274 research outputs found
Addition of Passive Acoustic Telemetry Mitigates Lost Data From Satellite-Tracked Manatees
Satellite-tracked manatees routinely lose satellite tags or tag functionality, resulting in the loss of valuable data on migration and habitat use patterns. Fortunately, some movement data from these animals remain salvageable because manatees typically retain a peduncle belt containing an acoustic transmitter that can be detected with a submersible hydrophone. We deployed an array of moored datalogging hydrophones at key locations in our study area to detect manatee belt-embedded acoustic transmitters, a technique not typically used to track manatees. Our array was successful in detecting five tagged manatees, and concurrently detected compatible acoustic tags of other estuarine fauna (e.g. Bull Sharks) tagged by local researchers. Moored datalogging hydrophones, therefore, provided a method to mitigate the loss of satellite tags from estuarine megafauna, and enhanced collaborative opportunities with researchers who tagged other species using compatible equipment
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Risk Factors for Appendiceal Cancer After Appendectomy
BackgroundAppendiceal cancer (AC) is a rare malignancy usually diagnosed incidentally after appendectomy. Risk factors for AC are poorly understood. We sought to provide a descriptive analysis for patients with AC discovered after appendectomy for acute appendicitis (AA).MethodsThe 2016-2017 American College of Surgeons-National Surgical Quality Improvement Program Procedure-Targeted Appendectomy database was queried for adult patients who underwent appendectomy for image-suspected AA. Patients with pathology consistent with AA were compared to patients found to have AC. A multivariable logistic regression model was used for analysis.ResultsFrom 21 058 patients, 203 (1.0%) were found to have AC on pathology. Compared to patients with AA, patients with AC were older (median, 48 vs. 40 years old, P < .001). The AA group had a similar rate of perforated appendix compared to the AC group (16.3% vs. 13.4% P = .32). After adjusting for covariates, associated risk factors for AC were: age ≥65 years old (odds ratio (OR) 2.25, 1.5-3.38, P < .001), absence of leukocytosis (OR 1.58, 1.16-2.17, P = .004), and operative time ≥1 hour (OR 1.57, 1.14-2.16, P = .006). Gender, race, and history of smoking were not independent associated risk factors for AC.ConclusionThe incidence of AC after appendectomy for suspected AA is approximately 1% in a large national analysis. These factors may be used to help identify patients at higher risk for AC after appendectomy
Hydrological and associated biogeochemical consequences of rapid global warming during the Paleocene-Eocene Thermal Maximum
The Paleocene-Eocene Thermal Maximum (PETM) hyperthermal, ~ 56 million years ago (Ma), is the most dramatic example of abrupt Cenozoic global warming. During the PETM surface temperatures increased between 5 and 9 °C and the onset likely took < 20 kyr. The PETM provides a case study of the impacts of rapid global warming on the Earth system, including both hydrological and associated biogeochemical feedbacks, and proxy data from the PETM can provide constraints on changes in warm climate hydrology simulated by general circulation models (GCMs). In this paper, we provide a critical review of biological and geochemical signatures interpreted as direct or indirect indicators of hydrological change at the PETM, explore the importance of adopting multi-proxy approaches, and present a preliminary model-data comparison. Hydrological records complement those of temperature and indicate that the climatic response at the PETM was complex, with significant regional and temporal variability. This is further illustrated by the biogeochemical consequences of inferred changes in hydrology and, in fact, changes in precipitation and the biogeochemical consequences are often conflated in geochemical signatures. There is also strong evidence in many regions for changes in the episodic and/or intra-annual distribution of precipitation that has not widely been considered when comparing proxy data to GCM output. Crucially, GCM simulations indicate that the response of the hydrological cycle to the PETM was heterogeneous – some regions are associated with increased precipitation – evaporation (P – E), whilst others are characterised by a decrease. Interestingly, the majority of proxy data come from the regions where GCMs predict an increase in PETM precipitation. We propose that comparison of hydrological proxies to GCM output can be an important test of model skill, but this will be enhanced by further data from regions of model-simulated aridity and simulation of extreme precipitation events
Using ecosystem landscape models to investigate industrial environmental impacts
ABSTRACT This article explores the use of ecosystem landscape models to estimate the environmental impacts of industrial activities at the regional / local scale. Integrated ecosystem and industrial modeling is first introduced within the context of life cycle assessment. Then, the use of integrated modeling to overcome problems stemming from the lumped parameter, static, site non-specific nature of life cycle assessment is discussed. Finally, the results of linking a handful of industrially relevant material and information flows demonstrate the ability of current ecosystem landscape models to respond to industrial burdens and estimate some environmental impacts
Fetal body MRI and its application to fetal and neonatal treatment: an illustrative review
This Review depicts the evolving role of MRI in the diagnosis and prognostication of anomalies of the fetal body, here including head and neck, thorax, abdomen and spine. A review of the current literature on the latest developments in antenatal imaging for diagnosis and prognostication of congenital anomalies is coupled with illustrative cases in true radiological planes with viewable three-dimensional video models that show the potential of post-acquisition reconstruction protocols. We discuss the benefits and limitations of fetal MRI, from anomaly detection, to classification and prognostication, and defines the role of imaging in the decision to proceed to fetal intervention, across the breadth of included conditions. We also consider the current capabilities of ultrasound and explore how MRI and ultrasound can complement each other in the future of fetal imaging
