Frequency-Dependent Pi Model of a Three-Core Submarine Cable for Time and Frequency Domain Analysis

In this paper, a Frequency-Dependent Pi Model (FDPi) of a three-core submarine cable is presented. The model is intended to be used for the representation of submarine cables in an Offshore Wind Power Plant (OWPP) scenario for both time and frequency domain analysis. The frequency-dependent variation of each conductive layer is modeled by a Foster equivalent network whose parameters are tuned by means of Vector Fitting (VF) algorithm. The complete formulation for the parameterization of the model is presented in detail, which allows an easy reproduction of the presented model. The validation of the model is performed via a comparison with a well-established reference model, the Universal Line Model (ULM) from PSCAD/EMTDC software. Two cable system case studies are presented. The first case study shows the response of the FDPi Model for a three-core submarine cable. On the other hand, the second case study depicts the response of three single-core underground cables laying in trefoil formation. This last case shows the applicability of the FDPi Model to other types of cable systems and indirectly validates the response of the aforementioned model with experimental results. Additionally, potential applications of the FDPi model are presented

Estado, protección social, agencias y generaciones

El libro comparte trabajos que son resultado de tesis del Doctorado en Trabajo Social y la Maestría en Trabajo Social y trabajos integradores finales de la Especialización en Seguridad Social y de la Especialización en Intervención Social con Niños, Niñas, Adolescentes y Jóvenes, todas de la Facultad de Trabajo Social de la UNLP. Les autores son docentes de la Facultad de Trabajo Social y/o egresados de la misma y fueron alumnes de posgrado de las mencionadas carreras. Entendemos que este libro se inscribe en la apuesta institucional de aportar a la comunicación pública de la ciencia, especialmente al desarrollo de estrategias de difusión del conocimiento científico. Cobra mayor relevancia la apuesta, ya que se trata de producciones surgidas en el marco de los posgrados en una universidad pública. Es decir, la lógica de producción de tesis o trabajos finales como proceso individual es interpelada desde una política de comunicación que invita al diálogo y a la diversificación de temas y voces en torno a tópicos sustantivos de la agenda pública. En ese sentido, este libro será de acceso abierto por lo que estará disponible en el marco de la serie Debates en Investigación y Posgrado de la Facultad de Trabajo Social. Queremos especialmente señalar que el libro incluye producciones de les primeres egresades de las carreras de especialización previamente mencionadas. Esto supone la culminación de un proceso institucional que supuso un trabajo mancomunado entre diferentes actores y actrices de la comunidad académica y científica local y nacional.Facultad de Trabajo Socia

EventPointer 3.0: flexible and accurate splicing analysis that includes studying the differential usage of protein-domains

Alternative splicing (AS) plays a key role in cancer: all its hallmarks have been associated with different mechanisms of abnormal AS. The improvement of the human transcriptome annotation and the availability of fast and accurate software to estimate isoform concentrations has boosted the analysis of transcriptome profiling from RNA-seq. The statistical analysis of AS is a challenging problem not yet fully solved. We have included in EventPointer (EP), a Bioconductor package, a novel statistical method that can use the bootstrap of the pseudoaligners. We compared it with other state-of-the-art algorithms to analyze AS. Its performance is outstanding for shallow sequencing conditions. The statistical framework is very flexible since it is based on design and contrast matrices. EP now includes a convenient tool to find the primers to validate the discoveries using PCR. We also added a statistical module to study alteration in protein domain related to AS. Applying it to 9514 patients from TCGA and TARGET in 19 different tumor types resulted in two conclusions: i) aberrant alternative splicing alters the relative presence of Protein domains and, ii) the number of enriched domains is strongly correlated with the age of the patients

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

Cursos vitales, envejecimiento y organización social de los cuidados

El presente trabajo propone compartir un andamiaje conceptual que viabilice la comprensión y análisis de los fenómenos sociales ligados al envejecimiento y la vejez. Reconociendo que en América Latina se produce el tránsito de una sociedad hacia la madurez demográfica como consecuencia de factores positivos (Huenchuan y Rodríguez-Piñero, 2010), y requiere del desarrollo de acciones político- institucionales que posibiliten atender la organización social y política de los cuidados. Se realizan aportes conceptuales desde el curso vital, reconociendo las nociones de trayectorias y expectativas sociales ligadas a la edad. La estructuración social de las edades opera en una tensión adultocéntrica que pone en jaque el deseo de envejecer. Y avanzamos en la identificación de la crisis de los cuidados como expresión de las contradicciones socio productiva del capitalismo financiero, y agregamos de la matriz cuatríada como modo de dominación.The present work proposes to share a conceptual scaffolding that enables the understanding and analysis of social phenomena linked to aging and old age. Recognizing that in Latin America the transition of a society towards demographic maturity occurs as a consequence of positive factors (Huenchuan and Rodríguez-Piñero, 2010), and requires the development of political-institutional actions that make it possible to address the social and political organization of care. Conceptual contributions are made from the life course, recognizing the notions of trajectories and social expectations linked to age. The social structuring of ages operates in an adult-centric tension that puts the desire to grow old in check. And we advance in the identification of the care crisis as an expression of the socio-productive contradictions of financial capitalism, and we add the fourfold matrix as a mode of domination.Facultad de Trabajo Socia

Individual risk prediction of nodal and distant metastasis for patients with typical bronchial carcinoid tumors

Objective: Bronchial typical carcinoid tumors are tow-grade malignancies. However, metastases are diagnosed in some patients. Predicting the individual risk of these metastases to determine patients eligible for a radical lymphadenectomy and patients to be followed-up because of distant metastasis risk is relevant. Our objective was to screen for predictive criteria of bronchial typical carcinoid tumor aggressiveness based on a logistic regression model using clinical, pathological and biomolecular data. Methods: A multicenter retrospective cohort study, including 330 consecutive patients operated on for bronchial typical carcinoid tumors and followed-up during a period more than 10 years in two university hospitals was performed. Selected data to predict the individual risk for both nodal and distant metastasis were: age, gender, TNM staging, tumor diameter and location (central/peripheral), tumor immunostaining index of p53 and Ki67, Bcl2 and the extracellular density of neoformed microvessels and of collagen/elastic extracellular fibers. Results: Nodal and distant metastasis incidence was 11% and 5%, respectively. Univariate analysis identified all the studied biomarkers as related to nodal metastasis. Multivariate analysis identified a predictive variable for nodal metastasis: neo angiogenesis, quantified by the neoformed pathological microvessels density. Distant metastasis was related to mate gender. Discussion: Predictive models based on clinical and biomolecular data could be used to predict individual risk for metastasis. Patients under a high individual risk for lymph node metastasis should be considered as candidates to mediastinal lymphadenectomy. Those under a high risk of distant metastasis should be followed-up as having an aggressive disease. Conclusion: Individual risk prediction of bronchial typical carcinoid tumor metastasis for patients operated on can be calculated in function of biomolecular data. Prediction models can detect high-risk patients and help surgeons to identify patients requiring radical lymphadenectomy and help oncologists to identify those as having an aggressive disease requiring prolonged follow-up. (C) 2008 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved