Infrared Imaging of Capella with the IOTA Closure Phase Interferometer

We present infrared aperture synthesis maps produced with the upgraded IOTA interferometer. Michelson interferograms on the close binary system Capella (Alpha Aur) were obtained in the H-band between 2002 November 12 and 16 using the IONIC3 beam combiner. With baselines of 15m < B < 38m, we were able to determine the relative position of the binary components with milliarcsecond (mas) precision and to track their movement along the approx. 14 degree arc covered by our observation run. We briefly describe the algorithms used for visibility and closure phase estimation. Three different Hybrid Mapping and Bispectrum Fitting techniques were implemented within one software framework and used to reconstruct the source brightness distribution. By dividing our data into subsets, the system could be mapped at three epochs, revealing the motion of the stars. The precise position of the binary components was also determined with model fits, which in addition revealed I_Aa/I_Ab=1.49 +/- 0.10 and apparent stellar uniform-disk (UD) diameters of Theta_Aa=8.9 +/- 0.6 mas and Theta_Ab=5.8 +/- 0.8 mas. To improve the u, v-plane coverage, we compensated this orbital motion by applying a rotation-compensating coordinate transformation. The resulting model-independent map with a beam size of 5.4 x 2.6 mas allows the resolution of the stellar surfaces of the Capella giants themselves.Comment: Accepted by the Astronomical Journal (2005-03-21

Spatial Resolution of a Micromegas-TPC Using the Charge Dispersion Signal

The Time Projection Chamber (TPC) for the International Linear Collider will need to measure about 200 track points with a resolution close to 100 $\mu$m. A Micro Pattern Gas Detector (MPGD) readout TPC could achieve the desired resolution with existing techniques using sub-millimeter width pads at the expense of a large increase in the detector cost and complexity. We have recently applied a new MPGD readout concept of charge dispersion to a prototype GEM-TPC and demonstrated the feasibility of achieving good resolution with pads similar in width to the ones used for the proportional wire TPC. The charge dispersion studies were repeated with a Micromegas TPC amplification stage. We present here our first results on the Micromegas-TPC resolution with charge dispersion. The TPC resolution with the Micromegas readout is compared to our earlier GEM results and to the resolution expected from electron statistics and transverse diffusion in a gaseous TPC.Comment: 5 pages, 8 figures, to appar in the Proceedings of the 2005 International Linear Collider Workshop (LCWS05), Stanford, 18-22 March 200

Vascular endothelial growth factor in premenopausal women--indicator of the best time for breast cancer surgery?

Timing of surgery in premenopausal patients with breast cancer remains controversial. Angiogenesis is essential for tumour growth and vascular endothelial growth factor (VEGF) is one of the most potent angiogenic cytokines. We aimed to determine whether the study of VEGF in relation to the menstrual cycle could help further the understanding of this issue of surgical intervention. Fourteen premenopausal women were recruited, along with three post-menopausal women, a woman on an oral contraceptive pill and a single male subject. Between eight and 11 samples were taken per person, over one menstrual cycle (over 1 month in the five controls) and analysed for sex hormones and VEGF165. Serum VEGF was significantly lower in the luteal phase and showed a significant negative correlation with progesterone in all 14 premenopausal women. No inter-sample variations of VEGF were noted in the controls. Serum from both phases of the cycle from one subject was added to MCF-7 breast cancer cells; VEGF expression in the supernatant was lower in the cells to which the luteal phase serum was added. The lowering of a potent angiogenic cytokine in the luteal phase suggests a possible decreased potential for micrometastasis establishment in that phase. This fall in VEGF may be an effect of progesterone and should be the focus of future studies

Mechanisms Underlying the Rapid Induction and Sustained Expression of Synaptic Homeostasis

SummaryHomeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic neurotransmitter release can be induced within minutes following postsynaptic glutamate receptor blockade. The rapid induction of synaptic homeostasis is independent of new protein synthesis and does not require evoked neurotransmission, indicating that a change in the efficacy of spontaneous quantal release events is sufficient to trigger the induction of synaptic homeostasis. Finally, both the rapid induction and the sustained expression of synaptic homeostasis are blocked by mutations that disrupt the pore-forming subunit of the presynaptic CaV2.1 calcium channel encoded by cacophony. These data confirm the presynaptic expression of synaptic homeostasis and implicate presynaptic CaV2.1 in a homeostatic retrograde signaling system

First astronomical unit scale image of the GW Ori triple. Direct detection of a new stellar companion

Young and close multiple systems are unique laboratories to probe the initial dynamical interactions between forming stellar systems and their dust and gas environment. Their study is a key building block to understanding the high frequency of main-sequence multiple systems. However, the number of detected spectroscopic young multiple systems that allow dynamical studies is limited. GW Orionis is one such system. It is one of the brightest young T Tauri stars and is surrounded by a massive disk. Our goal is to probe the GW Orionis multiplicity at angular scales at which we can spatially resolve the orbit. We used the IOTA/IONIC3 interferometer to probe the environment of GW Orionis with an astronomical unit resolution in 2003, 2004, and 2005. By measuring squared visibilities and closure phases with a good UV coverage we carry out the first image reconstruction of GW Ori from infrared long-baseline interferometry. We obtain the first infrared image of a T Tauri multiple system with astronomical unit resolution. We show that GW Orionis is a triple system, resolve for the first time the previously known inner pair (separation $\rho\sim$1.4 AU) and reveal a new more distant component (GW Ori C) with a projected separation of $\sim$8 AU with direct evidence of motion. Furthermore, the nearly equal (2:1) H-band flux ratio of the inner components suggests that either GW Ori B is undergoing a preferential accretion event that increases its disk luminosity or that the estimate of the masses has to be revisited in favour of a more equal mass-ratio system that is seen at lower inclination. Accretion disk models of GW Ori will need to be completely reconsidered because of this outer companion C and the unexpected brightness of companion B.Comment: 5 pages, 9 figures, accepted Astronomy and Astrophysics Letters. 201

