Imagen y pintura: producción artística

El mundo visual creado por la televisión y los mass media, heredado de la fotografía y el cine, se caracteriza por su condensación icónica. Su comportamiento hacia el espectador ya no es activo, sino que el espectador se deja llevar por el contenido y se acaba convirtiendo en un espectador de naturaleza ‘flotante’, perdiéndose entre dicha aglomeración y desembocando en su desarraigo visual inconsciente. Con la aparición de internet, ciertos espectadores volvieron al plano activo y aumentaron su rango visual. En el presente trabajo se lleva a cabo una producción pictórica que sigue el rastro de un tipo de imagen surgida del aprendizaje en el mundo visual ampliado que ofrecen los medios en desarrollo, traducida en pintura. A su vez, se desarrollan apreciaciones a cerca de esta en relación con el pensamiento contemporáneo, las formas y el contenido.Correcher Merlos, C. (2014). Imagen y pintura: producción artística. http://hdl.handle.net/10251/45963.Archivo delegad

Las entidades deportivas sin fines lucrativos ante el Impuesto sobre Sociedades: revisión crítica de los regímenes tributarios aplicables

La tesis doctoral, titulada “Las entidades deportivas sin fines lucrativos ante el Impuesto sobre Sociedades: revisión crítica de los regímenes tributarios aplicables", tiene por objeto de estudio el análisis crítico de la tributación de las entidades deportivas sin fines lucrativos públicas y privadas en el Impuesto sobre Sociedades, perspectiva que se logra a través de una revisión de los fundamentos y de la estructura de los regímenes fiscales aplicables. Por lo tanto, la pregunta que mejor condensaría la hipótesis principal a la que pretende hacer frente el trabajo de investigación realizado es la siguiente: ¿resulta adecuada la tributación de las entidades deportivas sin fines lucrativos públicas y privadas en el Impuesto sobre Sociedades? Para dar respuesta a esta gran pregunta de investigación, el trabajo se organiza en siete capítulos: En el primero de ellos se analiza el deporte y su organización. Dicha aproximación permite descubrir lo significativo que resulta para la ciudadanía, su complejidad como fenómeno susceptible de manifestarse de muy diversas modalidades y cómo su relación con el interés general puede hacer merecedoras de incentivos fiscales en mayor o menor grado a las entidades que canalizan en muchos casos la actividad deportiva de los ciudadanos. Para comprobar dicha relación con los fines de interés general, se analiza el modelo de organización deportiva y las entidades que lo conforman, también con la finalidad de comprobar cuáles de ellas carecen de ánimo de lucro. En el segundo capítulo, una vez identificadas las entidades deportivas sin fines lucrativos públicas y privadas, se determina su sujeción al Impuesto sobre Sociedades y se delimitan los tres regímenes fiscales que resultan de aplicación, reconociendo su articulación técnica a través del instituto jurídico de la exención y los fundamentos y finalidades que han motivado el establecimiento de unos regímenes fiscales especiales. Se trata del régimen de exención total, el régimen fiscal de las entidades sin fines lucrativos y el régimen de entidades parcialmente exentas. En el tercer capítulo de la tesis se estudian las distintas entidades deportivas sin fines lucrativos públicas y su tributación en el Impuesto sobre Sociedades, verificando su existencia en los tres niveles de la Administración territorial, así como el importante rol que adopta la denominada Administración institucional en el desarrollo deportivo. En particular, se profundiza en la idoneidad de los consorcios administrativos para el impulso del deporte y su tributación en el Impuesto objeto de análisis. En el cuarto capítulo se plantean los aspectos comunes de los dos regímenes de exención parcial que resultan aplicables a las entidades deportivas sin fines lucrativos privadas, esto es, el régimen fiscal de las entidades sin fines lucrativos y el régimen de entidades parcialmente exentas, con la finalidad de dotar al estudio de un carácter más unitario, evitar reiteraciones innecesarias y visibilizar la hipótesis acerca de la adecuación de estos regímenes fiscales a la justa contribución. En este sentido, se estudian posibles fuentes de ingresos y rentas de las entidades deportivas sin fines lucrativos privadas, se precisa cómo se determina la base imponible y se introducen los supuestos especiales de gastos no deducibles, esto es, los correspondientes a rentas exentas y las aplicaciones de resultados. En el quinto capítulo se examina la tributación de las entidades deportivas que pueden acogerse al régimen fiscal de las entidades sin fines lucrativos. Para ello, se delimitan las entidades deportivas que pueden optar por este régimen tributario, se analizan los requisitos de acceso a este régimen de carácter opcional y su incidencia sobre las entidades deportivas objeto de estudio, así como la tributación específica que resulta de la aplicación de este régimen tributario. En el sexto capítulo se investiga la tributación de las entidades deportivas sin fines lucrativos en el régimen fiscal de entidades parcialmente exentas. En primer lugar, se identifican las entidades deportivas que deben tributar de conformidad con este régimen fiscal y, en segundo lugar, se analiza el régimen jurídico tributario que resulta de aplicación, junto con la exención del deber de declarar regulada y sus efectos. En el séptimo capítulo, atendiendo a sus fundamentos, se realiza una valoración conjunta de los dos regímenes fiscales aplicables a las entidades deportivas sin fines lucrativos privadas y se ponen de manifiesto distintos modelos alternativos de imposición en aras de mejorar la tributación de todas las entidades sin fines lucrativos y, por extensión, de aquellas deportivas. Finalmente, en las conclusiones se exponen sucintamente los resultados de la investigación, resaltando aquellas reflexiones que se consideran más relevantes o más originales

