Moving Walkways, Escalators, and Elevators

We study a simple geometric model of transportation facility that consists of two points between which the travel speed is high. This elementary definition can model shuttle services, tunnels, bridges, teleportation devices, escalators or moving walkways. The travel time between a pair of points is defined as a time distance, in such a way that a customer uses the transportation facility only if it is helpful. We give algorithms for finding the optimal location of such a transportation facility, where optimality is defined with respect to the maximum travel time between two points in a given set.Comment: 16 pages. Presented at XII Encuentros de Geometria Computacional, Valladolid, Spai

Practical learning method for multi-scale entangled states

We describe a method for reconstructing multi-scale entangled states from a small number of efficiently-implementable measurements and fast post-processing. The method only requires single particle measurements and the total number of measurements is polynomial in the number of particles. Data post-processing for state reconstruction uses standard tools, namely matrix diagonalisation and conjugate gradient method, and scales polynomially with the number of particles. Our method prevents the build-up of errors from both numerical and experimental imperfections

Potential role of the anterior lateral line in sound localization in toadfish (Opsanus tau)

Author Posting. © The Company of Biologists, 2018. This article is posted here by permission of The Company of Biologists for personal use, not for redistribution. The definitive version was published in Journal of Experimental Biology 221 (2018): jeb180679, doi:10.1242/jeb.180679.Male oyster toadfish (Opsanus tau) acoustically attract females to nesting sites using a boatwhistle call. The rapid speed of sound underwater combined with the close proximity of the otolithic organs makes inner ear interaural time differences an unlikely mechanism to localize sound. To determine the role that the mechanosensory lateral line may play in sound localization, microwire electrodes were bilaterally implanted into the anterior lateral line nerve to record neural responses to vibrational stimuli. Highest spike rates and strongest phase-locking occurred at distances close to the fish and decreased as the stimulus was moved further from the fish. Bilateral anterior lateral line neuromasts displayed differential directional sensitivity to incoming vibrational stimuli, which suggests the potential for the lateral line to be used for sound localization in the near field. The present study also demonstrates that the spatially separated neuromasts of the toadfish may provide sufficient time delays between sensory organs for determining sound localization cues. Multimodal sensory input processing through both the inner ear (far field) and lateral line (near field) may allow for effective sound localization in fish.This study was funded by the National Science Foundation (IOS 1354745 to A.F.M.). C.A.R. was funded through a Rutherford Discovery Fellowship from the Royal Society of New Zealand and a Marine Biological Laboratory fellowship.2019-05-2

Coherent acoustic vibration of metal nanoshells

Using time-resolved pump-probe spectroscopy we have performed the first investigation of the vibrational modes of gold nanoshells. The fundamental isotropic mode launched by a femtosecond pump pulse manifests itself in a pronounced time-domain modulation of the differential transmission probed at the frequency of nanoshell surface plasmon resonance. The modulation amplitude is significantly stronger and the period is longer than in a gold nanoparticle of the same overall size, in agreement with theoretical calculations. This distinct acoustical signature of nanoshells provides a new and efficient method for identifying these versatile nanostructures and for studying their mechanical and structural properties.Comment: 5 pages, 3 figure

Caractérisation des sédiments des retenues pour la prévision des risques écotoxicologiques liés aux vidanges

