After the asylum : place, value and heritage in the redevelopment of historic former asylums

PhD ThesisStigma has been seen as a barrier to the adaptation and reuse of buildings and for historic former asylums, the fear of the “madhouse” has been argued to have transferred to the buildings themselves. They are buildings which are both socially and historically challenging. However, as these sites have closed and have begun to be converted into residential accommodation, the negative perceptions of the asylum appear to have eased, to be replaced by an appreciation of their built form through their architectural and heritage features. Research into the reuse of historic former asylum sites is limited, as is research exploring the subjective or emotional influences on property development decisions. This research addressed this gap by investigating the phenomenon of reuse of historic former asylums. It did so through the examination of the intersecting factors involved in that process; the perceptions of the stakeholders in respect of place attachments, stigmas, and values ascribed to the sites. It also investigated the perceptions that stakeholders had of themselves, each other and the re-development process. Three historic former asylums in the North of England were identified to provide context to this research: St Mary’s in Stannington, Northumberland, St George’s in Morpeth, Northumberland and Lancaster Moor Hospital in Lancaster. Within the context of each of these sites, interviews were carried out with the different stakeholder groups involved in the redevelopment of these sites. These stakeholders were planners, developers, heritage bodies, former staff members and the owners of the sites. The public was also surveyed in Morpeth and Lancaster through questionnaires, as were new residents of converted former asylum sites. Through the analysis from this data collection, it was found that an acceptable level of stigma surrounding these sites persisted; any stigma that remained did not prevent the reuse and redevelopments from taking place. The buildings were viewed as heritage buildings but predominantly from an age or aesthetical value perspective rather than being valued for their specific history. However, this history was not simply forgotten or erased, it was often incorporated or used in subtle ways within the developments, the level to which depended on the individual developer and site concerned. This research brought together two areas of research in the built environment which are not often combined: heritage and real estate. The examination of the reuse of historic former asylum sites showed more fully the valorisation process of a historic iii building through the redevelopment and reuse process. In doing so, it highlighted that the reuse and redevelopment process of historic former asylum sites was a complex one. The valorisation of the sites through their age and aesthetics was connected to their perceived economic value which enabled the sites to be converted by developers; as the sites become reappraised as heritage and therefore valued as such, this consequently created a perception of economic value and therefore a demand for the properties. This research project also highlighted that as well as a perception of value, people were attached to these sites, including some of the professional stakeholders involved in the development process. Former staff members were strongly attached due to the length of time they had spent working and living on the sites. Some of the development professionals also expressed attachment or a sense of responsibility for sites that they worked on. This was an unexpected finding as they only worked on the sites for a relatively short time and were seen by themselves, as professionals, to be objective in their working lives. This revealed an interesting juxtaposition in that the professionals felt that they were objective experts in the process, unhindered by the emotions those non-development stakeholders were thought to feel. In fact, many of those non-development stakeholders held pragmatic views about the need for something to happen with the empty sites, something not anticipated by the development stakeholders.AHR

Andrew Marvell : the most eclectic poet

The poetry of Andrew Marvell reflects all the literary styles and manners that illuminated his seventeenth-century milieu. Refracting rather than mirroring sources and influences, his work projects no single ray. Instead, like the soul in "The Garden," it "Waves in its Plumes the various Light." Even antithetical philosophies combine as in "A Dialogue between the Resolved Soul and Created Pleasure," where the Platonic, the Aristotelian, the metaphysical, and the classical are diffused

Extending the reach of the Fire Effects Planning Framework by taking a critical approach to science delivery and application

The Fire Effects Planning Framework (FEPF), developed under JFSP project (99-1-3-16) “Wildland fuels management: evaluating and planning risks and benefits,” was formally completed in June 2004. FEPF is a logical framework that uses available data (e.g., local, LANDFIRE data) and existing software (e.g., GIS, Farsite, FlamMap, expert knowledge) to produce maps of probable fire effects during the pre-season or in advance of a fire front. The initial project included significant technology transfer activities. As that project concluded, however, we continued to receive requests for assistance from field managers (District, Forest and Regional Forest Service offices), international organizations (Interior West Fire Council), and national fire planning organizations (Fire Program Analysis). These requests sought more information about the tool, assistance with using it for hazardous fuels planning, and guidance for incorporating FEPF into regional training courses. To enable us to continue our outreach efforts, we initiated JFSP 05-4-1-20 “Extending the reach of the the Fire Effects Planning Framework by taking a critical approach to science delivery and application”. This funding allowed us to meet requests for assistance and participation while allowing us to identify and concentrate on the most valuable transfer mechanisms. Our goal was to observe how field managers think about and use the tool, learn who they think the primary audience is, and then revise our materials and activities accordingly. FEPF is the only analysis tool we know of that helps managers (land and fire) articulate probable ecologic effects of fire and integrate these into fire decision-making and assessment. The technology and data used by FEPF is widely available. The scientific basis for crosswalk determinations are grounded in best available science, transparent, and easily updated as new information becomes available. As the federal fire agencies move toward more comprehensive implementation of Appropriate Management Response, FEPF remains the only process that can quickly and consistently indicate areas and conditions where fire may be neutral, beneficial or harmful to natural resources of interest. Thus, it provides the only existing process to link emergency fire operations (from full suppression to wildland fire use) with land management plans, a requirement of federal oversight entities (e.g., OIG)