Terrestrial environmental change across the onset of the PETM and the associated impact on biomarker proxies:A cautionary tale
The following supplementary information includes one dataset which contains 3 tables:
Biomarker distributions and proxies at Cobham, UK
Bulk and compound specific isotope data at Cobham (UK)
Model-derived mean annual surface temperature and precipitation estimates as a function of CO2 at Cobham (UK)
A human-derived prostate co-culture microtissue model using epithelial (RWPE-1) and stromal (WPMY-1) cell lines
The development and normal function of prostate tissue depends on signalling interactions between stromal and epithelial compartments. Development of a prostate microtissue composed of these two components can help identify substance exposures that could cause adverse effects in humans as part of a non-animal risk assessment. In this study, prostate microtissues composed of human derived stromal (WPMY-1) and epithelial (RWPE-1) cell lines grown in scaffold-free hydrogels were developed and characterized using immunohistochemistry, light microscopy, and qRT-PCR. Within 5 days after seeding, the microtissues self-organized into spheroids consisting of a core of stromal WPMY-1 cells surrounded by epithelial RWPE-1 cells. The RWPE-1 layer is reflective of intermediate prostatic epithelium, expressing both characteristics of the luminal (high expression of PSA) and basal (high expression of cytokeratins 5/6 and 14) epithelial cells. The response of the microtissues to an androgen (dihydrotestosterone, DHT) and an anti-androgen (flutamide) was also investigated. Treatment with DHT, flutamide or a mixture of DHT and flutamide indicated that the morphology and self-organization of the microtissues is androgen dependent. qRT-PCR data showed that a saturating concentration of DHT increased the expression of genes coding for the estrogen receptors (ESR1 and ESR2) and decreased the expression of CYP1B1 without affecting the expression of the androgen receptor. With further development and optimization RWPE-1/WPMY-1 microtissues can play an important role in non-animal risk assessments
A model-model and data-model comparison for the early Eocene hydrological cycle
A range of proxy observations have recently provided constraints on how
Earth's hydrological cycle responded to early Eocene climatic changes.
However, comparisons of proxy data to general circulation model (GCM)
simulated hydrology are limited and inter-model variability remains poorly
characterised. In this work, we undertake an intercomparison of GCM-derived
precipitation and <i>P</i> − <i>E</i> distributions within the extended EoMIP ensemble
(Eocene Modelling Intercomparison Project; Lunt et al., 2012), which includes
previously published early Eocene simulations performed using five GCMs
differing in boundary conditions, model structure, and precipitation-relevant
parameterisation schemes.
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We show that an intensified hydrological cycle, manifested in enhanced
global precipitation and evaporation rates, is simulated for all Eocene
simulations relative to the preindustrial conditions. This is primarily due to elevated
atmospheric paleo-CO<sub>2</sub>, resulting in elevated temperatures, although the
effects of differences in paleogeography and ice sheets are also important
in some models. For a given CO<sub>2</sub> level, globally averaged precipitation rates
vary widely between models, largely arising from different simulated surface
air temperatures. Models with a similar global sensitivity of precipitation
rate to temperature (d<i>P</i>∕d<i>T</i>) display different regional precipitation responses
for a given temperature change. Regions that are particularly sensitive to
model choice include the South Pacific, tropical Africa, and the Peri-Tethys,
which may represent targets for future proxy acquisition.
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A comparison of early and middle Eocene leaf-fossil-derived precipitation
estimates with the GCM output illustrates that GCMs generally underestimate
precipitation rates at high latitudes, although a possible seasonal bias of
the proxies cannot be excluded. Models which warm these regions, either via
elevated CO<sub>2</sub> or by varying poorly constrained model parameter values, are
most successful in simulating a match with geologic data. Further data from
low-latitude regions and better constraints on early Eocene CO<sub>2</sub> are now
required to discriminate between these model simulations given the large
error bars on paleoprecipitation estimates. Given the clear differences
between simulated precipitation distributions within the ensemble, our
results suggest that paleohydrological data offer an independent means by
which to evaluate model skill for warm climates
Intramolecular Modulation of Serine Protease Inhibitor Activity in a Marine Cyanobacterium with Antifeedant Properties
Extracts of the Floridian marine cyanobacterium Lyngbya cf. confervoides were found to deter feeding by reef fish and sea urchins (Diadema antillarum). This antifeedant activity may be a reflection of the secondary metabolite content, known to be comprised of many serine protease inhibitors. Further chemical and NMR spectroscopic investigation led us to isolate and structurally characterize a new serine protease inhibitor 1 that is formally derived from an intramolecular condensation of largamide D (2). The cyclization resulted in diminished activity, but to different extents against two serine proteases tested. This finding suggests that cyanobacteria can endogenously modulate the activity of their protease inhibitors
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