the transmission and survival of Borrelia burgdorferi in different hosts. The sigma factor RpoS (ÏS), as regulated by RpoN (Ï54), has been shown to regulate key virulence factors (e.g. OspC) required for these processes. As important, multiple signals (e.g. temperature, pH, cell density, oxygen) have been shown to increase the expression of ÏS-dependent genes; however, little is known about the signal transduction mechanisms that modulate the expression of rpoS. In this report we show that: (i) rpoS has a Ï54-dependent promoter that requires Rrp2 to activate transcription; (ii) Rrp2Î123, a constitutively active form of Rrp2, activated Ï54-dependent transcription of rpoS/P-lacZ reporter constructs in Escherichia coli; (iii) quantitative reverse transcription polymerase chain reaction (QRT-PCR) experiments with reporter cat constructs in B. burgdorferi indicated that Rrp2 activated transcription of rpoS in an enhancer-independent fashion; and finally, (iv) rpoN is required for cell density- and temperature-dependent expression of rpoS in B. burgdorferi, but histidine kinase Hk2, encoded by the gene immediately upstream of rrp2, is not essential. Based on these findings, a model for regulation of rpoS has been proposed which provides mechanisms for multiple signalling pathways to modulate the expression of the ÏS regulon in B. burgdorferi
Modeling the Subsurface Structure of Sunspots
While sunspots are easily observed at the solar surface, determining their
subsurface structure is not trivial. There are two main hypotheses for the
subsurface structure of sunspots: the monolithic model and the cluster model.
Local helioseismology is the only means by which we can investigate
subphotospheric structure. However, as current linear inversion techniques do
not yet allow helioseismology to probe the internal structure with sufficient
confidence to distinguish between the monolith and cluster models, the
development of physically realistic sunspot models are a priority for
helioseismologists. This is because they are not only important indicators of
the variety of physical effects that may influence helioseismic inferences in
active regions, but they also enable detailed assessments of the validity of
helioseismic interpretations through numerical forward modeling. In this paper,
we provide a critical review of the existing sunspot models and an overview of
numerical methods employed to model wave propagation through model sunspots. We
then carry out an helioseismic analysis of the sunspot in Active Region 9787
and address the serious inconsistencies uncovered by
\citeauthor{gizonetal2009}~(\citeyear{gizonetal2009,gizonetal2009a}). We find
that this sunspot is most probably associated with a shallow, positive
wave-speed perturbation (unlike the traditional two-layer model) and that
travel-time measurements are consistent with a horizontal outflow in the
surrounding moat.Comment: 73 pages, 19 figures, accepted by Solar Physic
Nuclear transparency from quasielastic A(e,e'p) reactions uo to Q^2=8.1 (GeV/c)^2
The quasielastic (e,ep) reaction was studied on targets of
deuterium, carbon, and iron up to a value of momentum transfer of 8.1
(GeV/c). A nuclear transparency was determined by comparing the data to
calculations in the Plane-Wave Impulse Approximation. The dependence of the
nuclear transparency on and the mass number was investigated in a
search for the onset of the Color Transparency phenomenon. We find no evidence
for the onset of Color Transparency within our range of . A fit to the
world's nuclear transparency data reflects the energy dependence of the free
proton-nucleon cross section.Comment: 11 pages, 6 figure
Lorentz breaking Effective Field Theory and observational tests
Analogue models of gravity have provided an experimentally realizable test
field for our ideas on quantum field theory in curved spacetimes but they have
also inspired the investigation of possible departures from exact Lorentz
invariance at microscopic scales. In this role they have joined, and sometime
anticipated, several quantum gravity models characterized by Lorentz breaking
phenomenology. A crucial difference between these speculations and other ones
associated to quantum gravity scenarios, is the possibility to carry out
observational and experimental tests which have nowadays led to a broad range
of constraints on departures from Lorentz invariance. We shall review here the
effective field theory approach to Lorentz breaking in the matter sector,
present the constraints provided by the available observations and finally
discuss the implications of the persisting uncertainty on the composition of
the ultra high energy cosmic rays for the constraints on the higher order,
analogue gravity inspired, Lorentz violations.Comment: 47 pages, 4 figures. Lecture Notes for the IX SIGRAV School on
"Analogue Gravity", Como (Italy), May 2011. V.3. Typo corrected, references
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