Identifying the Sweet Spot of Padel Rackets with a Robot

[EN] Although the vibration of rackets and the location of the sweet spot for players when hitting the ball is crucial, manufacturers do not specify this behavior precisely. This article analyses padel rackets, provides a solution to determine the sweet spot position (SSP), quantifies its behavior, and determines the level of vibration transmitted along the racket handle. The proposed methods serve to locate the SSP without quantifying it. This article demonstrates the development of equipment capable of analyzing the vibration behavior of padel rackets. To do so, it employs a robot that moves along the surface of the padel racket, striking it along its central line. Accelerometers are placed on a movable cradle where rackets are positioned and adjusted. A method for analyzing accelerometer signals to quantify vibration severity is proposed. The SSP and vibration behavior along the central line are determined and quantified. As a result of the study, 225 padel rackets are analyzed and compared. SSP is independent of the padel racket shape, balance, weight, moment of inertia, and padel racket shape (tear, diamond, or round) and is not located at the same position as the center of percussion.This research was partially funded by Sport Thinkers SL, Ontinyent, Spain.Blanes Campos, C.; Correcher Salvador, A.; Martínez-Turégano, J.; Ricolfe Viala, C. (2023). Identifying the Sweet Spot of Padel Rackets with a Robot. Sensors. 23(24):1-15. https://doi.org/10.3390/s23249908115232

Thermal and Electrical Parameter Identification of a Proton Exchange Membrane Fuel Cell Using Genetic Algorithm

