Zircon geochronology of intrusive rocks from Cap de Creus, eastern Pyrenees

New petrological and U–Pb zircon geochronological information has been obtained from intrusive plutonic rocks and migmatites from the Cap de Creus massif (Eastern Pyrenees) in order to constrain the timing of the thermal and tectonic evolution of this northeasternmost segment of Iberia during late Palaeozoic time. Zircons from a deformed syntectonic quartz diorite from the northern Cap de Creus Tudela migmatitic complex yield a mean age of 298.8±3.8 Ma. A syntectonic granodiorite from the Roses pluton in the southern area of lowest metamorphic grade of the massif has been dated at 290.8±2.9 Ma. All the analysed zircons from two samples of migmatitic rocks yield inherited ages from the Precambrian metasedimentary protolith (with two main age clusters at c. 730–542 Ma and c. 2.9–2.2 Ga). However, field structural relationships indicate that migmatization occurred synchronously with the emplacement of the quartz dioritic magmas at c. 299 Ma. Thus, the results of this study suggest that subduction-related calc-alkaline magmatic activity in the Cap de Creus was coeval and coupled with D2 dextral transpression involving NNW–SSE crustal shortening during Late Carboniferous – Early Permian time (c. 299–291 Ma). Since these age determinations are within the range of those obtained for undeformed (or slightly deformed) calc-alkaline igneous rocks from NE Iberia, it follows that the Cap de Creus massif would represent a zone of intense localization of D2 transpression and subsequent D3 ductile wrenching that extended into the Lower Permian during a transitional stage between the Variscan and Cimmerian cycles

Chronological link between deep-seated processes in magma chambers and eruptions: Pemo-Carboniferous magmatism in the core of Pangaea (southern Pyrenees)

In the Southern Pyrenees there are Upper Carboniferous–Lower Permian sedimentary basins with a significant volume of volcanic material derived from explosive eruptions (rhyolitic ignimbrites and andesitic flows). These basins are spatially associated with granodiorites and dacitic dykes emplaced in Variscan basement rocks. U–Pb SHRIMP dating of zircons extracted from three granodiorites, an andesitic flow, a dacitic dyke and six ignimbrites, revealed that magmatism occurred over an extended period of thirty eight million years, from ca. 304 Ma to ca. 266 Ma (Upper Carboniferous–Middle Permian). A scattering of zircon ages in each sample shows that the history of melt crystallization was complex, with more than one zircon-forming event in each magma chamber. The prolonged crystallization history was transferred to the product of the eruptions. A chronological link between the deep-seated magma chambers and processes in eruptions was identified on the basis of four overlapping intervals at: ca. 309–307 Ma (Upper Carboniferous), ca. 304– 296 Ma (Upper Carboniferous–Lower Permian), ca. 294–282 Ma (Lower Permian), and ca. 276 Ma (Lower Permian). The variation of zircon U/Th ratios exposes a tendency for an increase in mafic sources as crystallization advances in the Permian. Zircons probably crystallized from melt phases related to both a felsicintermediate metaluminous source from ca. 310–293 Ma (mostly 0.1 b Th/U b 0.6) to ca. 289–273 Ma (especially in the range 0.6 b Th/U b 1) and a mafic source (mostly 1.2 b Th/U b 1) at ca. 266–265 Ma. U–Pb zircon ages from volcanic and plutonic rocks of the Southern Pyrenees are consistent with the ages of the post-Variscan magmatism of Iberia associated with orocline generation and subduction of the Paleotethys Ocean (ca. 304–283 Ma), and in addition reveal a later magmatic event at ca. 276–266 Ma (Lower–Middle Permian). The location of the Iberian orocline in the core of Pangaea and near the western end of the subduction zone of the Paleotethys Ocean leads to the hypothesis that this later magmatic activity of the Southern Pyrenees could provide the missing link between the Variscan and Cimmerian cycles that acted sequentially in Permo- Carboniferous times

