Grid Cells Form a Global Representation of Connected Environments.

The firing patterns of grid cells in medial entorhinal cortex (mEC) and associated brain areas form triangular arrays that tessellate the environment [1, 2] and maintain constant spatial offsets to each other between environments [3, 4]. These cells are thought to provide an efficient metric for navigation in large-scale space [5-8]. However, an accurate and universal metric requires grid cell firing patterns to uniformly cover the space to be navigated, in contrast to recent demonstrations that environmental features such as boundaries can distort [9-11] and fragment [12] grid patterns. To establish whether grid firing is determined by local environmental cues, or provides a coherent global representation, we recorded mEC grid cells in rats foraging in an environment containing two perceptually identical compartments connected via a corridor. During initial exposures to the multicompartment environment, grid firing patterns were dominated by local environmental cues, replicating between the two compartments. However, with prolonged experience, grid cell firing patterns formed a single, continuous representation that spanned both compartments. Thus, we provide the first evidence that in a complex environment, grid cell firing can form the coherent global pattern necessary for them to act as a metric capable of supporting large-scale spatial navigation

Fracture toughness testing data. A bibliography

This bibliography is comprised of approximately 800 reference citations related to the mechanics of failure in aerospace structures. Most of the references are for documents that include fracture toughness testing data and its application or documents on the availability and usefulness of fracture mechanics analysis methodology. The bibliography represents a search of the literature published in the period April 1962 through April 1974 and is largely limited to documents published in the United States

Life prediction of materials exposed to monotonic and cyclic loading: A technology survey and bibliography

Announced survey directs attention toward low cycle fatigue and thermal fatigue experienced at elevated temperatures equivalent to those found in hot end of gas turbine engine. Majority of bibliographic references are on life prediction for materials exposed to monotonic and cyclic loading in high temperature environments

Fracture toughness testing data: A technology survey and bibliography

Announced survey includes reports covering fracture toughness testing for various structural materials including information on plane strain and developing areas of mixed mode and plane strain test conditions. Bibliography references cite work and conclusions in fracture toughness testing and application of fracture toughness test data, and in fracture mechanics analysis

Life prediction of materials exposed to monotonic and cyclic loading: Bibliography

This bibliography is comprised of approximately 1200 reference citations related to the mechanics of failure in aerospace structures. Most of the references are for information on life prediction for materials exposed to monotonic and cyclic loading in elevated temperature environments such as that in the hot end of a gas turbine engine. Additional citations listed are for documents on the thermal and mechanical effects on solar cells in the cryogenic vacuum environment; radiation effects on high temperature mechanical properties; and high cycle fatigue technology as applicable to gas turbine engine bearings. The bibliography represents a search of the literature published in the period April 1962 through April 1974 and is largely limited to documents published in the United States. It is a companion volume to NASA CR-134750, Life Prediction of Materials Exposed to Monotonic and cyclic Loading - A Technology Survey

Modulating medial septal cholinergic activity reduces medial entorhinal theta frequency without affecting speed or grid coding

Medial septal inputs to the hippocampal system are crucial for aspects of temporal and spatial processing, such as theta oscillations and grid cell firing. However, the precise contributions of the medial septum’s cholinergic neurones to these functions remain unknown. Here, we recorded neuronal firing and local field potentials from the medial entorhinal cortex of freely foraging mice, while modulating the excitability of medial septal cholinergic neurones. Alteration of cholinergic activity produced a reduction in the frequency of theta oscillations, without affecting the slope of the non-linear theta frequency vs running speed relationship observed. Modifying septal cholinergic tone in this way also led mice to exhibit behaviours associated with novelty or anxiety. However, grid cell firing patterns were unaffected, concordant with an absence of change in the slopes of the theta frequency and firing rate speed signals thought to be used by grid cells

