Andare oltre il modello di "innovazione senza ricerca"? La situazione nelle PMI del Lazio e le possibili linee di tendenza

Monograph

Modelli ed esperienze di innovazione sociale in Italia: secondo rapporto sull’innovazione sociale

Il rapporto sull’innovazione sociale in Italia pubblicato dal CERIIS (centro di ricerche internazionali sull’innovazione sociale) analizza il fenomeno dell’innovazione sociale nel nostro Paese, attraverso la rilevazione di quasi 500 progetti ed esperienze e l’approfondimento di 56 casi di maggior rilevanza. Sulla base di questa ampia analisi empirica, il rapporto illustra i modelli e le attuali tendenze maggiormente consolidate dell’innovazione sociale nel nostro Paese. In particolare, lo studio identifica le caratteristiche chiave dell’innovazione sociale e le principali condizioni che ne favoriscono lo sviluppo; evidenzia gli ambiti di rilievo sociale dove il fenomeno in questione risulta più frequente; le specificità dei soggetti tipicamente coinvolti e le modalità (appunto, innovative) con cui essi interagiscono nell’implementazione delle iniziative

La responsabilità sociale d'impresa nel quadro delle "Linee Guida OCSE destinate alle imprese multinazionali": un focus sulle PMI

La crescente attenzione dedicata al fenomeno della Responsabilità Sociale d’impresa a livello mondiale e la maggiore consapevolezza delle imprese sul loro ruolo sociale, ha portato numerosi attori economici ad adottare la RSI come strumento di risposta alle molteplici pressioni sociali, ambientali ed economiche, provenienti dai diversi portatori di interesse (stakeholder) operanti a molteplici livelli (locale, nazionale e sovra-nazionale). A ciò, si aggiunga l’impegno assunto a livello internazionale nello sviluppo di strumenti/programmi capaci di favorire la diffusione di tali pratiche nell’ambito dei diversi contesti aziendali. In questa sede si fa esplicito riferimento ai principi direttivi dell’OCSE destinati alle imprese multinazionali (2000). In particolare, questi suggeriscono alle imprese la necessità di tener conto delle specificità dei contesti sociali, economici ed istituzionali nei quali operano, allineando i propri interessi a quelli di altri interlocutori, direttamente o indirettamente, connessi all’impresa. Lo studio ha voluto indagare il fenomeno nell’ambito di contesti aziendali di piccole e medie dimensioni, alla luce delle specificità che caratterizzano il contesto economico produttivo nazionale.La crescente attenzione dedicata al fenomeno della Responsabilità Sociale d’impresa a livello mondiale e la maggiore consapevolezza delle imprese sul loro ruolo sociale, ha portato numerosi attori economici ad adottare la RSI come strumento di risposta alle molteplici pressioni sociali, ambientali ed economiche, provenienti dai diversi portatori di interesse (stakeholder) operanti a molteplici livelli (locale, nazionale e sovra-nazionale). A ciò, si aggiunga l’impegno assunto a livello internazionale nello sviluppo di strumenti/programmi capaci di favorire la diffusione di tali pratiche nell’ambito dei diversi contesti aziendali. In questa sede si fa esplicito riferimento ai principi direttivi dell’OCSE destinati alle imprese multinazionali (2000). In particolare, questi suggeriscono alle imprese la necessità di tener conto delle specificità dei contesti sociali, economici ed istituzionali nei quali operano, allineando i propri interessi a quelli di altri interlocutori, direttamente o indirettamente, connessi all’impresa. Lo studio ha voluto indagare il fenomeno nell’ambito di contesti aziendali di piccole e medie dimensioni, alla luce delle specificità che caratterizzano il contesto economico produttivo nazionale.Refereed Working Papers / of international relevanceMonograph

Structural Basis for the Interaction of the Myosin Light Chain Mlc1p with the Myosin V Myo2p IQ Motifs