[EN] Proton Exchange Membrane Fuel Cell (PEMFC) fuel cells is a technology successfully used in the production of energy from hydrogen, allowing the use of hydrogen as an energy vector. It is scalable for stationary and mobile applications. However, the technology demands more research. An important research topic is fault diagnosis and condition monitoring to improve the life and the efficiency and to reduce the operation costs of PEMFC devices. Consequently, there is a need of physical models that allow deep analysis. These models must be accurate enough to represent the PEMFC behavior and to allow the identification of different internal signals of a PEM fuel cell. This work presents a PEM fuel cell model that uses the output temperature in a closed loop, so it can represent the thermal and the electrical behavior. The model is used to represent a Nexa Ballard 1.2 kW fuel cell; therefore, it is necessary to fit the coefficients to represent the real behavior. Five optimization algorithms were tested to fit the model, three of them taken from literature and two proposed in this work. Finally, the model with the identified parameters was validated with real data.This research was funded by COLCIENCIAS (Administrative department of science, technology and innovation of Colombia) scholarship program PDBCEx, COLDOC 586, and the support provided by the Corporacion Universitaria Comfacauca, Popayan-ColombiaAriza-Chacón, HE.; Correcher Salvador, A.; Sánchez-Diaz, C.; Pérez-Navarro, Á.; García Moreno, E. (2018). Thermal and Electrical Parameter Identification of a Proton Exchange Membrane Fuel Cell Using Genetic Algorithm. Energies. 11(8):1-15. https://doi.org/10.3390/en11082099S115118Mehta, V., & Cooper, J. S. (2003). Review and analysis of PEM fuel cell design and manufacturing. Journal of Power Sources, 114(1), 32-53. doi:10.1016/s0378-7753(02)00542-6Wang, Y., Chen, K. S., Mishler, J., Cho, S. C., & Adroher, X. C. (2011). A review of polymer electrolyte membrane fuel cells: Technology, applications, and needs on fundamental research. Applied Energy, 88(4), 981-1007. doi:10.1016/j.apenergy.2010.09.030Amphlett, J. C., Baumert, R. M., Mann, R. F., Peppley, B. A., Roberge, P. R., & Harris, T. J. (1995). Performance Modeling of the Ballard Mark IV Solid Polymer Electrolyte Fuel Cell: I . Mechanistic Model Development. Journal of The Electrochemical Society, 142(1), 1-8. doi:10.1149/1.2043866Tao, S., Si-jia, Y., Guang-yi, C., & Xin-jian, Z. (2005). Modelling and control PEMFC using fuzzy neural networks. Journal of Zhejiang University-SCIENCE A, 6(10), 1084-1089. doi:10.1631/jzus.2005.a1084Amphlett, J. C., Mann, R. F., Peppley, B. A., Roberge, P. R., & Rodrigues, A. (1996). A model predicting transient responses of proton exchange membrane fuel cells. Journal of Power Sources, 61(1-2), 183-188. doi:10.1016/s0378-7753(96)02360-9Mo, Z.-J., Zhu, X.-J., Wei, L.-Y., & Cao, G.-Y. (2006). Parameter optimization for a PEMFC model with a hybrid genetic algorithm. International Journal of Energy Research, 30(8), 585-597. doi:10.1002/er.1170YE, M., WANG, X., & XU, Y. (2009). Parameter identification for proton exchange membrane fuel cell model using particle swarm optimization. International Journal of Hydrogen Energy, 34(2), 981-989. doi:10.1016/j.ijhydene.2008.11.026Askarzadeh, A., & Rezazadeh, A. (2011). A grouping-based global harmony search algorithm for modeling of proton exchange membrane fuel cell. International Journal of Hydrogen Energy, 36(8), 5047-5053. doi:10.1016/j.ijhydene.2011.01.070El-Fergany, A. A. (2018). Electrical characterisation of proton exchange membrane fuel cells stack using grasshopper optimiser. IET Renewable Power Generation, 12(1), 9-17. doi:10.1049/iet-rpg.2017.0232Li, Q., Chen, W., Wang, Y., Liu, S., & Jia, J. (2011). Parameter Identification for PEM Fuel-Cell Mechanism Model Based on Effective Informed Adaptive Particle Swarm Optimization. IEEE Transactions on Industrial Electronics, 58(6), 2410-2419. doi:10.1109/tie.2010.2060456Ali, M., El-Hameed, M. A., & Farahat, M. A. (2017). Effective parameters’ identification for polymer electrolyte membrane fuel cell models using grey wolf optimizer. Renewable Energy, 111, 455-462. doi:10.1016/j.renene.2017.04.036Sun, Z., Wang, N., Bi, Y., & Srinivasan, D. (2015). Parameter identification of PEMFC model based on hybrid adaptive differential evolution algorithm. Energy, 90, 1334-1341. doi:10.1016/j.energy.2015.06.081Gong, W., Yan, X., Liu, X., & Cai, Z. (2015). Parameter extraction of different fuel cell models with transferred adaptive differential evolution. Energy, 86, 139-151. doi:10.1016/j.energy.2015.03.117Turgut, O. E., & Coban, M. T. (2016). Optimal proton exchange membrane fuel cell modelling based on hybrid Teaching Learning Based Optimization – Differential Evolution algorithm. Ain Shams Engineering Journal, 7(1), 347-360. doi:10.1016/j.asej.2015.05.003Al-Othman, A. K., Ahmed, N. A., Al-Fares, F. S., & AlSharidah, M. E. (2015). Parameter Identification of PEM Fuel Cell Using Quantum-Based Optimization Method. Arabian Journal for Science and Engineering, 40(9), 2619-2628. doi:10.1007/s13369-015-1711-0Methekar, R. N., Prasad, V., & Gudi, R. D. (2007). Dynamic analysis and linear control strategies for proton exchange membrane fuel cell using a distributed parameter model. Journal of Power Sources, 165(1), 152-170. doi:10.1016/j.jpowsour.2006.11.047KUNUSCH, C., HUSAR, A., PULESTON, P., MAYOSKY, M., & MORE, J. (2008). Linear identification and model adjustment of a PEM fuel cell stack. International Journal of Hydrogen Energy, 33(13), 3581-3587. doi:10.1016/j.ijhydene.2008.04.052Li, C.-H., Zhu, X.-J., Cao, G.-Y., Sui, S., & Hu, M.-R. (2008). Identification of the Hammerstein model of a PEMFC stack based on least squares support vector machines. Journal of Power Sources, 175(1), 303-316. doi:10.1016/j.jpowsour.2007.09.049Fontes, G., Turpin, C., & Astier, S. (2010). A Large-Signal and Dynamic Circuit Model of a $\hbox{H}_{2}/\hbox{O}_{2}$ PEM Fuel Cell: Description, Parameter Identification, and Exploitation. IEEE Transactions on Industrial Electronics, 57(6), 1874-1881. doi:10.1109/tie.2010.2044731Cheng, S.-J., & Liu, J.-J. (2015). Nonlinear modeling and identification of proton exchange membrane fuel cell (PEMFC). International Journal of Hydrogen Energy, 40(30), 9452-9461. doi:10.1016/j.ijhydene.2015.05.109Buchholz, M., & Krebs, V. (2007). Dynamic Modelling of a Polymer Electrolyte Membrane Fuel Cell Stack by Nonlinear System Identification. Fuel Cells, 7(5), 392-401. doi:10.1002/fuce.200700013Meiler, M., Schmid, O., Schudy, M., & Hofer, E. P. (2008). Dynamic fuel cell stack model for real-time simulation based on system identification. Journal of Power Sources, 176(2), 523-528. doi:10.1016/j.jpowsour.2007.08.051Wang, C., Nehrir, M. H., & Shaw, S. R. (2005). Dynamic Models and Model Validation for PEM Fuel Cells Using Electrical Circuits. IEEE Transactions on Energy Conversion, 20(2), 442-451. doi:10.1109/tec.2004.842357Restrepo, C., Konjedic, T., Garces, A., Calvente, J., & Giral, R. (2015). Identification of a Proton-Exchange Membrane Fuel Cell’s Model Parameters by Means of an Evolution Strategy. IEEE Transactions on Industrial Informatics, 11(2), 548-559. doi:10.1109/tii.2014.2317982Salim, R., Nabag, M., Noura, H., & Fardoun, A. (2015). The parameter identification of the Nexa 1.2 kW PEMFC’s model using particle swarm optimization. Renewable Energy, 82, 26-34. doi:10.1016/j.renene.2014.10.012Pérez-Navarro, A., Alfonso, D., Ariza, H. E., Cárcel, J., Correcher, A., Escrivá-Escrivá, G., … Vargas, C. (2016). Experimental verification of hybrid renewable systems as feasible energy sources. Renewable Energy, 86, 384-391. doi:10.1016/j.renene.2015.08.03

