Campanha “Seu caminho”: Peças de comunicação para a marca Teagah

PCC(graduação) - Universidade Federal de Santa Catarina. Centro de Comunicação e Expressão. Design.Considerando a dificuldade existente para uma marca de roupas iniciante se destacar e se estabelecer no mercado, este projeto de conclusão de curso teve como objetivo desenvolver seis peças de comunicação de moda, que traduzam o conceito da marca, para postagem nas redes sociais. O cliente para qual este projeto foi desenvolvido foi a Teagah, uma marca iniciante de roupas streetwear, e a qual ainda não está consolidada no mercado. O desenvolvimento se deu através da união das metodologias Design Thinking e de Frascara, juntamente à técnicas do Design 3D, como a modelagem de roupas e cenários, além da aplicação de físicas reais ao modelo. Além disso, adicionou-se características de ambientação, texturização, iluminação e câmera mais realistas, para assim criar uma maior imersão do público alvo, a fim de captá-lo por este diferencial, que segue padrões de tendências do mercado, já exercidas pelas grandes marcas, dos mais diversos segmentos para além da moda. Com essas etapas, se alcançou os objetivos estabelecidos neste projeto e desenvolveu-se uma animação, que foi utilizada como peça principal, e mais cinco peças estáticas que a complementam.Considering the existing difficulty for a beginner clothing brand to stand out and establish itself in the market, this course conclusion project aimed to develop six pieces of fashion communication, which translate the brand's concept, for posting on social networks. The client for which this project was developed was Teagah, a new streetwear clothing brand, which is not yet consolidated in the market. The development took place through the union of Design Thinking and Frascara methodologies, together with 3D Design techniques, such as modeling clothes and scenarios, in addition to the application of real physics to the model. In addition, more realistic features of ambiance, texturing, lighting and camera were added, in order to create a greater immersion of the target audience, in order to capture it by this differential, which follows market trends standards, already exercised by the great brands, from the most diverse segments beyond fashion. With these steps, the objectives established in this project were achieved and an animation was developed, which was used as the main piece, and five more static pieces that complement it

Eficiência de uso de cobre em cultivares de soja

The objective of this work was to evaluate the effect of copper use efficiency in soybean cultivars, grown on a typical Ultisol with a high organic matter content, on soil chemical properties and on plant grain yield, nutritional state, and physiological components. The experiment was carried out in greenhouse conditions, in a 5×4 factorial arrangement, with five soybean cultivars (TMG 1066RR, BRS 360RR, NA 6262RR, BMX Turbo RR, and BRS 359RR) and four Cu rates (0, 2, 4, and 8 mg kg-1). Under the studied soil conditions, the DTPA-TEA and Mehlich-1 extractants were efficient in determining available Cu in the soil. Regardless of the cultivars, Cu application increased grain yield (GY), shoot dry weight yield (SDWY), number of pods per pot, GY/SDWY ratio, photosynthetic rate, stomatal conductance, internal CO2 concentration, transpiration rate, and chlorophyll content. However, Cu use efficiency varied significantly among the different soybean genotypes. Except for Cu, soil chemical attributes and foliar and grain nutrient contents are not influenced by Cu rates nor by soybean cultivars.O objetivo deste trabalho foi avaliar o efeito da eficiência do uso de cobre em cultivares de soja, cultivadas em Argissolo típico com alto teor de matéria orgânica, sobre os atributos químicos do solo e a produção de grãos, o estado nutricional e os componentes fisiológicos das plantas. O experimento foi realizado em condições de casa de vegetação, em arranjo fatorial 5×4, com cinco cultivares de soja (TMG 1066RR, BRS 360RR, NA 6262RR, BMX Turbo RR e BRS 359RR) e quatro doses de Cu (0, 2, 4 e 8 mg kg-1). Nas condições de solo estudadas, os extratores DTPA-TEA e Mehlich 1 foram eficientes na determinação do Cu disponível no solo. Independentemente das cultivares, a aplicação de cobre aumentou a produção de grãos (PG), a produção de massa seca da parte aérea (PMSPA), o número de vagens por vaso, a relação PG/PMSPA, a taxa fotossintética, a condutância estomática, a concentração interna de CO2, a taxa transpiratória e o teor de clorofila. No entanto, a eficiência do uso de Cu variou significativamente entre os diferentes genótipos de soja. Exceto para Cu, os atributos químicos do solo e os teores de nutrientes das folhas e dos grãos não são influenciados pelas doses de Cu nem pelas cultivares de soja

Evaluation of dispersive liquid–liquid microextraction in the stereoselective determination of cetirizine following the fungal biotransformation of hydroxyzine and analysis by capillary electrophoresis

