1,493 research outputs found

    CatRAPID signature: identification of ribonucleoproteins and RNA-binding regions

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    Motivation: Recent technological advances revealed that an unexpected large number of proteins interact with transcripts even if the RNA-binding domains are not annotated. We introduce catRAPID signature to identify ribonucleoproteins based on physico-chemical features instead of sequence similarity searches. The algorithm, trained on human proteins and tested on model organisms, calculates the overall RNA-binding propensity followed by the prediction of RNA-binding regions. catRAPID signature outperforms other algorithms in the identification of RNA-binding proteins and detection of non-classical RNA-binding regions. Results are visualized on a webpage and can be downloaded or forwarded to catRAPID omics for predictions of RNA targets

    IL COLLEGAMENTO STABILE DELL'AREA METROPOLITANA DELLO STRETTO DI MESSINA

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    In the age of globalization, unlike model of the historic city, the modern city is strongly influenced by the dynamics of economic flows and information and cultural contamination. Consequently, the operational approach of the traditional administrative machinery has proved inadequate to address the complexity of the problems and has generated a new model of governance of urban areas capable of interacting with the speed with which transformations take place. The speed of change is typical of the metropolitan city, which requires a new institutional framework that is equipped with tools and infrastructure suitable to govern the phenomena of mobility, economic development and transformations under synergistic and integrated. The metropolitan system of the Strait of Messina need for a stable connection that ensures, through the conurbation of the two shores, effective governance of the territory.DOI: http://dx.medra.org/10.19254/LaborEst.09.1

    NIGHT-Care: A Passive RFID System for Remote Monitoring and Control of Overnight Living Environment

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    AbstractAn Ambient Intelligence platform, NIGHTCare, for remote monitoring and control of overnight living environment is here proposed. The platform, entirely based on RFID passive technology is able to recognize nocturnal behaviors and activities, generates automatic alarms in case of anomalous or pathological events and support diagnostics. The results of a complete test in real scenario are presented, together with a numerical assessment of electromagnetic safety issues

    La elocuencia de los eufemismos. Un análisis semántico desde la perspectiva educativa

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    En el presente artículo se analiza el discurso que nombra, define y devela los lugares reservados a los sujetos dentro de las instituciones educativas. Lo dicho, en forma directa o indirecta, oculta la desigualdad subyacente. Lo emergente es un lenguaje lleno de eufemismos que explicita una asignación de destinos en función del estigma. Se aborda aquí aquello instaurado en el lenguaje que enmascara lealtades ideológicas

    The Fortification System of the Straits. The Evaluations as Decision Support in the Economic Development Strategies of the Metropolitan City

