Reshaping Ability Grouping Through Big Data

This Article examines whether incorporating data mining technologies in education can promote equality. Following many other spheres in life, big data technologies that include creating, collecting, and analyzing vast amounts of data about individuals are increasingly being used in schools. This process has already elicited widespread interest among scholars, parents, and the public at large. However, this attention has largely focused on aspects of student privacy and data protection and has overlooked the profound effects data mining may have on educational equality. This Article analyzes the effects of data mining on education equality by focusing on one educational practice--ability grouping--that is already being transformed by educational data mining

Consciousness science : real progress and lingering misconceptions.

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STUDI META ANALISIS PENGARUH RETURN ON ASSETS (ROA), KEPEMILIKAN MANAJERIAL, UKURAN PERUSAHAAN, DEBT TO ASSET RATIO (DAR) TERHADAP MANAJEMEN LABA

Penelitian ini bertujuan untuk menguji apakah profitabilitas, leverage, kepemilikan manajerial dan ukuran perusahaan mempengaruhi laba manajemen di Indonesia dan untuk menganalisis apakah variasi temuan disebabkan oleh model pengukuran efek moderasi manajemen laba atau pengukuran variabel penjelas. Penelitian ini menggunakan pendekatan teknik meta-analisis dengan sampel sebanyak 54 dari jurnal periode tahun 2016-2022. Hasil penelitian memperkuat temuan meta-analisis dari penelitian sebelumnya dimana manajemen laba dilakukan untuk tujuan yang berbeda tujuan. Bukti empiris menunjukkan bahwa atribut profitabilitas dan leverage yaitu; Return on Asset dan Debt to Equity Ratio ditemukan sebagai mekanisme pemantauan yang kuat yang dapat menekan manajemen laba. Bukti empiris mendukung beberapameta-analisis sebelumnya dalam bidang akuntansi dimana variabel pengukuran moderator berpengaruh terhadap heterogenitas temuan penelitian. Penelitian di masa depan harus mencakup korelasi matriks, dan mempertimbangkan langkah-langkah terperinci dari manajemen laba dan lebih banyak atribut dewan direksi untuk memfasilitasi penelitian menggunakan metaanalisis. Hasilnya menunjukkan bahwa nilai ROA, LEV, kepemilikan manajerial dan ukuranperusahaan dapat meningkatkan kepercayaan investor dengan membatasi manajemen laba.

Science Identity Development Trajectories in a Gateway College Chemistry Course: Predictors and Relations to Achievement and STEM Pursuit

This investigation of undergraduates’ heterogeneous science identity trajectories within a gateway chemistry course identified three latent classes (High and Stable, Moderate and Slightly Increasing, Moderate and Declining) using growth mixture modeling. Underrepresented minorities were more likely to exhibit Moderate-and-Slightly-Increasing science identities versus High-and-Stable patterns. Students with higher perceived competence were more likely classified into the High-and-Stable class compared to the other classes. Students classified into the High-and-Stable class scored significantly higher on the final exam and appeared to be more likely to remain in a STEM major across fall and spring semesters compared to the other two classes. Results suggest that some students’ identities shift within a single semester and supporting science perceived competence before college may support students’ science identity development

Using diffusion tensor imaging to identify corticospinal tract projection patterns in children with unilateral spastic cerebral palsy.

AIM: To determine whether diffusion tensor imaging (DTI) can be an independent assessment for identifying the corticospinal tract (CST) projecting from the more-affected motor cortex in children with unilateral spastic cerebral palsy (CP). METHOD: Twenty children with unilateral spastic CP participated in this study (16 males, four females; mean age 9y 2mo [standard deviation (SD) 3y 2mo], Manual Ability Classification System [MACS] level I-III). We used DTI tractography to reconstruct the CST projecting from the more-affected motor cortex. We mapped the motor representation of the more-affected hand by stimulating the more- and the less-affected motor cortex measured with single-pulse transcranial magnetic stimulation (TMS). We then verified the presence or absence of the contralateral CST by comparing the TMS map and DTI tractography. Fisher's exact test was used to determine the association between findings of TMS and DTI. RESULTS: DTI tractography successfully identified the CST controlling the more-affected hand (sensitivity=82%, specificity=78%). INTERPRETATION: Contralateral CST projecting from the lesioned motor cortex assessed by DTI is consistent with findings of TMS mapping. Since CST connectivity may be predictive of response to certain upper extremity treatments, DTI-identified CST connectivity may potentially be valuable for determining such connectivity where TMS is unavailable or inadvisable for children with seizures.K08 NS073796 - NINDS NIH HHS; TL1 RR024158 - NCRR NIH HHS; K01 NS062116 - NINDS NIH HHS; UL1 RR024156 - NCRR NIH HHS; KL2 RR024157 - NCRR NIH HHS; R01 HD076436 - NICHD NIH HHSPublished versio