AbstractWe developed a capillary electrophoresis (CE) and dispersive liquid–liquid microextraction (DLLME) method to stereoselectively analyze hydroxyzine (HZ) and cetirizine (CTZ) in liquid culture media. The CE analyses were performed on an uncoated fused-silica capillary; 50mmolL−1 sodium borate buffer (pH 9.0) containing 0.8% (w/v) S-β-CD was used as the background electrolyte. The applied voltage and temperature were +6kV and 15°C, respectively, and the UV detector was set to 214nm. Chloroform (300µL) and ethanol (400µL) were used as the extraction and disperser solvents, respectively, for the DLLME. Following the formation of a cloudy solution, the samples were subjected to vortex agitation at 2000rpm for 30s and to centrifugation at 3000rpm for 5min. The recoveries ranged from 87.4 to 91.7%. The method was linear over a concentration range of 250–12,500ngmL−1 for each HZ enantiomer (r>0.998) and 125–6250ngmL−1 for each CTZ enantiomer (r>0.998). The limits of quantification were 125 and 250ngmL−1 for CTZ and HZ, respectively. Among the six fungi studied, three species were able to convert HZ to CTZ enantioselectively, particularly the fungus Cunninghamella elegans ATCC 10028B, which converted 19% of (S)-HZ to (S)-CTZ with 65% enantiomeric excess

Infliximabe reduz débito cardíaco em pacientes com artrite reumatoide sem insuficiência cardíaca

OBJECTIVE: Human anti-tumor necrosis factor (TNF-α) monoclonal antibody (infliximab) is used to treat autoimmune diseases such as rheumatoid arthritis (RA). Although the risk of worsening heart failure has been described in patients under chronic treatment, the acute cardiovascular effects of this drug are unknown in RA patients without heart failure. METHODS: 14 RA patients with normal echocardiography and no history of heart failure were evaluated during the 2-hour infliximab (3-5 mg/kg) infusion period, using a noninvasive hemodynamic beat-to-beat system (Portapres). Stroke volume (SV); systolic, diastolic and mean blood pressures (SBP, DBP and MBP, respectively); cardiac output (CO); heart rate (HR); and total peripheral vascular resistance (PVR) were recorded. All patients also received saline infusion instead of infliximab as a control. Significant differences in hemodynamic parameters were determined using Tuckey's test. All values were expressed as mean ± standard deviation (SD). RESULTS: Fourteen RA patients (6M/8F) with mean age of 47.2 ± 8.8 years were evaluated. A significant decrease was found in cardiac output and stroke volume (7.04 ± 2.3 to 6.12 ± 2.1 l/min and 91 ± 29.0 to 83 ± 28.8 mL/beat, respectively) after infliximab infusion. Although not statistically significant, a progressive increase was detected in SBP, DBP and total PVR during infusion. Saline infusion did not cause significant hemodynamic changes in the same group of RA patients. No adverse effects were observed during the infusion period. CONCLUSION: Acute infliximab administration decreased cardiac output due to low stroke volume in RA patients without heart disease. The results also demonstrated that, in spite of its negative inotropic effect, infliximab enhanced BP, probably by increasing PVR.OBJETIVO: O inibidor de fator de necrose tumoral (TNF-α) infliximabe é usado no tratamento de doenças autoimunes como a artrite reumatoide (AR). Embora o risco de piora de insuficiência cardíaca em pacientes submetidos a tratamento crônico tenha sido descrito, os efeitos cardiovasculares agudos da infusão desta droga em pacientes com AR sem insuficiência cardíaca são desconhecidos. MÉTODOS: Pacientes com AR e ecocardiogramas normais e sem antecedentes de insuficiência cardíaca foram avaliados durante o período de infusão de infliximabe (3-5mg/kg), de 2 horas, utilizando um sistema de monitoramento hemodinâmico não invasivo batimento-a-batimento (Portapres). As variáveis avaliadas foram: volume sistólico (VS), pressão arterial sistólica, diastólica e média (PAS, PAD e PAM, respectivamente), débito cardíaco (DC), frequência cardíaca (FC) e resistência vascular periférica total (RVPT). Todos os voluntários também receberam infusão de soro fisiológico (SF) como estudo controle. Estatísticas foram avaliadas usando o teste de Tuckey. Os valores estão expressos em média ± desvio-padrão. RESULTADOS: Catorze pacientes (6M/8F), com idade média de 47,2 ± 8,8 anos, foram avaliados. Reduções significativas no débito cardíaco e volume sistólico foram encontradas após a infusão do infliximabe (7,04 ± 2,3 a 6,12 ± 2,1 L/min e 91 ± 29,0 a 83 ± 28,8 mL/batimento, respectivamente). Embora não estatisticamente significante, detectaram-se aumentos progressivos na PAS, PAD e RVPT durante a infusão. A infusão controle de SF não causou mudanças hemodinâmicas significativas nos pacientes estudados. Não foram observados efeitos adversos no período de infusão. CONCLUSÃO: A administração de infliximabe reduz agudamente o débito cardíaco devido a redução no volume sistólico em pacientes com AR sem insuficiência cardíaca. Nossos resultados mostram que, apesar do efeito inotrópico negativo, o infliximabe elevou a pressão arterial, provavelmente devido ao aumento na RVPT.698702Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES

Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate

The large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity in Wistar rats, indicating possible safety of this biofilm