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    The research analyzes the ability of the economic assessment to promote local development. At this stage, we try to shed more light on the importance of this matter, proposing a study on the one hand can highlight the features and the most important aspects of the evaluation and the other is able to demonstrate the operational validity of the latter in promote local development. Local development becomes an important tool for the exploitation of resources of a territory , which takes an active role , offering more and more exploitable resources over time . Finally, it is exposed to the concept of " cultural system " as a model of spatial development can promote the economy of the area and the redevelopment and improvement of the overall livability of a given territory. The culture thus becomes an increasingly important role for the marketi ! ng land , in order to improve the quality of life and promote the attractiveness and competitiveness of the territory, in order to activate the factors necessary for its development . The second part is exposed to the project concerning the creation of the cultural system as a process of planning for the future development of the city. A project that involves many actors, especially citizens increasingly seen as behind the choices of a city more efficient. In the context of the current localization economies , in fact , cities are having to compete with each other in pursuit of a development in the long term through investment in the territory and citizens , as an impetus to innovation and research . The three assets to be followed in order to enhance the city will be the ones to make it more welcoming and attractive , with a strong relational identity , sustainable and innovative . Understand, then , as Reggio Calabria to respond to the characteristics of " cultural system " is the goal of this work. Understand what are the reasons that lead a reality, such as that in question, as if to better integrate , to make a place more innovative, both in terms of territorial and cultural , without losing sight of the centrality of the person, respect and protection of human dignity , freedom, and the promotion of interpersonal relationships. Not far away are the days when any attempt to associate the terms " culture " and "economy" - when not even irreverent - seemed no doubt risky. Yet the idea that culture can be an engine of growth for the economy of a country is today widely demonstrated and shared by the scientific community. This is a significant mutation of trend that is gradually shifting the meaning of the function and use of the cultural property - until recent years reduced to a conceptual category in which the assets were intended as a memory of a cultural identity and therefore a vehicle for education and training - towards a vision that has enriched the profile of a conservative approach much more dynamic and economically productive . If you add to this the picture that is emerging in the era of globalization of markets and which tends , paradoxically, to strengthen the role and significance of territory in its specificity and cultural identity , it is not difficult to imagine how any policy intervention in the sector cultural , if on the one hand can not be separated from the concept of preservation , another must necessarily be open to an interpretation of the territory as a resource , developing planning skills with a strong innovative content. It requires, in this context, the need to "system" and to understand the change as the result of multiple and highly coordinated actions . If the strategies adopted to date , especially in Italy , have failed to ensure a real and sustainable economic development is compatible because, in reality, have segmented the field and separate the processes of development of cultural heritage from the local context in which they gravitate [ 1 ] . The advantage of the cultural consumption of a resource may induce socialized through its reuse by means of enhancement and management is a goal that can be checked with the help of different disciplines. The enhancement projects are a particular case within the realm of architectural design , but the economic evaluation together with the estimation disciplines continues to be a substantial contribution to the development of design processes . It presupposes , in the case of conservation projects , the presence of value judgments Quantitative alongside qualitative judgments , most often related to the historical interpretation of existing artifacts and building complexes . The transition from the formal model , which refers to private assets in the current market environment, the model which refers to the Economy substantial public goods with coordinates outside the market , in effect, shifts the focus from consumer use of resources: assets whose value is tied to the exchange and to the prevalence of the logic of the market, but rather resources whose value depends on the use, directly and indirectly from the use and non-use . The fact that we consider public goods as an economic resource , even if not placed in a context of market rules, raises complex issues , which are not exhausted by simple considerations on the scheme owner of the goods . On the one hand , as I said before, because of the difficulties to attribute a value in the monetary sense , and second, for the different meanings of technical feasibility , economic and financial continue to be a key stage in the planning of interventions on public resources . The territory has always been considered an integral part of our lives, recognized as a place of personal identity , cultural and religious . The desire to tradition, the rediscovery of ancient crafts and the production of typical signs are evident that without a strong local roots there is no significant experience in personal and social life . Among the main human needs is precisely the discovery of the territory, the sense of belonging to someone, even before something. The human being is always looking for a place that satisfies both environmentally and culturally, without which it would live dispersed. Precisely for this reason, in every historical moment has expressed a willingness to change the place where he lived apportandone valid media changes and trying to make it better and appropriate to meet his needs . In an increasingly globalized society , however , many regions are competing with each other and then it is even more difficult to enhance and encourage entrepreneurship in an area, and that is why we need rules and tools , able to promote the product area, also through a communication that is capable of enhancing the development potential and the socio-economic and environmental issues, whilst promoting local entrepreneurship . The territories , in fact, have to fit in the global market , using a fast market and explanatory , communicating the wealth of an area, its entrepreneurial vocations , the location opportunities , business opportunities . These are the tools that support the creation of local businesses and attracting capital from outside the territory , allow you to stimulate economic development . Through the challenges of globalization has been given a new role in the region , from a competition between economic actors in a competition between local systems. The territory is rediscovered as a complex system, hidden in a highly competitive global dimension : in this step to adopt a strategy of cultural system is critical to the necessity of dealing with homogeneous systems . A strategy that is able to exploit the opportunities offered by new communications technologies and extend business opportunities. This work is divided into two parts: the first part will present the concept of cultural and conceptual tools of economic evaluation applied to the product area. In particular, it analyzes the ability of this discipline to promote local development. At this stage, we try to shed more light on the importance of this matter, proposing a study on the one hand can highlight the features and the most important aspects of the evaluation and the other is able to demonstrate the operational validity of the latter in promote local development. The local development , in fact, becomes an important tool for the exploitation of resources of a territory , which takes an active role , offering more and more exploitable resources over time . Finally, it is exposed to the concept of " cultural system " as a model of spatial development can promote the economy of the area and the redevelopment and improvement of the overall livability of a given territory. The pattern of the district, in fact, is a reality for a long time active and dynamic in the industrial sector which today begins to be considered a great potential in the field of culture and urban development. The culture thus becomes an increasingly important role for territorial marketing in order to improve the quality of life and promote the attractiveness and competitiveness of the territory, in order to activate the factors necessary for its development . Concepts such as empowerment , innovation and creativity are , today , conditions that characterize the social, institutional , environmental and demographic constraints to economic growth of the post-industrialized countries . The Cultural District Evolved is based precisely on this assumption , for which this model aspires to become an important development trend in America, Europe and Italy . An example of a city that has been able to use culture as supporting its growth is Linz , a country capable of putting together a social progress , cultural and economic , as to be rated as one of the best achievements of the cultural district . The second part is exposed to the project concerning the creation of the cultural system as a process of planning for the future development of the city. A project that involves many actors, especially citizens increasingly seen as behind the choices of a city more efficient. In the context of the current localization economies , in fact , cities are having to compete with each other in pursuit of a development in the long term through investment in the territory and citizens , as an impetus to innovation and research . The three assets to be followed in order to enhance the city will be the ones to make it more welcoming and attractive , with a strong relational identity , sustainable and innovative . Understand, then , as Reggio Calabria to respond to the characteristics of " cultural system " is the goal of this work. Understand what are the reasons that lead a reality, such as that in question, as if to better integrate , to make a place more innovative, both in terms of territorial and cultural , without losing sight of the centrality of the person, respect and protection of human dignity , freedom, and the promotion of interpersonal relationships

