Frictional dissipation of polymeric solids vs interfacial glass transition

We present single contact friction experiments between a glassy polymer and smooth silica substrates grafted with alkylsilane layers of different coverage densities and morphologies. This allows us to adjust the polymer/substrate interaction strength. We find that, when going from weak to strong interaction, the response of the interfacial junction where shear localizes evolves from that of a highly viscous threshold fluid to that of a plastically deformed glassy solid. This we analyse as resulting from an interaction-induced ``interfacial glass transition'' helped by pressure

Stability of hexagonal solidification patterns

We investigate the dynamics of cellular solidification patterns using three-dimensional phase-field simulations. The cells can organize into stable hexagonal patterns or exhibit unsteady evolutions. We identify the relevant secondary instabilities of regular hexagonal arrays and find that the stability boundaries depend significantly on the strength of crystalline anisotropy. We also find multiplet states that can be reached by applying well-defined perturbations to a pre-existing hexagonal array.Comment: Minor changes, mainly in introduction and conclusion, one reference adde

Expected performances of a Laue lens made with bent crystals

In the context of the LAUE project devoted to build a Laue lens prototype for focusing celestial hard X-/soft gamma-rays, a Laue lens made of bent crystal tiles, with 20 m focal length, is simulated. The focusing energy passband is assumed to be 90--600 keV. The distortion of the image produced by the lens on the focal plane, due to effects of crystal tile misalignment and radial distortion of the crystal curvature, is investigated. The corresponding effective area of the lens, its point spread function and sensitivity are calculated and compared with those exhibited by a nominal Laue lens with no misalignment and/or distortion. Such analysis is crucial to estimate the optical properties of a real lens, in which the investigated shortcomings could be present.Comment: 20 pages, 14 figure

Perturbation of Tunneling Processes by Mechanical Degrees of Freedom in Mesoscopic Junctions

We investigate the perturbation in the tunneling current caused by non-adiabatic mechanical motion in a mesoscopic tunnel junction. A theory introduced by Caroli et al. \cite{bi1,bi2,bi3} is used to evaluate second order self-energy corrections for this non-equilibrium situation lacking translational invariance. Inelastic signatures of the mechanical degrees of freedom are found in the current-voltage $I(V)$ characteristics. These give rise to sharp features in the derivative spectrum, $d^2I/dV^2$.Comment: 22 pages LaTeX + 3 uuencoded PS picture

Driven activation versus thermal activation

Activated dynamics in a glassy system undergoing steady shear deformation is studied by numerical simulations. Our results show that the external driving force has a strong influence on the barrier crossing rate, even though the reaction coordinate is only weakly coupled to the nonequilibrium system. This "driven activation" can be quantified by introducing in the Arrhenius expression an effective temperature, which is close to the one determined from the fluctuation-dissipation relation. This conclusion is supported by analytical results for a simplified model system.Comment: 5 pages, 3 figure

Dry Friction due to Adsorbed Molecules

Using an adiabatic approximation method, which searches for Tomlinson model-like instabilities for a simple but still realistic model for two crystalline surfaces in the extremely light contact limit, with mobile molecules present at the interface, sliding relative to each other, we are able to account for the virtually universal occurrence of "dry friction." The model makes important predictions for the dependence of friction on the strength of the interaction of each surface with the mobile molecules.Comment: four pages of latex, figure provide

Compton telescope with coded aperture mask: Imaging with the INTEGRAL/IBIS Compton mode

Compton telescopes provide a good sensitivity over a wide field of view in the difficult energy range running from a few hundred keV to several MeV. Their angular resolution is, however, poor and strongly energy dependent. We present a novel experimental design associating a coded mask and a Compton detection unit to overcome these pitfalls. It maintains the Compton performance while improving the angular resolution by at least an order of magnitude in the field of view subtended by the mask. This improvement is obtained only at the expense of the efficiency that is reduced by a factor of two. In addition, the background corrections benefit from the coded mask technique, i.e. a simultaneous measurement of the source and background. This design is implemented and tested using the IBIS telescope on board the INTEGRAL satellite to construct images with a 12' resolution over a 29 degrees x 29 degrees field of view in the energy range from 200 keV to a few MeV. The details of the analysis method and the resulting telescope performance, particularly in terms of sensitivity, are presented

Computational Methods for the Integrative Analysis of Genomics and Pharmacological Data

Since the pioneering NCI-60 panel of the late'80's, several major screenings of genetic profiling and drug testing in cancer cell lines have been conducted to investigate how genetic backgrounds and transcriptional patterns shape cancer's response to therapy and to identify disease-specific genes associated with drug response. Historically, pharmacogenomics screenings have been largely heterogeneous in terms of investigated cell lines, assay technologies, number of compounds, type and quality of genomic data, and methods for their computational analysis. The analysis of this enormous and heterogeneous amount of data required the development of computational methods for the integration of genomic profiles with drug responses across multiple screenings. Here, we will review the computational tools that have been developed to integrate cancer cell lines' genomic profiles and sensitivity to small molecule perturbations obtained from different screenings

Static Versus Dynamic Friction: The Role of Coherence

A simple model for solid friction is analyzed. It is based on tangential springs representing interlocked asperities of the surfaces in contact. Each spring is given a maximal strain according to a probability distribution. At their maximal strain the springs break irreversibly. Initially all springs are assumed to have zero strain, because at static contact local elastic stresses are expected to relax. Relative tangential motion of the two solids leads to a loss of coherence of the initial state: The springs get out of phase due to differences in their sizes. This mechanism alone is shown to lead to a difference between static and dynamic friction forces already. We find that in this case the ratio of the static and dynamic coefficients decreases with increasing relative width of the probability distribution, and has a lower bound of 1 and an upper bound of 2.Comment: 10 pages, 2 figures, revtex