Tracing the Cambro-Ordovician ferrosilicic to calc-alkaline magmatic

U–Pb geochronological study of zircons from nodular granites and Qtz-diorites comprising part of Variscan high- grade metamorphic complexes in Gredos massif (Spanish Central System batholith) points out the significant presence of Cambro-Ordovician protoliths among the Variscan migmatitic rocks that host the Late Carboniferous intrusive granitoids. Indeed, the studied zone was affected by two contrasted tectono-magmatic episodes, Car- boniferous (Variscan) and Cambro-Ordovician. Three main characteristics denote a close relation between the Cambro-Ordovician protholiths of the Prado de las Pozas high-grade metamorphic complex, strongly reworked during the Variscan Orogeny, and other Cambro-Ordovician igneous domains in the Central Iberian Zone of the Iberian Massif: (1) geochemical features show the ferrosilicic signature of nodular granites. They plot very close to the average analysis of themetavolcanic rocks of the Ollo de Sapo formation (Iberia). Qtz-diorites present typical calc-alkaline signatures and are geochemically similar to intermediate cordilleran granitoids. (2) Both Qtz-diorite and nodular granite samples yield a significant population of Cambro-Ordovician ages, ranging between 483 and 473 Ma and between 487 and 457 Ma, respectively. Besides, (3) the abundance of zircon inher- itance observed on nodular granites matches the significant component of inheritance reported on Cambro- Ordovician metagranites and metavolcanic rocks of central and NW Iberia. The spatial and temporal coincidence of both peraluminous and intermediate granitoids, and specifically in nodular granites and Qtz-diorite enclaves of the Prado de las Pozas high-grade complex, is conducive to a common petrogenetic context for the formation of both magmatic types. Tectonic and geochemical characteristics describe the activity of a Cambro-Ordovician arc-back-arc tectonic set- ting associated with the subduction of the Iapetus–Tornquist Ocean and the birth of the Rheic Ocean. The exten- sional setting is favorable for the generation, emplacement, and fast rise of subduction-related cold diapirs, supported by the presence of typical calc-alkaline cordilleran granitoids contemporary with ferrosilicic volcanism

El Mes de la Entomología: acercando el laboratorio de investigación científica a las escuelas de nivel inicial de la Patagonia

Como investigadores en ciencias, entendemos que enseñar las ciencias naturales en la escuela primaria es un desafío para los docentes y una excelente oportunidad para sentar las bases del pensamiento científico. “El Mes de la Entomología” fue un proyecto llevado a cabo por investigadores y becarios del CONICET y del INTA Bariloche, cuyo objetivo principal fue mejorar el conocimiento existente sobre la biología de los insectos, de docentes y estudiantes de nivel primario de escuelas de Bariloche y escuelas rurales del NO de la Patagonia. Se resaltaron los aspectos positivos de los insectos, destacando tanto su importancia biológica y aplicada así como su diversidad y abundancia. Participaron un total de 12 escuelas de las 55 invitadas (entre privadas y públicas) y 600 estudiantes. “El Mes de la Entomología” fue una actividad que además sirvió tanto para explorar problemáticas científicas locales, como para acercar la figura del científico a los docentes y estudiantes.As science researchers we believe that teaching Natural Sciences at elementary school level is both a challenge for teachers and an excellent opportunity to establish the foundations of scientific thinking. “The Entomology Month” was a project, carried out by researchers and scholars from CONICET and INTA Bariloche, whose main objective was to improve the existing knowledge about insect biology. Activities were addressed to teachers and elementary school students from Bariloche and rural areas in NW Patagonia. The positive aspects of insects were especially highlighted, by enhancing their biological and applied importance, as well as their diversity and abundance. Twelve out of the 55 invited schools (both private and public) and 600 students were counted among the participants. The “Entomology Month” served both to address local scientist difficulties and to bring closer the figure of the scientist to teachers and students.Fil: Fischbein, Deborah. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Patagonia Norte. Estación Experimental Agropecuaria San Carlos de Bariloche. Laboratorio de Ecología de Insectos; ArgentinaFil: Pereira, Ana Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Patagonia Norte. Estación Experimental Agropecuaria San Carlos de Bariloche. Laboratorio de Ecología de Insectos; ArgentinaFil: Fernandez Ajó, Alejandro Apolo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Patagonia Norte. Estación Experimental Agropecuaria San Carlos de Bariloche. Laboratorio de Ecología de Insectos; ArgentinaFil: Corley, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Patagonia Norte. Estación Experimental Agropecuaria San Carlos de Bariloche. Laboratorio de Ecología de Insectos; Argentin

