Depression as a risk factor for adverse outcomes in coronary heart disease

BACKGROUND: Depression is firmly established as an independent predictor of mortality and cardiac morbidity in patients with coronary heart disease (CHD). However, it has been difficult to determine whether it is a causal risk factor, and whether treatment of depression can improve cardiac outcomes. In addition, research on biobehavioral mechanisms has not yet produced a definitive causal model of the relationship between depression and cardiac outcomes. DISCUSSION: Key challenges in this line of research concern the measurement of depression, the definition and relevance of certain subtypes of depression, the temporal relationship between depression and CHD, underlying biobehavioral mechanisms, and depression treatment efficacy. SUMMARY: This article examines some of the methodological challenges that will have to be overcome in order to determine whether depression should be regarded as a key target of secondary prevention in CHD

Child Anxiety Sensitivity in Juvenile Adolescent Twins

Child Anxiety Sensitivity in Juvenile Adolescent Twins. Researched by Laura Hazlett from the VCU Psychology Department. Help from faculty mentors Dr. John Hettema, Psychiatry and Dr. Roxann Roberson-Nay, Psychology. Anxiety sensitivity (AS) is a dispositional trait where one is fearful of anxiety symptoms, and is distinguishable from the trait of anxiety itself. (Eke & McNally, 1996). These fears of anxiety-related sensations are an important factor in predicting the emergence and severity of panic symptoms (McNally, 2002). The Child Anxiety Sensitivity Index (CASI) is the child version of an 18-item self-report questionnaire commonly used to measure anxiety sensitivity. Zinbarg et al. (1997) demonstrated that the ASI has three first-order factors: Physical Concerns (i.e. “It scares me when my heart beats fast “), Mental Incapacitation Concerns (i.e. “When I am afraid, I worry that I might be crazy”), and Social Concerns (i.e. “Other kids can tell when I feel shaky “). The aim of the current study is to examine the relationship between scores on the CASI and responses during a low-dose carbon dioxide breathing task designed to induce panic-related sensations. The participants in our study were monozygotic and dizygotic twin pairs ranging from ages nine to thirteen. Twins’ responses throughout the task were measured using the Subjective Units of Distress Scale (SUDS) and the Diagnostic Symptom Questionnaire (DSQ), which measures cognitive and physical panic symptoms. We hypothesize that there is a positive relationship between the CASI and anxious responding during the carbon dioxide breathing task, such that as CASI scores increase, so do scores on the DSQ and SUDS. The results support the hypothesis and show significant evidence of a relationship between the CASI and subjectively experienced distress and panic symptoms. So, the more fearful an individual is of panic symptoms, the more severely they experience those symptoms, which in turn causes greater subjective distress. This study contributes to identifying the overall relationship between the CASI, DSQ, and SUDS scores when looking at physical, mental, and social concerns that contribute to the fear of experiencing subjective anxious symptoms.https://scholarscompass.vcu.edu/uresposters/1058/thumbnail.jp

Classifying the embedded young stellar population in Perseus and Taurus & the LOMASS database

Context. The classification of young stellar objects (YSOs) is typically done using the infrared spectral slope or bolometric temperature, but either can result in contamination of samples. More accurate methods to determine the evolutionary stage of YSOs will improve the reliability of statistics for the embedded YSO population and provide more robust stage lifetimes. Aims. We aim to separate the truly embedded YSOs from more evolved sources. Methods. Maps of HCO+ J=4-3 and C18O J=3-2 were observed with HARP on the James Clerk Maxwell Telescope (JCMT) for a sample of 56 candidate YSOs in Perseus and Taurus in order to characterize emission from high (column) density gas. These are supplemented with archival dust continuum maps observed with SCUBA on the JCMT and Herschel PACS to compare the morphology of the gas and dust in the protostellar envelopes. The spatial concentration of HCO+ J=4-3 and 850 micron dust emission are used to classify the embedded nature of YSOs. Results. Approximately 30% of Class 0+I sources in Perseus and Taurus are not Stage I, but are likely to be more evolved Stage II pre-main sequence (PMS) stars with disks. An additional 16% are confused sources with an uncertain evolutionary stage. Conclusions. Separating classifications by cloud reveals that a high percentage of the Class 0+I sources in the Perseus star forming region are truly embedded Stage I sources (71%), while the Taurus cloud hosts a majority of evolved PMS stars with disks (68%). The concentration factor method is useful to correct misidentified embedded YSOs, yielding higher accuracy for YSO population statistics and Stage timescales. Current estimates (0.54 Myr) may overpredict the Stage I lifetime on the order of 30%, resulting in timescales of 0.38 Myr for the embedded phase.Comment: 33 pages, 21 figures, 6 tables, Accepted to be published in A&

The effectiveness of three types of practice in word recognition in grades II and III

