Le tecniche di costruzione nel trattato di Vincenzo Scamozzi, Dell’idea dell’architettura universale, capitolo VIII: analisi per un progetto di ricerca

El trabajo se desarrolla intencionalmente en el análisis de solo una parte de la vasta extensión del tratado, específicamente el Volumen II, y, en particular, el capítulo VIII, que contiene la mayoría de la información importante por la investigación. Se trata de una lectura crítica del Tratado, que tiene como objetivo investigar la información que forma parte de los conocimientos del autor sobre la tecnología de la construcción. La característica principal de este estudio es sobre todo un análisis de un texto antiguo, una primera aproximación al texto de V. Scamozzi al fin de obtener, a través de su caracterización preliminar, y la construcción de series de datos que permiten su efectiva caracterización, algunas de las posibles líneas de investigación que podrían constituir una base para seguir a través de una tesis doctoral

A case of Scalp Rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options

Rosacea is a common chronic inflammatory disorder showing a wide range of clinical features such as telangiectasia, erythema, papules, and pustules primarily involving the central part of face (forehead, cheeks and nose) although extra facial manifestation have been described. We describe a case of rosacea with predominant scalp involvement successfully treated with a 8-week-course of doxycycline 40 mg once a day and probiotic therapy twice a day (Bifidobacterium breve BR03, Lactobacillus salivarius LS01 1 × 10(9) UFC/dose)

Comparing annual and biennial crop cycle on the growth, yield and quality of saffron using three corm dimensions

Saffron (Crocus sativus L.) is a geophyte plant belonging to the Iridaceae family and it is appreciated for its red dried stigmas used as cooking spice and flavouring agent. Effects of crop cycle length and mother corm dimension, as well as their interaction, have been evaluated on the flowering (morphological traits of flowers, days to flowering, flowering interval and flower production), quantitative traits (stigma and daughter corm yield), vegetative development (leaf and daughter corm traits) and qualitative characteristics (coloring, bittering and aromatic powers) of spice. A two-year field study (2017–2019) was conducted to compare annual and biennial crop cycle of saffron using three corm dimensional classes (D1: 2.0–2.5 cm, D2: 2.6–3.5 cm and D3: 3.6–4.5 cm) according a split-plot design with 3 replications. The results showed that the corms of D3 class, planted in annual crop cycle, produced flowers with the highest stigma length (42.2 mm), and dry weight of stigmas (7.4 mg), stamens (11.4 mg) and tepals (40.7 mg). The highest number of flowers per m2 (311.8) and stigma yield (20.7 kg ha 1) were found when corms belonging to D2 class were planted in biennial crop cycle, meanwhile the highest daughter corms production (35.9 t ha 1) was obtained when corms belonged to D3 class were planted in annual crop cycle. Number of daughter corms per m2 with a horizontal diameter from 3.1 to 4.5 cm and weight from 10.1 to > 25 g decreased as increasing the crop cycle length. In biennial crop cycle, corms of D1 class produced more daughter corms belonged to 3.1–3.5 cm diameter class and to 15.1–20 g weight class compared to D2 and D3 classes. Regarding to the spice quality, coloring and bittering powers were positively influenced by biennial crop cycle. According to International Standardization Organization (ISO 3632) references, the maximum values of color (306.3 A1 % 1 cm 440 nm) and taste (116.2 A1 % 1 cm 257 nm) were reached in spice obtained from “biennial crop cycle x D2 class” interaction. No significant effect of all experimental factors on aromatic power was found. It was concluded that the evaluation of combination between crop cycle length and corm dimension is ecessary in the saffron management in order to achieve the optimum yield of stigmas and corms, to improve the qualitative traits of spice and to enhance the by-products as corms of D1 class

The Influence of Soil Physical and Chemical Properties on Saffron (Crocus sativus L.) Growth,Yield and Quality

Soil physical and chemical properties play a central role in plant growth, influencing the availability of air, nutrients, and water. The aim of this two-year study was to evaluate the effect of soil texture and chemical properties (pH, electrical conductivity, organic carbon, organic matter, total, and active lime) on saffron (Crocus sativus L.) growth, yield, and quality. Corms were planted in pots filled with seven different soil textures obtained mixing an increasing quantity (33% and 66%) of sand to a clay soil (S1) and to a clay loam soil (S2) compared to a full (100%) sandy soil as a control (S7). A randomized complete block design comprising of seven pots with different types of soil (S1, S2, S3, S4, S5, S6, and S7) replicated three times was used. The results showed that the highest flower number (320.3 nm2), stigma yield (2.0 gm2), daughter corm production (7.9 kgm2), and horizontal diameter (3.1 cm) were derived from S3 and S4 soils. These were characterized by a loam and sandy-loam texture, not very calcareous, with a sub-alkaline and neutral pH, low electrical conductivity, a content of organic matter between 5.46 and 8.67 g kg1, and a content of active lime between 21.25 and 26.25 g kg1. According to the International Organization for Standardization (ISO) references, although all spice samples belonged to the first qualitative category, S1, S3, and S2 soils recorded the highest value for coloring power (290.5, 289.1, and 287.6 A1m 440 nm, respectively). The highest values of bittering (109.2 A1m 257 nm) and aromatic (26.6 A1m 330 nm) power were reached by S3 soil. Positive correlations were found both between color with clay and organic matter, and aroma with total calcium carbonate. In conclusion, the assessment of soil conditions is particularly important to obtain the best saffron performance in terms of stigma and daughter corms yield as well as spice qualitative traits