MPC for optimal dispatch of an AC-linked hybrid PV/wind/biomass/H2 system incorporating demand response

[EN] A Model Predictive Control (MPC) strategy based on the Evolutionary Algorithms (EA) is proposed for the optimal dispatch of renewable generation units and demand response in a grid-tied hybrid system. The generating system is based on the experimental setup installed in a Distributed Energy Resources Laboratory (LabDER), which includes an AC micro-grid with small scale PV/Wind/Biomass systems. Energy storage is by lead-acid batteries and an H2 system (electrolyzer, H2 cylinders and Fuel Cell). The energy demand is residential in nature, consisting of a base load plus others that can be disconnected or moved to other times of the day within a demand response program. Based on the experimental data from each of the LabDER renewable generation and storage systems, a micro-grid operating model was developed in MATLAB(C) to simulate energy flows and their interaction with the grid. The proposed optimization algorithm seeks the minimum hourly cost of the energy consumed by the demand and the maximum use of renewable resources, using the minimum computational resources. The simulation results of the experimental micro-grid are given with seasonal data and the benefits of using the algorithm are pointed out.Acevedo-Arenas, CY.; Correcher Salvador, A.; Sánchez-Diaz, C.; Ariza-Chacón, HE.; Alfonso-Solar, D.; Vargas-Salgado, C.; Petit-Suarez, JF. (2019). MPC for optimal dispatch of an AC-linked hybrid PV/wind/biomass/H2 system incorporating demand response. Energy Conversion and Management. 186:241-257. https://doi.org/10.1016/j.enconman.2019.02.044S24125718

Generación de vídeos para TikTok como herramienta de evaluación de prácticas de automática. Primeros resultados

[ES] Este artículo presenta los primeros resultados de un proyecto de innovación educativa en la UPV que aplica una metodología de evaluación de prácticas mediante la generación de vídeos para la red social TikTok. El objetivo principal del proyecto es mejorar la motivación de los alumnos por las prácticas de la asignatura y su evaluación. Para ello se ha diseñado una metodología mediante la cual los alumnos deben generar una serie de vídeos como evidencias de evaluación de las actividades prácticas. Estos vídeos se comparten en TikTok y parte de la calificación se obtiene del éxito del vídeo en la red. La actividad resulta motivadora y los alumnos la valoran de manera muy positiva.[EN] This paper presents the first results of an educational innovation project at the UPV that applies a practice evaluation methodology by generating videos for the TikTok social network. The project's main objective is to improve the student's motivation for the practices of the subject and its evaluation. To this end, a methodology has been designed through which students must generate videos as evidence for assessing practical activities. These videos are shared on TikTok, and part of the rating is obtained from the video's success on the network. The activity is motivating, and the students value it very positively.Correcher Salvador, A.; Blanes Campos, C.; Cordero París, FM.; Ivorra Martínez, E.; Martínez Turégano, J.; Ricolfe Viala, C. (2023). Generación de vídeos para TikTok como herramienta de evaluación de prácticas de automática. Primeros resultados. Editorial Universitat Politècnica de València. 357-366. https://doi.org/10.4995/INRED2023.2023.1654635736

Experimental verification of hybrid renewable systems as feasible energy sources

[EN] Renewable energies are a central element in the search for energy sustainability, so they are becoming a substantial component of the energy scenario of every country, both as systems connected to the grid or in stand-alone applications. Feasibility of these renewable energy systems could be necessary not only in their application in isolated areas, but also in systems connected to the grid, in this last case when their contribution reaches a substantial fraction of the total electricity demand. To overcome this reliability problem, hybrid renewable systems could become essential and activities to optimize their design should be addressed, both in the simulation and in the experimental areas. In this paper, a laboratory to simulate and verify the reliability of hybrid renewable systems is presented and its application to the feasibility analysis of multicomponent systems including photovoltaic panels, wind generator and biomass gasification plant, plus energy storage in a battery bank, are described.Pérez-Navarro, Á.; Alfonso-Solar, D.; Ariza-Chacón, HE.; Cárcel Carrasco, FJ.; Correcher Salvador, A.; Escrivá-Escrivá, G.; Hurtado, E.... (2016). Experimental verification of hybrid renewable systems as feasible energy sources. Renewable Energy. 86(2):384-391. doi:10.1016/j.renene.2015.08.030S38439186

Characterization of a preclinical PET insert in a 7 tesla MRI scanner: beyond NEMA testing