    Aerated Buffalo Slurry Improves Spinach Plant Growth and Mitigates CO2 and N2O Emissions from Soil

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    Manure management is the main strategy for mitigating gas emissions from livestock farming. In this study, a laboratory-scale experiment was set up to identify suitable conditions to be applied in a farm-scale experiment. The liquid fraction (LF) of slurry was aerobically treated and greenhouse gas emissions from soil were evaluated. Furthermore, the value of treated LF as a fertilizer on spinach plants was also tested. The aeration of LF determined an increase in mean alkalinity due to ammonia loss. The mass fraction of heavy metals also decreased, likely due to the reduction in solubility. After being applied on soil, aerated LF determined lower CO2 and N2O emissions compared to untreated LF due to a reduced nitrogen load. Spinach plants fertilized with treated LF showed a lush growth and exhibited a lower heavy metal mass fraction as well as a higher content of antioxidants compared to plants fertilized with untreated slurry. Our results show that aeration might be an effective alternative for slurry management as it is able to produce an eco-friendly final product with a high fertilizing value

    Characterizing psychological dimensions in non-pathological subjects through autonomic nervous system dynamics

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    The objective assessment of psychological traits of healthy subjects and psychiatric patients has been growing interest in clinical and bioengineering research fields during the last decade. Several experimental evidences strongly suggest that a link between Autonomic Nervous System (ANS) dynamics and specific dimensions such as anxiety, social phobia, stress, and emotional regulation might exist. Nevertheless, an extensive investigation on a wide range of psycho-cognitive scales and ANS non-invasive markers gathered from standard and non-linear analysis still needs to be addressed. In this study, we analyzed the discerning and correlation capabilities of a comprehensive set of ANS features and psycho-cognitive scales in 29 non-pathological subjects monitored during resting conditions. In particular, the state of the art of standard and non-linear analysis was performed on Heart Rate Variability, InterBreath Interval series, and InterBeat Respiration series, which were considered as monovariate and multivariate measurements. Experimental results show that each ANS feature is linked to specific psychological traits. Moreover, non-linear analysis outperforms the psychological assessment with respect to standard analysis. Considering that the current clinical practice relies only on subjective scores from interviews and questionnaires, this study provides objective tools for the assessment of psychological dimensions

