3,656 research outputs found
A comparative re-examination of Anglo-Irish relations in nineteenth-century Manchester, Liverpool and Newcastle-upon-Tyne.
Large charts relating to this thesis have not been filmed, please apply direct to the issuing universitySIGLEAvailable from British Library Document Supply Centre-DSC:DX202167 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Efficacy of a Workbook to Promote Forgiveness: A Randomized Controlled Trial with University Students
Objective
The present study investigated the efficacy of a 6-hour self-directed workbook adapted from the REACH Forgiveness intervention. Method
Undergraduates (N = 41) were randomly assigned to either an immediate treatment or waitlist control condition. Participants were assessed across 3 time periods using a variety of forgiveness outcome measures. Results
The 6-hour workbook intervention increased forgiveness, as indicated by positive changes in participants’ forgiveness ratings that differed by condition. In addition, benchmarking analysis showed that the self-directed workbook intervention is at least as efficacious as the delivery of the REACH Forgiveness model via group therapy. Conclusion
A self-directed workbook intervention adapted from the REACH Forgiveness intervention provides an adjunct to traditional psychotherapy that could assist the mental health community to manage the burden of unforgiveness among victims of interpersonal harm
Development and validation of a chemostat gut model to study both planktonic and biofilm modes of growth of Clostridium difficile and human microbiota
Copyright: 2014 Crowther et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The human gastrointestinal tract harbours a complex microbial community which exist in planktonic and sessile form. The degree to which composition and function of faecal and mucosal microbiota differ remains unclear. We describe the development and characterisation of an in vitro human gut model, which can be used to facilitate the formation and longitudinal analysis of mature mixed species biofilms. This enables the investigation of the role of biofilms in Clostridium difficile infection (CDI). A well established and validated human gut model of simulated CDI was adapted to incorporate glass rods that create a solid-gaseous-liquid interface for biofilm formation. The continuous chemostat model was inoculated with a pooled human faecal emulsion and controlled to mimic colonic conditions in vivo. Planktonic and sessile bacterial populations were enumerated for up to 46 days. Biofilm consistently formed macroscopic structures on all glass rods over extended periods of time, providing a framework to sample and analyse biofilm structures independently. Whilst variation in biofilm biomass is evident between rods, populations of sessile bacterial groups (log10 cfu/g of biofilm) remain relatively consistent between rods at each sampling point. All bacterial groups enumerated within the planktonic communities were also present within biofilm structures. The planktonic mode of growth of C. difficile and gut microbiota closely reflected observations within the original gut model. However, distinct differences were observed in the behaviour of sessile and planktonic C. difficile populations, with C. difficile spores preferentially persisting within biofilm structures. The redesigned biofilm chemostat model has been validated for reproducible and consistent formation of mixed species intestinal biofilms. This model can be utilised for the analysis of sessile mixed species communities longitudinally, potentially providing information of the role of biofilms in CDI.Peer reviewe
Cenozoic evolution of the eastern Black Sea: a test of depth-dependent stretching models
Subsidence analysis of the eastern Black Sea basin suggests that the stratigraphy of this deep, extensional basin can be explained by a predominantly pure-shear stretching history. A strain-rate inversion method that assumes pure-shear extension obtains good fits between observed and predicted stratigraphy. A relatively pure-shear strain distribution is also obtained when a strain-rate inversion algorithm is applied that allows extension to vary with depth without assuming its existence or form. The timing of opening of the eastern Black Sea, which occupied a back-arc position during the closure of the Tethys Ocean, has also been a subject of intense debate; competing theories called for basin opening during the Jurassic, Cretaceous or Paleocene/Eocene. Our work suggests that extension likely continued into the early Cenozoic, in agreement with stratigraphic relationships onshore and with estimates for the timing of arc magmatism. Further basin deepening also appears to have occurred in the last 20 myr. This anomalous subsidence event is focused in the northern part of the basin and reaches its peak at 15–10 Ma. We suggest that this comparatively localized shortening is associated with the northward movement of the Arabian plate. We also explore the effects of paleowater depth and elastic thickness on the results. These parameters are controversial, particularly for deep-water basins and margins, but their estimation is a necessary step in any analysis of the tectonic subsidence record stored in stratigraphy. <br/