[EN] This study evaluates the performance of the Bruker positron emission tomograph (PET) insert combined with a BioSpec 70/30 USR magnetic resonance imaging (MRI) scanner using the manufacturer acceptance protocol and the NEMA NU 4-2008 for small animal PET. The PET insert is made of 3 rings of 8 monolithic LYSO crystals (50 x 50 x 10 mm(3)) coupled to silicon photomultipliers (SiPM) arrays, conferring an axial and transaxial FOV of 15 cm and 8 cm. The MRI performance was evaluated with and without the insert for the following radiofrequency noise, magnetic field homogeneity and image quality. For the PET performance, we extended the NEMA protocol featuring system sensitivity, count rates, spatial resolution and image quality to homogeneity and accuracy for quantification using several MRI sequences (RARE, FLASH, EPI and UTE). The PET insert does not show any adverse effect on the MRI performances. The MR field homogeneity is well preserved (Diameter Spherical Volume, for 20 mm of 1.98 +/- 4.78 without and -0.96 +/- 5.16 Hz with the PET insert). The PET insert has no major effect on the radiofrequency field. The signal-to-noise ratio measurements also do not show major differences. Image ghosting is well within the manufacturer specifications (<2.5%) and no RF noise is visible. Maximum sensitivity of the PET insert is 11.0% at the center of the FOV even with simultaneous acquisition of EPI and RARE. PET MLEM resolution is 0.87 mm (FWHM) at 5 mm off-center of the FOV and 0.97 mm at 25 mm radial offset. The peaks for true/noise equivalent count rates are 410/240 and 628/486 kcps for the rat and mouse phantoms, and are reached at 30.34/22.85 and 27.94/22.58 MBq. PET image quality is minimally altered by the different MRI sequences. The Bruker PET insert shows no adverse effect on the MRI performance and demonstrated a high sensitivity, sub-millimeter resolution and good image quality even during simultaneous MRI acquisition.We acknowledge the KU Leuven core facility, Molecular Small Animal Imaging Center (MoSAIC), for their support with obtaining scientific data presented in this paper. This work was supported by Stichting tegen Kanker (2015-145, Christophe M. Deroose) and Hercules foundation (AKUL/13/029, Uwe Himmelreich) for the purchase of the PET and MRI equipment respectively. The work was supported by the following funding organizations: European Commission for the PANA project (H2020-NMP-2015-two-stage, grant 686009) and the European ERA-NET project 'CryptoView' (3rd call of the FP7 program Infect-ERA).Gsell, W.; Molinos, C.; Correcher, C.; Belderbos, S.; Wouters, J.; Junge, S.; Heidenreich, M.... (2020). Characterization of a preclinical PET insert in a 7 tesla MRI scanner: beyond NEMA testing. Physics in Medicine and Biology. 65(24):1-16. https://doi.org/10.1088/1361-6560/aba08cS1166524Balezeau, F., Eliat, P.-A., Cayamo, A. B., & Saint-Jalmes, H. (2011). Mapping of low flip angles in magnetic resonance. Physics in Medicine and Biology, 56(20), 6635-6647. doi:10.1088/0031-9155/56/20/008Benlloch, J. M., González, A. J., Pani, R., Preziosi, E., Jackson, C., Murphy, J., … Schwaiger, M. (2018). The MINDVIEW project: First results. European Psychiatry, 50, 21-27. doi:10.1016/j.eurpsy.2018.01.002Cal-Gonzalez, J., Rausch, I., Shiyam Sundar, L. K., Lassen, M. L., Muzik, O., Moser, E., … Beyer, T. (2018). Hybrid Imaging: Instrumentation and Data Processing. Frontiers in Physics, 6. doi:10.3389/fphy.2018.00047Clark, D. P., & Badea, C. T. (2014). Micro-CT of rodents: State-of-the-art and future perspectives. Physica Medica, 30(6), 619-634. doi:10.1016/j.ejmp.2014.05.011Drzezga, A., Souvatzoglou, M., Eiber, M., Beer, A. J., Fürst, S., Martinez-Möller, A., … Schwaiger, M. (2012). First Clinical Experience with Integrated Whole-Body PET/MR: Comparison to PET/CT in Patients with Oncologic Diagnoses. Journal of Nuclear Medicine, 53(6), 845-855. doi:10.2967/jnumed.111.098608Gonzalez, A. J., Aguilar, A., Conde, P., Hernandez, L., Moliner, L., Vidal, L. F., … Benlloch, J. M. (2016). A PET Design Based on SiPM and Monolithic LYSO Crystals: Performance Evaluation. IEEE Transactions on Nuclear Science, 63(5), 2471-2477. doi:10.1109/tns.2016.2522179Gonzalez, A. J., Pincay, E. J., Canizares, G., Lamprou, E., Sanchez, S., Catret, J. V., … Correcher, C. (2019). Initial Results of the MINDView PET Insert Inside the 3T mMR. IEEE Transactions on Radiation and Plasma Medical Sciences, 3(3), 343-351. doi:10.1109/trpms.2018.2866899Grant, A. M., Lee, B. J., Chang, C.-M., & Levin, C. S. (2017). Simultaneous PET/MR imaging with a radio frequency-penetrable PET insert. Medical Physics, 44(1), 112-120. doi:10.1002/mp.12031Habte, F., Ren, G., Doyle, T. C., Liu, H., Cheng, Z., & Paik, D. S. (2013). Impact of a Multiple Mice Holder on Quantitation of High-Throughput MicroPET Imaging With and Without Ct Attenuation Correction. Molecular Imaging and Biology, 15(5), 569-575. doi:10.1007/s11307-012-0602-yHammer, B. E., Christensen, N. L., & Heil, B. G. (1994). Use of a magnetic field to increase the spatial resolution of positron emission tomography. Medical Physics, 21(12), 1917-1920. doi:10.1118/1.597178Jadvar, H., & Colletti, P. M. (2014). Competitive advantage of PET/MRI. European Journal of Radiology, 83(1), 84-94. doi:10.1016/j.ejrad.2013.05.028Judenhofer, M. S., Catana, C., Swann, B. K., Siegel, S. B., Jung, W.