151 research outputs found
Biochemical approaches on commercial strains of Agaricus subrufescens growing under two environmental cultivation conditions
In the present work, the effect of the cultivation process, in the field and under a con- trolled environment, on biochemical parameters by using commercial strains of A. subrufescens were evaluated. The results obtained revealed that the strains cultivated in the field presented higher levels for most of the parameters evaluated (organic acids (20.5–48.0 g/100 g dw), tocopherols (107.0–198.6 μg/100 g dw), and phenolic acids and related compounds (245.2–359.0 μg/100 g dw and 10.6–23.7 μg/100 g dw, respectively)), except for the carbohydrates (53.4–72.6 g/100 g dw), energetic value (373–380 Kcal/100 g dw), and total free sugars (28.8–43.1 g/100 g dw), parameters in which the strains grown in a controlled environment present better results. For both cultivation systems, similar results were obtained regarding saturated, monounsaturated, and polyunsaturated fatty acids, as well as antioxidant and antimicrobial activities. These data contribute to the knowledge and highlight the characterized strains and the cultivation process, which can be used to obtain ingredients with potential applicability as a source of functional compounds.This research was funded by the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP no. 19/00419-8 and 2018/21492-2). The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020); national funding by FCT, P.I., through the institutional scientific employment program-contract for A.F., C.P. and L.B. contracts. This work is funded by the European Structural and Investment Funds (FEEI) through the Regional Operational Program North 2020, within the scope of Project Mobilizador ValorNatural®.info:eu-repo/semantics/publishedVersio
mHealth in urology
Introduction: Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps) have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with the aim of assessing the level of participation of healthcare professionals (HCP) and scientific Urology associations in their development. Material and Methods: A systematic search was performed on PubMed, Apple's App Store and Google's Play Store, for Urology apps, available in English. Apps were reviewed by three graders to determine the app's platform, target customer, developer, app type, app category, price and the participation of a HCP or a scientific Urology association in the development. Results: The search yielded 372 apps, of which 150 were specific for Urology. A fifth of all apps had no HCP involvement (20.7%) and only a third had been developed with a scientific Urology association (34.7%). The lowest percentage of HCP (13.4%) and urological association (1.9%) involvement was in apps designed for the general population. Furthermore, there was no contribution from an Urology society in "Electronic Medical Record" nor in "Patient Information" apps. A limitation of the study is that only Android and iOS apps were reviewed. Conclusions: Despite the increasing Mobile Health (mHealth) market, this is the first study that demonstrates the lack of expert participation in the design of Urology apps, particularly in apps designed for the general public. Until clear regulation is enforced, the urological community should help regulate app development. Maintaining a register of certified apps or issuing an official scientific seal of approval could improve overall app quality. We propose that urologists become stakeholders in mHealth, shaping future app design and promoting peer-review app validation
Controle da ferrugem da folha do trigo (Puccinia triticina) em diferentes momentos de aplicação de fungicida
Concept of temperature in multi-horizon spacetimes: Analysis of Schwarzschild-De Sitter metric
In case of spacetimes with single horizon, there exist several
well-established procedures for relating the surface gravity of the horizon to
a thermodynamic temperature. Such procedures, however, cannot be extended in a
straightforward manner when a spacetime has multiple horizons. In particular,
it is not clear whether there exists a notion of global temperature
characterizing the multi-horizon spacetimes. We examine the conditions under
which a global temperature can exist for a spacetime with two horizons using
the example of Schwarzschild-De Sitter (SDS) spacetime. We systematically
extend different procedures (like the expectation value of stress tensor,
response of particle detectors, periodicity in the Euclidean time etc.) for
identifying a temperature in the case of spacetimes with single horizon to the
SDS spacetime. This analysis is facilitated by using a global coordinate chart
which covers the entire SDS manifold. We find that all the procedures lead to a
consistent picture characterized by the following features: (a) In general, SDS
spacetime behaves like a non-equilibrium system characterized by two
temperatures. (b) It is not possible to associate a global temperature with SDS
spacetime except when the ratio of the two surface gravities is rational (c)
Even when the ratio of the two surface gravities is rational, the thermal
nature depends on the coordinate chart used. There exists a global coordinate
chart in which there is global equilibrium temperature while there exist other
charts in which SDS behaves as though it has two different temperatures. The
coordinate dependence of the thermal nature is reminiscent of the flat
spacetime in Minkowski and Rindler coordinate charts. The implications are
discussed.Comment: 12 page
Changes in selected haematological parameters associated with JAK1/JAK2 inhibition observed in patients with rheumatoid arthritis treated with baricitinib
Objective To characterise changes in selected haematological parameters following once-daily oral baricitinib dosing.Methods Data were pooled from eight randomised clinical trials (four phase 3, three phase 2, one phase 1b) and one long-term extension. Changes in haematological parameters were evaluated up to 128 weeks (N=2387); overall safety of baricitinib was assessed up to 6 years (N=3492).Results Mean absolute neutrophil counts decreased (-1.36x10(9)/L) within 1 month, followed by stabilisation within the normal reference range through week 128. The incidence of serious infections was not elevated in patients with neutropenia during the 24-week placebo-controlled period. Mean lymphocyte counts increased (+0.30x10(9)/L) within 1 month, then decreased to baseline (weeks 12-24). Mean platelet counts increased at week 2 (+51x10(9)/L), then decreased towards baseline. Overall, mean haemoglobin concentrations decreased (-0.12 mmol/L), then returned to baseline; however, reduced baseline haemoglobin concentrations observed in the highest baseline high-sensitivity C reactive protein quartile increased over time. Permanent drug discontinuation occurred due to laboratory abnormalities related to neutrophil count in 8 (0.2%), lymphocyte counts in 6 (0.2%), platelet counts in 8 (0.2%), and haemoglobin levels in 16 (0.5%) of all baricitinib-treated patients (N=3492 with 7993 total person-years of exposure).Conclusions Moderate decreases in neutrophils were seen during baricitinib treatment; however, serious infection was uncommon in patients with neutropenia. Transient increases were observed in lymphocytes and platelets, which returned to baseline over time. Changes in haemoglobin concentration were generally small. Haematological abnormalities seldom led to drug discontinuation.Pathophysiology and treatment of rheumatic disease
Butterflies (Lepidoptera: Papilionoidea and Hesperioidea) of the Parque EcolĂłgico JoĂŁo Vasconcelos Sobrinho, Caruaru, Pernambuco, Brazil
270MO An international update of the EORTC questionnaire for assessing quality of life in breast cancer patients: Results of the validation study phase IV EORTC QLQ-BR42
Mensuração do tamanho cardĂaco pelo mĂ©todo VHS (vertebral heart size) em cĂŁes sadios da raça American pit bull terrier
Aplicação aérea de fungicidas com diferentes equipamentos e volumes sobre a produtividade, qualidade de grãos e controle de doenças em arroz irrigado
- …