Calmodulin, regulatory, and essential myosin light chain are evolutionary conserved proteins that, by binding to IQ motifs of target proteins, regulate essential intracellular processes among which are efficiency of secretory vesicles release at synapsis, intracellular signaling, and regulation of cell division. The yeast Saccharomyces cerevisiae calmodulin Cmd1 and the essential myosin light chain Mlc1p share the ability to interact with the class V myosin Myo2p and Myo4 and the class II myosin Myo1p. These myosins are required for vesicle, organelle, and mRNA transport, spindle orientation, and cytokinesis. We have used the budding yeast model system to study how calmodulin and essential myosin light chain selectively regulate class V myosin function. NMR structural analysis of uncomplexed Mlc1p and interaction studies with the first three IQ motifs of Myo2p show that the structural similarities between Mlc1p and the other members of the EF-hand superfamily of calmodulin-like proteins are mainly restricted to the C-lobe of these proteins. The N-lobe of Mlc1p presents a significantly compact and stable structure that is maintained both in the free and complexed states. The Mlc1p N-lobe interacts with the IQ motif in a manner that is regulated both by the IQ motifs sequence as well as by light chain structural features. These characteristic allows a distinctive interaction of Mlc1p with the first IQ motif of Myo2p when compared with calmodulin. This finding gives us a novel view of how calmodulin and essential light chain, through a differential binding to IQ1 of class V myosin motor, regulate this activity during vegetative growth and cytokinesis

A New Approach to Enhance the Strategic Impact of Digital Education in Universities and to Foster the Development of a High Performing Common EU Smart Education Ecosystem

In response to the negative COVID-19 impacts, it is urgent to support digital transformation plans at all levels of educational online activities. Fundamental it is also to support new inclusive digital pedagogical methods and skills for a resilient free adoption of digital tools for academic teachers (digital integrated learning, advanced multimedia, but also hybrid and interactive new methodologies, 3D, VR, holographic tools, etc.) and allow effective use for students, including participants with fewer opportunities: physically impaired (deaf, blind, paralytic), cognitive impaired and low-income students. This to create the condition of a more EU integrated strategy to consent the proposal for a Council Recommendation on the enabling factors for successful digital education by 2022–2025. We are following and improving the recommendations of OECD and UN, of EU Future Government 2030+, of EU’s strategy for e-Skills in the 21st Century, of KES international network and of FOME - Future of Management Education international scientific alliance. Also, some new EU Directives will imply a real digital revolution in educational processes and learning skills. So digital technologies have made this transition possible: surely, there have been a number of e-learning platforms for some years now, but their role has only in the last months gained massive relevance concurrently with the pandemic global situation. Only a few EU Universities are already ready for good quality distance learning, with tools for course management, including live sessions, interactive teaching and collaborative activities. Most EU Universities had to cope with the emergency situation that called for a quick organizational and cultural rearrangement and a change of learning strategies, which perhaps represented the most difficult step for teachers and students. Digital technologies are becoming very relevant at the EU level for teachers and students. However, the current limitations on the movement of people and teaching hours may restrict this type of delivery. For this reason, the described EDU-GATE initiative is providing a detailed European multi-sectoral analysis indicating the comparison of current situations of teaching digitalization (As-Is and To-Be analysis), together with a transversal needs’ analysis. Also, a smart innovative curriculum, including the most advanced educational design and delivering techniques, has been created for the improvement of teachers’ skills. Almost 12 innovative multimedia e-modules have been prepared, permitting effective learning activities and to share best practices in the EU

How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons

COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March-April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients' management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons' personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon-patient/family communication. From the Italian surgeons' perspective, COVID-related measures will continue to influence future surgical clinical practice

La politica anticorruzione nei Gruppi internazionali: la strategia della corporate e la sua realizzazione nelle societ\ue0 controllate

Il volume ha l'obiettivo di spiegare come nei Gruppi internazionali la corporate agisca per minimizzare il rischio di corruzione in tutto il sistema aziendale di cui \ue8 alla guida. facendo una disamina organica ed esaustiva della complessiva azione stratgica attuata dalla corporate contro il rischio di corruzione, il libro compie un excursus sui risultati di tredici casi costituiti da altrettanti Gruppi italinai internazionali. Questo sutdio, oltre a descrivere in maniera strutturale i contenuti politici della corporate, enuncia le ragioni per cui quello contro la corruzione sia un impegno ineluttabile. espone poi come la politica anticorruzione venga efficacemente implementata da tutte le societ\ue0 controllate e in particolare da quelle nelle aree geografiche maggiormente problematiche. Il libro conclude la sua indagine, mettendo in evidenza l'innovazione del business model nel neutralizzare il rischio di corruzion