Early Carboniferous synorogenic basins evolution of the Ossa-Morena and

The stratigraphic record of the Early Carboniferous in Iberia reveals that synorogenic deposition was important and occurred simultaneously in basins influenced by extension and contraction with gravitational instability. In NW Iberia (Galicia – Trás-os-Montes Zone) contraction was dominant and the deposition took place in a forebulge outwards from the nappe stacking front. Here, synorogenic deposits were strongly affected by folding and thrusting as they were imbricated and incorporated in the allochthonous pile. In a different way, in SW Iberia (Ossa-Morena Zone) synorogenic deposition was influenced by extension and happened simultaneously with the onset of significant magmatism

Oral anticoagulants: A plausible new treatment for Alzheimer's disease?

Alzheimer's disease (AD) and cardiovascular disease (CVD) are strongly associated. Both are multifactorial disorders with long asymptomatic phases and similar risk factors. Indeed, CVD signatures such as cerebral microbleeds, micro-infarcts, atherosclerosis, cerebral amyloid angiopathy and a procoagulant state are highly associated with AD. However, AD and CVD co-development and the molecular mechanisms underlying such associations are not understood. Here, we review the evidence regarding the vascular component of AD and clinical studies using anticoagulants that specifically evaluated the development of AD and other dementias. Most studies reported a markedly decreased incidence of composite dementia in anticoagulated patients with atrial fibrillation, with the highest benefit for direct oral anticoagulants. However, sub-analyses by differential dementia diagnosis were scarce and inconclusive. We finally discuss whether anticoagulation could be a plausible preventive/therapeutic approach for AD and, if so, which would be the best drug and strategy to maximize clinical benefit and minimize potential risks.R. Toribio-Fernandez and M. Cortes-Canteli were supported by a Sara Borrell (CD20/00110) and Miguel Servet type II (CPII21/00007) research contracts from Instituto de Salud Carlos III co-funded by the European Union (Fondo Social Europeo Plus), respectively. C. Tristao-Pereira was supported by a la Caixa Foundation predoctoral fellowship (ID 100010434, LCF/BQ/DI19/11730052) and C. Ceron by a predoctoral fellowship from Fundación Española de Trombosis y Hemostasia (FETH-SETH). The CNIC is a Severo Ochoa Center of Excellence (CEX2020-001041-S).S

Plan de Negocio Corn Island Sushine S.A.

Seminario Desarrollo de Emprendedores. 2013. Carrera CUSE .Empresa que se dedica a la producción y comercialización de chileros a base de chile Bhut Jolokia, habanero y cabro; todos realizados con recetas tradicionales nicaragüenses. La empresa ofrece cada uno de los chiles en presentaciones diferentes. La producción se lleva a cabo en las oficinas centrales ubicadas en Carretera a Masaya. La empresa espera que su producto sea de consumo masivo, es por esta razón que su mercado meta no está segmentado ni dirigido hacia ningún nivel socio-económico especifico; es generalizado debido a sus precios accesibles. El producto será principalmente distribuido en los supermercados más importantes del país, pulperías de los principales departamentos y tiendas de conveniencia

Generating Linked-Data based Domain-Specific Sentiment Lexicons from Legacy Language and Semantic Resources

