Brain Abnormalities in Individuals with a Desire for a Healthy Limb Amputation: Somatosensory, Motoric or Both? A Task-Based fMRI Verdict

Body integrity dysphoria (BID), a long-lasting desire for the amputation of physically healthy limbs, is associated with reduced fMRI resting-state functional connectivity of somatosensory cortices. Here, we used fMRI to evaluate whether these findings could be replicated and expanded using a task-based paradigm. We measured brain activations during somatosensory stimulation and motor tasks for each of the four limbs in ten individuals with a life-long desire for the amputation of the left leg and fourteen controls. For the left leg, BID individuals had reduced brain activation in the right superior parietal lobule for somatosensory stimulation and in the right paracentral lobule for the motor task, areas where we previously found reduced resting-state functional connectivity. In addition, for somatosensory stimulation only, we found a robust reduction in activation of somatosensory areas SII bilaterally, mostly regardless of the stimulated body part. Areas SII were regions of convergent activations for signals from all four limbs in controls to a significantly greater extent than in subjects with BID. We conclude that BID is associated with altered integration of somatosensory and, to a lesser extent, motor signals, involving limb-specific cortical maps and brain regions where the first integration of body-related signals is achieved through convergence

Knowledge integration and dynamic organizational adaptation in family firms

The speed of change in competitive environments has prompted firms to develop processes directed at enabling organizational adaptation. This is captured by the concept of dynamic capabilities. We focus on a particular form of business organization, that is, the family firm. Specifically, we argue that knowledge integration—a dynamic capability through which family members' specialized knowledge is recombined— guides the evolution of capabilities. We present a general framework illustrating factors that affect knowledge integration in family firms. We conclude that only those family firms that are able to effectively integrate individual family members' specialized knowledge will be successful in dynamic markets by changing their capabilities over time

En Italie, un pilier qui vacille

No abstract availabl

Micro-Foundations of Organizational Adaptation : A Field Study in the Evolution of Product Development Capabilities in a Design Firm

The aim of this dissertation is to improve knowledge of how organizations adapt to their dynamic environments, by developing a detailed understanding of the configuration and evolution of organizational replicators. Among open questions in the literature on organizational adaptation, I have explored the following: How can the structure of organizational replicators and the nature of their components be realistically described? How do different organizational replicators interact with each other at different levels within and across organizational boundaries? How do replicators evolve? Why do firms need dynamic capabilities? I’ve addressed these questions by means of an embedded, longitudinal field study of Alessi, an Italian firm founded in 1921, active in the development and production of hundreds of design household products. Data analysis has been carried out in two steps. First, a longitudinal analysis of available primary and archival data has provided an in-depth understanding of the composite nature of organizational replicators, their mutual relationships, their evolution, their outcome stability. Second, a more structured investigation relying on Optimal Matching Analysis allowed to reliably develop an understanding of replicators complexity and of the mechanisms behind their evolution. There are four key findings. First, replicators are not simply behavioral entities—routines in the “narrow sense”. Reliable performance of a capability requires additional elements of physical, intellectual and social capital, which are essential components of replicators (or “Replication Base—RB”, as I suggest to label these more articulated organizational traits). Second, interactions among components of Replication Bases at different levels within and outside the organization suggest a more articulated perspective on how organizational knowledge develops. Components of Replication Bases are often located at different positions within the organization. Over time, knowledge of a particular organizational process takes different forms across the organizational hierarchy. What is local search at one level of analysis, gradually becomes sophisticated foresight at different, typically higher, levels. Third, over time Replication Bases evolve by means of a complex interplay between random mutations and intentional interventions, supported by articulated learning processes. Finally, development of higher-level replicators is not the ultimate answer to the challenge of adaptation. Rather, it allows managers to focus their intentional interventions to the higher-level problems posed by the dynamism of competitive environments. Part of this liberated managerial attention and resources are focused on the crucial, non-routine task of understanding how the organization’s idiosyncratic attributes affect its prospects in the specific competitive context. Taken together, these findings outline the microfoundations of a framework for interpreting organizational adaptation

A farewell to the business: Championing exit and continuity in entrepreneurial family firms

What factors influence exit from the founder's business and subsequent entrepreneurial renewal in a generational family firm? Guided by this research question, we trace the development of the Italian Falck Group from its inception as a steel company in 1906 – ascension as the largest privately owned steel producer in Italy – losses in the 1970s and 1980s leading to business exit from steel industry in the 1990s – followed by successful entry in the renewable energy business. A combination of insights from the literature and triangulation of data from multiple primary and secondary sources leads to the development of a model describing how inhibitors of exit from the founder's business can be transformed into facilitators of change. The critical role of farsighted ‘family champion of continuity’ is found central in redirecting the family from its anchoring in past activities to focus on future entrepreneurial endeavours. While the commitment to the founder's business continues, the family champion aided by business savvy and astute non-family executives ably modifies its meaning of ‘continuity of the founder's business’ from ‘steel production’ to ‘continuity of the entrepreneurial spirit of the family’, hence preserving the institutional identity. Insights from this study can help generational family firms which plan to exit from a failing course of action to regenerate so as to create trans-generational value

Capabilities unveiled. The role of ordinary activities in the evolution of product development processes.

In contrast to the prevailing interpretation of capabilities as collectives, this inductive study of product development in a leading design firm highlights the centrality of the myriad ordinary activities that may shape the evolution of capabilities. A detailed comparison of 90 diverse product development processes over a 15-year period shows, first, that mindful microactivities carried out by individuals in and around the organization and at all levels of the organizational hierarchy are central in shaping the content of the product development capability and its dynamic adaptation. Understanding organizational renewal and competitive advantage may hence require a partial shift in focus from capabilities as aggregate entities, to the practical realities of core organizational processes. Second, this more fine-grained perspective leads to a set of insights on how organizational renewal may be partially shaped by timely managerial interventions aimed at encoding successful experiments into higher-level organizational capabilities. Third, higher-level capabilities resulting from the conversion of heterogeneous experiences display higher process homogeneity and a permanent increase in performance, because of stabilization of managerial attention. My findings contribute to unveiling the concept of capabilities, extending prior research on dynamic capabilities and organizational renewal and providing a lens for research on the microfoundations of capability evolution and organizational advantage

Quali fattori influenzano la probabilità di diventare imprenditore?

Sebbene un’opportunità imprenditoriale possa esistere come fenomeno oggettivo, un individuo o un’impresa sono nelle condizioni di coglierla e concretizzarla solo dopo averne riconosciuta l’esistenza e il valore. Le opportunità imprenditoriali sono però il frutto di asimmetrie nelle convinzioni degli individui e delle organizzazioni, che generano il differenziale nella percezione del valore delle risorse che determina l’esistenza dell’opportunità stessa. Ne consegue che in un dato istante temporale non tutte le opportunità imprenditoriali sono note a ciascuno degli agenti economici operanti nel sistema socio-economico