Cobalamin deficiency resulting in a rare haematological disorder: a case report

INTRODUCTION: We present the case of a patient with a cobalamin deficiency resulting in pancytopaenia, emphasizing the importance to define, diagnose and treat cobalamin deficiency. CASE PRESENTATION: A 52-year-old man from the Democratic Republic of Congo presented to the emergency department with shortness of breath and a sore tongue. Physical examination was unremarkable. His haemoglobin was low and the peripheral blood smear revealed pancytopaenia with a thrombotic microangiopathy. The findings were low cobalamin and folate levels, and high homocysteine and methylmalonate levels. Pernicious anaemia with chronic atrophic gastritis was confirmed by gastric biopsy and positive antiparietal cell and anti-intrinsic factor antibodies. Cobalamin with added folate was given. Six months later, the patient was asymptomatic. CONCLUSION: Cobalamin deficiency should always be ruled out in a patient with pancytopaenia. Our case report highlights a life-threatening cobalamin deficiency completely reversible after treatment

Motor Cortex Electrical Stimulation Augments Sprouting of the Corticospinal Tract and Promotes Recovery of Motor Function

The corticospinal system—with its direct spinal pathway, the corticospinal tract (CST) – is the primary system for controlling voluntary movement. Our approach to CST repair after injury in mature animals was informed by our finding that activity drives establishment of connections with spinal cord circuits during postnatal development. After incomplete injury in maturity, spared CST circuits sprout, and partially restore lost function. Our approach harnesses activity to augment this injury-dependent CST sprouting and to promote function. Lesion of the medullary pyramid unilaterally eliminates all CST axons from one hemisphere and allows examination of CST sprouting from the unaffected hemisphere. We discovered that 10 days of electrical stimulation of either the spared CST or motor cortex induces CST axon sprouting that partially reconstructs the lost CST. Stimulation also leads to sprouting of the cortical projection to the magnocellular red nucleus, where the rubrospinal tract originates. Coordinated outgrowth of the CST and cortical projections to the red nucleus could support partial re-establishment of motor systems connections to the denervated spinal motor circuits. Stimulation restores skilled motor function in our animal model. Lesioned animals have a persistent forelimb deficit contralateral to pyramidotomy in the horizontal ladder task. Rats that received motor cortex stimulation either after acute or chronic injury showed a significant functional improvement that brought error rate to pre-lesion control levels. Reversible inactivation of the stimulated motor cortex reinstated the impairment demonstrating the importance of the stimulated system to recovery. Motor cortex electrical stimulation is an effective approach to promote spouting of spared CST axons. By optimizing activity-dependent sprouting in animals, we could have an approach that can be translated to the human for evaluation with minimal delay

Evidence for a minimal role of stimulus awareness in reversal of threat learning

In an ever-changing environment, survival depends on learning which stimuli represent threat, and also on updating such associations when circumstances shift. It has been claimed that humans can acquire physiological responses to threat-associated stimuli even when they are unaware of them, but the role of awareness in updating threat contingencies remains unknown. This complex process-generating novel responses while suppressing learned ones-relies on distinct neural mechanisms from initial learning, and has only been shown with awareness. Can it occur unconsciously? Here, we present evidence that threat reversal may not require awareness. Participants underwent classical threat conditioning to visual stimuli that were suppressed from awareness. One of two images was paired with an electric shock; halfway through the experiment, contingencies were reversed and the shock was paired with the other image. Despite variations in suppression across participants, we found that physiological responses reflected changes in stimulus-threat pairings independently of stimulus awareness. These findings suggest that unconscious affective processing may be sufficiently flexible to adapt to changing circumstances

A Comparing Method of Two Team Behaviours in the Simulation Coach Competition

Proceeding of: Third International Conference on Modeling Decisions for Artificial Intelligence, MDAI 2006, Tarragona, Spain, April 3-5, 2006.The main goal of agent modelling is to extract and represent the knowledge about the behaviour of other agents. Nowadays, modelling an agent in multi-agent systems is increasingly becoming more complex and significant. Also, robotic soccer domain is an interesting environment where agent modelling can be used. In this paper, we present an approach to classify and compare the behaviour of a multi-agent system using a coach in the soccer simulation domain of the RoboCup.Publicad

p53-Dependent Transcriptional Responses to Interleukin-3 Signaling

p53 is critical in the normal response to a variety of cellular stresses including DNA damage and loss of p53 function is a common feature of many cancers. In hematological malignancies, p53 deletion is less common than in solid malignancies but is associated with poor prognosis and resistance to chemotherapy. Compared to their wild-type (WT) counterparts, hematopoietic progenitor cells lacking p53 have a greater propensity to survive cytokine loss, in part, due to the failure to transcribe Puma, a proapoptotic Bcl-2 family member. Using expression arrays, we have further characterized the differences that distinguish p53−/− cells from WT myeloid cells in the presence of Interleukin-3 (IL-3) to determine if such differences contribute to the increased clonogenicity and survival responses observed in p53−/− cells. We show that p53−/− cells have a deregulated intracellular signaling environment and display a more rapid and sustained response to IL-3. This was accompanied by an increase in active ERK1/2 and a dependence on an intact MAP kinase signaling pathway. Contrastingly, we find that p53−/− cells are independent on AKT for their survival. Thus, loss of p53 in myeloid cells results in an altered transcriptional and kinase signaling environment that favors enhanced cytokine signaling