    Enrichment, isolation and biodegradation potential of psychrotolerant polychlorinated-​biphenyl degrading bacteria from the Kongsfjorden (Svalbard Islands, High Arctic Norway)

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    Persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs), have been detected in abiotic Arctic matrices: surface sediments and seawater from coastal areas in the Kongsfjorden were collected and analyzed. Levels of PCBs varied depending on the sampling site. Total PCB concentrations were between 11.63 (site C2W) and 27.69 pg l− 1 (site AW). These levels were comparable to those reported previously in lake sediments from the northern Svalbard. The occurrence and biodegradation potential of cold-adapted PCB-oxidizing bacteria in seawater and sediment along the fjord was also evaluated. After enrichment with biphenyl, 246 isolates were obtained with 45 of them that were able to grow in the presence of the PCB mixture Aroclor 1242, as the sole carbon source. The catabolic gene bphA was harbored by 17 isolates with affiliates to the genera Algoriphagus, Devosia and Salinibacterium that have been never reported as able to utilize PCBs, thus deserving further investigation. The total removal of Aroclor 1242 and selected PCB congeners was evaluated at 4 and 15 °C for eight bphA-harboring isolates and Gelidibacter sp. DS-10. With few exceptions, tested strains showed greater efficiency at 15 than at 4 °C. Isolates were able to reduce most chromatographic peaks by > 50%, with some di- and trichlorobiphenyls that were quite totally removed (> 90%)

    Real vs. immersive-virtual emotional experience: Analysis of psycho-physiological patterns in a free exploration of an art museum

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    [EN] Virtual reality is a powerful tool in human behaviour research. However, few studies compare its capacity to evoke the same emotional responses as in real scenarios. This study investigates psycho-physiological patterns evoked during the free exploration of an art museum and the museum virtualized through a 3D immersive virtual environment (IVE). An exploratory study involving 60 participants was performed, recording electroencephalographic and electrocardiographic signals using wearable devices. The real vs. virtual psychological comparison was performed using self-assessment emotional response tests, whereas the physiological comparison was performed through Support Vector Machine algorithms, endowed with an effective feature selection procedure for a set of state-of-the-art metrics quantifying cardiovascular and brain linear and nonlinear dynamics. We included an initial calibration phase, using standardized 2D and 360 degrees emotional stimuli, to increase the accuracy of the model. The self-assessments of the physical and virtual museum support the use of IVEs in emotion research. The 2-class (high/low) system accuracy was 71.52% and 77.08% along the arousal and valence dimension, respectively, in the physical museum, and 75.00% and 71.08% in the virtual museum. The previously presented 360 degrees stimuli contributed to increasing the accuracy in the virtual museum. Also, the real vs. virtual classifier accuracy was 95.27%, using only EEG mean phase coherency features, which demonstrates the high involvement of brain synchronization in emotional virtual reality processes. These findings provide an important contribution at a methodological level and to scientific knowledge, which will effectively guide future emotion elicitation and recognition systems using virtual reality.This work was supported by Ministerio de Economia y Competitividad de Espana (URL: http://www.mineco.gob.es/; Project TIN201345736-R and DPI2016-77396-R); Direccion General de Trafico, Ministerio Del Interior de Espana (URL: http://www.dgt.es/es/; Project SPIP2017-02220); and the Institut Valencia d'Art Modern (URL: https://www.ivam.es/).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Marín-Morales, J.; Higuera-Trujillo, JL.; Greco, A.; Guixeres, J.; Llinares Millán, MDC.; Gentili, C.; Scilingo, EP.... (2019). Real vs. immersive-virtual emotional experience: Analysis of psycho-physiological patterns in a free exploration of an art museum. 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