Method and apparatus for controllably heating fluid Patent

Using heat control unit to preheat circulating flui

Bringing Comfort to the Enemy: The Past, Present, and Future of Habeas Corpus Petitions in Light of the Formalistic Application of Boumediene

Such trials would hamper the war effort and bring aid and comfort to the enemy. effective fettering of a field commander than to allow the very enemies he is ordered to reduce to submission to call him to account in his own civil courts and divert his efforts and attention from the military offensive abroad to the legal defensive at home. Nor is it unlikely that the result of such enemy litigiousness would be a conflict between judicial and military opinion highly comforting to enemies of the United States.(1

Bringing Comfort to the Enemy: The Past, Present, and Future of Habeas Corpus Petitions in Light of the Formalistic Application of Boumediene

Such trials would hamper the war effort and bring aid and comfort to the enemy. effective fettering of a field commander than to allow the very enemies he is ordered to reduce to submission to call him to account in his own civil courts and divert his efforts and attention from the military offensive abroad to the legal defensive at home. Nor is it unlikely that the result of such enemy litigiousness would be a conflict between judicial and military opinion highly comforting to enemies of the United States.(1

Aspects of International Law Affecting the Naval Commander

The subject assigned for this lecture The Aspects of In­ternational Law affecting the Naval Commander is one particu­larly cogent to the members of this audience. Particularly im­portant because each of you, during periods of foreign duty, may expect to encounter problems of International Law and encounter them, not in a detached academic sort of a way, but directly-face to face-as it were

Exploring the Role of Selenocysteine Biosynthesis Enzyme SEPHS2 in Cancer

Selenium is a micronutrient that is used by the selenocysteine biosynthesis pathway to produce the amino acid selenocysteine, which is required in selenoproteins. Many of the 25 human selenoproteins, such as glutathione peroxidases and thioredoxin reductases, play important roles in maintaining cellular redox homeostasis. In this study we characterize how this metabolic pathway is upregulated in cancer cells and how this increase in activity creates a unique vulnerability. We have outlined the evidence and underlying mechanisms for how many metabolites normally produced in cells are highly toxic, and we describe this concept as illustrated in selenocysteine metabolism. My thesis explores how SEPHS2, an enzyme in the selenocysteine biosynthesis pathway, is essential for survival of cancer, but not normal cells. SEPHS2 is required in cancer cells to detoxify selenide, an intermediate that is formed during selenocysteine biosynthesis. Breast and other cancer cells are selenophilic, owing to a secondary function of the cystine/glutamate antiporter SLC7A11 that promotes selenium uptake and selenocysteine biosynthesis, which, by allowing production of selenoproteins such as GPX4, protects cells against ferroptosis. However, this activity also becomes a liability for cancer cells because selenide is poisonous and must be processed by SEPHS2. These results show that SEPHS2 is a cancer specific target and indicates the therapeutic potential of SEPHS2 inhibition in the treatment of cancer. Collectively, this thesis identifies SEPHS2 as a targetable vulnerability of cancer cells, defines the role of selenium metabolism in cancer, and outlines a roadmap for future studies regarding toxic metabolites and cancer

Is There a Policy That Reduces Mass Public Shooting Deaths?

The fact that an individual is willing to commit the most serious crime that carries with it the most serious punishment means that that person is unlikely to be deterred by laws with less serious consequences. This situation is compounded by the fact that many multiple victim public shooters are expecting, even planning, to die in the commission of their crimes. Combining newly developed and traditional difference-in-differences methodologies, we analyze several policies that have been suggested as possibly effective in reducing deaths due to mass public shootings. We find that none of the proposed policies significantly reduce such deaths. However, we find evidence that mass public shooting deaths are lower in places that allow the carrying of concealed firearms

The Effectiveness of Measures to Increase Appellate Court Efficiency and Decision Output

This Article will examine the effectiveness of measures commonly employed to increase appellate court productivity. Part I of the Article sets forth some common design problems and explains how the research technique employed in the present study avoids these problems by using a multiple time-series research design. Part II applies this design to state court data. Part II also describes the dependent variable, the number of appeals decided per judge, used in the regression analysis. Part III discusses the results of that analysis-the impact of each change listed above on judicial productivity. The Article, although not advocating the adoption of the discussed efficiency measures, concludes that the failure to enact any type of efficiency measure will cause appellate courts to fall behind in the handling of their caseloads