-I., Nutt, R. E., … Pichler, B. J. (2007). PET/MR Images Acquired with a Compact MR-compatible PET Detector in a 7-T Magnet. Radiology, 244(3), 807-814. doi:10.1148/radiol.2443061756Kinahan, P. E., Townsend, D. W., Beyer, T., & Sashin, D. (1998). Attenuation correction for a combined 3D PET/CT scanner. Medical Physics, 25(10), 2046-2053. doi:10.1118/1.598392Ko, G. B., Yoon, H. S., Kim, K. Y., Lee, M. S., Yang, B. Y., Jeong, J. M., … Lee, J. S. (2016). Simultaneous Multiparametric PET/MRI with Silicon Photomultiplier PET and Ultra-High-Field MRI for Small-Animal Imaging. Journal of Nuclear Medicine, 57(8), 1309-1315. doi:10.2967/jnumed.115.170019Lee, B. J., Grant, A. M., Chang, C.-M., Watkins, R. D., Glover, G. H., & Levin, C. S. (2018). MR Performance in the Presence of a Radio Frequency-Penetrable Positron Emission Tomography (PET) Insert for Simultaneous PET/MRI. IEEE Transactions on Medical Imaging, 37(9), 2060-2069. doi:10.1109/tmi.2018.2815620Loening, A. M., & Gambhir, S. S. (2003). AMIDE: A Free Software Tool for Multimodality Medical Image Analysis. Molecular Imaging, 2(3), 131-137. doi:10.1162/153535003322556877Mannheim, J. G., Schmid, A. M., Schwenck, J., Katiyar, P., Herfert, K., Pichler, B. J., & Disselhorst, J. A. (2018). PET/MRI Hybrid Systems. Seminars in Nuclear Medicine, 48(4), 332-347. doi:10.1053/j.semnuclmed.2018.02.011Maramraju, S. H., Smith, S. D., Junnarkar, S. S., Schulz, D., Stoll, S., Ravindranath, B., … Schlyer, D. J. (2011). Small animal simultaneous PET/MRI: initial experiences in a 9.4 T microMRI. Physics in Medicine and Biology, 56(8), 2459-2480. doi:10.1088/0031-9155/56/8/009Molinos, C., Sasser, T., Salmon, P., Gsell, W., Viertl, D., Massey, J. C., … Heidenreich, M. (2019). Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner. Frontiers in Medicine, 6. doi:10.3389/fmed.2019.00088Nagy, K., Tóth, M., Major, P., Patay, G., Egri, G., Häggkvist, J., … Gulyás, B. (2013). Performance Evaluation of the Small-Animal nanoScan PET/MRI System. Journal of Nuclear Medicine, 54(10), 1825-1832. doi:10.2967/jnumed.112.119065Nanni, C., & Torigian, D. A. (2008). Applications of Small Animal Imaging with PET, PET/CT, and PET/MR Imaging. PET Clinics, 3(3), 243-250. doi:10.1016/j.cpet.2009.01.002Omidvari, N., Cabello, J., Topping, G., Schneider, F. R., Paul, S., Schwaiger, M., & Ziegler, S. I. (2017). PET performance evaluation of MADPET4: a small animal PET insert for a 7 T MRI scanner. Physics in Medicine & Biology, 62(22), 8671-8692. doi:10.1088/1361-6560/aa910dOmidvari, N., Topping, G., Cabello, J., Paul, S., Schwaiger, M., & Ziegler, S. I. (2018). MR-compatibility assessment of MADPET4: a study of interferences between an SiPM-based PET insert and a 7 T MRI system. Physics in Medicine & Biology, 63(9), 095002. doi:10.1088/1361-6560/aab9d1Raylman, R. R., Majewski, S., Lemieux, S. K., Velan, S. S., Kross, B., Popov, V., … Marano, G. D. (2006). Simultaneous MRI and PET imaging of a rat brain. Physics in Medicine and Biology, 51(24), 6371-6379. doi:10.1088/0031-9155/51/24/006Roncali, E., & Cherry, S. R. (2011). Application of Silicon Photomultipliers to Positron Emission Tomography. Annals of Biomedical Engineering, 39(4), 1358-1377. doi:10.1007/s10439-011-0266-9Schug, D., Lerche, C., Weissler, B., Gebhardt, P., Goldschmidt, B., Wehner, J., … Schulz, V. (2016). Initial PET performance evaluation of a preclinical insert for PET/MRI with digital SiPM technology. Physics in Medicine and Biology, 61(7), 2851-2878. doi:10.1088/0031-9155/61/7/2851Shao, Y., Cherry, S. R., Farahani, K., Meadors, K., Siegel, S., Silverman, R. W., & Marsden, P. K. (1997). Simultaneous PET and MR imaging. Physics in Medicine and Biology, 42(10), 1965-1970. doi:10.1088/0031-9155/42/10/010Steinert, H. C., & von Schulthess, G. K. (2002). Initial clinical experience using a new integrated in-line PET/CT system. The British Journal of Radiology, 75(suppl_9), S36-S38. doi:10.1259/bjr.75.suppl_9.750036Stortz, G., Thiessen, J. D., Bishop, D., Khan, M. S., Kozlowski, P., Retière, F., … Sossi, V. (2017). Performance of a PET Insert for High-Resolution Small-Animal PET/MRI at 7 Tesla. Journal of Nuclear Medicine, 59(3), 536-542. doi:10.2967/jnumed.116.187666Townsend, D. W. (2008). Combined Positron Emission Tomography–Computed Tomography: The Historical Perspective. Seminars in Ultrasound, CT and MRI, 29(4), 232-235. doi:10.1053/j.sult.2008.05.006Vandenberghe, S., & Marsden, P. K. (2015). PET-MRI: a review of challenges and solutions in the development of integrated multimodality imaging. Physics in Medicine and Biology, 60(4), R115-R154. doi:10.1088/0031-9155/60/4/r115Vaquero, J. J., & Kinahan, P. (2015). Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems. Annual Review of Biomedical Engineering, 17(1), 385-414. doi:10.1146/annurev-bioeng-071114-040723Von Schulthess, G. K., & Schlemmer, H.-P. W. (2008). A look ahead: PET/MR versus PET/CT. European Journal of Nuclear Medicine and Molecular Imaging, 36(S1), 3-9. doi:10.1007/s00259-008-0940-9Wehner, J., Weissler, B., Dueppenbecker, P. M., Gebhardt, P., Goldschmidt, B., Schug, D., … Schulz, V. (2015). MR-compatibility assessment of the first preclinical PET-MRI insert equipped with digital silicon photomultipliers. Physics in Medicine and Biology, 60(6), 2231-2255. doi:10.1088/0031-9155/60/6/2231Wehrl, H. F., Judenhofer, M. S., Thielscher, A., Martirosian, P., Schick, F., & Pichler, B. J. (2010). Assessment of MR compatibility of a PET insert developed for simultaneous multiparametric PET/MR imaging on an animal system operating at 7 T. Magnetic Resonance in Medicine, 65(1), 269-279. doi:10.1002/mrm.22591Yamamoto, S., Imaizumi, M., Kanai, Y., Tatsumi, M., Aoki, M., Sugiyama, E., … Hatazawa, J. (2010). Design and performance from an integrated PET/MRI system for small animals. 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The MINDVIEW project: First results

