COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Géodynamique andine : résumés étendus = Andean geodynamics : extended abstracts

Un échantillonnage paléomagnétique détaillé (100 sites) de la marge nord-chilienne entre 22 et 26°S montre des rotations horaires variables pouvant atteindre 60° localement. Ces rotations ne sont pas limitées à l'arc mésozoïque mais sont aussi enregistrées par les formations paléogènes. Notre étude montre l'importance des rotations dans les processus tectoniques au cours du Tertiaire. (Résumé d'auteur

Newcastle disease virus f glycoprotein expressed from a recombinant vaccinia virus vector protects chickens against live-virus challenge

Chickens were immunised using a vaccinia recombinant virus (vaccinia-Italien-F), expressing the F protein of Newcastle disease virus (NDV). Immunisation was successful using either TK cells infected with the vaccinia-Italien-F virus, the recombinant virus grown in tk cells and inoculated intra-cerebrally in one-day-old chickens or the recombinant virus given by wing-web to adult chickens after adaptation by alternate passage in chick embryo fibroblasts and chickens. The use of recombinant viruses expressing the F protein of NDV as vaccines would allow joint application of vaccination and eradication programmes for NDV. Therefore, recombinant viruses obtained in chickens virus vectors are needed. © 1988, Taylor & Francis Group, LLC. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Evaluation of the use of monoclonal antibodies to hemagglutinin and fusion glycoproteins of Newcastle disease virus for virus identification and strain differentiation purposes

Monoclonal antibodies detect evident antigenic variations in NDV HN and F protein. However, the A/PMV-1 viruses can be identified by HI test using a preparation made of the combination of two different monoclonals. A primary evaluation of the pathogenicity of the isolated viruses can be made by HI test using monoclonal antibodies but needs always confirmation using conventional pathogenicity tests. © 1987 Springer-Verlag.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Antigenic and biological characterization of avian paramyxovirus type 1 isolates from pigeons

21 A/PMV-1 viruses were isolated from pigeons and characterized using polyclonal and monoclonal antisera in hemagglutination inhibition, sero-neutralization and immunoprecipitation studies. Polyclonal and monoclonal antibodies directed against the HN and F proteins of Italien virus reacted with all pigeon isolates showing a close relationship between chicken velogenic and pigeon viruses. Differences in the M.W. of F0, P and M proteins were however observed between pigeon and chicken Italien virus. Marked differences in virulence were recorded among pigeon isolates; these were reflected by great variation in the IVPI of the different strains. © 1986 Springer-Verlag.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Protective Effects Of Hn And F Glycoprotein-Specific Monoclonal Antibodies On Experimental Newcastle Disease

Monoclonal antibodies directed against two different epitopes of HN protein of NDV Italien neutralised this virus in both in vitro and in vivo tests. Moreover, the combination of these two HN monoclonal antibodies neutralised the Italien virus synergistically. Five monoclonal antibodies directed against the F protein of NDV had variable neutralising activity against NDV Italien. Passive protection afforded by some anti F monoclonal antibodies was higher than that observed with the combination of the two HN monoclonal antibodies and even equivalent or better than that obtained with rabbit polyclonal antiserum. The importance of the F protein in the immune response against NDV is demonstrated. © 1986, Taylor & Francis Group, LLC. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Opsonization of Toxoplasma gondii tachyzoites with nonspecific immunoglobulins promotes their phagocytosis by macrophages and inhibits their proliferation in nonphagocytic cells in tissue culture.

We have recently shown that Toxoplasma gondii tachyzoites grown in in vitro culture can bind unspecific immunoglobulin (Ig) through their Fc moiety. We show now that Fc receptors are also present on T. gondii within the host animal, and that intraperitoneal parasites in immunocompetent mice are saturated with unspecific Ig. We have also investigated the effect of the parasite's Fc receptor on the interaction of tachyzoites with mammalian cells, using the Vero cell line as a model for nonphagocytic host cells and murine peritoneal macrophages in primary culture as a model for phagocytic cells. Coating of tachyzoites with parasite-unrelated Ig did not enhance their invasive capacity in either target cell type, but slightly decreased the parasite proliferation. Moreover, phagocytosis by macrophages was increased by approximately 50% when parasites were coated with unspecific Ig. These results indicate that the Fc receptor on T. gondii affects the balance between invasion and phagocytosis in a way that is detrimental to the parasites.Comparative StudyJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Thoracoscopy in oesophagectomy for oesophageal cancer

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Histochemical and biochemical characteristics of four major muscles of the ham

International audienceReduction of salt content in processed food is an important issue for both human nutrition and industry. Ham is composed of different muscles and the impact of salt reduction on each of them is unknown. To analyze and understand the effect of salting on the evolution of ham, it is essential to know the characteristics of muscles before applying any technological treatment. Muscles semi-membranosus, biceps femoris, rectus femoris and gluteus medius were selected on their physiological differences. These muscles were finely characterized in their structure and biochemical composition. Each muscle was then cured and cooked with two brines, which brought respectively 1.3% and 1.8% of sodium chloride in the meat. Cooking yield was determined. Significant differences were observed between muscles for physical, biochemical or histological parameters of non-cured muscles and between muscles and salt contents for cooking yield. Thus, muscle characteristics have to be taken into account in any study on the optimization of salting meat

Histochemical and biochemical characteristics of four major muscles of the ham

International audienceReduction of salt content in processed food is an important issue for both human nutrition and industry. Ham is composed of different muscles and the impact of salt reduction on each of them is unknown. To analyze and understand the effect of salting on the evolution of ham, it is essential to know the characteristics of muscles before applying any technological treatment. Muscles semi-membranosus, biceps femoris, rectus femoris and gluteus medius were selected on their physiological differences. These muscles were finely characterized in their structure and biochemical composition. Each muscle was then cured and cooked with two brines, which brought respectively 1.3% and 1.8% of sodium chloride in the meat. Cooking yield was determined. Significant differences were observed between muscles for physical, biochemical or histological parameters of non-cured muscles and between muscles and salt contents for cooking yield. Thus, muscle characteristics have to be taken into account in any study on the optimization of salting meat