Condutas iniciais na Síndrome Coronariana aguda e seu desfecho sobre os quadros de Taquiarritmias: uma revisão sistemática com metanálise: Initial conducts in acute Coronary Syndrome and its outcome on Tachyarrhythmia frames: a systematic review with meta-analysis

Este artigo tem por objetivo realizar uma revisão sistemática de literatura sobre condutas iniciais diante de um quadro síndrome coronariana aguda e seu impacto sobre quadros de taquiarritmias. Trata-se de uma revisão sistemática de literatura baseada em buscas nas bases de dados Biblioteca Virtual em Saúde – BVS, Google Acadêmico, Lilacs, Pubmed e Scientific Electronic Library Online – SciELO. A pesquisa utilizou-se dos seguintes descritores, segundo o DeCS, com seus correspondentes no idioma inglês e espanhol: Arritmias Cardíacas; Taquicardia; Síndrome Coronariana Aguda. Os principais resultados obtidos apontam que a síndrome coronariana aguda, um evento isquêmico do miocárdio, decorrente da hipoperfusão cardíaca, pode resultar em taquiarritmias supraventriculares (TSV) e ventriculares (TV), tendo seu desfecho clínico e prognóstico dependente do intervalo de tempo desde o início do evento e do tipo de taquiarritmia desencadeada. A partir disto, surge a questão sobre quais condutas iniciais tomadas diante de SCA minimizaria desfechos clínicos de taquiarritmias, a fim de garantir um manejo adequado e minimização da morbimortalidade

High anti-SARS-CoV-2 antibody seroconversion rates before the second wave in Manaus, Brazil, and the protective effect of social behaviour measures: results from the prospective DETECTCoV-19 cohort

Background: The city of Manaus, Brazil, has seen two collapses of the health system due to the COVID-19 pandemic. We report anti-SARS-CoV-2 nucleocapsid IgG antibody seroconversion rates and associated risk factors in Manaus residents before the second wave of the epidemic in Brazil. Methods: A convenience sample of adult (aged ≥18 years) residents of Manaus was recruited through online and university website advertising into the DETECTCoV-19 study cohort. The current analysis of seroconversion included a subgroup of DETECTCoV-19 participants who had at least two serum sample collections separated by at least 4 weeks between Aug 19 and Oct 2, 2020 (visit 1), and Oct 19 and Nov 27, 2020 (visit 2). Those who reported (or had no data on) having a COVID-19 diagnosis before visit 1, and who were positive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at visit 1 were excluded. Using an in-house ELISA, the reactivity index (RI; calculated as the optical density ratio of the sample to the negative control) for serum anti-SARS-CoV-2 nucleocapsid IgG antibodies was measured at both visits. We calculated the incidence of seroconversion (defined as RI values ≤1·5 at visit 1 and ≥1·5 at visit 2, and a ratio >2 between the visit 2 and visit 1 RI values) during the study period, as well as incidence rate ratios (IRRs) through cluster-corrected and adjusted Poisson regression models to analyse associations between seroconversion and variables related to sociodemographic characteristics, health access, comorbidities, COVID-19 exposure, protective behaviours, and symptoms. Findings: 2496 DETECTCoV-19 cohort participants returned for a follow-up visit between Oct 19 and Nov 27, 2020, of whom 204 reported having COVID-19 before the first visit and 24 had no data regarding previous disease status. 559 participants were seropositive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at baseline. Of the remaining 1709 participants who were seronegative at baseline, 71 did not meet the criteria for seroconversion and were excluded from the analyses. Among the remaining 1638 participants who were seronegative at baseline, 214 showed seroconversion at visit 2. The seroconversion incidence was 13·06% (95% CI 11·52–14·79) overall and 6·78% (5·61–8·10) for symptomatic seroconversion, over a median follow-up period of 57 days (IQR 54–61). 48·1% of seroconversion events were estimated to be asymptomatic. The sample had higher proportions of affluent and higher-educated people than those reported for the Manaus city population. In the fully adjusted and corrected model, risk factors for seroconversion before visit 2 were having a COVID-19 case in the household (IRR 1·49 [95% CI 1·21–1·83]), not wearing a mask during contact with a person with COVID-19 (1·25 [1·09–1·45]), relaxation of physical distancing (1·31 [1·05–1·64]), and having flu-like symptoms (1·79 [1·23–2·59]) or a COVID-19 diagnosis (3·57 [2·27–5·63]) between the first and second visits, whereas working remotely was associated with lower incidence (0·74 [0·56–0·97]). Interpretation: An intense infection transmission period preceded the second wave of COVID-19 in Manaus. Several modifiable behaviours increased the risk of seroconversion, including non-compliance with non-pharmaceutical interventions measures such as not wearing a mask during contact, relaxation of protective measures, and non-remote working. Increased testing in high-transmission areas is needed to provide timely information about ongoing transmission and aid appropriate implementation of transmission mitigation measures. Funding: Ministry of Education, Brazil; Fundação de Amparo à Pesquisa do Estado do Amazonas; Pan American Health Organization (PAHO)/WHO.World Health OrganizationRevisión por pare