The Ursinus Weekly, November 15, 1948

Seniors to feature Bud Williams\u27 band at December ball • Philip to produce Handel\u27s Messiah for eleventh year • Wallick to leave in December; Will study at Edinburgh • WSSF starts campaign with goal set at $1,000 • Wallace claims UN is success despite Russian difficulties • Pre-meds offered much for money • Juniors to sponsor tux raffle as part of money-raising drive • What do you like best about Ursinus? • Applications due for grad exam • Y to conduct prejudice poll • Pettit appointed assistant registrar • Editorials: Varsity letters; Passing fancies • Letters to the editor • Alumni-society notes • Life of sea calls energetic students for vacation trips • Critic rings bell on Curtain Club\u27s local talent show • Curtain Club stages varied talent show • Don\u27t look now but here\u27s a fan of college males • Coed in top bunk describes 3 ways of making a bed • Haverford thumps Bruin booters 8-1 • Inside on intramurals • Loss of four stars from soccer squad to hurt \u2749 plans • Bruins to face Susquehanna as grid campaign concludes • Cadets wallop Grizzlies 31-0 for sixth triumph of season • Beaver bows 6-2 to Snell\u27s belles • Player of the week • Harriers place 12th in Allentown meet • Lehigh beaten 3-2 in 2nd soccer win • Jay-vees trip Beaver coeds 5-1 to maintain undefeated record • MacWilliams star of hockey win • Campus briefs: International Relations Club; Curtain Club; Phys Ed Club; Canterbury Club; Cub and Key; English Club; Beardwood Chemical Society; Glee Club; WSGA; French Club; German Club; Business Administration Clubhttps://digitalcommons.ursinus.edu/weekly/3127/thumbnail.jp

The Ursinus Weekly, October 18, 1948

Sophs apparently foiled as freshmen prexy, Lee Trimble, is safely hidden • WAA introduces \u2752 to Ursinus sports • Dale White elected editor of Lantern as Wentzel resigns • Football, fun, light fantastic promise successful old timers\u27 day celebration • Forum to feature election discussion • Grads get degrees on Founders\u27 Day • Five men appointed to act with faculty committees • Dressner, Buchanan picked as council representatives • German club plans dinner; to make Philadelphia trip • Thespians greet applicants at first meeting of year • Former student to return in concert with soprano • Frosh show ends customs for men • NSA head requests college democracy • A happy thought for hapless frosh • Freshman reviews first two weeks • Frosh live again after customs end • Soph ruler reveals innermost thoughts • Junior looks back on freshman year • Frosh views hist.1 with heavy heart • Modern miss visits ancient Latin lands • Subs work all year but get no credit • Dickinson romps to 24-0 victory over bear; Gerry Miller features with 85 yard runback • Bears seek victory on old timers\u27 day • Coeds triumph 5-2 in season\u27s opener • Mules trip bruins in soccer opener • Church colleges hit by Lafayette prexy • Footlighters start ambitious season • Staiger writes article for organic chemistry journal • Pre-meds plan activities; members need high gradeshttps://digitalcommons.ursinus.edu/weekly/1598/thumbnail.jp

Repeat controlled human malaria infection of healthy UK adults with blood-stage plasmodium falciparum:Safety and parasite growth dynamics