Describing Self-confidence in Ultrasound Performance with Increased Exposure
Presented as a poster at 2020 IUSM Education Day
Recommended from our members
Subsurface Oil-Shale Samples of the Lower Permian Wolfcampian and Lower Leonardian Mudrocks and Upper Leonardian Spraberry Formation, Midland Basin, West Texas: Core Sampling for Measured Vitrinite-Reflectance (Ro) Determination
This report summarizes activities carried out by the Bureau of Economic Geology (BEG) during fiscal year (FY) 2014 for the National Coal Resources Data System State Cooperative Program (NCRDS project). In a continuation of the sampling strategy for measured vitrinite-reflectance (Ro) determination initiated 5 years ago (Hentz and others, 2009) and conducted during the following four years (Hentz and others, 2010, 2011, 2012, 2014), this report provides a collection of oil-shale samples from the prolific Lower Permian Wolfcampian and lower Leonardian mudrocks and upper Leonardian Spraberry Formation of the Midland Basin in West Texas (Fig. 1).Bureau of Economic Geolog
Cost-Effectiveness of Skin Surveillance Through a Specialized Clinic for Patients at High Risk of Melanoma
Purpose
Clinical guidelines recommend that people at high risk of melanoma receive regular surveillance to
improve survival through early detection. A specialized High Risk Clinic in Sydney, Australia was
found to be effective for this purpose; however, wider implementation of this clinical service requires evidence of cost-effectiveness and data addressing potential overtreatment of suspicious
skin lesions.
Patients and Methods
A decision-analytic model was built to compare the costs and benefits of specialized surveillance
compared with standard care over a 10-year period, from a health system perspective. A high-risk
standard care cohort was obtained using linked population data, comprising the Sax Institute’s 45
and Up cohort study, linked to Medicare Benefits Schedule claims data, the cancer registry, and
hospital admissions data. Benefits were measured in quality-adjusted life-years gained. Sensitivity
analyses were undertaken for all model parameters.
Results
Specialized surveillance through the High Risk Clinic was both less expensive and more effective
than standard care. The mean saving was A5,564 to $8,092) per patient, and the
mean quality-adjusted life-year gain was 0.31 (95% CI, 0.27 to 0.35). The main drivers of the differences were detection of melanoma at an earlier stage resulting in less extensive treatment and
a lower annual mean excision rate for suspicious lesions in specialized surveillance (0.81; 95% CI,
0.72 to 0.91) compared with standard care (2.55; 95% CI, 2.34 to 2.76). The results were robust
when tested in sensitivity analyses.
Conclusion
Specialized surveillance was a cost-effective strategy for the management of individuals at high risk
of melanoma. There were also fewer invasive procedures in specialized surveillance compared with
standard care in the community
The SAMI Galaxy Survey: Revising the Fraction of Slow Rotators in IFS Galaxy Surveys
The fraction of galaxies supported by internal rotation compared to galaxies
stabilized by internal pressure provides a strong constraint on galaxy
formation models. In integral field spectroscopy surveys, this fraction is
biased because survey instruments typically only trace the inner parts of the
most massive galaxies. We present aperture corrections for the two most widely
used stellar kinematic quantities and . Our
demonstration involves integral field data from the SAMI Galaxy Survey and the
ATLAS Survey. We find a tight relation for both and
when measured in different apertures that can be used as a linear
transformation as a function of radius, i.e., a first-order aperture
correction. We find that and radial growth curves are
well approximated by second order polynomials. By only fitting the inner
profile (0.5), we successfully recover the profile out to one
if a constraint between the linear and quadratic parameter in the
fit is applied. However, the aperture corrections for and
derived by extrapolating the profiles perform as well as applying
a first-order correction. With our aperture-corrected
measurements, we find that the fraction of slow rotating galaxies increases
with stellar mass. For galaxies with 11, the fraction
of slow rotators is percent, but is underestimated if galaxies
without coverage beyond one are not included in the sample
( percent). With measurements out to the largest aperture radius
the slow rotator fraction is similar as compared to using aperture corrected
values ( percent). Thus, aperture effects can significantly bias
stellar kinematic IFS studies, but this bias can now be removed with the method
outlined here.Comment: Accepted for Publication in the Monthly Notices of the Royal
Astronomical Society. 16 pages and 11 figures. The key figures of the paper
are: 1, 4, 9, and 1
Method and system for aligning fibers during electrospinning
A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used
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