L'acumulation de sédiments dans les retenues de barrages hydro-électriques nécessite de procéder à des opérations régulières de désenvasement indispensables à leur bon fonctionnement.Ces opérations de vidange ont le plus souvent un effet destructeur sur la faune et la flore aquatique.Cet effet destructeur est principalement lié à une diminution de la concentration en oxygène dissous et une augmentation de la teneur en matières en suspension.La méthodologie présentée a pour but d'estimer préalablement à toute vidange les risques écotoxicologlques correspondant à une telle opération. Elle implique d'une part la description et l'analyse physico-chimique des sédiments en place, d'autre part la mesure en laboratoire de la consommation en oxygène dissous des matériaux remis en suspension au cours du temps.La fiabilité d'une telle procédure a été montrée en particulier à l'occasion de vidanges de retenues situées sur le cours de l'Isère.Le protocole est décrit précisément de façon à pouvoir guider les exploitants de retenues à l'occasion des opérations de vidange qu'ils dirigent.Sediment silting up in hydroelectric dams Implies regular draining operations in order to prevent disfunction of the dams.These operations often lead to drastic lethal affects on aquatic fauna and flora.A toxicological study has clearly shown two main factors responsible for acute toxicological effects : dissolved oxygen deficit and suspended solids increase.These effects have been quantified by experimental tests on Brown trout fry (Salmo trutta fario) the results of which are summarized.The second step consisted in the prediction of water quality evolution downstream during dam draining operation, regarding both factors suspected, in order to assess ecotoxicological hazard.The proposed methodology based on a sedimentological study made in Grangent dam, located on river Loire and immediately downstream of St. Etienne urban area, and in St. Hilaire dam situated on the river Isère downstream partIt consists in sampling cored sediments and in measuring dissolved oxygen kinetic by mixing sediments with water In a reactor.The sample conservation as carried out in jar glasses kept at 4 °C.Results are reproducible as long as residual dissolved oxygen concentration is higher than 3 mg/l. If this condition is respected, oxygen consumption is strictly dependent on suspended sediment concentration.An increase in test water temperature makes the oxygen consumption rise.In accordance with these results, recommendations for dissolved oxygen measures are about 5 g/l suspended sediment concentration, with an experimental temperature reaching the temperature observed during dam draining.The variability of the results for different samples depends on the dam studied. Surface tore samples collected in St. Hilaire dam consume dissolved oxygen faster than the same bottom tore samples.However, in Grangent dam, only one surface core sample collected near the dam construction has clearly shown reducing properties. The difference between two dam sediments is very important : Grangent dam sediment have, on average, dissolved oxygen consumption three more times higher than St. Hilaire in the same duration.Taking into account dissolved oxygen kinetics by mixed sediments, and a simple aeration model using water and sediment deposits from downstream dam, may expert both suspended sediment and oxygen consumption evolution.Hazardous mortality of trout fario fry in downstream dam are quickly graphically visualized.Dam draining operator may so assess, for different suspended sediment land the harmful exposition to fish at any distance from it.This knowledge allows him to plan more strictly floodgate working : pointly dissolved oxygen continuous measurement on downstream dam is sufficient to give a mark related to model hazard assessment.The model reliability has been demonstrated by the examination of data collected during St. Hilaire dam draining operation

Multilayer Pressure Vessel Materials Testing and Analysis

To provide NASA a comprehensive suite of materials strength, fracture toughness and crack growth rate test results for use in remaining life calculations for aging multilayer pressure vessels, Southwest Research Institute (R) (SwRI) was contracted in two phases to obtain relevant material property data from a representative vessel. This report describes Phase 1 of this effort which includes a preliminary material property assessment as well as a fractographic, fracture mechanics and fatigue crack growth analyses of an induced flaw in the outer shell of a representative multilayer vessel that was subjected to cyclic pressure test. SwRI performed this Phase 1 effort under contract to the Digital Wave Corporation in support of their contract to Jacobs ATOM for the NASA Ames Research Center

Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study.

Low-grade inflammation is a risk factor for depression, psychosis and other major psychiatric disorders. It is associated with poor response to antidepressant and antipsychotics, and could potentially be a treatment target. However, there is limited data on the prevalence of low-grade inflammation in major psychiatric disorders, and on the characteristics of patients who show evidence of inflammation. We examined the prevalence of low-grade inflammation and associated socio-demographic and clinical factors in acute psychiatric inpatients. An anonymised search of the electronic patient records of Cambridgeshire and Peterborough NHS Foundation Trust was used to identify patients aged 18-65 years who were hospitalised between 2013 and 2016 (inclusive). We excluded patients on antibiotics or oral steroids, or with missing data. Inflammation was defined using serum C-reactive protein (>3 mg/L) or total white cell count (>9.4 × 109/L) as measured within 14 days of admission. Out of all 599 admissions, the prevalence of inflammation (serum CRP >3 mg/L) in the ICD-10 diagnostic groups of psychotic disorders (F20-29), mood disorders (F30-39), neurotic disorders (F40-48) and personality disorders (F60-69) was 32%, 21%, 22% and 42%, respectively. In multivariable analyses, low-grade inflammation was associated with older age, black ethnicity, being single, self-harm, diagnoses of schizophrenia, bipolar disorder, current treatments with antidepressants, benzodiazepines, and with current treatment for medical comorbidities. A notable proportion of acutely unwell psychiatric patients from all ICD-10 major diagnostic groups show evidence of low-grade inflammation, suggesting inflammation may be relevant for all psychiatric disorders