Thesis (Ed.M.)--Boston Universit

Synthetic Mudscapes: Human Interventions in Deltaic Land Building

In order to defend infrastructure, economy, and settlement in Southeast Louisiana, we must construct new land to mitigate increasing risk. Links between urban environments and economic drivers have constrained the dynamic delta landscape for generations, now threatening to undermine the ecological fitness of the entire region. Static methods of measuring, controlling, and valuing land fail in an environment that is constantly in flux; change and indeterminacy are denied by traditional inhabitation. Multiple land building practices reintroduce deltaic fluctuation and strategic deposition of fertile material to form the foundations of a multi-layered defence strategy. Manufactured marshlands reduce exposure to storm surge further inland. Virtual monitoring and communication networks inform design decisions and land use becomes determined by its ecological health. Mudscapes at the threshold of land and water place new value on former wastelands. The social, economic, and ecological evolution of the region are defended by an expanded web of growing land

Halothane hepatitis with renal failure treated with hemodialysis and exchange transfusion

A 38-year-old white female, hepatitis B antigen negative, developed fluminating hepatic failure associated with oliguria and severe azotemia after two halothane anesthesia and without exposure to other hepatotoxic drugs or blood transfusions. She was treated with multiple hemodialysis and exchange blood transfusion. The combined treatment corrected the uremic abnormalities and improved her level of consciousness. The liver and kidney function gradually improved, and she made a complete recovery, the first recorded with hepatic and renal failure under these post-anesthetic conditions. Further evaluation of this combined treatment used for this patient is warranted. © 1974 The Japan Surgical Society

Medical Professionals' Perspectives on Prescribed and Over-The-Counter Medicines Containing Codeine: A Cross-Sectional Study

Objectives: To explore prescribing practitioners' perspectives on prescribed codeine use, their ability to identify dependence and their options for treatment in the UK. Design: Cross-sectional design using a questionnaire containing closed-ended and open-ended items. Setting: A nationally representative sample of prescribing professionals working in the UK. Participants: 300 prescribing professionals working in primary care and pain settings. Results: Participants stated that they regularly reviewed patients prescribed codeine, understood the risks of dependence and recognised the potential for codeine to be used recreationally. Over half the participants felt patients were unaware of the adverse health consequences of high doses of combination codeine medicines. One-quarter of participants experienced patient resentment when asking about medicines containing codeine. Just under 40% of participants agreed that it was difficult to identify problematic use of codeine without being informed by the patient and did not feel confident in identification of codeine dependence. Less than 45% of all participants agreed that codeine dependence could be managed effectively in general practice. Slow or gradual withdrawal was the most popular suggested treatment in managing dependence. Education and counselling was also emphasised in managing codeine-dependent patients in primary care. Conclusions: Communication with patients should involve assessment of patient understanding of their medication, including the risk of dependence. There is a need to develop extra supports for professionals including patient screening tools for identifying codeine dependence. The support structure for managing codeine-dependent patients in primary care requires further examination

A microarray analysis of sex- and gonad-biased gene expression in the zebrafish: Evidence for masculinization of the transcriptome

<p>Abstract</p> <p>Background</p> <p>In many taxa, males and females are very distinct phenotypically, and these differences often reflect divergent selective pressures acting on the sexes. Phenotypic sexual dimorphism almost certainly reflects differing patterns of gene expression between the sexes, and microarray studies have documented widespread sexually dimorphic gene expression. Although the evolutionary significance of sexual dimorphism in gene expression remains unresolved, these studies have led to the formulation of a hypothesis that male-driven evolution has resulted in the masculinization of animal transcriptomes. Here we use a microarray assessment of sex- and gonad-biased gene expression to test this hypothesis in zebrafish.</p> <p>Results</p> <p>By using zebrafish Affymetrix microarrays to compare gene expression patterns in male and female somatic and gonadal tissues, we identified a large number of genes (5899) demonstrating differences in transcript abundance between male and female <it>Danio rerio</it>. Under conservative statistical significance criteria, all sex-biases in gene expression were due to differences between testes and ovaries. Male-enriched genes were more abundant than female-enriched genes, and expression bias for male-enriched genes was greater in magnitude than that for female-enriched genes. We also identified a large number of genes demonstrating elevated transcript abundance in testes and ovaries relative to male body and female body, respectively.</p> <p>Conclusion</p> <p>Overall our results support the hypothesis that male-biased evolutionary pressures have resulted in male-biased patterns of gene expression. Interestingly, our results seem to be at odds with a handful of other microarray-based studies of sex-specific gene expression patterns in zebrafish. However, ours was the only study designed to address this specific hypothesis, and major methodological differences among studies could explain the discrepancies. Regardless, all of these studies agree that transcriptomic sex differences in <it>D. rerio </it>are widespread despite the apparent absence of heterogamety. These differences likely make important contributions to phenotypic sexual dimorphism in adult zebrafish; thus, from an evolutionary standpoint, the precise roles of sex-specific selection and sexual conflict in the evolution of sexually dimorphic gene expression are very important. The results of our study and others like it set the stage for further work aimed at directly addressing this exciting issue in comparative genomics.</p