Assessment of the anthropogenic sediment budget of a littoral cell system (Northern tuscany, italy)

In the present study we describe a straightforward and highly replicable methodology to assess the anthropogenic sediment budget within a coastal system (the Northern Tuscany littoral cell, Italy), specifically selected in a partially natural and partially highly urbanized coastal area, characterized by erosion and accretion processes. The anthropogenic sediment budget has been here calculated as an algebraic sum of sediment inputs, outputs and transfer (m3 ) within a 40 year time interval (1980–2020). Sediment management strongly influences the sediment budget and, even if its evaluation is crucial to assess the efficiency of a coastal management policy, it is often difficult to quantify the anthropogenic contribution to sedimentary processes. Different types of intervention are carried out by a variety of competent authorities over time (Municipalities, Marinas, Port Authorities), and the correct accountability of sediment budget is no longer known, or possible, for the scientific community. In the Northern Tuscany littoral cell, sedimentation is concentrated in a convergent zone and updrift of port structures, which have determined a series of actions, from offshore dumping and disposal into confined facilities (sediment output), to bypassing and redistribution interventions (sediment transfer); conversely, river mouths and coastal areas protected by groins and barriers are subjected to severe erosion and coastline retreat, resulting in many beach nourishments (sediment input). The majority of coastal protection interventions were carried out to redistribute sand from one site to another within the study area (2,949,800 m3 ), while the sediment input (1,011,000 m3 ) almost matched the sediment output (1,254,900 m3 ) in the considered time interval. A negative anthropogenic sediment budget (−243,900 m3 ) is here documented

Anthropic pressures on Nature 2000 Sites: recommendations and monitoring criteria for the pollution emergency response activities within the Orbetello lagoon

L’elevato valore naturalistico e socioeconomico di un Sito Natura 2000 richiede che tutte le attività antropiche che si svolgono al suo interno (es. pesca, turismo, trasporti, attività industriali, etc.) siano gestite in maniera tale da non pregiudicare le specie e gli habitat per i quali l’area è stata designata. Molti di questi Siti sono ambienti di transizione, ovvero zone che costituiscono il passaggio naturale tra terra e mare. La loro posizione di interfaccia tra questi due ambienti li rende ecosistemi unici e biologicamente molto produttivi, sede di meccanismi di regolazione dei processi interattivi della biosfera nelle due fasi, terrestre e marina. In alcuni Siti la presenza di attività antropiche diffuse e prolungate nel tempo ha portato al riscontro di stati di contaminazione elevata, fino all’inclusione di queste zone, o parti di esse, tra i Siti di bonifica di Interesse Nazionale (SIN). Il presente lavoro descrive le linee di indirizzo e le attività di monitoraggio da attuare per la salvaguardia della salute pubblica e dell’ambiente nel corso degli interventi di messa in sicurezza di emergenza predisposti nell’area lagunare antistante l’area industriale Ex Sitoco, all’interno della perimetrazione del SIN di Orbetello, incluso in un Sito di Importanza Comunitaria. Le matrici ambientali potenzialmente a rischio a causa dell’esecuzione di tali interventi sono: acqua, sedimento, biocenosi acquatiche, avifauna, uomo. È altresì importante valutare gli effetti che le ipotetiche modifiche su microscala, apportate a livello di ogni matrice, potrebbero causare nel lungo periodo su macroscala.The high naturalistic and socio-economic value of Natura 2000 sites requires that all human activities performed within their borders (e.g. fishing, tourism, transports, industrial activities) are regulated. Indeed, the site management should assure the effective safeguard of all species and habitats of European interest included in the protected area. A lot of such sites are located in transitional environments, that are areas characterised by a natural progression from the terrestrial to the water environments. Such environments include unique and very productive habitats, and they represent the regulation mechanisms of the interactive processes of the terrestrial and marine biosphere. In some sites, the presence of human activities that are distributed both in space and time has led to high levels of contamination, that in some cases even required their inclusion in Reclamation Sites of National Interest (SIN). The present study describes the planning and monitoring activities to be performed in order to safeguard human and environment health during the actions of MISE in the lagoonal area in front of the industrial area Ex Sitoco, within the borders of the Orbetello SIN, included in a SCI. The environmental parameters that are potentially at risk due to such activities are: water, sediment, water biocenosis, birds, humans. Furthermore, it is important to evaluate the effects that potential variations at the microscale level may cause at the macroscale level

CubeSat Active Thermal Management in Support of Cooled Electro-Optical Instrumentation for Advanced Atmospheric Observing Missions

The need for advanced cooled electro-optical instrumentation in remote observations of the atmosphere is well known and demonstrated by SABER on the TIMED mission. The relatively new use of small satellites in remote earth observing missions as, well as the challenges, are epitomized by the upcoming NOAA EON-IR 12U CubeSat missions. These advanced CubeSat missions, which hope to accomplish scientific objectives on the same scale as larger more traditional satellites, require advanced miniaturized cryocoolers and active methods for thermal management and power control. The active CryoCubeSat project (ACCS) is a demonstration of such a technology. Utilizing Ultrasonic Additive Manufacturing (UAM) techniques, a Mechanical Pumped Fluid Loop (MPFL), and miniature pumps and cryocoolers to create a closed loop fluid-based heat interchange system. The ACCS project creates a two-stage thermal control system targeting 6U CubeSat platforms. The first stage is composed of a miniature Ricor K508N cryocooler while the second is formed by a UAM fabricated heat exchanger MPFL system powered by a micro TCS M510 pump. The working fluid is exchanged between a built-in chassis heat exchanger and a deployable tracking radiator. This work details the theory design and testing of a relevant ground-based prototype and the analysis and modeling of the results as well as the development of a design tool to help in customized active thermal control designs for small satellites. Ultimately, the ACCS project hopes to enable a new generation of advanced CubeSat atmospheric observing missions