Contrast Leakage Patterns from Dynamic Susceptibility Contrast Perfusion MRI in the Grading of Primary Pediatric Brain Tumors

BACKGROUND AND PURPOSE: The pattern of contrast leakage from DSC tissue signal intensity time curves have shown utility in distinguishing adult brain neoplasms, but has limited description in the literature for pediatric brain tumors. The purpose of this study is to evaluate the utility of grading pediatric brain tumors with this technique. MATERIALS AND METHODS: A retrospective review of tissue signal-intensity time curves from 63 pediatric brain tumors with preoperative DSC perfusion MR imaging was performed independently by 2 neuroradiologists. Tissue signal-intensity time curves were generated from ROIs placed in the highest perceived tumor relative CBV. The postbolus portion of the curve was independently classified as returning to baseline, continuing above baseline (T1-dominant contrast leakage), or failing to return to baseline (T2*-dominant contrast leakage). Interobserver agreement of curve classification was evaluated by using the Cohen κ. A consensus classification of curve type was obtained in discrepant cases, and the consensus classification was compared with tumor histology and World Health Organization grade. RESULTS: Tissue signal-intensity time curve classification concordance was 0.69 (95% CI, 0.54–0.84) overall and 0.79 (95% CI, 0.59–0.91) for a T1-dominant contrast leakage pattern. Twenty-five of 25 tumors with consensus T1-dominant contrast leakage were low-grade (positive predictive value, 1.0; 95% CI, 0.83–1.00). By comparison, tumors with consensus T2*-dominant contrast leakage or return to baseline were predominantly high-grade (10/15 and 15/23, respectively) with a high negative predictive value (1.0; 95% CI, 0.83–1.0). For pilomyxoid or pilocytic astrocytomas, a T1-dominant leak demonstrated high sensitivity (0.91; 95% CI, 0.70–0.98) and specificity (0.90, 95% CI, 0.75–0.97). CONCLUSIONS: There was good interobserver agreement in the classification of DSC perfusion tissue signal-intensity time curves for pediatric brain tumors, particularly for T1-dominant leakage. Among patients with pediatric brain tumors, a T1-dominant leakage pattern is highly specific for a low-grade tumor and demonstrates high sensitivity and specificity for pilocytic or pilomyxoid astrocytomas

Effects of Whole-Body Vibration Compared to a Community-Based Exercise Program for Improving Older Adults\u27 Balance and Mood

Background: Whole-body vibration (WBV) may be an effective means of improving body composition and physical functioning in older adults, and the benefits may be comparable to traditional exercise modalities. The aim of this study was to test the effects of WBV on older adults’ balance and mood state. Materials and Methods: Thirty-one participants (5 male, M age= 89.8 ±8.8, and 26 female, M age = 74.5±8.1) were randomly assigned to WBV or a community-based exercise program (CBEP). The intervention lasted 6 months, with participants doing WBV 10-15 min, 5 d/wk or CBEP 50 min, 2 d/wk. The Sensory Organization Test (SOT) was used to assess overall balance. SOT data were collected using the NeuroCom (Clackamas, OR), which assesses three sensory systems associated with postural control: somatosensory, visual, and vestibular. Total mood disturbance (TMD) was assessed over the previous 6 months using the Profile of Mood States (POMS). Data were collected pre- post-intervention. Results: Controlling for age and gender, a 2 (group) x 2 (time) repeated measures MANCOVA revealed no group, time, or group x time interaction effects (all p\u3e.05); however, the proportion of variance accounted for by the group x time interaction was 14%, which is moderate. Delta values for the WBV and CBEP for SOT were +2.00 and +5.31, respectively; and for TMD +5.66 and -0.19, respectively. Conclusion: No between or within group differences suggest that 6-months of WBV or CBEP produce similar results among older adults. The restrictive sample size and relatively low statistical power limit the finding’s generalizability