Home economics rehabilitation : a selected, annotated bibliography

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Evaluation Research and Institutional Pressures: Challenges in Public-Nonprofit Contracting

This article examines the connection between program evaluation research and decision-making by public managers. Drawing on neo-institutional theory, a framework is presented for diagnosing the pressures and conditions that lead alternatively toward or away the rational use of evaluation research. Three cases of public-nonprofit contracting for the delivery of major programs are presented to clarify the way coercive, mimetic, and normative pressures interfere with a sound connection being made between research and implementation. The article concludes by considering how public managers can respond to the isomorphic pressures in their environment that make it hard to act on data relating to program performance.This publication is Hauser Center Working Paper No. 23. The Hauser Center Working Paper Series was launched during the summer of 2000. The Series enables the Hauser Center to share with a broad audience important works-in-progress written by Hauser Center scholars and researchers

Genetic Architecture of Soybean Yield and Agronomic Traits

Soybean is the world’s leading source of vegetable protein and demand for its seed continues to grow. Breeders have successfully increased soybean yield, but the genetic architecture of yield and key agronomic traits is poorly understood. We developed a 40-mating soybean nested association mapping (NAM) population of 5,600 inbred lines that were characterized by single nucleotide polymorphism (SNP) markers and six agronomic traits in field trials in 22 environments. Analysis of the yield, agronomic, and SNP data revealed 23 significant marker-trait associations for yield, 19 for maturity, 15 for plant height, 17 for plant lodging, and 29 for seed mass. A higher frequency of estimated positive yield alleles was evident from elite founder parents than from exotic founders, although unique desirable alleles from the exotic group were identified, demonstrating the value of expanding the genetic base of US soybean breeding

Fifteen years of the Australian imaging, biomarkers and lifestyle (AIBL) study: Progress and observations from 2,359 older adults spanning the spectrum from cognitive normality to Alzheimer\u27s disease

Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer\u27s disease dementia (AD)) as an \u27Inception cohort\u27 who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an \u27Enrichment cohort\u27 (as of 10 April 2019). Objective: Here we provide an overview of these Inception and Enrichment cohorts of more than 8,500 person-years of investigation. Methods: Participants underwent reassessment every 18 months including comprehensive cognitive testing, neuroimaging (magnetic resonance imaging, MRI; positron emission tomography, PET), biofluid biomarkers and lifestyle evaluations. Results: AIBL has made major contributions to the understanding of the natural history of AD, with cognitive and biological definitions of its three major stages: preclinical, prodromal and clinical. Early deployment of Aβ-amyloid and tau molecular PET imaging and the development of more sensitive and specific blood tests have facilitated the assessment of genetic and environmental factors which affect age at onset and rates of progression. Conclusion: This fifteen-year study provides a large database of highly characterized individuals with longitudinal cognitive, imaging and lifestyle data and biofluid collections, to aid in the development of interventions to delay onset, prevent or treat AD. Harmonization with similar large longitudinal cohort studies is underway to further these aims

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

SummaryWe describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers

Educational Experiences Given to Newly Blinded Homemakers by Rehabilitation Teachers of the Blind

It was the overall purpose of this study to provide a descriptive survey of the educational experiences given to newly blinded homemakers by rehabilitation teachers. More specifically, the intention was to determine the subject matter and techniques given to the homemakers; to determine specific background characteristics of the teachers, including age, sex, visual impairment, and employment; to determine the resources and services utilized by rehabilitation teachers; to determine the types of clientele the teachers; and finally, to compare the characteristics of the rehabilitation teachers with the number of educational experiences they frequently give to newly blinded homemakers. The 66 rehabilitation teachers included in this study were found to be a heterogeneous group. The ages of the group range from 22-63 years of age, the mean age being 39. The majority of the teachers, 74.2%, were female. Most of the teachers who were visually impaired, 78.8%, were congenitally blind; 27.3% were totally blind. All of the rehabilitation teachers indicated they had received formal education beyond high school, with an average of 5.1 years post-high school education. The teachers were all employed by the state, serving a mean of 7.5 years as aids to the blind. Teaching materials ranged from books in braille to books in print, including state manuals. All but one of the teachers taught both men and women who were not full-time homemakers; one teacher taught a full-time female homemaker exclusively. There were many different subjects within the area home economics taught to the newly blind homemakers. The study found no significant relationships between the variable ages, years in present position, years of visual impairment, classes in high school home economics, classes in college level home economics, classes in home economics through the Extension Service, workshops in home economics, and total classes and workshops in home economics. However, there were two significant differences found: a relationship was found between the variables of years of education beyond high school and the number of items taught often; also, differences were found between the sex of the teachers and the educational experiences they gave to the newly blinded homemakers. Overall, the group of rehabilitation teachers was heterogeneous. Advisor: Lois O. Schwab

AIDA DART asteroid deflection test: Planetary defense and science objectives

International audienc