Dermoscopy and methyl aminolevulinate: A study for detection and evaluation of field cancerization

Actinic keratosis (AK) is a keratinocyte intraepidermal neoplasia UV light – induced that frequently appears in sun-exposed areas of the skin. Although historically AK was de fi ned as “ precancerous ” , actually it is considered as the earliest stage of squamous cell carcinoma (SCC) in situ. Since AKs can progress into invasive SCC, their treatment isrecommended. AKsrarely developasa singlelesion;usually multiplelesions commonly affect anen- tire area of chronically actinic damaged skin. This has led to the concept of “ fi eld cancerization ” , an area chroni- cally sun-exposed that surrounds peripherally visible lesions, in which are individualized subclinical alterations. One of the main principles endpoint in the management of AKs is the evaluation and the treatment of fi eld cancerization. In this view, in order to detect and quantify fi eld cancerization, we employed a method based on the topical application of methyl aminolevulinate (MAL) and the detection of the fl uorescence emitted by its metabolite Protoporphyrin IX (PpIX); then, considering the extension and the intensity of measured fl uores- cence, we create a score of fi eld cancerization. The results show that patients underwent to daylight PDT had a reduction of total score, from T0 to T2. Whereas in the group untreated we observed a stability of total score or a slightly worse. So, the method and the score used allows to evaluate with a good approximation the dimension of fi eld cancerization and show the modi fi cation of it after treatment

Energy, Environmental, and Economic Sustainability of Saffron Cultivation: Insights from the First European (Italian) Case Study

Saffron (Crocus sativus L.) stands as a valuable agricultural commodity, witnessing an increasing market inclination toward environmentally sustainable and eco-friendly products. The current literature on the environmental impact and profitability of saffron cultivation is limited, underscoring a notable gap in comprehending the sustainability aspects of this crop. This study utilized a comprehensive multi-model approach to assess the sustainability of annual saffron cultivation, representing the first global detailed evaluation, conducted within a European context (Southern Italy). Energy analysis, physical and monetized life cycle assessment (LCA), and life cycle costing (LCC) were used for a cradle-to-farm gate assessment. One hectare of cultivated saffron, one saffron production yield (stigma, corm, and flower), and 1 kg of stigma yield were used as functional units. The total energy input was 65,073 MJ ha−1, being 33% direct, 67% indirect, 72% renewable, and 28% non-renewable. The majority (55%) of energy is derived from corm production. For 1 kg of saffron the energy efficiency, specific energy, and productivity were 2.98, 4.64 MJ kg−1, and 0.22 kg MJ−1, respectively, while these values dropped significantly for 1 kg of stigma. The multi-indicator LCA analysis using the ReCiPe 2016 model revealed significant contributions to various environmental impact categories. Results align with prior research, pinpointing fertilization and mechanical operations as the primary drivers of diverse environmental impacts. A noticeable carbon intensity was estimated, with a relevant contribution from corm production and human labor, aspects overlooked in previous LCA studies. Saffron cultivation maintains economic viability, with production costs at EUR 98,435 per ha−1 and a net return margin of EUR 172,680 per ha−1, bolstered by the high market price and by-product revenue. Monetization of LCA results revealed that external costs were EUR 15,509 per ha−1, being only 14% of the total cost. Investments in improving yield and resource efficiency have the potential to increase the eco-efficiency of saffron cultivation

Socio-economic risks posed by a new plant disease in the Mediterranean basin

Xylella fastidiosa (Wells 1987, hereafter Xf), the causal agent of several devastating plant diseases, is threatening new countries of the Euro-Mediterranean, Balkans, Middle East, and North Africa (MENA) regions. In this perspective, a study was carried out to: (a) explore the potential establishment and spread and losses caused by Xf in Euro-Mediterranean countries (i.e., France, Greece, Italy, Portugal, and Spain) and the Balkans (i.e., Albania, Bosnia and Herzegovina, Croatia, Montenegro, North Macedonia, Serbia, and Slovenia); (b) assess the potential introduction of Xf in the MENA countries (i.e., Algeria, Egypt, Israel, Jordan, Lebanon, Libya, Morocco, Palestine, Syria, Tunisia, and Turkey); and (c) project the socio-economic impacts of Xf on olives, grapes, citrus, and almonds in these countries. A novel socio-economic risk assessment technique was developed and applied for these purposes. It revealed that Albania had the highest risk for Xf dispersal. In addition, the risk assessment also confirmed the vulnerability of Euro-Mediterranean countries in terms of Xf dispersal. In the MENA and Balkans regions, countries with fragmented and small farms are likely to face the worst social impacts, whereas the Euro-Mediterranean region runs the highest economic losses on the target crops

