Il Cristo in forma Pietatis del Rosso Fiorentino fra devozione e bellezza

<p>Differential distribution pattern of root- identified proteins in the four conditions described: TT, 42T, 42FS and 42RS.</p

Low temperatures reduce skin healing in the Jacaré do Pantanal (Caiman yacare, Daudin 1802)

Studies of skin wound healing in crocodilians are necessary given the frequent occurrence of cannibalism in intensive farming systems. Air temperature affects tissue recovery because crocodilians are ectothermic. Therefore, the kinetics of skin wound healing in Caiman yacare were examined at temperatures of 33°C and 23°C. Sixteen caiman were selected and divided into two groups of eight maintained at 23°C or 33°C. The studied individuals' scars were photographed after 1, 2, 3, 7, 15 and 30 days of the experimental conditions, and samples were collected for histological processing after 3, 7, 15 and 30 days. Macroscopically, the blood clot (heterophilic granuloma) noticeably remained in place covering the wound longer for the caiman kept at 23°C. Microscopically, the temperature of 23°C slowed epidermal migration and skin repair. Comparatively, new blood vessels, labeled using von Willebrand factor (vWF) antibody staining, were more frequently found in the scars of the 33°C group. The collagen fibers in the dermis were denser in the 33°C treatment. Considering the delayed healing at 23°C, producers are recommended to keep wounded animals at 33°C, especially when tanks are cold, to enable rapid wound closure and better repair of collagen fibers because such lesions tend to compromise the use of their skin as leather.Fundação de Amparo à Pesquisa do Estado de Mato Grosso (FAPEMAT), 715823/2008São Paulo Research Foundation (FAPESP), 2010/04527-

Identification of characteristics predictive of long-term survival with durvalumab or durvalumab plus tremelimumab in metastatic urothelial carcinoma

Abstract Background This retrospective analysis of data from clinical trials in metastatic urothelial carcinoma (mUC) was conducted to determine baseline patient characteristics associated with long-term survival (LTS) following treatment with immune checkpoint inhibitors. Methods Data for this analysis were from patients with platinum-refractory mUC who received durvalumab or durvalumab plus tremelimumab in phase 1/2 studies. The primary outcome measure was LTS. Patients were categorised as overall survival (OS) ≥ 2 years (from first dose) or OS < 2 years. A univariable analysis assessed independent associations with LTS and multivariable logistic regression was employed including each variable with P ≤ 0.05 as covariates. Results Among 360 patients, 88 (24.4%) had OS ≥ 2 years and 272 (75.6%) had OS < 2 years. In univariable analysis, several baseline characteristics and laboratory measurements were associated with LTS including sex, ECOG PS, PD-L1 expression, prior surgery, time from initial diagnosis, lymph node-only involvement, visceral disease, haemoglobin level, absolute neutrophil count, neutrophil–lymphocyte ratio and lactate dehydrogenase level. In multivariable analysis, LTS was significantly associated with ECOG PS, PD-L1 expression, haemoglobin level and absolute neutrophil count. Conclusions Several baseline clinical characteristics and laboratory measurements were associated with LTS for patients with platinum-refractory mUC treated with durvalumab or durvalumab plus tremelimumab

Leveraging Context-Awareness for Personalization in a User Generated Services Platform

<p>Abstrak <br />Kecacingan merupakan penyakit yang masih banyak di negara berkembang. Infeksi cacing dapat menimbulkan penurunan respon terhadap antigen yang terjadi akibat modified Th2 response. Vaksin BCG merupakan antigen yang dikenal sebagai penginduksi respon sel Th1. Tujuan penelitian ini adalah untuk mengetahui perbedaan kadar IFN-γ<br />dan IL-10 pada orang dewasa terinfeksi Ascaris lumbricoides dengan tidak terinfeksi yang diinduksi vaksi BCG.<br />Penelitian dilakukan di Kelurahan Muara Fajar Kecamatan Rumbai Pesisir Pekanbaru dengan menggunakan rancangan cross sectinal study. Populasi penelitian ini adalah orang dewasa kelurahan Muara Fajar Kecamatan<br />Rumbai Pesisir Pekanbaru yang terinfeksi dan tidak terinfeksi Ascaris lumbricoides. Status kecacingan didapatkan dari pemeriksaan feses dengan metode kato-katz. Kadar IFN-γ dan IL-10 didapatkan dengan pemeriksaan laboratorium dengan metode ELISA. Pengolahan dan analisa data menggunakan uji t. Hasil penelitian didapatkan rerata kadar IFNγ adalah 16,55±14,13 pg/mg dan kadar IL-10 36,13±8,83 pg/ml. Pada orang dewasa yang tidak terinfeksi Ascaris lumbricoides didapatkan kadar rata-rata IFN-γ adalah 199,36±121,86 pg/ml dan kadar IL-10 10,57±9,20 pg/ml.<br />Terdapat perbedaan bermakna kadar  IFN-γ dan IL-10 antara orang dewasa yang terinfeksi Ascaris lumbricoides dengan tidak terinfeksi (p&lt;0,05). Kesimpulan hasil penelitian ini ialah infeksi Ascaris lumbricoides dapat menekan produksi IFN-γ terhadap pemberian vaksin BCG.<br />Kata kunci: ascaris lumbricoides, vaksin BCG, interferon gamma (IFN-γ), interleukin 10 (IL-10)</p><p> </p><p>Abstract <br />Worm infestation still happened in the develop country. Worm infection can also make low respond on antigen that is caused by modified Th2 response. BCG vaccine is antigen as known as induction Th1 cell respond. The objective of this study was to  know the differences IFN-γ and IL-10 an adult who infected Ascaris lumbricoides to uninfected who inducted by BCG vaccine. The research was conducted in Muara Fajar district Rumbai Pesisir<br />Pekanbaru by Cross Sectinal Study. The research population were adults in Muara Fajar district Rumbai Pesisir Pekanbaru who infected and uninfected Ascaris lumbricoides. Worm infection was getting checked in fesses by katokatz method.<br />IFN-y and IL-10 were getting laboratory checked by ELISA method.<br />The data was analyzed by t-tes. The mean IFN-y of the adult who infected Ascaris lumbricoides were 16.55±14.13 pg/mg and IL-10 36.13±8.83 pg/ml and the adult who uninfected Ascaris lumbricoides were 199,36±121,86 pg/ml and IL-10 10.57±9.20 pg/ml. There was significant difference of IFN-y and IL-10 between adult who infected Ascaris lumbricoides with uninfected (p&lt;0,05). It can be concluded that Ascaris lumbricoides infection can pressure IFN-y production on given BCG vaccine. </p><p>Keywords: ascaris lumbricoides, BCG vaccine, interferon gamma (IFN-γ), Interleukin 10 (IL-10)<br /><br /><br /><br /></p

Differential distribution pattern of leaf- identified proteins in the four conditions described: TT, 42T, 42FS and 42RS.

<p>Differential distribution pattern of leaf- identified proteins in the four conditions described: TT, 42T, 42FS and 42RS.</p