In endemic settings it is known that natural malaria immunity is gradually acquired following repeated exposures. Here we sought to assess whether similar acquisition of blood-stage malaria immunity would occur following repeated parasite exposure by controlled human malaria infection (CHMI). We report the findings of repeat homologous blood-stage Plasmodium falciparum (3D7 clone) CHMI studies VAC063C (ClinicalTrials.gov NCT03906474) and VAC063 (ClinicalTrials.gov NCT02927145). In total, 24 healthy, unvaccinated, malaria-naïve UK adult participants underwent primary CHMI followed by drug treatment. Ten of these then underwent secondary CHMI in the same manner, and then six of these underwent a final tertiary CHMI. As with primary CHMI, malaria symptoms were common following secondary and tertiary infection, however, most resolved within a few days of treatment and there were no long term sequelae or serious adverse events related to CHMI. Despite detectable induction and boosting of anti-merozoite serum IgG antibody responses following each round of CHMI, there was no clear evidence of anti-parasite immunity (manifest as reduced parasite growth in vivo) conferred by repeated challenge with the homologous parasite in the majority of volunteers. However, three volunteers showed some variation in parasite growth dynamics in vivo following repeat CHMI that were either modest or short-lived. We also observed no major differences in clinical symptoms or laboratory markers of infection across the primary, secondary and tertiary challenges. However, there was a trend to more severe pyrexia after primary CHMI and the absence of a detectable transaminitis post-treatment following secondary and tertiary infection. We hypothesize that this could represent the initial induction of clinical immunity. Repeat homologous blood-stage CHMI is thus safe and provides a model with the potential to further the understanding of naturally acquired immunity to blood-stage infection in a highly controlled setting. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT03906474, NCT02927145

Allogeneic haematopoietic stem cell transplantation for mitochondrial neurogastrointestinal encephalomyopathy

Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is a rare fatal autorecessive disease. Halter et al. report outcomes from all known haematopoietic stem cell transplantations worldwide from sibling or unrelated donors for MNGIE between 2005 and 2011. In some of the recipients, correction of the underlying metabolic defect results in gradual clinical improvemen

Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions.

The development of a highly effective vaccine remains a key strategic goal to aid the control and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte-binding protein homolog 5 (RH5) has emerged as the most promising blood-stage P. falciparum candidate antigen to date, capable of conferring protection against stringent challenge in Aotus monkeys. We report on the first clinical trial to our knowledge to assess the RH5 antigen - a dose-escalation phase Ia study in 24 healthy, malaria-naive adult volunteers. We utilized established viral vectors, the replication-deficient chimpanzee adenovirus serotype 63 (ChAd63), and the attenuated orthopoxvirus modified vaccinia virus Ankara (MVA), encoding RH5 from the 3D7 clone of P. falciparum. Vaccines were administered i.m. in a heterologous prime-boost regimen using an 8-week interval and were well tolerated. Vaccine-induced anti-RH5 serum antibodies exhibited cross-strain functional growth inhibition activity (GIA) in vitro, targeted linear and conformational epitopes within RH5, and inhibited key interactions within the RH5 invasion complex. This is the first time to our knowledge that substantial RH5-specific responses have been induced by immunization in humans, with levels greatly exceeding the serum antibody responses observed in African adults following years of natural malaria exposure. These data support the progression of RH5-based vaccines to human efficacy testing

Vaccination with Plasmodium vivax Duffy-binding protein inhibits parasite growth during controlled human malaria infection

There are no licensed vaccines against Plasmodium vivax. We conducted two phase 1/2a clinical trials to assess two vaccines targeting P. vivax Duffy-binding protein region II (PvDBPII). Recombinant viral vaccines using chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) vectors as well as a protein and adjuvant formulation (PvDBPII/Matrix-M) were tested in both a standard and a delayed dosing regimen. Volunteers underwent controlled human malaria infection (CHMI) after their last vaccination, alongside unvaccinated controls. Efficacy was assessed by comparisons of parasite multiplication rates in the blood. PvDBPII/Matrix-M, given in a delayed dosing regimen, elicited the highest antibody responses and reduced the mean parasite multiplication rate after CHMI by 51% (n = 6) compared with unvaccinated controls (n = 13), whereas no other vaccine or regimen affected parasite growth. Both viral-vectored and protein vaccines were well tolerated and elicited expected, short-lived adverse events. Together, these results support further clinical evaluation of the PvDBPII/Matrix-M P. vivax vaccine

Sleeping Beauty Must Die: The Plots of Perrault’s “La belle au bois dormant”

Charles Perrault’s “Sleeping Beauty” does not end with a kiss, but with an ogress throwing herself into a vat of slimy creatures after a botched attempt at eating her family. Rather than account for the ogress story line through source study, this essay examines the narrative processes that connect the sleep plot and the ogress plot, demonstrating that substitution is the organizing principle of the tale. Reading the princess and the ogress as substitutes for each other elucidates the tale’s underlying anxiety: the woman who withdraws from the world, whether in sleep or appetite, is a danger to society and to narrative