Monitoring chemotherapy-induced alopecia with trichoscopy

Background: Chemotherapy-induced alopecia (CIA) ranks among the psychologically most devastating effects of cancer treatment for oncological patients, with an overall incidence of 65%. Nowadays trichoscopy is largely employed in the diagnosis of alopecia, but no description of CIA trichoscopic pattern is present in literature. Aims: We want to create an organic description of CIA trichoscopic aspects. Methods: Oncological patients candidate to chemotherapy drugs, afferent to our trichological outpatient were studied. Anamnesis, clinical exam, clinical global photography, pull test, trichogram, and trichoscopy were conducted at the different moments of therapeutic treatment. Results: A definite trichoscopic pattern in the different phases of treatment was observed. After the first 3 weeks of chemotherapy rare and scattered black dots, broken hairs, flame hairs and pohl pinkus appeared. At the end of chemotherapy besides the features described above, numerous thin hair in regrowth were detected, together to rare terminal hair, scattered black dots and circle hair. Three months after chemotherapy a progressive increase of follicular units and elongation of the existing hair were visible. Conclusions: We propose an description of CIA trichoscopic pattern and its evolution during the different phases of chemotherapy

Site fidelity of Hippocampus guttulatus Cuvier, 1829 at Mar Piccolo of Taranto (Southern Italy; Ionian Sea)

AbstractLack of detailed knowledge on ecological niche, life cycles, spatial distribution, reproductive biology and space use strongly affects the selection of useful tools and measures in the conservation of threatened marine species. Especially for sedentary and slow species, behaviour and movement capacities are supposed to be the most important functional traits. Indeed, behavioural variability concerning available space and the close presence of individuals is considered a crucial trait for the population dynamics assessments, especially when disturbances of various causes are present in the environment. The present study aimed to investigate the site fidelity and degree of movement of Hippocampus guttulatus, an emblematic and threatened Mediterranean seahorse species. With this aim, a number of seahorses were tagged and monitored throughout two years within a limited area of the lagoon of Mar Piccolo of Taranto (Southern Italy). The studied individuals were initially morphometrically measured for size, sex and life-cycle stage and subsequently monitored through repeated four-month surveys each year. Obtained results indicated high site fidelity regardless of habitat type. Movement pattern was in line with the data on congeneric species, although values were slightly higher. The analyses showed differences in movement degree among different sexes and life-cycle stages and indicated greater mobility of adult females compared to males and juveniles. The investigated parameters showed a great variability suggesting that even small-scale environmental factors can influence the species mobility. Finally, a change in the population structure has been observed, with the loss of large individuals in 2016 and reduced recruitment in 2017. These findings indicated the possible presence of stressors that could lead to the alteration of the seahorse population at Mar Piccolo of Taranto

Accumulation and aberrant composition of cholesteryl esters in Scrapie-infected N2a cells and C57BL/6 mouse brains

<p>Abstract</p> <p>Objective</p> <p>Cholesterol changes have been described in prion-cell models and in experimental rodent scrapie; yet, the pattern of this association is still controversial.</p> <p>Methods</p> <p>To shed light on the matter, we analysed and compared cholesterol variations in ScN2a cells and in brains of Scrapie-infected C57Bl/6 mice, using two different methods: a fluorimetric-enzymatic cholesterol assay, and high performance liquid chromatography-mass spectroscopy (HPLC-MS).</p> <p>Results</p> <p>Compared to uninfected controls, similar cholesterol metabolism anomalies were observed in infected cells and brains by both methods; however, only HPLC-MS revealed statistically significant cholesterol variations, particularly in the cholesteryl esters (CE) fraction. HPLC-MS analyses also revealed different fatty acid composition of the CE fraction in cells and brains. In N2a cells, their profile reflected that of serum, while in normal brains cholesteryl-linoleate only was found at detectable levels. Following prion infection, most CE species were increased in the CE pool of ScN2a cells, whereas a conspicuous amount of cholesteryl-arachidonate only was found to contribute to the cerebral increase of CE. Of interest, oral pravastatin administration to Scrapie-infected mice, was associated with a significant reduction of cerebral free cholesterol (FC) along with a concomitant further increase of the CE pool, which included increased amounts of both cholesteryl-linoleate and cholesteryl-arachidonate.</p> <p>Conclusion</p> <p>Although mechanistic studies are needed to establish the pathophysiological relevance of changes in cerebral CE concentrations, to the best of our knowledge this is the first report to provide evidence of increased cholesterol esterification in brains of prion-infected mice, untreated and treated with pravastatin.</p