Transposable element activation promotes neurodegeneration in a Drosophila model of Huntington's disease

Huntington's disease (HD) is an autosomal dominant disorder with progressive motor dysfunction and cognitive decline. The disease is caused by a CAG repeat expansion in the IT15 gene, which elongates a polyglutamine stretch of the HD protein, Huntingtin. No therapeutic treatments are available, and new pharmacological targets are needed. Retrotransposons are transposable elements (TEs) that represent 40% and 30% of the human and Drosophila genomes and replicate through an RNA intermediate. Mounting evidence suggests that mammalian TEs are active during neurogenesis and may be involved in diseases of the nervous system. Here we show that TE expression and mobilization are increased in a Drosophila melanogaster HD model. By inhibiting TE mobilization with Reverse Transcriptase inhibitors, polyQ-dependent eye neurodegeneration and genome instability in larval brains are rescued and fly lifespan is increased. These results suggest that TE activation may be involved in polyQ-induced neurotoxicity and a potential pharmacological target

First tests for an online treatment monitoring system with in-beam PET for proton therapy

PET imaging is a non-invasive technique for particle range verification in proton therapy. It is based on measuring the beta+ annihilations caused by nuclear interactions of the protons in the patient. In this work we present measurements for proton range verification in phantoms, performed at the CNAO particle therapy treatment center in Pavia, Italy, with our 10 x 10 cm^2 planar PET prototype DoPET. PMMA phantoms were irradiated with mono-energetic proton beams and clinical treatment plans, and PET data were acquired during and shortly after proton irradiation. We created 1-D profiles of the beta+ activity along the proton beam-axis, and evaluated the difference between the proximal rise and the distal fall-off position of the activity distribution. A good agreement with FLUKA Monte Carlo predictions was obtained. We also assessed the system response when the PMMA phantom contained an air cavity. The system was able to detect these cavities quickly after irradiation.Comment: 11 pages, 6 figures, Proceedings for International Workshop on Radiation Imaging Detectors, 201

Emergence and Genetic Variation of Neuraminidase Stalk Deletions in Avian Influenza Viruses

When avian influenza viruses (AIVs) are transmitted from their reservoir hosts (wild waterfowl and shorebirds) to domestic bird species, they undergo genetic changes that have been linked to higher virulence and broader host range. Common genetic AIV modifications in viral proteins of poultry isolates are deletions in the stalk region of the neuraminidase (NA) and additions of glycosylation sites on the hemagglutinin (HA). Even though these NA deletion mutations occur in several AIV subtypes, they have not been analyzed comprehensively. In this study, 4,920 NA nucleotide sequences, 5,596 HA nucleotide and 4,702 HA amino acid sequences were analyzed to elucidate the widespread emergence of NA stalk deletions in gallinaceous hosts, the genetic polymorphism of the deletion patterns and association between the stalk deletions in NA and amino acid variants in HA. Forty-seven different NA stalk deletion patterns were identified in six NA subtypes, N1–N3 and N5–N7. An analysis that controlled for phylogenetic dependence due to shared ancestry showed that NA stalk deletions are statistically correlated with gallinaceous hosts and certain amino acid features on the HA protein. Those HA features included five glycosylation sites, one insertion and one deletion. The correlations between NA stalk deletions and HA features are HA-NA-subtype-specific. Our results demonstrate that stalk deletions in the NA proteins of AIV are relatively common. Understanding the NA stalk deletion and related HA features may be important for vaccine and drug development and could be useful in establishing effective early detection and warning systems for the poultry industry

POSIDUNE, Interaction des sables et Posidonia oceanica avec l'environnement des dunes naturelles - Beachmed-e , INTERREG III C

Le sous-projet POSIDUNE du projet Beachmed-e INTERREG III C est un projet pluridisciplinaire qui regroupe des organismes et des institutions de recherche \ue9tudiant les syst\ue8mes naturels de d\ue9fense des cotes: les dunes et les prairies de Posidonia oceanica. En effet, les dunes coti\ue8res et les d\ue9pots de biomasses v\ue9g\ue9tales repr\ue9sentent deux \ue9l\ue9ments importants qui contribuente \ue0 la r\ue9silience et \ue0 l'\ue9quilibre du syst\ue8me plage-dune. Les dunes coti\ue8res constituent une d\ue9fense naturelle de la cote et \ue9galement un habitat de grande valeur naturelle et paysag\ue8re. Les dunes ont des effets positifs sur la plage et en g\ue9n\ue9ral sur l'environnement cotier car elles constituent: 1) une digue pour les eaux, 2) une r\ue9serve de sable qui alimente la plage lors de bilan s\ue9dimentaire n\ue9gatif, 3) une barri\ue8re physique pour prot\ue9ger les territoires situ\ue9s en arri\ue8re. Les actions finalis\ue9es \ue0 la protection des dunes se r\ue9v\ue8lent donc particuli\ue8rment strat\ue9giqies pour la d\ue9fense des littoraux