[EN] We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from C-11-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that C-11-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naive, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia. (c) 2018 Elsevier Masson SAS. All rights reserved.This project is funded by EU grant FP7-HEALTH-F2-2013-603002.Benlloch Baviera, JM.; González Martínez, AJ.; Pani, R.; Preziosi, E.; Jackson, C.; Murphy, J.; Barbera Ballester, J.... (2018). The MINDVIEW project: First results. European Psychiatry. 50:21-27. https://doi.org/10.1016/j.eurpsy.2018.01.002S212750Gonzalez, A. J., Gonzalez-Montoro, A., Aguilar, A., Conde, P., Canizares, G., Hernandez, L., … Benlloch, J. M. (2016). A brain PET insert MR compatible: Final design and first results. 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop (NSS/MIC/RTSD). doi:10.1109/nssmic.2016.8069619Dahl, K., Schou, M., Ulin, J., Sjöberg, C.-O., Farde, L., & Halldin, C. (2015). 11C-carbonylation reactions using gas–liquid segmented microfluidics. RSC Advances, 5(108), 88886-88889. doi:10.1039/c5ra20646d[26] Långström B and Sjöberg CO, System for controlling environment in reaction box, From PCT Int. Appl. (2013), WO 2013103312 A1 20130711.Autret, A., Bert, J., Strauss, O., & Visvikis, D. (2012). Projector with realistic detector scatter modelling for PET list-mode reconstruction. 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC). doi:10.1109/nssmic.2012.6551759[10] Young JW Head and Face Antropometry of Adult U.S. Citizens, Civil Aeromedical Institute, Federal Aviation Administration, U.S. Department of Transportation, Report number DOT/FAA/AM-93/10, July 1993.Braff, D. L. (1990). Sensorimotor Gating and Schizophrenia. Archives of General Psychiatry, 47(2), 181. doi:10.1001/archpsyc.1990.01810140081011Preziosi, E., Sánchez, S., González, A. J., Pani, R., Borrazzo, C., Bettiol, M., … Benlloch, J. M. (2016). Performance study of a PET scanner based on monolithic scintillators for different DoI-dependent methods. Journal of Instrumentation, 11(12), C12076-C12076. doi:10.1088/1748-0221/11/12/c12076Howes, O., McCutcheon, R., & Stone, J. (2015). Glutamate and dopamine in schizophrenia: An update for the 21st century. Journal of Psychopharmacology, 29(2), 97-115. doi:10.1177/0269881114563634Moliner, L., Correcher, C., González, A. J., Conde, P., Hernández, L., Orero, A., … Benlloch, J. M. (2013). Implementation and analysis of list mode algorithm using tubes of response on a dedicated brain and breast PET. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 702, 129-132. doi:10.1016/j.nima.2012.08.029Zelano, J., Mikulovic, S., Patra, K., Kühnemund, M., Larhammar, M., Emilsson, L., … Kullander, K. (2013). The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants. Experimental Neurology, 239, 73-81. doi:10.1016/j.expneurol.2012.09.006Antich, P., Malakhov, N., Parkey, R., Slavin, N., & Tsyganov, E. (2002). 3D position readout from thick scintillators. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 480(2-3), 782-787. doi:10.1016/s0168-9002(01)01214-1Gonzalez-Montoro, A., Benlloch, J. M., Gonzalez, A. J., Aguilar, A., Canizares, G., Conde, P., … Sanchez, F. (2017). Performance Study of a Large Monolithic LYSO PET Detector With Accurate Photon DOI Using Retroreflector Layers. IEEE Transactions on Radiation and Plasma Medical Sciences, 1(3), 229-237. doi:10.1109/trpms.2017.2692819Rahman, O., Takano, A., Amini, N., Dahl, K., Kanegawa, N., Långström, B., … Halldin, C. (2015). Synthesis of ([11C]carbonyl)raclopride and a comparison with ([11C]methyl)raclopride in a monkey PET study. Nuclear Medicine and Biology, 42(11), 893-898. doi:10.1016/j.nucmedbio.2015.07.003Howes, O. D., Kambeitz, J., Kim, E., Stahl, D., Slifstein, M., Abi-Dargham, A., & Kapur, S. (2012). The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment. 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Journal of Nuclear Medicine, 54(3), 388-396. doi:10.2967/jnumed.112.107995Jackson, C., O’Neill, K., Wall, L., & McGarvey, B. (2014). High-volume silicon photomultiplier production, performance, and reliability. Optical Engineering, 53(8), 081909. doi:10.1117/1.oe.53.8.081909Rahman, O., Långström, B., & Halldin, C. (2016). Alkyl Iodides and [11 C]CO in Nickel-Mediated Cross-Coupling Reactions: Successful Use of Alkyl Electrophiles containing a β Hydrogen Atom in Metal-Mediated [11 C]Carbonylation. ChemistrySelect, 1(10), 2498-2501. doi:10.1002/slct.201600643Sullivan, J. M., Lim, K., Labaree, D., Lin, S., McCarthy, T. J., Seibyl, J. P., … Morris, E. D. (2012). Kinetic Analysis of the Metabotropic Glutamate Subtype 5 Tracer [18F]FPEB in Bolus and Bolus-Plus-Constant-Infusion Studies in Humans. Journal of Cerebral Blood Flow & Metabolism, 33(4), 532-541. doi:10.1038/jcbfm.2012.195Levin, C. S. (2003). Detector design issues for compact nuclear emission cameras dedicated to breast imaging. 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Transferrin Isoforms, Old but New Biomarkers in Hereditary Fructose Intolerance

