Magnetohydrodynamics predicts heavy-tailed distributions of axion-photon conversion

The interconversion of axionlike particles (ALPs) and photons in magnetised astrophysical environments provides a promising route to search for ALPs. The strongest limits to date on light ALPs use galaxy clusters as ALP-photon converters. However, such studies traditionally rely on simple models of the cluster magnetic fields, with the state-of-the-art being Gaussian random fields (GRFs). We present the first systematic study of ALP-photon conversion in more realistic, turbulent fields from dedicated magnetohydrodynamic (MHD) simulations, which we compare with GRF models. For GRFs, we analytically derive the distribution of conversion ratios at fixed energy and find that it follows an exponential law. We find that the MHD models agree with the exponential law for typical, small-amplitude mixings but exhibit distinctly heavy tails for rare and large mixings. We explain how non-Gaussian features, e.g.~coherent structures and local spikes in the MHD magnetic field, are responsible for the heavy tail. Our results suggest that limits placed on ALPs using GRFs are robust.Comment: 18 pages, 9 figures. v2: major changes to match the published version. Extended appendix to include details on the statistical analysi

Investigating the gamma-ray burst from decaying MeV-scale axion-like particles produced in supernova explosions

We investigate the characteristics of the gamma-ray signal following the decay of MeV-scale Axion-Like Particles (ALPs) coupled to photons which are produced in a Supernova (SN) explosion. This analysis is the first to include the production of heavier ALPs through the photon coalescence process, enlarging the mass range of ALPs that could be observed in this way and giving a stronger bound from the observation of SN 1987A. Furthermore, we present a new analytical method for calculating the predicted gamma-ray signal from ALP decays. With this method we can rigorously prove the validity of an approximation that has been used in some of the previous literature, which we show here to be valid only if all gamma rays arrive under extremely small observation angles (i.e. very close to the line of sight to the SN). However, it also shows where the approximation is not valid, and offers an efficient alternative to calculate the ALP-induced gamma-ray flux in a general setting when the observation angles are not guaranteed to be small. We also estimate the sensitivity of the Fermi Large Area Telescope (Fermi-LAT) to this gamma-ray signal from a future nearby SN and show that in the case of a non-observation the current bounds on the ALP-photon coupling $g_{a\gamma}$ are strengthened by about an order of magnitude. In the case of an observation, we show that it may be possible to reconstruct the product $g_{a\gamma}^2 m_a$, with $m_a$ the mass of the ALP.Comment: 28 pages, 9 figure

Costimulatory Molecules and Immune Checkpoints Are Differentially Expressed on Different Subsets of Dendritic Cells

Dendritic cells (DCs) play a crucial role in initiating and shaping immune responses. The effects of DCs on adaptive immune responses depend partly on functional specialization of distinct DC subsets, and partly on the activation state of DCs, which is largely dictated by environmental signals. Fully activated immunostimulatory DCs express high levels of costimulatory molecules, produce pro-inflammatory cytokines, and stimulate T cell proliferation, whereas tolerogenic DCs express low levels of costimulatory molecules, produce immunomodulatory cytokines and impair T cell proliferation. Relevant to the increasing use of immune checkpoint blockade in cancer treatment, signals generated from inhibitory checkpoint molecules on DC surface may also contribute to the inhibitory properties of tolerogenic DCs. Yet, our knowledge on the expression of inhibitory molecules on human DC subsets is fragmentary. Therefore, in this study, we investigated the expression of three immune checkpoints on peripheral blood DC subsets, in basal conditions and upon exposure to pro-inflammatory and anti-inflammatory stimuli, by using a flow cytometric panel that allows a direct comparison of the activatory/inhibitory phenotype of DC-lineage and inflammatory DC subsets. We demonstrated that functionally distinct DC subsets are characterized by differential expression of activatory and inhibitory molecules, and that cDC1s in particular are endowed with a unique immune checkpoint repertoire characterized by high TIM-3 expression, scarce PD-L1 expression and lack of ILT2. Notably, this unique cDC1 repertoire was subverted in a group of patients with myelodysplastic syndromes included in the study. Applied to the characterization of DCs in the tumor microenvironment, this panel has the potential to provide valuable information to be used for investigating the role of DC subsets in cancer, guiding DC-targeting treatments, and possibly identifying predictive biomarkers for clinical response to cancer immunotherapy

‘Can you dig it?’ Developing an approach to validly assessing diverse skills in an archaeological context

This paper outlines a case study of an assessment development process which contrasts with more recent ‘top-down’ trends in assessment which tend to leave assessment development processes opaque to users. This paper describes the processes of a collaborative, multi-agency project which set out to develop an assessment framework which would appropriately recognise the various skills present in the Higher Education Field Academy; a widening participation programme aiming to boost the educational aspirations, enthusiasm and attainment of secondary school students through their engagement in archaeological excavation. The case study describes the stages of building an assessment framework that was sympathetic to the intentions of a learning programme whilst providing robust observation-based outcomes that avoided heavy assessment processes that could corrupt learning relationships. The challenges involved in this development process have important parallels with vocational assessment; not least in providing an example of a localised development of an observation-based assessment model which can be used in diverse settings. The insights gained from this case study are useful for others who are engaged in localised assessment development processes

Feebly-interacting particles: FIPs 2022 Workshop Report

Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs

Feebly Interacting Particles: FIPs 2022 workshop report

Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs

Feebly-interacting particles: FIPs 2022 workshop report

Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs

Feebly-interacting particles: FIPs 2022 workshop report

Particle physics today faces the challenge of explaining the mystery of dark matter, the origin of matter over anti-matter in the Universe, the origin of the neutrino masses, the apparent fine-tuning of the electro-weak scale, and many other aspects of fundamental physics. Perhaps the most striking frontier to emerge in the search for answers involves new physics at mass scales comparable to familiar matter, below the GeV-scale, or even radically below, down to sub-eV scales, and with very feeble interaction strength. New theoretical ideas to address dark matter and other fundamental questions predict such feebly interacting particles (FIPs) at these scales, and indeed, existing data provide numerous hints for such possibility. A vibrant experimental program to discover such physics is under way, guided by a systematic theoretical approach firmly grounded on the underlying principles of the Standard Model. This document represents the report of the FIPs 2022 workshop, held at CERN between the 17 and 21 October 2022 and aims to give an overview of these efforts, their motivations, and the decadal goals that animate the community involved in the search for FIPs

Radiation-induced graft copolymerization of hydrophilic monomers onto polyphosphazenes

Grafting of N-vinyl-2-pyrrolidone onto poly|(trifluoroethoxy)phosphazenel and poly |bis (phenoxy)phosphazenel | films was carried out by direct irradiation at 0.5 Gy/s and 20\ub0C, using different monomer/methanol mixtures. The grafting reaction kinetics was followed. The improvement of biocompatibility produced by grafting N-vinyl-2-pyrrolidone onto the two polyphosphazenes was evaluated by means of \u201cin vivo\u201d tests