We present a methodology for legacy language resource adaptation that generates domain-specific sentiment lexicons organized around domain entities described with lexical information and sentiment words described in the context of these entities. We explain the steps of the methodology and we give a working example of our initial results. The resulting lexicons are modelled as Linked Data resources by use of established formats for Linguistic Linked Data (lemon, NIF) and for linked sentiment expressions (Marl), thereby contributing and linking to existing Language Resources in the Linguistic Linked Open Data cloud

Ventricular Septal Perforation after Biventricular Takotsubo Cardiomyopathy Successfully Repaired with an Amplatzer Device: First Report in the Literature

A 79-year-old female was admitted with sudden onset dyspnea, mild oppressive chest pain, and severe anxiety disorder. Patient had history of hypertension, dyslipidemia, smoking, and chronic obstructive pulmonary disease. On admission blood pressure was 160/90 and heart rate was 130 bpm. Transthoracic echocardiography (TE) and contrast tomography showed a thin septum with an abnormal left and right ventricular contraction with an “apical ballooning” pattern and mild increase of cardiac enzymes. At the 4th day of admission, the patient presented symptoms and signs of congestive heart failure and developed cardiogenic shock. EKG showed an inversion of T waves in all precordial leads. In a new TE, a ventricular septal perforation (VSP) in the apical portion of the septum was seen. Coronary angiogram showed angiographically “normal” coronary arteries. With a diagnosis of VSP in takotsubo cardiomyopathy, a percutaneous procedure to repair the VSP was performed 11 days after admission. The VSP was closed with an Amplatzer device. TE performed 24 hours after showed significant improvement of ventricular function and good apposition of the Amplatzer device. Three days later she was discharged from the hospital. To our knowledge, this is the first reported case of a VSP in a TCM repaired percutaneously with an occluder device

El Mes de la Entomología: acercando el laboratorio de investigación científca a las escuelas de nivel inicial de la Patagonia = Entomology Month: Bringing Scientifc Research Closer to Elementary Schools in Patagonia

Como investigadores en ciencias, entendemos que enseñar las ciencias naturales en la escuela primaria es un desafío para los docentes y una excelente oportunidad para sentar las bases del pensamiento científico. “El Mes de la Entomología” fue un proyecto llevado a cabo por investigadores y becarios del CONICET y del INTA Bariloche, cuyo objetivo principal fue mejorar el conocimiento existente sobre la biología de los insectos, de docentes y estudiantes de nivel primario de escuelas de Bariloche y escuelas rurales del NO de la Patagonia. Seresaltaron los aspectos positivos de los insectos, destacando tanto su importancia biológica y aplicada así como su diversidad y abundancia. Participaron un total de 12 escuelas de las 55 invitadas (entre privadas y públicas) y 600 estudiantes. “El Mes de la Entomología” fue una ctividad que además sirvió tanto para explorar problemáticas científicas locales, como para acercar la figura del científico a los docentes y estudiantes.As science researchers we believe that teaching Natural Sciences at elementary school level is both a challenge for teachers and an excellent opportunity to establish the foundations of scientifc thinking. “The Entomology Month” was a project, carried out by researchers and scholars from CONICET and INTA Bariloche, whose main objective was to improve the existing knowledge about insect biology. Activities were addressed to teachers and elementary school students from Bariloche and rural areas in NW Patagonia. The positive aspects of insects were especially highlighted, by enhancing their biological and applied importance, as well as their diversity and abundance. Twelve out of the 55 invited schools (both private and public) and 600 students were counted among the participants. The “Entomology Month” served both to address local scientist diffculties and to bring closer the fgure of the scientist to teachers and students.EEA BarilocheFil: Fischbein, Deborah. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Ecología de Poblaciones de Insectos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas, ArgentinaFil: Pereira, Ana Julia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Ecología de Poblaciones de Insectos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas, ArgentinaFil: Fernandez Ajo, Alejandro Apolo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Ecología de Poblaciones de Insectos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas, ArgentinaFil: Corley, Juan Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Grupo de Ecología de Poblaciones de Insectos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas, Argentin