Hereditary Fructose Intolerance (HFI) is an autosomal recessive inborn error of metabolism characterised by the deficiency of the hepatic enzyme aldolase B. Its treatment consists in adopting a fructose-, sucrose-, and sorbitol (FSS)-restrictive diet for life. Untreated HFI patients present an abnormal transferrin (Tf) glycosylation pattern due to the inhibition of mannose-6-phosphate isomerase by fructose-1-phosphate. Hence, elevated serum carbohydrate-deficient Tf (CDT) may allow the prompt detection of HFI. The CDT values improve when an FSS-restrictive diet is followed; however, previous data on CDT and fructose intake correlation are inconsistent. Therefore, we examined the complete serum sialoTf profile and correlated it with FSS dietary intake and with hepatic parameters in a cohort of paediatric and adult fructosemic patients. To do so, the profiles of serum sialoTf from genetically diagnosed HFI patients on an FSS-restricted diet (n = 37) and their age-, sex- and body mass index-paired controls (n = 32) were analysed by capillary zone electrophoresis. We found that in HFI patients, asialoTf correlated with dietary intake of sucrose (R = 0.575, p < 0.001) and FSS (R = 0.475, p = 0.008), and that pentasialoTf+hexasialoTf negatively correlated with dietary intake of fructose (R = −0.386, p = 0.024) and FSS (R = −0.400, p = 0.019). In addition, the tetrasialoTf/disialoTf ratio truthfully differentiated treated HFI patients from healthy controls, with an area under the ROC curve (AUROC) of 0.97, 92% sensitivity, 94% specificity and 93% accuracy.This work was supported by Exp. No. 2018111095, Basque Government, Health Department to J.D.H., and by FEDER; Federación Española de Enfermedades Raras (FI18053)