SMART precision interferometry at 794 nm

Single-mode fibers have been used in the near-infrared to dramatically reduce calibration error for long-baseline interferometry. We have begun an effort to apply the advantages of spatial filtering at visible wavelengths for precision measurements of pulsating Cepheids using the IOTA interferometer. Rather than employing photometric taps to calibrate fluctuating coupling efficiency, we are using an "asymmetric" coupler which allows this calibration to be done without losing photons. The Single-Mode Asymmetric Recombination Technique (SMART) experiment has finished lab-testing, and has been installed at IOTA for full commissioning in Summer 2002. We report the results of lab characterization and first sky tests, as well as first fringes on a star using a visible-wavelength single-mode coupler. With both lab and sky experience using unpolarized light, we have found that circular silica fibers are quite practical for precision interferometric measurements. We conclude that circular fibers (as opposed to polarization maintaining fibers) have an undeserved poor reputation and that birefringence effects pose no significant difficulty

Physical Orbit for Lambda Virginis and a Test of Stellar Evolution Models

Lambda Virginis (LamVir) is a well-known double-lined spectroscopic Am binary with the interesting property that both stars are very similar in abundance but one is sharp-lined and the other is broad-lined. We present combined interferometric and spectroscopic studies of LamVir. The small scale of the LamVir orbit (~20 mas) is well resolved by the Infrared Optical Telescope Array (IOTA), allowing us to determine its elements as well as the physical properties of the components to high accuracy. The masses of the two stars are determined to be 1.897 Msun and 1.721 Msun, with 0.7% and 1.5% errors respectively, and the two stars are found to have the same temperature of 8280 +/- 200 K. The accurately determined properties of LamVir allow comparisons between observations and current stellar evolution models, and reasonable matches are found. The best-fit stellar model gives LamVir a subsolar metallicity of Z=0.0097, and an age of 935 Myr. The orbital and physical parameters of LamVir also allow us to study its tidal evolution time scales and status. Although currently atomic diffusion is considered to be the most plausible cause of the Am phenomenon, the issue is still being actively debated in the literature. With the present study of the properties and evolutionary status of LamVir, this system is an ideal candidate for further detailed abundance analyses that might shed more light on the source of the chemical anomalies in these A stars.Comment: 43 Pages, 13 figures. Accepted for publication in Ap

An examination of the precipitation delivery mechanisms for Dolleman Island, eastern Antarctic Peninsula

Copyright @ 2004 Wiley-BlackwellThe variability of size and source of significant precipitation events were studied at an Antarctic ice core drilling site: Dolleman Island (DI), located on the eastern coast of the Antarctic Peninsula. Significant precipitation events that occur at DI were temporally located in the European Centre for Medium-Range Weather Forecasting (ECMWF) reanalysis data set, ERA-40. The annual and summer precipitation totals from ERA-40 at DI both show significant increases over the reanalysis period. Three-dimensional backwards air parcel trajectories were then run for 5 d using the ECMWF ERA-15 wind fields. Cluster analyses were performed on two sets of these backwards trajectories: all days in the range 1979–1992 (the climatological time-scale) and a subset of days when a significant precipitation event occurred. The principal air mass sources and delivery mechanisms were found to be the Weddell Sea via lee cyclogenesis, the South Atlantic when there was a weak circumpolar trough (CPT) and the South Pacific when the CPT was deep. The occurrence of precipitation bearing air masses arriving via a strong CPT was found to have a significant correlation with the southern annular mode (SAM); however, the arrival of air masses from the same region over the climatological time-scale showed no such correlation. Despite the dominance in both groups of back trajectories of the westerly circulation around Antarctica, some other key patterns were identified. Most notably there was a higher frequency of lee cyclogenesis events in the significant precipitation trajectories compared to the climatological time-scale. There was also a tendency for precipitation trajectories to come from more northerly latitudes, mostly from 50–70°S. The El Niño Southern Oscillation (ENSO) was found to have a strong influence on the mechanism by which the precipitation was delivered; the frequency of occurrence of precipitation from the east (west) of DI increased during El Niño (La Niña) events

Characterizing closure-phase measurements at IOTA

We are working towards imaging the surfaces and circumstellar envelopes of Mira stars in the near-infrared, using the IOTA interferometer and the IONIC integrated-optics 3-beam combiner. In order to study atmospheric structures of these stars, we installed 3 narrow-band filters that subdivide H-band into 3 roughly equal-width sub-bands - a central one for continuum, and 2 adjacent ones to sample Mira star's (mostly water) absorption-bands. We present here our characterization of the IOTA 3-Telescope interferometer for closure-phase measurements with broad and narrow-band filters in the H atmospheric window. This includes characterizing the stability, chromaticity, and polarization effects of the present IOTA optics with the IONIC beam-combiner, and characterizing the accuracy of our closure phase measurements