Bioinformatics approaches applied to the discovery of antifungal peptides

Antifungal peptides (AFPs) comprise a group of substances with a broad spectrum of activities and complex action mechanisms. They develop in nature via an evolutionary process resulting from the interactions between hosts and pathogens. The AFP database is experimentally verified and curated from research articles, patents, and public databases. In this review, we compile information about the primary databases and bioinformatics tools that have been used in the discovery of AFPs during the last 15 years. We focus on the classification and prediction of AFPs using different physicochemical properties, such as polarity, hydrophobicity, hydrophilicity, mass, acidic, basic, and isoelectric indices, and other structural properties. Another method for discovering AFPs is the implementation of a peptidomic approach and bioinformatics filtering, which gave rise to a new family of peptides that exhibit a broad spectrum of antimicrobial activity against Candida albicans with low hemolytic effects. The application of machine intelligence in the sphere of biological sciences has led to the development of automated tools. The progress made in this area has also paved the way for producing new drugs more quickly and effectively. However, we also identified that further advancements are still needed to complete the AFP libraries

Optics outreach activities with elementary school kids from public education in Mexico

This work shows the results obtained from the “O4K” Project supported by International Society for Optics and Photonis (SPIE) and the Universidad Autonoma de Nuevo Leon (UANL) through its SPIE Student Chapter and the Dr. Juan Carlos Ruiz-Mendoza, outreach coordinator of the Facultad de Ciencias Fisico Matematicas of the UANL. Undergraduate and graduate students designed Optics representative activities using easy-access materials that allow the interaction of children with optics over the exploration, observation and experimentation, taking as premise that the best way to learn Science is the interaction with it. Several activities were realized through the 2011-2013 events with 1,600 kids with ages from 10 to 12; the results were analyzed using surveys. One of the principal conclusions is that in most of the cases the children changed their opinions about Sciences in a positive wa

Metodologías activas flexibles para la enseñanza en los Estudios LGBTIQ+ de la UCM en modo sincrónico y asincrónico: Campus Virtual, Redes Sociales y entornos online como herramientas para la innovación docente y participación del alumnado

Memoria del Proyecto de Innovación Docente Curso 2022021, Ciencias Sociales nº 39

Patrimonio cultural : Contextos en transición: pedagogía, cultura y economía sustentable en comunidades americanas

El presente documento es una recopilación de experiencias que fueron parte del I Encuentro Internacional de Patrimonio Cultural celebrado en la Corporación Universitaria Minuto de Dios – UNIMINUTO en septiembre del 2019; así como de otros aportes de investigadores colombianos a la comprensión de temas relacionados con la tradición, la cultura, la memoria y el ecosistema natural en el cual como humanos nos desenvolvemos. Los aportes tienen origen en reflexiones de diferentes países desde Argentina hasta Canadá y cumple con el propósito de realizar un diálogo multidisciplinar de los aspectos que componen el patrimonio cultural en el continente americano

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO

Gestión del conocimiento. Perspectiva multidisciplinaria

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, es una publicación internacional, seriada, continua, arbitrada de acceso abierto a todas las áreas del conocimiento, es el esfuerzo de investigadores de varios países del mundo, orientada a contribuir con procesos de gestión del conocimiento científico, tecnológico y humanístico que consoliden la transformación del conocimiento en diferentes escenarios, tanto organizacionales como universitarios, para el desarrollo de habilidades cognitivas del quehacer diario. En este sentido, partiendo de los aportes teóricos y prácticos que presentan los autores, resultados de sus trabajos de investigación, análisis de diversas teorías, propuestas, enfoques, así como experiencias que se han dado a nivel del tema de gestión del conocimiento, presentamos a la comunidad internacional el libro Gestión del conocimiento. Perspectivas multidisciplinarias, que permitirá un mayor conocimiento y aplicación de estos conceptos, traduciéndose en una mejor aplicación y posicionamiento de las organizaciones en la utilización del conocimiento, la apropiación y transformación del mismo

Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary file