Proyecto de instalaciones eléctricas de MY y BT e incendios de centro logístico de Zaragoza

Proyecto de instalación eléctrica de MT y BT e incendios en nave logística

The Chilean Rural Practitioner Programme: a multidimensional strategy to attract and retain doctors in rural areas

Developing countries currently face internal and external migration of their health workforce and interventions are needed to attract and retain health professionals in rural areas. Evidence of multidimensional interventions, however, is scarce. This study explores a long-standing strategy to attract and retain doctors to rural areas in Chile: the Rural Practitioner Programme. The main objective is to describe the programme, characterize its multidimensional set of incentives and appraise preliminary programme outcomes

Bibliometric analysis of the Spanish Journal of Chemotherapy (1996-2000).

[ES] Se ha realizado un estudio bibliométrico de la producción científica española en materia de quimioterapia antimicrobiana y antiparasitaria a través de los artículos recogidos en Revista Española de Quimioterapia durante el periodo 1996-2000. Para ello se analizaron los veinte nú-meros de la revista correspondientes a los cinco años estudiados mediante la aplicación de los principales indicadores de bibliometría: tipología de los artículos, producción, áreas de Bradford y estimación de Lotka, índice de colaboración, procedencia institucional, localización geográfica, materia y publicidad. Son mayoría los artículos originales, se ha identificado un grupo minoritario de autores muy productivos y un grado adecuado de colaboración. Las comunidades autónomas de Madrid y Valencia concentran el mayor porcentaje de la producción científica. La procedencia de los trabajos fue principalmente del medio hospitalario. La materia más estudiada fue la de los antimicrobianos.Se ha observado una disminución de la publicidad. [EN] A bibliometric study of the output of Spanish scientific research into antimicrobial and antiparasitic chemotherapy was carried out, based on articles published in the Spanish Journal of Chemotherapy from 1996 to 2000. The 20 issues of the journal corresponding to the 5-year period studied were analyzed using the main indicators for bibliometry: article typology; output; Bradford's Law and Lotka's estimation; collaboration index; institutional origin; geographic location; subject; and advertising. The majority of the articles were original, and a small group of high-output authors and an appropriate level of contribution were identified. The greatest percentage of scientific output was from the autonomous regions of Madrid and Valencia. The majority of studies included in the analysis were hospital-based and the most researched topic was antimicrobial drugs. A reduction in the amount of advertising was noted.S

Anticoagulation Management With Coumarinic Drugs in Chilean Patients

Warfarin and acenocoumarol are used in various cardiovascular disorders to improve the prognosis of patients with thromboembolic disease. However, there is a lack of substantial efficacy and safety data on antithrombotic prophylaxis in several countries, particularly in Latin America. The aim of this study was to provide information about the efficacy of anticoagulants in Chilean patients. Data were collected from databases of the Western Metropolitan Health Service, Santiago, Chile. We identified 6280 records of patients receiving anticoagulant treatment. The three most common diagnoses were rhythm disorder (43.7%), venous thrombosis (22%), and valvular prosthesis (10.7%). The majority of patients (98.5%) received acenocoumarol while 1.5% of patients received warfarin, at weekly therapeutic doses of 13.6 mg and 30.4 mg, respectively. For total diagnoses, the median time in the therapeutic range was 50%. However, better results, 66.7%, were observed when a telemedicine strategy was used only in Santiago Province. Our findings emphasize that in Chile, where the number of patients receiving anticoagulant treatment increases every year, telemedicine, by committed teams, improves the use of oral anticoagulants and is able to increase quality indicators of anticoagulant treatment care

<i>Vachellia farnesiana</i> Pods or a Polyphenolic Extract Derived from Them Exert Immunomodulatory, Metabolic, Renoprotective, and Prebiotic Effects in Mice Fed a High-Fat Diet

Obesity causes systemic inflammation, hepatic and renal damage, as well as gut microbiota dysbiosis. Alternative vegetable sources rich in polyphenols are known to prevent or delay the progression of metabolic abnormalities during obesity. Vachellia farnesiana (VF) is a potent source of polyphenols with antioxidant and anti-inflammatory activities with potential anti-obesity effects. We performed an in vivo preventive or an interventional experimental study in mice and in vitro experiments with different cell types. In the preventive study, male C57BL/6 mice were fed with a Control diet, a high-fat diet, or a high-fat diet containing either 0.1% methyl gallate, 10% powdered VFP, or 0.5%, 1%, or 2% of a polyphenolic extract (PE) derived from VFP (Vachellia farnesiana pods) for 14 weeks. In the intervention study, two groups of mice were fed for 14 weeks with a high-fat diet and then one switched to a high-fat diet with 10% powdered VFP for ten additional weeks. In the in vitro studies, we evaluated the effect of a VFPE (Vachellia farnesiana polyphenolic extract) on glucose-stimulated insulin secretion in INS-1E cells or of naringenin or methyl gallate on mitochondrial activity in primary hepatocytes and C2C12 myotubes. VFP or a VFPE increased whole-body energy expenditure and mitochondrial activity in skeletal muscle; prevented insulin resistance, hepatic steatosis, and kidney damage; exerted immunomodulatory effects; and reshaped fecal gut microbiota composition in mice fed a high-fat diet. VFPE decreased insulin secretion in INS-1E cells, and its isolated compounds naringenin and methyl gallate increased mitochondrial activity in primary hepatocytes and C2C12 myotubes. In conclusion VFP or a VFPE prevented systemic inflammation, insulin resistance, and hepatic and renal damage in mice fed a high-fat diet associated with increased energy expenditure, improved mitochondrial function, and reduction in insulin secretion