Dual mode nanoparticles: CdS coated iron nanoparticles

Reverse micelles can be used in a sequential fashion to make core-shell nanoparticles. Using this technique it is possible to make a magnetic quantum dot, by coating an iron core with a cadmium sulfide shell. Transmission electron microscopy indicated core-shell morphology and narrow size distribution of the obtained particles. Collectively, x-ray powder diffraction and x-ray photoelectron spectroscopy verified the presence of cadmium sulfide on the surface of the nanoparticles. Optical properties of the coated particles were demonstrated using fluorescence spectroscopy. A vibrating sample magnetometer was used to determine magnetic properties. Dual mode cadmium sulfide coatediron core-shell nanoparticles make unique candidates for the use in biomedical applications

Resolved Young Binary Systems And Their Disks

We have conducted a survey of young single and multiple systems in the Taurus–Auriga star-forming region with the Atacama Large Millimeter Array (ALMA), substantially improving both the spatial resolution and sensitivity with which individual protoplanetary disks in these systems have been observed. These ALMA observations can resolve binary separations as small as 25–30 au and have an average 3σ detection level of 0.35 mJy, equivalent to a disk mass of 4 × 10−5 M ⊙ for an M3 star. Our sample was constructed from stars that have an infrared excess and/or signs of accretion and have been classified as Class II. For the binary and higher-order multiple systems observed, we detect λ = 1.3 mm continuum emission from one or more stars in all of our target systems. Combined with previous surveys of Taurus, our 21 new detections increase the fraction of millimeter-detected disks to over 75% in all categories of stars (singles, primaries, and companions) earlier than spectral type M6 in the Class II sample. Given the wealth of other information available for these stars, this has allowed us to study the impact of multiplicity with a much larger sample. While millimeter flux and disk mass are related to stellar mass as seen in previous studies, we find that both primary and secondary stars in binary systems with separations of 30–4200 au have lower values of millimeter flux as a function of stellar mass than single stars. We also find that for these systems, the circumstellar disk around the primary star does not dominate the total disk mass in the system and contains on average 62% of the total mass

Detection of s-Triazine pesticides in natural waters by modified large-volume direct injection HPLC

There is a need for simple and inexpensive methods to quantify potentially harmful persistent pesticides often found in our water-ways and water distribution systems. This paper presents a simple, relatively inexpensive method for the detection of a group of commonly used pesticides (atrazine, simazine and hexazinone) in natural waters using large-volume direct injection high performance liquid chromatography (HPLC) utilizing a monolithic column and a single wavelength ultraviolet–visible light (UV–vis) detector. The best results for this system were obtained with a mobile phase made up of acetonitrile and water in a 30:70 ratio, a flow rate of 2.0 mL min−1, and a detector wavelength of 230 nm. Using this method, we achieved retention times of less than three minutes, and detection limits of 5.7 μg L−1 for atrazine, 4.7 μg L−1 for simazine and 4.0 μg L−1 for hexazinone. The performance of this method was validated with an inter-laboratory trial against a National Association of Testing Authorities (NATA) accredited liquid chromatography–mass spectrometry/mass spectrometry (LC–MS/MS) method commonly used in commercial laboratories

Resolved Young Binary Systems And Their Disks

We have conducted a survey of young single and multiple systems in the Taurus–Auriga star-forming region with the Atacama Large Millimeter Array (ALMA), substantially improving both the spatial resolution and sensitivity with which individual protoplanetary disks in these systems have been observed. These ALMA observations can resolve binary separations as small as 25–30 au and have an average 3σ detection level of 0.35 mJy, equivalent to a disk mass of 4 × 10−5 M ⊙ for an M3 star. Our sample was constructed from stars that have an infrared excess and/or signs of accretion and have been classified as Class II. For the binary and higher-order multiple systems observed, we detect λ = 1.3 mm continuum emission from one or more stars in all of our target systems. Combined with previous surveys of Taurus, our 21 new detections increase the fraction of millimeter-detected disks to over 75% in all categories of stars (singles, primaries, and companions) earlier than spectral type M6 in the Class II sample. Given the wealth of other information available for these stars, this has allowed us to study the impact of multiplicity with a much larger sample. While millimeter flux and disk mass are related to stellar mass as seen in previous studies, we find that both primary and secondary stars in binary systems with separations of 30–4200 au have lower values of millimeter flux as a function of stellar mass than single stars. We also find that for these systems, the circumstellar disk around the primary star does not dominate the total disk mass in the system and contains on average 62% of the total mass