8 research outputs found
Etude mécanistique et synthèse d'inhibiteurs de l'UDP-Galactopyranose mutase
No full textPARIS-BIUSJ-Thèses (751052125) / SudocPARIS-BIUSJ-Physique recherche (751052113) / SudocSudocFranceF
A new methodology for the synthesis of fluorinated exoglycals and their time-dependent inhibition against UDP-galactopyranose mutase
No full text
A new methodology for the synthesis of fluorinated exoglycals and their time-dependent inhibition against UDP-galactopyranose mutase
No full textSynthesis of galactosides locked in a 1,4 B boat conformation and functionalized at the anomeric position.
No full textSynthesis of galactosides locked in a 1,4 B boat conformation and functionalized at the anomeric position.
No full textStructural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design
No full textInternational audienc
Developing an asymmetric, stereo-divergent route to selected 6-deoxy-6-fluoro-hexoses
No full textFree radical bromination and nucleophilic fluorination allows the conversion of Me sorbate into the 6-fluoro analog which undergoes sequential asym. dihydroxylation reactions. A range of 6-deoxy-6-fluoro-sugars were prepd. by using different combinations of ligands. While the enantiomeric excesses obtained were comparable to those from other 6-substituted sorbates, the regioselectivity of dihydroxylation was moderate, with both 2,3- and 4,5-diols being obtained. A successful temporary persilylation strategy was evolved to convert the products of dihydroxylation rapidly to the fluoro-sugars 6-deoxy-6-fluoro-L-idose, 6-fluoro-L-fucose and 6-deoxy-6-fluoro-D-galactose, which were obtained in overall yields of 4%, 6% and 8% from Me 6-fluoro-hexa-2E,4E-dienoate
